12 results about "Pimelic acid" patented technology

This invention relates to the field of polymer materials technology, specifically to a modified sealing material based on polyphenylene sulfide (PPS) and its preparation method. This invention overcomes the problems of poor mechanical properties and poor thermal stability of existing sealing materials. In this application, PPS resin, nano-hexagonal boron nitride, calcium pimecronate, and a composite antioxidant are mixed to obtain a premix. This premix, PPS-grafted maleic anhydride, modified silica fume, and modified glass fiber are added stepwise through a twin-screw extruder, followed by extrusion granulation. Finally, variable mold temperature injection molding is used, with the mold temperature rising and then rapidly cooled during the filling stage to obtain the modified sealing material. This invention constructs a microscopic synergistic reinforcing network through a flexible polydopamine layer and a rigid inorganic phase, supplemented by rapid heating and cooling injection molding to eliminate residual internal stress and induce uniform and rapid crystallization of PPS, significantly improving the mechanical strength, fatigue life, and thermal stability of the molded part.

The invention discloses a wound repair material and a preparation method thereof, and relates to the technical field of medical materials. The wound repair material is prepared from the following raw materials in parts by weight: 50 to 60 parts of bioactive glass, 15 to 30 parts of chitosan, 10 to 20 parts of functional materials and 300 to 450 parts of deionized water. The preparation method comprises the following steps: reacting oleamide propyl dimethylamine with 4-chlorobutanol to generate an intermediate 1, reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate an intermediate 2, and reacting the intermediate 2 with 4, 4 '-{[6-((1-carboxyl-2-mercaptoethyl) amino)-1, 3, 5-triazine-2, 4-diyl] bis (nitrounit)} bis [4-(2-carboxyethyl) pimelic acid] under the action of a photoinitiator to generate the functional material. The wound repair material prepared by the invention has excellent antibacterial property and hemostatic property.

The invention discloses a display protective film and a preparation method thereof, and relates to the technical field of film materials. When the display protective film is prepared, nano silicon dioxide is sequentially reacted with 2-(p-aminophenyl) ethyltriethoxysilane, 1-pyrazole methanol and zinc chloride to prepare modified nano silicon dioxide; the preparation method comprises the following steps: polymerizing ethylene glycol, dimethyl terephthalate, dimethyl phosphonite and dimethyl 4-pyridyl-4-pimelate to prepare polyester; the preparation method comprises the following steps: reacting polyester with 1-bromohexane to prepare modified polyester; and mixing the modified polyester, the modified nano silicon dioxide and a reversible cross-linking agent, and carrying out melt extrusion, sheet casting and two-way stretching to obtain the display protection film. The prepared display protective film has excellent antibacterial, self-repairing and mechanical properties.

The application belongs to the technical field of medicines, and particularly relates to a pirfenidone co-crystal, a preparation method thereof, a pharmaceutical composition and application. The pirfenidone co-crystal is prepared from pirfenidone and a co-crystal ligand, and the co-crystal ligand is selected from one of heptanedioic acid, cinnamic acid and saccharin. The pirfenidone co-crystal can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a wound repairing material and a preparation method thereof, and relates to the technical field of medical materials. The wound repairing material comprises the following raw materials in parts by weight: 50-60 parts of bioactive glass, 15-30 parts of chitosan, 10-20 parts of functional material, and 300-450 parts of deionized water. The intermediate 1 is generated by the reaction of oleamide propyl dimethylamine and 4-chlorobutanol, the intermediate 2 is generated by the reaction of the intermediate 1 and 5,10,15,20-tetra(4-carboxyphenyl)porphyrin, and the functional material is generated by the reaction of the intermediate 2 and 4,4'-{[6-((1-carboxyl-2-mercaptoethyl)amino)-1,3,5-triazine-2,4-diyl]bis(nitrene)}bis[4-(2-carboxyethyl)heptanedioic acid] under the action of a photoinitiator. The wound repairing material prepared by the application has excellent antibacterial performance and hemostatic performance.

