Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polyurethane material with side chain possessing fluorophosphatidylcholine and its preparation method

A technology of fluorine-containing phosphatidylcholine and polyurethane materials, which is applied in the field of new polyurethane materials and its preparation, can solve the problems of inability to carry out secondary processing, poor compatibility, and limited application fields, and achieve excellent biocompatibility, low Effect of water absorption and ease of migration

Inactive Publication Date: 2005-01-26
SICHUAN UNIV
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

④ Blending of polyurethane and phosphatidylcholine polymer [WO 87 / 02684], but the compatibility of phosphatidylcholine polymer and polyether polyurethane is too poor
Although this composite material has excellent mechanical properties and blood compatibility, it cannot be processed twice, which limits its application fields.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polyurethane material with side chain possessing fluorophosphatidylcholine and its preparation method
  • Polyurethane material with side chain possessing fluorophosphatidylcholine and its preparation method
  • Polyurethane material with side chain possessing fluorophosphatidylcholine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、2、4～9

[0073] At first add the THF / DMAc mixed solvent of volume ratio 1: 5 in a reactor that stirrer, thermometer, reflux device are equipped with, the weight ratio of the amount of its addition and the reactant added is 4: 1, then according to table 1 For the listed formula quantity, add polycarbonate diols or polyether diols with different molecular weights for stirring, and heat up to 50-80°C, then add chain extender HFDEAPC or HFDEAPC and 1,4- For the mixture of butanediol or ethylenediamine, fully stir to dissolve the reactants completely, and finally add diisocyanate according to the formula amount, raise the temperature to 80-100°C, react for 4-6 hours, stop stirring and cool down. That is, a side chain fluorine-containing phosphatidylcholine polyurethane solution with a solid content of about 20% is obtained.

Embodiment 3

[0075] First, add difluorotetrachloroethane / DMF mixed solvent with a volume ratio of 1:3 in a reaction kettle equipped with a stirrer, a thermometer, and a reflux device, and the weight ratio of the amount added to the added reactant is 4:1 , and then according to the formulation amount listed in Table 1, add polyether diol PPG with a molecular weight of 2000 for stirring, and after heating up to 70°C, add chain extender HFDEAPC and 1,4-butanediol according to the formulation amount Stir the mixture fully to dissolve the reactants completely, and finally add isophorone diisocyanate IPDI according to the formula amount, raise the temperature to 90-100°C, react for 5 hours, stop stirring and cool down. That is, a side chain fluorine-containing phosphatidylcholine polyurethane solution with a solid content of about 20% is obtained.

Embodiment 1

[0088] Example 1 22.8±4.1 35.5±0.9 387.8±45.1

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a polyurethane material with side chain possessing fluorophosphatidylcholine and its preparation method, which is prepared through alternating copolymerization of a soft segment composed of polyether dihydroxy alcohol and / or polycarbonate diatomic alcohol and a rigid chain segment formed by diisocyanate and chain expanding agent, characterized in that the copolymer comprises the following repetition structural elements, wherein the partial rigid chain segment side chain contains fluorine-containing phosphatidyl choline groups, whose weight average molecular weight is 30000-60000.

Description

1. Technical field [0001] The invention belongs to the technical field of polymer biomedical materials and their preparation, and in particular relates to a novel polyurethane material with fluorine-containing phosphatidylcholine in a side chain and a preparation method thereof. 2. Background technology [0002] Polyurethane has excellent physical and mechanical properties and good biocompatibility, and has been widely used in the field of biomedical engineering, such as interventional catheters, artificial cardiac pacemakers and total artificial hearts, etc., but there are still some problems. For example, when in contact with blood, although the blood compatibility of polyurethane is better than other materials, there is still thrombus formation on its surface, and during long-term use in the body, it is found that polyurethane will undergo aging degradation and calcification in the body, resulting in cracks in the material , or even completely destroyed. Therefore, the b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/08C08G18/40C08G18/72C08K5/521
Inventor 钟银屏傅强谭鸿李洁华谢兴益何成生樊翠蓉
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com