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Porous hollow silica n anop articles, preparation method of the silica nanoparticles, and drug carriers and pharmaceutical composition comprising the silica nanoparticles

A technology of porous silica and silica, applied in nanostructure manufacturing, nanotechnology, nanotechnology, etc., can solve the difficulty of controlling pore size, difficult to control drug release characteristics, nanoscale hollow particles are not suitable for use as drug carriers, etc. problem, to achieve sustained and stable release

Inactive Publication Date: 2010-03-31
IND ACADEMIC CORP FOUND YONSEI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The disadvantage faced by using templates in the current technology is that it is difficult to prepare nanoscale hollow particles in a stable form
Another disadvantage is that the particles are only loaded with a very limited amount of drug due to the very small lumen
Furthermore, there are difficulties in controlling the pore size of the shell surrounding the lumen, thus making it difficult to control the release profile of the drug
Therefore, the nanoscale hollow particles are not suitable for use as drug carriers

Method used

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  • Porous hollow silica n anop articles, preparation method of the silica nanoparticles, and drug carriers and pharmaceutical composition comprising the silica nanoparticles
  • Porous hollow silica n anop articles, preparation method of the silica nanoparticles, and drug carriers and pharmaceutical composition comprising the silica nanoparticles
  • Porous hollow silica n anop articles, preparation method of the silica nanoparticles, and drug carriers and pharmaceutical composition comprising the silica nanoparticles

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Embodiment approach

[0099] Hereinafter, the present invention will be explained in more detail with reference to the following examples. However, these examples should not be considered as limiting the scope of the invention.

Embodiment 1

[0102] Hollow silica nanoparticles surface-modified with polyethylene glycol were prepared according to the following method. The preparation method is shown in figure 1 middle. figure 2 Schematic diagrams showing the products prepared by the following steps: (A) hollow silica nanoparticles with hydroxyl groups on the surface, (B) hollow silica nanoparticles with amino groups on the surface, and (C) polyethylene oxide nanoparticles on the surface. Diol-modified hollow silica nanoparticles.

[0103] (1) Preparation of magnetic nanoparticles

[0104] Iron triacetylacetonate (0.2 mol), 1,2-hexadecanediol (1 mol), dodecanoic acid (0.6 mol) and dodecylamine (0.6 mol) were thermally decomposed: at 150°C for 30 minutes and 30 minutes at 290°C to synthesize magnetite (Fe 3 o 4 ). The magnetic nanoparticles were purified using pure ethanol. A transmission electron micrograph (TEM) of the magnetite (3a) is shown in image 3 (a).

[0105] (2) Preparation of magnetic nanocluster...

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Abstract

Porous hollow silica nanoparticles are provided. Each of the silica nanoparticles comprises a core having a large inner cavity and a porous silica shell surrounding the core. Due to the presence of the cavities in the cores, the porous hollow silica nanoparticles exhibit much higher drug loading efficiency than conventional particles for drug carriers. In addition, the pore size range of the porous silica shells is optimized by surface functional groups bonded to the silica shells and / or a biocompatible polymer bonded to the silica shells via the surface functional groups to ensure a steady and stable release of a drug from the silica nanoparticles. Therefore, the porous hollow silica nanoparticles can be effectively used for the preparation of drug carriers. Further provided are a method for the preparation of the silica nanoparticles and drug carriers comprising the silica nanoparticles.

Description

technical field [0001] The present invention relates to porous hollow silica nanoparticles each comprising a core with a large lumen and a silica shell surrounding the core, wherein the shell has pores of controlled size to allow large amounts of drug to persist and stabilize way of release. The present invention also relates to a preparation method of the silicon dioxide nanoparticle, a drug carrier and a pharmaceutical composition containing the silicon dioxide nanoparticle. Background technique [0002] Since the 1970s, significant progress has been made in the development of drug delivery systems based on controlled release technologies. Many products related to drug delivery systems are currently commercially available and under development. [0003] Extensive research on drug carriers is being actively conducted in various fields, including non-parenteral drug delivery systems (such as oral, pulmonary, nasal and ocular drug delivery) and parenteral drug delivery syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B82B3/00
CPCB82Y30/00A61K9/5192A61K9/5115
Inventor 咸承柱徐桭锡许镛敏尹昊勤梁在文李在元康珍英
Owner IND ACADEMIC CORP FOUND YONSEI UNIV
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