Dispersible tablet containing cefixime and preparation method thereof

Abstract

The invention belongs to the technical field of pharmaceutical preparation, and in particular relates to a cefixime dispersible tablet and a method for preparing the same. The method comprises the following steps: firstly, weighing cefixime, starch, microcrystalline cellulose, partially cross-linked polyvinylpyrrolidone, partially cross-linked sodium carboxymethyl cellulose, and partially low substituted-hydroxypropyl cellulose, and mixing the components evenly; secondly, dripping 5 percent polyvinylpyrrolidone K30 ethanol solution into the mixture prepare a soft material, and performing granulating through a sieve of between 18 and 24 meshes; thirdly, drying wet particles at a temperature of between 50 and 80 DEG C, palletizing the particles through the sieve of between 18 and 24 meshes, adding the remaining cross-linked polyvinylpyrrolidone, the remaining cross-linked sodium carboxymethyl cellulose, and the remaining low substituted-hydroxypropyl cellulose, magnesium stearate and superfine silica gel powder into the mixture to be mixed evenly, and tabletting the mixture to obtain the required cefixime dispersible tablet. The cefixime dispersible tablet has the characteristics of rapid disintegration with water, even dispersion, high dissolution, and convenient taking and carrying around.

Description

technical field

[0001] The invention relates to a pharmaceutical composition containing cefixime, more specifically, the invention relates to a dispersible tablet of cefixime. The present invention also relates to a preparation method of the cefixime dispersible tablet. Background technique

[0002] Cefixime (Cefixime) is an oral semi-synthetic cephalosporin antibiotic stable to β-lactamase. It is the first oral third-generation cephalosporin researched and developed by Japan Fujisawa Company. It was first listed in Japan in 1987. Cefixime is characterized by broad antibacterial spectrum, enzyme resistance, long-acting, and convenient oral administration. It has good antibacterial effect on other drug-resistant bacteria that cannot be combated by oral cephalosporins, including Escherichia coli, Klebsiella pneumoniae, and Neisseria gonorrhoeae.

[0003] The antibacterial mechanism of cefixime is similar to that of other third-generation cephalosporins. It binds to one or mor...