41 results about "Oxidized Ascorbic Acid" patented technology

Cosmetic composition for the oxidative treatment of hair or skin, prepared by mixing of at least two components, in which dehydroascorbic acid or a dehydroascorbic acid salt or a dehydroascorbic acid derivative is generated from ascorbic acid, ascorbic acid derivative and ascorbic acid salt prior to application by an enzyme that catalyzes the enzymatical oxidation of said of ascorbic acid as well as a process for carrying out the oxidative treatment of keratin, particularly for the oxidative post-treatment of reduced hair in the process of permanent deformation of hair using said composition.

Compounds of the formula: are described wherein: A1 is ascorbic acid, dehydroascorbic acid, ascorbyl-2-phosphate, an analog thereof, or a salt thereof; L is a linking group coupled to A1 at the C5 or C6 position thereof; and B1 is an active agent such as an imaging agent or therapeutic agent (e.g. a bisphosphonate), along with pharmaceutically acceptable salts and prodrugs thereof. The compounds are useful for, among other things, improving cartilage uptake of active agents administered for joint diseases such as osteoarthritis and rheumatoid arthritis, and for improving gastrointestinal absorption of bisphosphonates.

The invention belongs to the technical field of biology, relates to environment-sensitive tumor-targeting polymer micelle and a preparation method thereof, and especially relates to a cell microenvironment-sensitive oxidized ascorbic acid-modified tumor-targeting polymer micelle administration system and a preparation method thereof. An administration system realizes delivery in tumor by a glucose transporter mechanism, the polymer micelle of which the inner core has a disulfide bond crosslinked barrier is designed by use of the GSH characteristics of high density in the cell microenvironment, drug release characteristics trigged by the cell microenvironment are obtained, and the environment-sensitive tumor-targeting polymer micelle has a high transport capability, a fast transport rate and difficult saturation. Compared with polypeptide protein molecules, the environment-sensitive tumor-targeting polymer micelle has the characteristics of simple synthesis preparation, high stability and no immunogenicity. Through synergism of targeting and structure stabilization, drug delivery to a target position and a target cell is realized so that drug delivery efficiency is greatly improved and thus the environment-sensitive tumor-targeting polymer micelle has a good clinical application prospect.

Dehydroascorbic acid and polymeric / monomeric derivatives and isomers thereof are useful for artificially coloring the skin and more particularly as a skin self-tanning agent; the dehydroascorbic acid may be formed “in situ” from ascorbic acid or a derivative or salt thereof via chemical oxidation and / or via enzymatic oxidation, and a two-component agent thereof includesa) a first component (B) containing, in a physiologically acceptable medium, at least ascorbic acid or a derivative or salt thereof;b) a second component (C) containing, in a physiologically acceptable medium, at least one chemical oxidizing agent and / or one enzymatic oxidizing agent; components (B) and (C) being stored separately.

A process for manufacturing a black leaf tea that is infusible in hot or cold water. The process involves macerating freshly plucked tea leaves, allowing them to ferment, firing the leaves to arrest fermentation and then drying them to yield black leaf tea, wherein the tea leaves are treated with a solubilising compound selected ascorbic acid, dehydroascorbic acid, 1-scorbamic acid, 5-phenyl-3,4-diketo-gamma-butyrolactone (4-phenyl-2,3-diketo-gamma-butyrolactone) or their salts and mixtures thereof in an amount that is sufficient for the black leaf tea to be soluble in water at 5 to 100° C.

