24 results about "Pimelic acid" patented technology

This invention relates to the field of polymer materials technology, specifically to a modified sealing material based on polyphenylene sulfide (PPS) and its preparation method. This invention overcomes the problems of poor mechanical properties and poor thermal stability of existing sealing materials. In this application, PPS resin, nano-hexagonal boron nitride, calcium pimecronate, and a composite antioxidant are mixed to obtain a premix. This premix, PPS-grafted maleic anhydride, modified silica fume, and modified glass fiber are added stepwise through a twin-screw extruder, followed by extrusion granulation. Finally, variable mold temperature injection molding is used, with the mold temperature rising and then rapidly cooled during the filling stage to obtain the modified sealing material. This invention constructs a microscopic synergistic reinforcing network through a flexible polydopamine layer and a rigid inorganic phase, supplemented by rapid heating and cooling injection molding to eliminate residual internal stress and induce uniform and rapid crystallization of PPS, significantly improving the mechanical strength, fatigue life, and thermal stability of the molded part.

The invention discloses a wound repair material and a preparation method thereof, and relates to the technical field of medical materials. The wound repair material is prepared from the following raw materials in parts by weight: 50 to 60 parts of bioactive glass, 15 to 30 parts of chitosan, 10 to 20 parts of functional materials and 300 to 450 parts of deionized water. The preparation method comprises the following steps: reacting oleamide propyl dimethylamine with 4-chlorobutanol to generate an intermediate 1, reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate an intermediate 2, and reacting the intermediate 2 with 4, 4 '-{[6-((1-carboxyl-2-mercaptoethyl) amino)-1, 3, 5-triazine-2, 4-diyl] bis (nitrounit)} bis [4-(2-carboxyethyl) pimelic acid] under the action of a photoinitiator to generate the functional material. The wound repair material prepared by the invention has excellent antibacterial property and hemostatic property.

The invention discloses a display protective film and a preparation method thereof, and relates to the technical field of film materials. When the display protective film is prepared, nano silicon dioxide is sequentially reacted with 2-(p-aminophenyl) ethyltriethoxysilane, 1-pyrazole methanol and zinc chloride to prepare modified nano silicon dioxide; the preparation method comprises the following steps: polymerizing ethylene glycol, dimethyl terephthalate, dimethyl phosphonite and dimethyl 4-pyridyl-4-pimelate to prepare polyester; the preparation method comprises the following steps: reacting polyester with 1-bromohexane to prepare modified polyester; and mixing the modified polyester, the modified nano silicon dioxide and a reversible cross-linking agent, and carrying out melt extrusion, sheet casting and two-way stretching to obtain the display protection film. The prepared display protective film has excellent antibacterial, self-repairing and mechanical properties.

A diaminopimelate dehydrogenase mutant and a use in D-amino acid synthesis. A diaminopimelate dehydrogenase mutant obtained by performing molecular modification on a Bacillus thermozeamaize diaminopimelate dehydrogenase, a nucleic acid encoding the diaminopimelate dehydrogenase mutant, a recombinant expression vector containing the nucleic acid, a recombinant expression transformant containing the recombinant expression vector, and a use of the diaminopimelate dehydrogenase mutant in the synthesis of a D-amino acid by means of the asymmetric reductive amination of a 2-keto acid. Compared with other D-biphenylalanine synthesis methods, the present invention has a simple route, a high theoretical yield, good atom economy, and a product optical purity of more than 99%. Therefore, the present invention relates to an environmentally-friendly, highly-stereoselective and green biological synthesis method, and has good prospects for application in actual production of D-biphenylalanine and other D-amino acids.

The application relates to the field of polypropylene materials, in particular to a high-rigidity low-warp polypropylene material for automobile structural parts and a preparation method thereof. The polypropylene material comprises the following components calculated in parts by mass: 50-65 parts of polypropylene resin, 10-15 parts of talcum powder, 2-5 parts of a compatilizer, 0.2-0.6 parts of an antioxidant, 0.5-1.5 parts of a lubricant, and 15-30 parts of modified glass fiber. The modified glass fiber is alkali-free chopped glass fiber grafted with a beta nucleating agent, and the beta nucleating agent comprises one or more of metal glutarate, metal pimelate, metal adipate, metal terephthalate and metal phthalate. By adding the modified glass fiber grafted with the beta nucleating agent, the warp deformation of the polypropylene material caused by the anisotropic distribution of the glass fiber is improved, the assembly precision of the automobile structural parts is met, and excellent rigidity is simultaneously achieved.

