45 results about "2-cyclohexenone" patented technology

The invention provides a method for preparing 3,3,5-trimethyl-cyclohexanone by selectively hydrogenating isophorone (namely 3,3,5-trimethyl-2- cyclohexenone). The method comprises the step of selectively hydrogenating to reduce isophorone into 3,3,5-trimethyl-cyclohexanone through combined use of supported Pd or Pt catalyst and co-catalyst under the condition that the reaction temperature is 20-100 DEG C. The method is remarkably characterized in that the byproduct 3,3,5-trimethyl-cyclohexanol is inhibited by adding the preferred cocatalyst, so that the product 3,3,5-trimethyl-cyclohexanone has relatively high selectivity and yield on the premise of realizing the high conversion rate of the isophorone under a relatively mild condition.

A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase, a 4-acetylbutyrate dehydratase, a 3-hydroxycyclohexanone dehydrogenase, a 2-cyclohexenone hydratase, a cyclohexanone dehydrogenase and an enzyme selected from a 3-oxopimeloyl-CoA synthetase, a 3-oxopimeloyl-CoA hydrolase (acting on thioester), and a 3-oxopimeloyl-coA transferase. Each these pathways can include a PEP carboxykinase. A method for producing cyclohexanone includes culturing these non-naturally occurring microbial organisms.

The invention relates to a new use of a compound. In the invention, (4-hydroxy-2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone is obtained from extract of Antrodia camphorata by separation and purification, and the cyclohexenone compound can be used for suppressing the growth of lymphoma tumor cells and can also be used in medical composition for suppressing the growth of the lymphoma tumor cells.

The invention relates to a new use of a compound, and a medical composition for inhibiting growth of oral cancer tumor cells. A antrodia cinnamomea extract is subjected to separating and purifying to prepare 4-hydroxy-2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone. The pimelie kelone compound can be provided for inhibiting the growth of the oral cancer tumor cells. Meanwhile, the pimelie kelone compound can be provided for preparing the medical composition for inhibiting the growth of the oral cancer tumor cells.

The invention discloses a method for preparing 2-cyclohexenone compound, which comprises the following steps: under the action of a metallic catalyst MYn.L, 1, 6-heptadiyne compound showed in formula (I) taken as a raw material is reacted in an ionic liquid at a temperature of between 0 and 150 DEG C; after the reaction liquid is treated, the 2-cyclohexenone compound showed in formula (II) is prepared; and at the same time, the ionic liquid fixed with the metallic catalyst can be recycled. The method has the advantages of simple and reliable operation, high yield and selectivity, repeated recycling and use of the noble metal catalyst, environmental protection, and the like. Because the cyclohexenone compound is a good raw material for synthesizing medicines, pesticides and chemical products, the method has wide industrial application prospect.

The invention relates to a new purpose of a compound. In the invention, antrodia camphorata extract is separated and purified to obtain 4-hydroxy-2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone. The cyclohexenone compound can be used for inhibiting growth of pancreatic cancer tumor cells and simultaneously can be used for pharmaceutical compositions for inhibiting growth of pancreatic cancer tumor cells.

The invention discloses a new compound and the usage, in particular to a 4-hydroxy-2, 3- dimethoxy -6-methyl-5 (3, 7, 11- trimethyl-2, 6, 10-dodecatrien) -2- cyclohexenone (4-hydroxy- 2, 3-dimethoxy -6- methy-5 (3, 7, 11-trimethyl -dodeca-2, 6, 10- trienyl) -cyclohex-2-enone) separated from antrodia camphorate extract and the application in inhibiting the growth of tumor cell. The new compound isfirstly seen in antrodia camphorate. The 4-hydroxy-2, 3- dimethoxy -6-methyl-5 (3, 7, 11- trimethyl-2, 6, 10-dodecatrien) -2- cyclohexenone (4-hydroxy- 2, 3-dimethoxy -6- methy-5 (3, 7, 11-trimethyl -dodeca-2, 6, 10- trienyl) -cyclohex-2-enone) separated from antrodia camphorate extract and the application in inhibiting the growth of tumor cell has the advantages of inhibiting the growth of breast cancer, liver cancer and prostate cancer tumor cell, being a component of drug combination inhibiting the growth of the tumor cell at the same time or further being applied in preventing cardiovascular disease or being added into healthy food by right of antioxidant activity.