The present invention relates to the field of pharmaceutical technology, and particularly, to a pirfenidone co-crystal and a method for preparing same, a pharmaceutical composition, and use thereof. The pirfenidone co-crystal provided in the present invention is prepared from pirfenidone and a co-crystal ligand selected from one of pimelic acid, cinnamic acid, and saccharin. The pirfenidone co-crystal provided in the present invention can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a kind of polypropylene microcellular foaming material with high beta crystal content and a preparation method thereof.The nano calcium carbonate or partially organicized nano calcium-based montmorillonite is mixed with pimelic acid to obtain nano-particle loaded calcium pimelate, then polypropylene resin and nano-particle loaded calcium pimelate are mixed, extruded, granulated, and molded to obtain a sample to be foamed, the sample to be foamed is sealed in an autoclave, and a two-step temperature control foaming is used to obtain a polypropylene microcellular foaming material with high beta crystal content.The polypropylene microcellular foaming material prepared by the method has stable cell quality and a beta crystal content of more than 50%.

The invention relates to the technical field of essence, and particularly discloses an ester compound with fresh fruit fragrance and a preparation method thereof. The chemical name of the prepared compound is 4-methoxycarbonyl-4-carbobenzoxycarbonyl-1, 7-dimethyl pimelate, and the compound provided by the invention has a fresh citrus fruity fragrance and a little fresh flower sweet fragrance, is elegant in fragrance and long in fragrance holding time, and has important application in the field of daily chemical flavoring.

The invention relates to a novel tizanidine salt and a preparation method thereof, and belongs to the technical field of pharmaceutical chemicals. The novel tizanidine salt is obtained by selecting low-corrosivity and weak-acidity organic carboxylic acid as a ligand through a cooling crystallization or solvent evaporation crystallization mode. Wherein the organic carboxylic acid is selected from salicylic acid, p-hydroxybenzoic acid, maleic acid and pimelic acid. The formed tizanidine salicylate is in a P21 / n space group of a monoclinic system; the tizanidine p-hydroxybenzoate is an orthorhombic crystal system and has a Pbcn space group; the alpha crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the beta crystal form of the tizanidine maleate is a P21 / c space group of a monoclinic system; the tizanidine pimelate is an orthorhombic crystal system and has a Pna21 space group. The dissolution rate and the inherent dissolution rate of the tizanidine are improved in a mode of forming salt through crystal engineering, the obtained novel tizanidine salt has good stability, the bioavailability of the tizanidine is improved so that the tizanidine salt can give full play to the curative effect, the preparation condition is mild, the reproducibility is good, and large-scale production is easy to realize.

This invention discloses a compound containing diacylpropidine, its preparation method, and its applications. Remdesivir, acyclovir, vidarabine, and stavudine, along with succinic anhydride, are reacted in dichloromethane to obtain an intermediate containing a monocarboxylic acid; or remdesivir, acyclovir, vidarabine, and stavudine, along with pimelic acid, are condensed in EDC·HCl to obtain an intermediate containing a monocarboxylic acid; a diacylpropidine-containing linker is then condensed with the intermediate containing the monocarboxylic acid in EDC·HCl to obtain a compound containing diacylpropidine. This compound can form covalent bonds with target proteins, achieving irreversible binding, providing a new mechanism of action and binding mode, improving the binding efficacy and duration of action of small molecule inhibitors, and enhancing the intensity and duration of drug action.

This invention relates to the field of papermaking technology, specifically disclosing a method for preparing high-strength antibacterial eco-paper. The method comprises bleached hardwood pulp, bleached softwood pulp, biodegradable polyester fiber powder, inorganic silver ion antibacterial agent, and water. The steps include: S1 preparing an intermediate by reacting 2,6-diaminopimelic acid with a silane coupling agent HK-560, then esterifying and polycondensing it with prepolymer PLA and prepolymer PBAT, followed by melt spinning to obtain biodegradable polyester fiber; S2 soaking and mixing bleached hardwood pulp and bleached softwood pulp to obtain mixed pulp; S3 subjecting the mixed pulp to descaling treatment; S4 obtaining a finely ground mixed pulp via a disc mill; S5 adding biodegradable polyester fiber powder, followed by paper forming, pressing, dewatering, and two-stage drying to obtain eco-paper. This invention introduces chemically cross-linkable biodegradable polyester fiber powder into the paper, forming a composite cross-linked structure of hydrogen bonds and covalent bonds. This improves the mechanical properties and structural stability of the paper while also providing biodegradability, combining practicality and environmental friendliness.

The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX− is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fatty acids, acidic amino acids, keto acids and aromatic carboxylic acids, m is an integer number comprised between 1 and 22, n is comprised between 2 and 20.