The invention relates to a biodegradable hollow plate master batch and a preparation process thereof. The biodegradable hollow plate master batch is prepared from the following raw materials in parts by weight: 30-50 parts of a first monomer; 5-30 parts of a second monomer; 3-20 parts of a third monomer; 2 to 12 parts of biomass filler; the first monomer is one of a cyclohexane dibasic alcohol compound, a polyester copolymer, organic acid esters, aromatic polyester and the like, and the second monomer is one of a dicarboxylic acid compound, succinic acid and the like; the dicarboxylic acid compound comprises adipic acid and pimelic acid. According to the invention, a first monomer is a cyclohexanediyl alcohol compound, the cyclohexanediyl alcohol compound is 1, 4-cyclohexanedimethanol, and a second monomer is succinic acid; the third monomer is polyethylene glycol terephthalate and has the characteristics of transparency, toughness, chemical corrosion resistance and the like, the mechanical property, the degradation property and the environmental friendliness of the material are practically balanced, and a material-level solution is provided for sustainable development.

The application belongs to the technical field of medicines, and particularly relates to a pirfenidone co-crystal, a preparation method thereof, a pharmaceutical composition and application. The pirfenidone co-crystal is prepared from pirfenidone and a co-crystal ligand, and the co-crystal ligand is selected from one of heptanedioic acid, cinnamic acid and saccharin. The pirfenidone co-crystal can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a wound repairing material and a preparation method thereof, and relates to the technical field of medical materials. The wound repairing material comprises the following raw materials in parts by weight: 50-60 parts of bioactive glass, 15-30 parts of chitosan, 10-20 parts of functional material, and 300-450 parts of deionized water. The intermediate 1 is generated by the reaction of oleamide propyl dimethylamine and 4-chlorobutanol, the intermediate 2 is generated by the reaction of the intermediate 1 and 5,10,15,20-tetra(4-carboxyphenyl)porphyrin, and the functional material is generated by the reaction of the intermediate 2 and 4,4'-{[6-((1-carboxyl-2-mercaptoethyl)amino)-1,3,5-triazine-2,4-diyl]bis(nitrene)}bis[4-(2-carboxyethyl)heptanedioic acid] under the action of a photoinitiator. The wound repairing material prepared by the application has excellent antibacterial performance and hemostatic performance.

The invention discloses a metal ion complex for inhibiting urease and / or nitration and a preparation method thereof, the general molecular formula of the structure is M (DEP) (phen), M is a metal ion, DEP is diethyl pimelate, and phen is phenanthroline. Diethyl pimelate and phenanthroline are selected as ligands, preparation work is carried out through a multidentate coordination method, the technology is simple, the preparation difficulty is low, urease performance is remarkably inhibited, the degradation speed of urea can be effectively slowed down, the loss amount of nitrogen in soil is reduced, then the utilization rate of the nitrogen is increased, and favorable conditions are created for crop growth; the fertilizer can effectively reduce the conversion process from ammonium nitrogen to nitrate nitrogen in soil, reduces the nitrogen discharge amount in the fertilizer release process, is environment-friendly, and can improve the absorption efficiency of fertilizer nutrients.

