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2 results about "Dehydroascorbic acid" patented technology
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Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid (vitamin C). It is actively imported into the endoplasmic reticulum of cells via glucose transporters. It is trapped therein by reduction back to ascorbate by glutathione and other thiols. The (free) chemical radical semidehydroascorbic acid (SDA) also belongs to the group of oxidized ascorbic acids.
Dehydroascorbic acid-modified hemoglobin-based barley saponin targeted nanoparticles and their preparation method
This invention discloses dehydroascorbic acid-modified hemoglobin-based Paris polyphylla saponin-targeted nanoparticles and their preparation method, belonging to the field of drug delivery system technology. These targeted nanoparticles use hemoglobin as a drug carrier and Paris polyphylla saponin VII as the core active ingredient. The process involves first synthesizing a DSPE-PEG-DHA polymer, then utilizing the property of Hb exposing its hydrophobic region under acidic conditions to encapsulate PSVII within Hb via a self-assembly method, and finally modifying it with DSPE-PEG-DHA to obtain the target nanoparticles PSHb@DPD. This invention significantly enhances the targeting and cellular uptake efficiency of nanoparticles by specifically binding DHA to glucose transporters highly expressed in osteosarcoma cells. It exhibits strong toxicity to osteosarcoma MG63 cells and effectively inhibits their migration, while showing no significant toxicity to normal vascular endothelial cells and excellent biocompatibility.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY