Noggin-derived peptide and use thereof
A BMP-4, BMP-7 technology, applied in the field of peptides and compositions containing the peptides, can solve the problems of stability and high molecular weight, poor application, high cost and the like
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Synthetic example
[0088] [Synthesis Example: Synthesis of Glu-Leu-Ile-Glu-His-Linker-Arg-Pro-Ala-Asp (SEQ ID NO: 1)]
[0089] 700 mg of chlorotrityl chloride (CTL) resin (Nova Biochem, Cat No. 01-64-0021 ) was put into the reactor and stirred for 3 minutes after adding 10 mL of dichloromethane (MC). After removing the solvent, 10 mL of dimethylformamide (DMF) was added. Then, after stirring for 3 minutes, the solvent was removed again. After adding 10 mL of dichloromethane (DCM) to the reactor, 200 mmol of Fmoc-Asp(tBu)-OH (Bachem, Swiss) and 400 mmol of diisopropylethylamine (DIEA) were added and dissolved well by stirring. After stirring the reaction for 1 h, the mixture was washed and dissolved with methanol and DIEA (2:1) in DCM. After reacting for 10 minutes, the mixture was washed with excess DCM / DMF (1:1). After removing the solvent, 10 mL of DMF was then added and stirred for 3 minutes, and the solvent was removed again. After adding 10 mL of deprotection solution (20% piperidine in...
Embodiment 2
[0110] [Example 2: Preparation of nanopeptides]
[0111] 50 mg of the peptide prepared in Synthesis Example was accurately weighed, and dissolved into 500 mL of distilled water by shaking well. The resulting solution was mixed with 5 g of lecithin, 0.3 mL of sodium oleate, 50 mL of ethanol and a small amount of oil, and the volume was adjusted to 1 L with distilled water. The solution was prepared into 100 nm-sized nanobodies using a microfluorometer under high pressure. Nanobodies were prepared at a final concentration of about 50 ppm, and they were used as ingredients in cosmetics.
preparation example 1
[0112] [Preparation Example 1: Lotion]
[0113] A body lotion containing the peptide nanobody prepared in Example 2 was prepared according to a commonly used method as follows.
[0114] 【Table 2】
[0115] Element
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