To provide methods and systems to decompose contaminated plastic waste and transform it into value-added products.SOLUTION: A method for decomposing contaminated plastic waste comprises the steps of: (a) adding contaminated plastic waste to a reaction vessel; (b) adding aqueous nitric acid (HNO3) to the reaction vessel to give a mixture, wherein the weight ratio of plastic waste to aqueous nitric acid is greater than 1:3; and (c) subjecting the mixture obtained in (b) to conditions effective to decompose the plastic waste to produce decomposition products, wherein the decomposition products comprise: (i) succinic acid, glutaric acid, adipic acid, pimelic acid, and azelaic acid, and (ii) at least one of C8 to C20 dicarboxylic acid substituted with a single nitro group, or the salts or esters thereof.SELECTED DRAWING: None

The invention relates to the field of polypropylene materials, in particular to a high-rigidity low-warpage polypropylene material for automobile structural parts and a preparation method of the high-rigidity low-warpage polypropylene material. The polypropylene material comprises the following components in parts by mass: 50-65 parts of polypropylene resin; 10 to 15 parts of talcum powder; 2 to 5 parts of compatilizer; 0.2 part to 0.6 part of an antioxidant; 0.5 to 1.5 parts of a lubricant; 15 to 30 parts of modified glass fiber; wherein the modified glass fiber is alkali-free chopped glass fiber grafted with a beta nucleating agent, and the beta nucleating agent comprises one or more of glutaric acid metal salt, pimelic acid metal salt, adipic acid metal salt, terephthalic acid metal salt and phthalic acid metal salt. By adding the modified glass fiber with the surface grafted with the beta nucleating agent, buckling deformation, caused by anisotropic distribution of the glass fiber, of the polypropylene material is improved, the assembly precision of automobile structural parts is met, and meanwhile the excellent rigidity is achieved.

A gold-based alloy solder paste with good dispensing performance, comprising, in mass percentage, 87-93% of gold-based alloy powder, the gold-based alloy powder containing 75-90% of gold; and 7-13% of flux, the flux mainly comprising modified rosin, organic solvent, active agent and thixotropic agent; the modified rosin being hydrogenated rosin and polymerized rosin; the organic solvent being two or more of ethylene glycol, glycerol, isopropyl alcohol, diethylene glycol ethyl ether, propylene glycol methyl ether or dipropylene glycol butyl ether; the active agent being one or more of acetic acid, glutaric acid, o-hydroxybenzoic acid, pimelic acid and heptanedioic acid; and the thixotropic agent being ethylene bis-stearamide and modified fatty acid amide resin; the gold-based alloy solder paste prepared by the application is free of halogen, easy to clean, low in oxygen content, has bright solder joints and high expansion rate, can realize continuous dispensing, and is applied to the field of high-reliability electronic packaging.

The invention discloses a novel binuclear chiral catalyst for preparing S-epichlorohydrin with high optical purity as well as a synthesis method and an application method of the novel binuclear chiral catalyst. The molecular formula of the catalyst is [Co2L (Y) 2]. NH2O, L is a Salen tetradentate ligand formed by condensation of (R, R)-1, 2-cyclohexanediamine, 3-tert-butyl-2, 5-dihydroxybenzaldehyde and 4-oxa-1, 7-pimelic acid, and Y is a sulfonate radical or an acetate radical. The preparation method comprises the following steps: carrying out acidic hydrolysis on 2-cyanoethyl ether to obtain 4-oxa-1, 7-pimelic acid; 2-tert-butylhydroquinone is subjected to protection, formylation and deprotection, and benzaldehyde is prepared; carrying out condensation on the Salen ligand and (R, R)-1, 2-cyclohexanediamine to generate dialdehyde, and cyclizing the dialdehyde with (R, R)-1, 2-cyclohexanediamine to obtain a Salen ligand; and finally, complexing with cobalt acetate and acid under nitrogen to separate out a catalyst crystal. When the catalyst is used for epoxy chloropropane water-phase resolution and gas-phase detection, the reaction is terminated when ee is greater than or equal to 99.5%, the catalyst is directly filtered and recovered, the S-epoxy chloropropane is obtained through reduced pressure distillation, the ee is still greater than or equal to 99.0% after the catalyst is circulated for five times, and the recovery rate is greater than or equal to 92%.

