Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antrodia camphoratea pimelie kelone compound for treating autoimmune disease and medicine composition

An autoimmune disease, the technology of cyclohexenone, which is applied in the field of compounds for the treatment of immune-related diseases, can solve the problems that have not been seen in the treatment of autoimmune diseases with the extract of Antrodia camphorata

Active Publication Date: 2012-09-26
GOLDEN BIOTECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although it can be known from many current experiments that the extract of Antrodia Cinnamomea has the aforementioned effects, and its components have been analyzed one after another, but it has not been seen that the extract of Antrodia Antrodia has been used to treat autoimmune diseases, and whether the extract of Antrodia Antrodia What kind of active ingredients in the extract can effectively improve the symptoms of autoimmune diseases needs further experimental research to distinguish, so if we can find out the real effective ingredients contained in the extract, and use this natural ingredient for prevention or treatment In autoimmune diseases such as systemic lupus erythematosus, it will help to alleviate the side effects or complications caused by the treatment of autoimmune diseases with chemical drugs such as steroids

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antrodia camphoratea pimelie kelone compound for treating autoimmune disease and medicine composition
  • Antrodia camphoratea pimelie kelone compound for treating autoimmune disease and medicine composition
  • Antrodia camphoratea pimelie kelone compound for treating autoimmune disease and medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 4-Hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-2,6,10-dodecatriene)-2-cyclohexenone separate

[0028] Put about 100 grams of Antrodia antrodia mycelium, fruiting bodies or a mixture of the two into a conical flask, add an appropriate proportion of water and alcohols (for example, an aqueous alcohol solution of more than 70%), and heat the mixture at 20-25°C. Stir and extract for at least 1 hour, then filter with filter paper and a 0.45mm filter membrane to collect the extract.

[0029] The Antrodia camphorata extract collected above was analyzed by using a high performance liquid chromatography (High Performance Liquid chromatography) with an RP 18 chromatographic tube (column), and methanol (A) and 0.1% to 0.5% acetic acid aqueous solution ( B) as mobile phase (mobile phase) (the solution ratio is: 0-10 minutes, B ratio is 95%-20%; 10-20 minutes, B ratio is 20%-10%; 20-35 minutes, B ratio is The ratio is 10% to 10%; 35 to 40 minutes, the ratio of B is 10% to 95%...

Embodiment 2

[0032] Evaluation of the efficacy of cyclohexenone compounds from Antrodia antrodia in the prevention or treatment of autoimmune diseases such as systemic lupus erythematosus

[0033] When people with autoimmune diseases are clinically diagnosed, it is often found that the content of autoantibodies and immune complexes in the patient's body increases significantly, and the antigens that these antibodies fight are often widely distributed in the nucleus, cytoplasm or normal body proteins on the cell membrane in the body. Therefore, general clinical laboratories often use the appearance and changes of antinuclear antibodies (ANA) as the basis for screening patients with autoimmune diseases. Targets of antinuclear antibodies associated with systemic lupus erythematosus include double-stranded deoxyribonucleic acid (dsDNA), RNA-associated ribonucleoproteins such as Sm, Ro, La, RNP, phospholipids, and ribosomal phospholipids. Among them, anti-dsDNA, anti-Sm and aPL antibodies have ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to an antrodia camphorate cyclohexanedione compound used for treating autoimmune diseases and a medical composition thereof. The antrodia camphorate cyclohexanedione compound is about 4-hydroxyl-2, 3-dimethoxy-6-methyl-5(3, 7, 11-trimethyl-2, 6, 10-dodecatrien)-2-cyclohexanedione which is separated from antrodia camphorate extract and can relieve systemic erythromelalgia lupus and other symptoms caused by autoimmune diseases. Antrodia camphorate cyclohexanedione in the invention can reduce the content of urine protein of the mammalians with systemic erythromelalgia lupusand the thickness of the antinuclear antibody in blood, relieves kidney inflammation and lesion, lowers the harm of antinuclear antibody on autogenous tissues, and achieves the effect of treating autoimmune diseases such as systemic erythromelalgia lupus, and the like, and the diseases related to kidney by using natural materials without side effects.

Description

technical field [0001] The present invention relates to a compound used for treating immune-related diseases, in particular to a compound isolated and purified from the extract of Antrodia camphorata (Antrodia camphorata), which can be used to treat autoimmune diseases such as systemic lupus erythematosus. A hexenone compound, and a pharmaceutical composition of the compound. Background technique [0002] There are many kinds of autoimmune diseases (autoimmune diseases) that cause damage to autologous tissues due to abnormal responses of the immune system, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (Rheumatoid arthritis), scleroderma (Scleroderma), Polymyositis and dermatomyositis, Anaphylactoid purpura, Sjogren syndrome, etc. Others such as primary biliary system cirrhosis, chronic activity Diseases such as chronic hepatitis and Hashimoto's thyroiditis are also related to autoimmunity; among them, systemic lupus erythematosus (SLE) or systemic lupus e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/517C07C45/78A61K31/122A61P37/02
CPCC07C403/02A61K31/122C07C2101/16A61P37/00A61P37/02A61P37/06C07C2601/16
Inventor 刘胜勇温武哲郭茂田
Owner GOLDEN BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com