The invention discloses a nano copper oxide with the activity of an ascorbic acid oxidization mimic enzyme, and aims at effectively catalyzing ascorbic acid oxidization to generate dehydroascorbic acid under aerobic environment and keeping the activity of the ascorbic acid oxidization mimic enzyme under strong acid, strong base or high temperature. By utilizing an ultraviolet spectrophotometry, the influences, on the nano copper oxide as ascorbic acid oxidase, of the temperature, pH and reaction time are respectively researched. The steady-state kinetic parameters of the nano copper oxide as the ascorbic acid oxidase are equivalent to the natural ascorbic acid oxidase, and the stability of the nano copper oxide as the ascorbic acid oxidase is obviously stronger than the natural ascorbic acid oxidase. By utilizing a deoxidization experiment and a fluorescence analysis method, a mechanism of the nano copper oxide as the ascorbic acid oxidase to catalyze ascorbic acid oxidization is verified. The activity of the ascorbic acid oxidization mimic enzyme shows a relatively tempting application prospect in the technical fields of nano enzymes, nanometers and bionic.

The present invention describes a novel process for large-scale purification of therapeutic grade quality of recombinant human GCSF from microbial cells, wherein the protein is expressed as inclusion bodies. The Inclusion bodies are solubilized and refolded under redox condition. The Redox condition is provided by using ascorbic acid, dehydroascorbic acid and reduced gluthathione. The process involves the novel use of aqueous two phase extraction step to purify refolded GCSF after removal of denaturant. After this step GCSF is further purified using chromatography techniques for removal of related impurities. The GCSF obtained has good purity and yields which are essential for a production scale process. The host cell related contaminants like proteins, DNA and endotoxins are reduced using the purification processes of the invention.

The invention discloses green and environment-friendly conductive nano-copper ink and a preparation method thereof. The preparation method utilizes cavitation and acoustic flow effects of high-energyultrasonic waves in a liquid phase to change a chemical reaction mechanism so as to efficiently obtain nano-copper particles, and the preparation method specifically comprises the following steps thatfirstly, using ascorbic acid as a reducing agent, taking copper hydroxide as a copper source, then using the dispersion effect of dehydroascorbic acid which is a product generated after ascorbic acidreaction, combining a special effect of a ultrasonic wave in the liquid phase, and therefore efficiently synthesizing a required copper nanoparticle solution; and then, separating and obtaining purecopper nanoparticles from the copper nanoparticle dispersion liquid, after repeatedly washing, adding various organic solvents, and mixing to obtain the nano-copper conductive ink. The preparation method has the advantages of unique reaction mechanism, novel preparation means, simple process, low cost, high yield efficiency, environmental friendliness, easiness in large-scale production and the like, and has a wide application prospect in the field of printed electronics.

The invention relates to fermented milk with DHA (dehydroascorbic acid) and EPA (eicosapentaenoic acid) and a preparation method thereof; the fermented milk is prepared by fermenting, by bacteria, milk with trehalose, white granulated sugar, a stabilizer, whey protein powder, fish oil or fish oil powder, an antioxidant, an emulsifier and a sweetener; sterilizing; filling with opaque oxygen-tight packaging material. Through burdening, preparation, and packaging study and design for the fermented milk with DHA and EPA, the technical problem that the fermented milk with fish oil or fish oil power products has unstable flavor is solved, product stability in shelf life is guaranteed, and the fermented milk with DHA and EPA is provided, having good flavor.

A process for manufacturing a black leaf tea that is infusible in hot or cold water. The process involves macerating freshly plucked tea leaves, allowing them to ferment, firing the leaves to arrest fermentation and then drying them to yield black leaf tea, wherein the tea leaves are treated with a solubilising compound selected ascorbic acid, dehydroascorbic acid, 1-scorbamic acid, 5-phenyl-3,4-diketo-gamma-butyrolactone (4-phenyl-2,3-diketo-gamma-butyrolactone) or their salts and mixtures thereof in an amount that is sufficient for the black leaf tea to be soluble in water at 5 to 100° C.

The invention relates to a preparation method for high-purity solid dehydroascorbic acid, which is obtained by the following steps: 1. oxidizing L-vitamin C (Vc); 2. removing active carbon and lower alcohol solvent; and 3. refining the dehydroascorbic acid. Compared with the previous method, the invention adopts the high efficiency liquid chromatography to analyze and monitor the process of oxidizing L-vitamin C so as to ensure the thorough reaction of the L-vitamin C, and adopts the column chromatography to refine the dehydroascorbic acid. The method has the advantages of simple process, easy control, safety without toxic substance and no environmental pollution. The analysis of the high efficiency liquid chromatography indicates that the content of dehydroascorbic acid in the solid prepared by the preparation method is up to more than 95% by using the area normalization method.