The present invention relates to the field of pharmaceutical technology, and particularly, to a pirfenidone co-crystal and a method for preparing same, a pharmaceutical composition, and use thereof. The pirfenidone co-crystal provided in the present invention is prepared from pirfenidone and a co-crystal ligand selected from one of pimelic acid, cinnamic acid, and saccharin. The pirfenidone co-crystal provided in the present invention can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a kind of polypropylene microcellular foaming material with high beta crystal content and a preparation method thereof.The nano calcium carbonate or partially organicized nano calcium-based montmorillonite is mixed with pimelic acid to obtain nano-particle loaded calcium pimelate, then polypropylene resin and nano-particle loaded calcium pimelate are mixed, extruded, granulated, and molded to obtain a sample to be foamed, the sample to be foamed is sealed in an autoclave, and a two-step temperature control foaming is used to obtain a polypropylene microcellular foaming material with high beta crystal content.The polypropylene microcellular foaming material prepared by the method has stable cell quality and a beta crystal content of more than 50%.

A thermoplastic molding composition comprising at least one thermoplastic polyamide, as com-ponent A; red phosphorous, as component B; at least one fibrous and / or particulate filler, as component C; and wherein component A comprises at least one polyamide of A1) units derived from 1, 5-pentanediamine as component A1; A2) units derived from at least one aliphatic dicarboxylic acid, preferably selected from the group consisting of adipic acid, succinic acid, glutaric acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, tridecanedioic acid, tetradecanedioic acid, pentadecanedioic acid, hexadecanedioic acid, heptadecanedioic acid, and octadecanedioic acid, as component A2; A3) units derived from at least one aromatic dicarboxylic acid, preferably selected from the group consisting of terephthalic acid, isophthalic acid, and phthalic acid, as component A3; wherein the molar ratio of component A1 to the sum of components A2 and A3 is 1-1.05 to 0.95; a process for preparing of the inventive thermoplastic molding composition; the use of the in-ventive thermoplastic molding composition for producing fibers, foils or moldings; and fibers, foils or moldings comprising the inventive thermoplastic molding composition.

The invention discloses a production method of a BOPP capacitor film. The capacitor film comprises an upper surface layer, a base layer and a lower surface layer, the upper surface layer is composed of PP, boron nitride, a cycloolefin polymer, calcium pimelate, paraffin and an antioxidant; the base layer is prepared from PP, low-molecular-weight polybutylene, chopped glass fibers, pimelic acid modified oyster shell powder and a coupling agent; the lower surface layer is composed of PP, magnesium salt whiskers, liquid ethylene propylene diene monomer and kaolin. The capacitor film prepared by the invention has relatively good mechanical properties and heat resistance.

The invention relates to the technical field of essence, and particularly discloses an ester compound with fresh fruit fragrance and a preparation method thereof. The chemical name of the prepared compound is 4-methoxycarbonyl-4-carbobenzoxycarbonyl-1, 7-dimethyl pimelate, and the compound provided by the invention has a fresh citrus fruity fragrance and a little fresh flower sweet fragrance, is elegant in fragrance and long in fragrance holding time, and has important application in the field of daily chemical flavoring.

The invention relates to a novel tizanidine salt and a preparation method thereof, and belongs to the technical field of pharmaceutical chemicals. The novel tizanidine salt is obtained by selecting low-corrosivity and weak-acidity organic carboxylic acid as a ligand through a cooling crystallization or solvent evaporation crystallization mode. Wherein the organic carboxylic acid is selected from salicylic acid, p-hydroxybenzoic acid, maleic acid and pimelic acid. The formed tizanidine salicylate is in a P21 / n space group of a monoclinic system; the tizanidine p-hydroxybenzoate is an orthorhombic crystal system and has a Pbcn space group; the alpha crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the beta crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the tizanidine pimelate is an orthorhombic crystal system and has a Pna21 space group. The dissolution rate and the inherent dissolution rate of the tizanidine are improved in a mode of forming salt through crystal engineering, the obtained novel tizanidine salt has good stability, the bioavailability of the tizanidine is improved so that the tizanidine salt can give full play to the curative effect, the preparation condition is mild, the reproducibility is good, and large-scale production is easy to realize.

