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Co-conveying nano composition of phenylethyl resorcinol and preparation method and application of co-conveying nano composition

A technology of phenylethyl resorcinol and nano composition, which is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problem of insignificant whitening effect and phenylethylresorcinol It is easy to cause allergies, high retention, etc., to achieve the effect of increasing skin penetration and retention, no drug leakage, and reducing irritation

Active Publication Date: 2018-11-06
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a kind of phenylethyl resorcinol in order to solve the problems in the prior art that high concentration phenylethylresorcinol is easy to cause allergies and conventional concentration of phenylethylresorcinol cosmetics has no significant whitening effect. Co-transported nanocomposition, phenylethyl resorcinol has a high drug loading capacity, no significant skin irritation, multi-target multi-mechanism whitening and anti-oxidation, good skin permeability, high retention, and good whitening effect

Method used

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  • Co-conveying nano composition of phenylethyl resorcinol and preparation method and application of co-conveying nano composition
  • Co-conveying nano composition of phenylethyl resorcinol and preparation method and application of co-conveying nano composition
  • Co-conveying nano composition of phenylethyl resorcinol and preparation method and application of co-conveying nano composition

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preparation example Construction

[0091] The present invention also provides a preparation method for co-transporting nanocomposites of phenylethylresorcinol described in the above technical solution, comprising the following steps:

[0092] A. Dissolving phenylethyl resorcinol, other water-insoluble whitening active ingredients, emulsifiers, and co-emulsifiers with complex lipids to obtain an oil phase;

[0093] B. Dissolving other water-soluble whitening active ingredients and polyols in water to obtain an aqueous phase;

[0094] C. Mix and emulsify the oil phase obtained in step A with the water phase obtained in step B, and micronize to obtain a micron-scale dispersion;

[0095] D, the micron-scale dispersion obtained in step C is subjected to nano-processing to obtain a nano-scale dispersion, which is a co-transport nanocomposite of phenylethyl resorcinol;

[0096] There is no sequence between the steps A and B.

[0097] According to the water solubility of other whitening active ingredients, the presen...

Embodiment 1

[0115] 4.0% polyoxyethylene sorbitan fatty acid ester, 1.0% polyoxyethylene castor oil, 25.0% 1,3-propylene glycol, 3.0% hydrogenated polydecene, 0.1% phenylethyl resorcinol, 5.0% papaya Protease and 0.4% phloretin were stirred and dissolved in a water bath at 40°C to obtain an oil phase, which was set aside;

[0116] Stir and dissolve 0.1% heparin sodium, 0.1% vitamin C ethyl ether, 0.05% allantoin, 0.05% carnosine, 5.0% glycerin and 59.29% water in a water bath at 40°C to obtain an aqueous phase for later use;

[0117] After the oil phase and the water phase are obtained, add the oil phase to the water phase at a rate of 1 drop / second under the condition of a water bath at 40°C, and control the stirring rate at 15 rpm during the dropping process. Shear emulsification for 1min to make a micron-sized dispersion;

[0118] The micron-scale dispersion was subjected to high-pressure homogenization treatment under the condition of a pressure of 1200 bar, and the circulation was pe...

Embodiment 2

[0121] 15.0% polyoxyethylene castor oil, 2.0% polyoxyethylene hydrogenated castor oil, 7.0% 1,2-hexanediol, 3.0% isopropyl myristate, 1.0% phenylethyl resorcinol, 0.5% licorice Subacid, 1.0% curcumin, and 2.0% salicylic acid were stirred and dissolved in a water bath at 45°C to obtain an oil phase, which was set aside;

[0122] Stir and dissolve 6.0% nicotinamide, 6.0% vitamin C ethyl ether, 10.0% glycerin and 46.5% water in a water bath at 45°C to obtain an aqueous phase for later use;

[0123] After the oil phase and the water phase are obtained, add the oil phase to the water phase at a rate of 2 drops / second under the condition of a water bath at 45°C, and control the stirring rate at 10 rpm during the dropping process. Shear emulsification for 3 minutes to make a micron-scale dispersion;

[0124] The micron-scale dispersion was subjected to high-pressure homogenization treatment under the condition of a pressure of 1000 bar, and the circulation was repeated twice to obta...

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Abstract

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a co-delivery nano composition of phenylethyl resorcinol and its preparation method and application. Background technique [0002] Healthy and fair skin is the focus of most women's attention. Oriental women have always advocated the whitening effect of "skin like snow, condensed like fat". However, the current whitening skin care products on the market generally have the following problems: [0003] 1. Single whitening mechanism: most products only target one melanin formation and transfer mechanism, and cannot achieve full-effect whitening; [0004] 2. Poor product stability: When making most whitening products on the market, whitening ingredients are directly added to the formula, which can easily lead to discoloration and odor change of the product, and even layering and thickening of the paste; [0005] 3. Low whitening efficiency: Due to the skin's own barrier, it is difficult fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/11A61Q19/02A61Q19/08A61Q19/00
CPCA61K8/11A61K8/347A61K2800/10A61K2800/592A61K2800/782A61Q19/00A61Q19/02A61Q19/08
Inventor 刘卫陈家铃吴培诚吴航航郭赛红闻庆
Owner WUHAN BEST CARRIER NANO TECH
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