The invention provides a method for synchronously detecting L-ascorbic acid, D-ascorbic acid and dehydroascorbic acid in milk powder. According to the method, deoxidized sodium thiosulfate and metaphosphoric acid mixed solution is used as an extracting liquid, active ascorbic acid can be effectively protected, the stability of the ascorbic acid can be improved, light-resistant operation is not required, experimental operation is simple and convenient, and the extract has stable property in 24 hours at low temperature. The chromatographic condition has small damage to a chromatographic column,and the service life of the chromatographic column can be prolonged; a mobile phase is formed by monopotassium phosphate and decyl amine, the resolution can be improved by the concentration of the mobile phase, two geometric isomers can still be effectively separated when the ascorbic acid has relatively high concentration, mutual interference can be avoided, and the content of active ascorbic acid can be accurately detected. The method has the advantages of simple operation, small chemical reagent dosage and good extract stability, has a relative standard deviation of 7.82 percent, can be used for multi-union detection, and has an important meaning for accurately detecting the true content of active ascorbic acid in milk powder.

The invention discloses a method for simultaneously determining content of reduced ascorbic acid, dehydroascorbic acid and total ascorbic acid in fruit. The method comprises the following steps: adding oxalic acid into a fresh fruit to extract the total ascorbic acid; separating extracting solution into two portions; adding copper sulfate into one portion for oxidization, and determining the content of the total ascorbic acid by means of a 2,4-dinitrophenylhydrazine colorimetric method; adding an antioxidant, thiourea into the other portion, and determining the content of the dehydroascorbic acid by means of the 2,4-dinitrophenylhydrazine colorimetric method; oxidizing the reduced ascorbic acid in a test sample into the dehydroascorbic acid by activated carbon, then adding 2,4-dinitrophenylhydrazine to generate red osazone, and performing colorimetric determination at a position of 500nm; deducting the obtained content of the total ascorbic acid from the obtained content of the dehydroascorbic acid before the oxidization to obtain the content of the reduced ascorbic acid. According to method disclosed by the invention, the contents of three different kinds of ascorbic acids in fruits such as apple and pear are determined, a standard curve is stable, a linear scope is 1-10mu. g / mL, and a correlation coefficient reaches 0.99 or more.

The present invention provides a gypsum composition, a gypsum board and their preparation method and the use of DHA as an anti-sagging additive in a gypsum product. Said gypsum board comprises set gypsum prepared from the composition; while said composition comprises gypsum, and an anti-deformation additive, wherein the anti-deformation additive comprises at least one selected from a group consisting of dehydroascorbic acid, dehydroascorbate and semidehydroascorbic acid. The set gypsum prepared from the said composition shows better anti-sagging or deformation resisting property. The gypsum product of the present invention is hardly distorted and has stronger stability even in the condition of high humidity, thus improve the quality of the gypsum product to meet the demands of the customer.

The invention discloses an ozone remover and a preparation method thereof. The ozone remover is prepared from the following components in percentage by mass: 0.1 to 5 percent of a plant extracting solution, 0.1 to 0.5 percent of a water-based defoaming agent, 0.2 to 0.6 percent of a wetting agent, 0.2 to 0.3 percent of a water-retaining agent, 0.3 to 0.5 percent of a buffering agent and 93.1 to 99.1 percent of water. According to the invention, the plant extracting solution is used as a main active component, the ozone remover is obtained by compounding the plant extracting solution with the water-based defoaming agent, the wetting agent, the water-retaining agent, the buffering agent and water and can directly and effectively reduce the ozone concentration so as to achieve the ozone elimination purpose, and the plant extracting liquid can directly react with ozone and can be oxidized into monodehydroascorbic acid (MDHA), dehydroascorbic acid (DHA) and other components capable of beingabsorbed by plants, such that the secondary pollution cannot be generated and the environmental protection is achieved.