The application belongs to the technical field of polymer materials, and particularly relates to a PP-R cold and hot water pipe and a preparation method thereof. The PP-R cold and hot water pipe provided by the application comprises PP-R resin, composite nucleating agent, impact agent, filler, gamma-aminopropyl triethoxysilane, polyvinyl alcohol, antioxidant and color masterbatch. The reaction product of benzoic anhydride and p-phenylenediamine is reacted with cerium nitrate to generate a diamide carboxylate, which is compounded with calcium pimelate to form a beta nucleating agent, so that the low-temperature plasticity of the PP-R cold and hot water pipe is improved. The low-impact polypropylene is used to wrap modified nano zeolite powder as the impact agent, so that the impact resistance and high-temperature performance of the PP-R cold and hot water pipe are improved. The cooling rate of the PP-R cold and hot water pipe after extrusion molding is controlled, and heat preservation treatment is performed, so that the internal stress of the PP-R cold and hot water pipe is effectively eliminated, and the beta crystal content and crystallization ability are improved. The carbon nanofiber and nano silicon dioxide are selected to jointly form the filler, so that the mechanical properties of the PP-R cold and hot water pipe are improved.

This invention discloses a compound containing diacylpropidine, its preparation method, and its applications. Remdesivir, acyclovir, vidarabine, and stavudine, along with succinic anhydride, are reacted in dichloromethane to obtain an intermediate containing a monocarboxylic acid; or remdesivir, acyclovir, vidarabine, and stavudine, along with pimelic acid, are condensed in EDC·HCl to obtain an intermediate containing a monocarboxylic acid; a diacylpropidine-containing linker is then condensed with the intermediate containing the monocarboxylic acid in EDC·HCl to obtain a compound containing diacylpropidine. This compound can form covalent bonds with target proteins, achieving irreversible binding, providing a new mechanism of action and binding mode, improving the binding efficacy and duration of action of small molecule inhibitors, and enhancing the intensity and duration of drug action.

The application belongs to the technical field of bio-chemical industry, and particularly relates to D-amino acid dehydrogenase mutants and application thereof in synthesis of chiral D-amino acids. In order to obtain D-amino acid dehydrogenase mutants with better catalytic performance, meso-diaminopimelic acid dehydrogenase from Symbiobacterium thermophilum is reformed by using a two-round fast evolution strategy based on Rosetta software, and D-amino acid dehydrogenase mutants capable of efficiently catalyzing reductive amination of various alpha-keto acid substrates to generate corresponding D-amino acids are obtained. The D-amino acid dehydrogenase mutants obtained by the application have high catalytic activity, wide substrate spectrum and strict stereoselectivity, and can be used for biological catalytic synthesis of various high-value chiral D-amino acids, with a highest substrate concentration of 0.5M, a substrate conversion rate of >99%, and an ee value of >99%, and have high practical application value.

This invention relates to the field of papermaking technology, specifically disclosing a method for preparing high-strength antibacterial eco-paper. The method comprises bleached hardwood pulp, bleached softwood pulp, biodegradable polyester fiber powder, inorganic silver ion antibacterial agent, and water. The steps include: S1 preparing an intermediate by reacting 2,6-diaminopimelic acid with a silane coupling agent HK-560, then esterifying and polycondensing it with prepolymer PLA and prepolymer PBAT, followed by melt spinning to obtain biodegradable polyester fiber; S2 soaking and mixing bleached hardwood pulp and bleached softwood pulp to obtain mixed pulp; S3 subjecting the mixed pulp to descaling treatment; S4 obtaining a finely ground mixed pulp via a disc mill; S5 adding biodegradable polyester fiber powder, followed by paper forming, pressing, dewatering, and two-stage drying to obtain eco-paper. This invention introduces chemically cross-linkable biodegradable polyester fiber powder into the paper, forming a composite cross-linked structure of hydrogen bonds and covalent bonds. This improves the mechanical properties and structural stability of the paper while also providing biodegradability, combining practicality and environmental friendliness.

The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX− is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fatty acids, acidic amino acids, keto acids and aromatic carboxylic acids, m is an integer number comprised between 1 and 22, n is comprised between 2 and 20.