The present invention relates to synthesis process of 4-(1, 5-dimethyl-1-vinyl-4-hexenyl) phenol, normally named as antifeedant, and the synthesis process is superior to available ones. The synthesis process has geraniol as main material and includes the reaction with vinyl ethyl ether to 3-vinyl-rhodinal, condensation with formaldehyde to obtain 3, 7-dimethyl-2-methylene-3-vinyl-6-octenyl aldehyde, conjugate addition with ethyl acetyl acetate, cyclization and condensation to 4-(1, 5-dimethyl-1-vinyl-4-hexenyl)-2-cyclohexene ketone, and dehydrogenation to obtain the product 4-(1, 5-dimethyl-1-vinyl-4-hexenyl) phenol. The present invention uses natural product as main material, and has simple reaction process, high selectivity and high yield.

The invention relates to a method for synthesizing an astaxanthin intermediate. The method specifically comprises the following steps: 1) adding lithium into liquid ammonia to implement a reaction, introducing acetylene to synthesize acetylene-based lithium, replacing the liquid ammonia with an organic solvent, and adding 1-butene-3-ketone to implement a reaction continuously, so as to generate 3-methyl-1-amylene-4-alkyne-3-lithium alkoxide; 2) adding lithium into the liquid ammonia to implement a reaction, and further adding the product obtained in the step 1) to generate 3-methyl-1-amylene-4-alkynyl based lithium-3-lithium alkoxide; 3) performing a condensation reaction on the product obtained in the step 2) with heterogeneous diketone so as to generate a condensation compound; 4) performing acid hydrolysis on the condensation compound obtained in the step 3), and treating with a reduction triple bond so as to obtain 2,4,4-trimethyl-6-hydroxy-3-(3-methyl-1,4-dipentene-3-hydroxy)-2-cyclohexenone; 5) enabling 2,4,4-trimethyl-6-hydroxy-3-(3-methyl-1,4-dipentene-3-hydroxy)-2-cyclohexenone to react with hydrobromic acid and triphenylphosphine in sequence, thereby finally generating the astaxanthin intermediate. By adopting the method, multiple times of introduction and repeated hydrolysis of extra protection groups are avoided, so that the raw materials are saved, and the preparation route is simplified.

The invention relates to a method for synthesizing 4-(1,5-dimethyl-1-vinyl-4-hexenyl)phenol. 4-(1,5-Dimethyl-1-vinyl-4-hexenyl)phenol is also known as an antifeedant. The disadvantage of the current synthesis method of this substance is that there are many synthesis steps, most of which are between 5 and 15 steps , the reaction conditions are complicated, the reagents used are expensive, and the yield is also low. The method of the present invention uses geraniol as a raw material, reacts with vinyl ether to obtain 3-vinyl citronellal through Claisen rearrangement, and then reacts with hexahydropyridine for enamination and then conjugates with butenone Addition and cyclocondensation give 4-(1,5-dimethyl-1-vinyl-4-hexenyl)-2-cyclohexenone, and then dehydrogenate to get the product. The method uses natural products as raw materials, and the reaction process is simple to operate, easy to realize, high in selectivity and high in yield.

The invention relates to an antrodia camphorate cyclohexanedione compound used for treating autoimmune diseases and a medical composition thereof. The antrodia camphorate cyclohexanedione compound is about 4-hydroxyl-2, 3-dimethoxy-6-methyl-5(3, 7, 11-trimethyl-2, 6, 10-dodecatrien)-2-cyclohexanedione which is separated from antrodia camphorate extract and can relieve systemic erythromelalgia lupus and other symptoms caused by autoimmune diseases. Antrodia camphorate cyclohexanedione in the invention can reduce the content of urine protein of the mammalians with systemic erythromelalgia lupusand the thickness of the antinuclear antibody in blood, relieves kidney inflammation and lesion, lowers the harm of antinuclear antibody on autogenous tissues, and achieves the effect of treating autoimmune diseases such as systemic erythromelalgia lupus, and the like, and the diseases related to kidney by using natural materials without side effects.