The invention relates to a gas field gas dehydrated ethanediol regenerator corrosion inhibitor, which is applied to the technical field of oil gas field gas extraction equipment corrosion inhibition and belongs to a special composite corrosion inhibitor for inhibiting the corrosion of a gas field gas dehydrated ethanediol regenerator. The gas field gas dehydrated ethanediol regenerator corrosion inhibitor comprises the following ingredients in weight parts: 0.35 to 0.55 part of imidazolone, 0.09 to 0.15 part of dormison, 0.1 to 0.5 part of 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDPA), 16 to 18 parts of triethanolamine, 0.35 to 0.55 part of Mannich base, 0.09 to 0.15 part of dehydroascorbic acid and 0.02 to 0.1 part of ditertbutylhydroquinone. The gas field gas dehydrated ethanediol regenerator corrosion inhibitor has the effect that the serious corrosion problems of serious corrosion in parts of process pipelines, valves, regeneration towers and the like of the existing gas field gas dehydrated ethanediol regenerating system , even perforation and the like are solved.

The invention relates to the technical field of seafood processing, and provides a method for extracting krill oil with high fatty acid content from antarctic krill in order to solve the problems thata solvent cannot be removed thoroughly, the cost is high, the extraction rate is low, the fatty acid content in the antarctic krill oil is low existing in a traditional extraction technology of antarctic krill oil. The method comprises the following steps that (1) antarctic krill is subjected to freeze drying, the tissue is crushed, and antarctic krill powder is obtained; (2) an organic solvent is added to conduct leaching, vortex and centrifugalization, and the supernatant liquid is taken; and (3) the supernatant liquid is extracted, concentrated and washed, a superstratum organic phase is taken and subjected to rotary steaming, and the krill oil with the high fatty acid content is obtained. The antarctic krill oil extracted by adopting the method has the high fatty acid content, wherein, EPA (eicosapentaenoic acid) and DHA (dehydroascorbic acid) account for 48.8% and 27.8% of the total amount of the fatty acid in the antarctic krill oil.

The invention relates to a pharmaceutical composition for treating African swine fever and application thereof, in particular to a pharmaceutical composition for generating a safe amount of nitric oxide in vivo and application of the pharmaceutical composition. The pharmaceutical composition comprises the following components: an NO toxicity reducing agent, an NO extender and a nitric oxide synthase inducer. The invention provides the pharmaceutical composition which is high in universality and extremely effective in treating pathogenic microorganism infection. The NO toxicity reducing agent is selected from 5-methyltetrahydrofolic acid, NMN and dehydroascorbic acid, the NO extender is selected from arginine, and the nitric oxide synthase inducer is selected from phytohemagglutinin. The present invention provides a new pharmaceutical activity of 5-methyltetrahydrofolate, which has a variety of active effects on the immune system caused by pathogen infection, and can be used for treating or preventing diseases caused by viral infections and other pathogen infections, and in particular, the composition of the present invention is used for preventing or treating African swine fever.

Disclosed is an agent which has a destructive effect on malignant tumors and contains alpha-ketoglutaric acid, N-acetyl-seleno-L-methionine, N-acetyl-L-methionine, and a compound that is capable of forming azomethine and is selected among the group 5-hydroxymethylfurfural, dehydroascorbic acid, maltol, and vanillin as an active substance, 5-hydroxymethylfurfural being preferred. The inventive agent can be used in the form of an infusion, in an oral or rectal form of administration, or as an irrigation in cancer therapy.

The invention relates to stable liquid compositions containing the oxidized form of vitamin C known as dehydroascorbic acid (DHAA). The compositions comprise DHAA and a pharmacologically acceptable liquid organic polyol solvent. The polyol solvent comprises about 50% or greater of the total weight of the composition. The compositions are useful as dietary supplements, skin-enhancers, concentrates, or research solutions.

