Nicardipine hydrochloride dispersion piece and method for making same

A technology of nicardipine hydrochloride and nicardipine hydrochloride, which is applied in the field of preparation of nicardipine hydrochloride dispersible tablets, can solve the problems of long tablet disintegration time, single taking method, and low bioavailability, and achieve rapid drug dissolution, Short disintegration time and convenient administration

Inactive Publication Date: 2008-04-09
刘全胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Nicardipine hydrochloride is almost tasteless, almost insoluble in water, its tablet disintegration time is long, absorption is poor, bioavailability is low, and the method of administration is single

Method used

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  • Nicardipine hydrochloride dispersion piece and method for making same
  • Nicardipine hydrochloride dispersion piece and method for making same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Nicardipine Hydrochloride 10g

[0020] Microcrystalline Cellulose 50g

[0021] Sodium carboxymethyl starch 2.5g

[0022] Hypromellose 5g

[0023] Croscarmellose Sodium 30g

[0024] Stevioside 2g

[0025] Magnesium stearate 0.5g

[0026] Take the prescribed amount of nicardipine hydrochloride, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, and stevioside, sieve them, mix them evenly, make a soft material with an appropriate amount of 40% ethanol solution, and pass through a 20-mesh sieve. Granules, dried at 60°C for 4 hours, sieved with a 20-mesh sieve, added magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0028] Nicardipine Hydrochloride 10g

[0029] Microcrystalline Cellulose 30g

[0030] Starch 10g

[0031] Hypromellose 13.5g

[0032] Croscarmellose Sodium 35g

[0033] Sodium saccharin 1g

[0034] Magnesium stearate 0.5g

[0035] Take the prescribed amount of nicardipine hydrochloride, microcrystalline cellulose, starch, hypromellose, croscarmellose sodium, and sodium saccharin, sieve, mix evenly, and make a soft material with an appropriate amount of 50% ethanol solution, pass 20 Granulate with a mesh sieve, dry at 50°C for 6 hours, granulate with a 20-mesh sieve, add magnesium stearate, mix evenly, and tablet.

Embodiment 3

[0037] Nicardipine Hydrochloride 10g

[0038] Microcrystalline Cellulose 40g

[0039] Cross-linked polyvinylpyrrolidone 30g

[0040] Sodium carboxymethyl starch 10g

[0041] Hypromellose 8.5g

[0042] Stevioside 1g

[0043] Magnesium stearate 0.5g

[0044] Get the prescribed amount of nicardipine hydrochloride, microcrystalline cellulose, sodium carboxymethyl starch, hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, stevioside, sieve, mix evenly, and make a soft material with an appropriate amount of 40% ethanol solution, pass Granulate with a 20-mesh sieve, dry at 65°C for 5 hours, granulate with a 20-mesh sieve, add magnesium stearate, mix evenly, and tablet.

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PUM

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Abstract

The invention discloses a nicardipine hydrochloride dispersible tablet which is characterized in that the nicardipine hydrochloride dispersible tablet is composed of components with the following weight percentage: 8 to 12 percent of nicardipine hydrochloride, 35 to 55 percent of starch, one or more than one of microcrystalline cellulose and lactose, 35 to 50 percent of sodium carboxymethyl starch, one or more than one of hydroxypropyl cellulose, hydroxypropyl methylcellulose, crosslinked polyvinyl pyrrolidone, and crosslinked sodium carboxymethyl cellulose, 5 to 2.5 percent of saccharin sodium or stevioside, and 0.25 to 1 percent of magnesium stearate. The disintegration time of the nicardipine hydrochloride dispersible tablet is short, the dispersed state is good, the drug is dissolved rapidly, the administration is convenient and flexible, the tablet can not only be sucked and swallowed, but also can be taken after being dispersed by adding water. The invention also discloses a preparation method of the nicardipine hydrochloride dispersible tablet.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy and relates to a pharmaceutical method, in particular to a preparation method of nicardipine hydrochloride dispersible tablets. Background technique [0002] Nicardipine hydrochloride is a clinical dihydropyridine calcium channel blocker (slow channel blocker or calcium ion antagonist), which can inhibit the influx of transmembrane calcium ions in myocardial and vascular smooth muscle without changing the blood calcium concentration. Nicardipine hydrochloride has a high degree of vascular selectivity, and its calcium ion antagonistic effect on vascular smooth muscle is stronger than that on cardiac muscle. [0003] The antihypertensive mechanism of nicardipine hydrochloride is mainly by blocking extracellular calcium ions from entering vascular smooth muscle cells through voltage-dependent L-type calcium channels, weakening the coupling of excitation and contraction, and reducing the contraction r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K9/20A61K47/32A61K47/38A61P9/12
Inventor 刘全胜
Owner 刘全胜
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