Penetrating pharmaceutical foam

A technology of foaming and foaming emulsions, which is applied in drug delivery, pharmaceutical formulations, animal repellents, etc. It can solve problems such as not suitable, shaving foam is not easy to break, and active ingredients cannot be administered locally, so as to achieve uniform distribution , the effect of uniform absorption

Inactive Publication Date: 2006-11-01
FOAMIX LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Shaving foams, by definition, are not breakable and thus not conducive to topical administration of active ingredients, especially for topical administration of skin penetrating compositions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0214] Example 1 - Production of Pharmaceutical or Cosmetic Foam Carriers and Compositions - General Method

[0215] A method of preparing a pharmaceutical foam carrier generally includes the following steps.

[0216] Step 1 - Water phase: Dissolve gelling agent and surfactant in water while stirring. The solution was warmed to 50-70°C. Add the water-soluble cosmetic or pharmaceutical active ingredient* and optional water-soluble ingredients to the aqueous mixture while stirring.

[0217] Step 2 - Hydrophobic phase: Heat the hydrophobic solvent to the same temperature. Add the oil-soluble cosmetic or pharmaceutical active ingredient* and optional oil-soluble formulation ingredients to the hydrophobic phase mixture while stirring.

[0218] Step 3 - Gradually pour the warm hydrophobic phase into the warm aqueous phase while stirring, followed by homogenization with Ultraturax. The mixture was allowed to cool to ambient temperature.

[0219] Step 4 - Add the mixture to an ae...

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PUM

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Abstract

The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surface-active agent and a gelling agent. The foam carrier further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Description

field of invention [0001] The present invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surfactant and a gelling agent. The foam carrier further comprises active agents and excipients that provide beneficial therapeutic properties. Background of the invention [0002] Foam products are used for topical application of drugs and cosmetics. Aerosol products, especially foams, have complex physico-chemical structures that do not form under arbitrary circumstances. Precisely, a special balance between the foam-forming components is important. Slight shifts in composition may have led to foam collapse; thus, formulations of per se active substances may not be formulated as foams without further preparation. [0003] The inventors of the present invention have developed a series of novel emulsion-based foam formulations. See eg commonly assigned co-pending application WO 2004 / 037225. [0004] US Patent No. 6...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K8/04A61K8/365A61K8/40A61K8/42A61K31/167A61K31/196A61K31/496A61Q19/00C08J9/00
CPCA61K9/0014A61K9/122A61K47/10A01N25/16A61K8/342A61K8/37A61K8/39A61K8/731A61Q19/00A61K8/046A61K2800/91A01N53/00A61K9/113A61K8/06
Inventor D·塔玛金D·弗里德曼M·艾尼
Owner FOAMIX LTD
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