Compounds of the formula: are described wherein: A1 is ascorbic acid, dehydroascorbic acid, ascorbyl-2-phosphate, an analog thereof, or a salt thereof; L is a linking group coupled to A1 at the C5 or C6 position thereof; and B1 is an active agent such as an imaging agent or therapeutic agent (e.g. a bisphosphonate), along with pharmaceutically acceptable salts and prodrugs thereof. The compounds are useful for, among other things, improving cartilage uptake of active agents administered for joint diseases such as osteoarthritis and rheumatoid arthritis, and for improving gastrointestinal absorption of bisphosphonates.

The invention relates to fermented milk with DHA (dehydroascorbic acid) and EPA (eicosapentaenoic acid) and a preparation method thereof; the fermented milk is prepared by fermenting, by bacteria, milk with trehalose, white granulated sugar, a stabilizer, whey protein powder, fish oil or fish oil powder, an antioxidant, an emulsifier and a sweetener; sterilizing; filling with opaque oxygen-tight packaging material. Through burdening, preparation, and packaging study and design for the fermented milk with DHA and EPA, the technical problem that the fermented milk with fish oil or fish oil power products has unstable flavor is solved, product stability in shelf life is guaranteed, and the fermented milk with DHA and EPA is provided, having good flavor.

A gas concentration regulator for culturing anaerobic bacteria, comprising: (a) dehydroascorbic acid; (c) a transition metal catalyst; (d) activated carbon; (e) at least one element selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, and alkaline earth metal hydroxides; and (f) water.

Processes to produce dehydroascorbic acid at the time of use are provided, so that this unstable form of vitamin C can be conveniently utilized for dietary purposes. Products produced by these processes are also described.

The invention relates to a gas field gas dehydrated ethanediol regenerator corrosion inhibitor, which is applied to the technical field of oil gas field gas extraction equipment corrosion inhibition and belongs to a special composite corrosion inhibitor for inhibiting the corrosion of a gas field gas dehydrated ethanediol regenerator. The gas field gas dehydrated ethanediol regenerator corrosion inhibitor comprises the following ingredients in weight parts: 0.35 to 0.55 part of imidazolone, 0.09 to 0.15 part of dormison, 0.1 to 0.5 part of 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDPA), 16 to 18 parts of triethanolamine, 0.35 to 0.55 part of Mannich base, 0.09 to 0.15 part of dehydroascorbic acid and 0.02 to 0.1 part of ditertbutylhydroquinone. The gas field gas dehydrated ethanediol regenerator corrosion inhibitor has the effect that the serious corrosion problems of serious corrosion in parts of process pipelines, valves, regeneration towers and the like of the existing gas field gas dehydrated ethanediol regenerating system , even perforation and the like are solved.

A gas concentration regulator for use in culture of anaerobic bacteria, including: (a) dehydroascorbic acid; (c) a transition metal catalyst; (d) activated carbon; (e) at least one selected from the group consisting of an alkali metal carbonate, an alkali metal hydroxide, and an alkaline earth metal hydroxide; and (f) water.

The invention provides a tracer corrosion and scale inhibitor. The tracer corrosion and scale inhibitor comprises a component A and a component B, wherein the component A comprises the following components in parts by weight: 10 to 15 parts of styrene sulfonate, 10 to 20 parts of dehydroascorbic acid or dehydroisoascorbic acid, 5 to 10 parts of styrene ketone, 5 to 10 parts of tracer scale inhibition dispersion agent, and 15 to 20 parts of low phosphorus corrosion and scale inhibitor; and the component B comprises 10 to 20 parts of zinc sulfate, and 5 to 10 parts of sodium molybdate. The tracer corrosion and scale inhibitor provided in the invention has good scale inhibition effect and can realize the online monitoring and automatic administration.

The present invention relates to the use of dehydroascorbic acid (DHA) or functional analogs for protecting plants from pathogens, in particular from nematode infection. The invention also provides a composition containing the same, a method for preparing the same and a method for preventing and treating plant diseases.