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Dispersible tablet containing cefixime and preparation method thereof

A technology of cefixime and dispersible tablets, which is applied in the field of pharmaceutical compositions containing cefixime, and can solve problems such as poor disintegration performance, slow onset of action, and limitations

Inactive Publication Date: 2009-04-08
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the poor solubility of cefixime in water, ordinary tablets have the disadvantages of poor disintegration performance and slow onset of action, which limits and weakens the protective effect of cefixime on the gastrointestinal tract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 100g of cefixime, 20g of pregelatinized starch, 40g of microcrystalline cellulose, and 20g of cross-linked polyvinylpyrrolidone, and mix them uniformly; add 5% PVP K30 ethanol liquid to make a soft material, pass through a 18-30 mesh sieve to granulate, Dry the wet granules at 50-80°C, sieve the granules with 18-30 mesh, add 3g of magnesium stearate and 1g of micro-powder silica gel, mix well, and press into tablets to make 1000 pieces of products.

Embodiment 2

[0019] Weigh 50g of cefixime, 20g of microcrystalline cellulose, 10g of cross-linked polyvinylpyrrolidone, and 10g of low-substituted hydroxypropyl cellulose, and mix them evenly; add 5% PVP K30 ethanol liquid dropwise to make a soft material, and pass through a 18-30 mesh sieve. Dry the wet granules at 50-80°C, sieve the granules with 18-30 mesh, add 10g of cross-linked polyvinylpyrrolidone, 10g of low-substituted hydroxypropyl cellulose, 5g of magnesium stearate, mix well, and press into tablets , made into 1000 pieces of products.

Embodiment 3

[0021] Weigh 50g of cefixime, 20g of lactose, 10g of guar gum, 20g of cross-linked polyvinylpyrrolidone, 1g of sodium lauryl sulfate, and 2g of stevioside, and mix them uniformly; Granulate with a 18-30 mesh sieve, dry the wet granules at 50-80°C, sieve the granules with a 18-30 mesh sieve, add 2g of talc powder and 1g of micronized silica gel, mix well, and press into tablets to make 1,000 pieces of product.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparation, and in particular relates to a cefixime dispersible tablet and a method for preparing the same. The method comprises the following steps: firstly, weighing cefixime, starch, microcrystalline cellulose, partially cross-linked polyvinylpyrrolidone, partially cross-linked sodium carboxymethyl cellulose, and partially low substituted-hydroxypropyl cellulose, and mixing the components evenly; secondly, dripping 5 percent polyvinylpyrrolidone K30 ethanol solution into the mixture prepare a soft material, and performing granulating through a sieve of between 18 and 24 meshes; thirdly, drying wet particles at a temperature of between 50 and 80 DEG C, palletizing the particles through the sieve of between 18 and 24 meshes, adding the remaining cross-linked polyvinylpyrrolidone, the remaining cross-linked sodium carboxymethyl cellulose, and the remaining low substituted-hydroxypropyl cellulose, magnesium stearate and superfine silica gel powder into the mixture to be mixed evenly, and tabletting the mixture to obtain the required cefixime dispersible tablet. The cefixime dispersible tablet has the characteristics of rapid disintegration with water, even dispersion, high dissolution, and convenient taking and carrying around.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing cefixime, more specifically, the invention relates to a dispersible tablet of cefixime. The present invention also relates to a preparation method of the cefixime dispersible tablet. Background technique [0002] Cefixime (Cefixime) is an oral semi-synthetic cephalosporin antibiotic stable to β-lactamase. It is the first oral third-generation cephalosporin researched and developed by Japan Fujisawa Company. It was first listed in Japan in 1987. Cefixime is characterized by broad antibacterial spectrum, enzyme resistance, long-acting, and convenient oral administration. It has good antibacterial effect on other drug-resistant bacteria that cannot be combated by oral cephalosporins, including Escherichia coli, Klebsiella pneumoniae, and Neisseria gonorrhoeae. [0003] The antibacterial mechanism of cefixime is similar to that of other third-generation cephalosporins. It binds to one or mor...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/20A61P31/04
Inventor 张耀春司成桃
Owner BEIJING TRADE STAR MEDICAL TECH
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