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Preparation for composition of vitamin and mineral matter

A preparation process and vitamin technology, which are applied in the directions of pharmaceutical combinations, active ingredients of heterocyclic compounds, and medical preparations containing active ingredients, etc. Mixing and other problems to achieve the effect of simplifying the production process, stabilizing the vitamin content and reducing the dosage

Active Publication Date: 2009-04-08
HANGZHOU MINSHENG HEALTHCARE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation process is not suitable for tablets, because the coated pellets have a large particle size and are round, and are easily broken after tablet compression, which cannot improve the stability of the composition. The fluidity is too good, and it is not easy to combine with Mix other ingredients in the

Method used

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  • Preparation for composition of vitamin and mineral matter
  • Preparation for composition of vitamin and mineral matter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription ingredient Prescription amount

[0029] Vitamin A 2500×10 3 IU

[0030] Vitamin D 200×10 3 IU

[0031] Vitamin B 1 2.5g

[0032] Vitamin B 2 2.5g

[0033] Vitamin B 6 0.25g

[0034] Vitamin B 12 0.5mg

[0035] Vitamin C 25g

[0036] Vitamin E 5g

[0037] Niacinamide 7.5g

[0038] Calcium pantothenate 2.5g

[0039] Choline Bitartrate 25g

[0040] Iodine 50mg

[0041] L-lysine salt 12.5g

[0042] Inositol 25g

[0043] Potassium 5g

[0044] Iron 5g

[0045] Copper 0.5g

[0046] Magnesium 0.5g

[0047] Manganese 0.5g

[0048] Zinc 0.25g

[0049] Calcium hydrogen phosphate 279g

[0050] Starch 50g

[0051] Lactose 30g

[0052] Microcrystalline Cellulose 200g

[0053] Dextrin 20g

[0054] Croscarmellose Sodium 15g

[0055] Low-substituted hydroxypropyl cellulose 15g

[0056] Tartaric acid 8g

[0057] Talc powder 5g

[0058] Micronized silica gel 12g

[0059] Magnesium Stearate 6g

[00...

Embodiment 2

[0073] Prescription ingredient Prescription amount

[0074] Vitamin A 5000×10 3 IU

[0075] Vitamin D 400×10 3 IU

[0076] Vitamin B 1 5g

[0077] Vitamin B 2 5g

[0078] Vitamin B 6 0.5g

[0079] Vitamin B 12 1mg

[0080] Vitamin C 50g

[0081] Vitamin E 10g

[0082] Niacinamide 15g

[0083] Calcium Pantothenate 5g

[0084] Choline Bitartrate 50g

[0085] Iodine 100mg

[0086] L-lysine salt 25g

[0087] Inositol 50g

[0088] Potassium 10g

[0089] Iron 10g

[0090] Copper 1g

[0091] Magnesium 1g

[0092] Manganese 0.5g

[0093] Zinc 0.5g

[0094] Calcium hydrogen phosphate 558g

[0095] Starch 50g

[0096] Lactose 50g

[0097] Microcrystalline Cellulose 100g

[0098] Dextrin 50g

[0099] Croscarmellose Sodium 25g

[0100] Low-substituted hydroxypropyl cellulose 25g

[0101] Tartaric acid 16g

[0102] Talc powder 15g

[0103] Micronized silica gel 12g

[0104] Magnesium Stearate 10g

[0105] ...

Embodiment 3

[0109] Prescription ingredient Prescription amount

[0110] Vitamin A 5000×10 3 IU

[0111] β-carotene 0.6g

[0112] Vitamin D 75 x 10 3 IU

[0113] Vitamin B 1 5g

[0114] Vitamin B 2 5g

[0115] Vitamin B 6 0.5g

[0116] Vitamin B 12 2mg

[0117] Vitamin C 100g

[0118] Vitamin E 5g

[0119] Niacinamide 15g

[0120] Calcium Pantothenate 5g

[0121] Choline Bitartrate 50g

[0122] Folic Acid 400mg

[0123] Inositol 50g

[0124] Potassium 10g

[0125] Iron 15g

[0126] Copper 1g

[0127] Selenium 50mg

[0128] Manganese 1g

[0129] Zinc 5g

[0130] Calcium hydrogen phosphate 558g

[0131] Starch 50g

[0132] Lactose 30g

[0133] Microcrystalline Cellulose 200g

[0134] Croscarmellose Sodium 30g

[0135] Low-substituted hydroxypropyl cellulose 15g

[0136] Tartaric acid 8g

[0137] Talc powder 5g

[0138] Micronized silica gel 10g

[0139] Magnesium Stearate 10g

[0140] ...

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Abstract

The invention provides a process for preparing a composition of vitamins and minerals, which contains the following components in each 1,000 tablets: 1 to 5 x 10<6>IU of vitamin A, 0 to 2 grams of beta-carotene, 0.75 to 4 x 10<5>IU of vitamin D, 0 to 30 milligrams of vitamin K, 0.5 to 5 grams of vitamin B1, 0.5 to 5 grams of vitamin B2, 0.25 to 1 gram of vitamin B6, 0.5 to 2 milligrams of vitamin B12, 25 to 100 grams of vitamin C, 0 to 0.4 grams of folic acid, 0 to 30 milligrams of biotin, 5 to 15 grams of vitamin E, 5 to 15 grams of nicotinamide, 2.5 to 10 grams of calcium pantothenate, 0 to 50 grams of heavy choline bitartrate, 0 to 100 milligrams of iodine, 0 to 25 grams of L-lysine salt, 0 to 50 grams of inositol, 5 to 10 grams of potassium, 5 to 15 grams of iron, 0.5 to 1 grams of copper, 0 to 50 milligrams of selenium, 0 to 120 grams of magnesium, 0 to 2 grams of manganese, 0.25 to 15 grams of zinc, 0 to 20 milligrams of chromium, 0 to 25 milligrams of molybdenum, 163 to 558 grams of bicalcium phosphate, 0 to 600 grams of calcium carbonate, 50 to 100 grams of starch, 30 to 60 grams of lactose, 100 to 200 grams of microcrystalline cellulose, 20 to 50 grams of dextrin, 15 to 50 grams of cross-linked sodium carboxymethyl cellulose, 0 to 30 grams of low substituted hydroxypropyl cellulose, 8 to 16 grams of tartaric acid, 5 to 20 grams of talcum powder, 8 to 12 grams of superfine silica gel powder, and 6 to 10 grams of magnesium stearate. The process is characterized in that the vitamin C adopts powder coating, and the coating material is methyl acrylate copolymer, preferably a mixture of a methacrylic acid / ethyl acrylate (1 to 1) copolymer and an ethyl acrylate / methyl methacrylate (2 to 1) copolymer, wherien the weight ratio of mixture is between 1 to 4 and 4 to 1. The composition of the vitamins and the minerals has simple preparation process and convenient operation, and can improve the stability of the vitamins.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food, and in particular relates to a preparation technology of a vitamin and mineral composition. Background technique [0002] With the development of the economy and the improvement of residents' income levels, great changes have taken place in people's dietary structure and lifestyle, and people's health concepts have also changed. The health concept of supplementing an appropriate amount of vitamins and minerals every day has been accepted. Accepted by the general public. However, vitamins are a class of compounds that are easily damaged by external conditions such as light, humidity, and heat, and they are quite sensitive to the physical and chemical environments in which they live. Because most vitamins contain unsaturated carbon atoms, double bonds, hydroxyl groups or other chemical structures that are extremely sensitive to chemical reactions, when these chemical structures ar...

Claims

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Application Information

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IPC IPC(8): A61K31/51A61K31/714A61K31/525A61K31/4415A61K31/375A61K31/59A61K31/122A61K31/355A61K31/14A61K31/197A61K31/205A61K31/455A61K33/00A61P3/02
Inventor 竺福江陈丽珍郭殿武杨民锋吴春霞
Owner HANGZHOU MINSHENG HEALTHCARE CO LTD
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