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Method for preparing aquogel matrix for ultraviolet light three-dimensional (3D) printing

A 3D printing and hydrogel technology, applied in the field of biomaterial preparation, can solve the problems of difficult to maintain printing size, reduce 3D printing efficiency, slow gel forming, etc., achieve low cost, improve 3D printing efficiency, and simple preparation method Effect

Inactive Publication Date: 2015-08-26
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing natural polymers or synthetic polymers undergo grafting reactions, grafted with photoactive groups such as acryloyl groups, and almost all of them can undergo UV polymerization to form gels. However, when these gel matrices are used for UV 3D During printing, during the forming process of ultraviolet light irradiation, due to the obvious polymerization inhibition effect of oxygen in the system, the gel forming is slow, and the gel forming time even reaches more than 10 minutes, resulting in difficulties in shaping during printing and difficulty in maintaining the print size. Greatly reduce the efficiency of 3D printing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] A preparation method of a hydrogel matrix for ultraviolet light 3D printing, the preparation method is carried out in the following steps:

[0027] a. Preparation of maleylated chitosan

[0028] Chitosan and maleic anhydride are placed in an aprotic solvent, the mass volume ratio of chitosan and aprotic solvent is 1:10-200, and the molar ratio of the amino group on the chitosan molecular chain to the anhydride group of maleic anhydride is 1 : 0.1~10, stir well at room temperature, react at 25~90℃, the reaction time is 12~48 hours, after the reaction, add anhydrous Acetone until no precipitation occurs in the mixed solution, collect the precipitate, and vacuum-dry the precipitate at room temperature for 2 days to obtain maleylated chitosan with a molar substitution degree of 0.05-0.5.

[0029] Chitosan, the N-deacetylated product of chitin, is a hydrophilic natural polymer with many excellent properties, such as good biocompatibility, biodegradability, regenerative, ant...

Embodiment 1

[0048] Weigh 5g of chitosan and 0.25g of maleic anhydride, add them to 50mL of dimethylformamide, stir well at room temperature, and react at 25°C for 12 hours. After the reaction, add anhydrous acetone until no precipitation occurs. , collected the precipitate, and dried it under vacuum for 2 days at room temperature to obtain a maleylated chitosan with a molar substitution of 0.05.

[0049] Weigh 5g of polyvinyl alcohol and 49.59g of thioglycolic acid, add them to 1000mL of deionized water, add 5mL of hydrochloric acid, stir well, and react at 25°C for 12 hours. After the reaction, add absolute ethanol until no precipitation occurs, collect The precipitate was vacuum-dried at room temperature for 3 days to obtain mercaptolated polyvinyl alcohol with a molar substitution of 0.01.

[0050] Weigh 2g of maleylated chitosan, 2g of mercaptolated polyvinyl alcohol, 0.05g of 2-hydroxyl-2-methyl-1-p-hydroxyethyl ether base phenylacetone, and add to 95.95g of Na with a pH of 7.0 ...

Embodiment 2

[0052] Weigh 5g of chitosan and 25g of maleic anhydride, add them into 1000mL of dimethylacetamide, stir evenly at room temperature, and react at 90°C for 48 hours. After the reaction, add anhydrous acetone until no precipitation occurs. The precipitate was collected and vacuum-dried at room temperature for 2 days to obtain maleylated chitosan with a molar substitution of 0.5.

[0053] Weigh 5g of polyvinyl alcohol and 165.3g of thioglycolic acid, add them to 100mL of deionized water, add 1mL of hydrochloric acid, stir well, and react at 80°C for 48 hours. After the reaction, add absolute ethanol until no precipitation occurs, collect The precipitate was vacuum-dried at room temperature for 3 days to obtain mercaptolated polyvinyl alcohol with a molar substitution of 0.1.

[0054] Weigh 8 g of maleylated chitosan, 10 g of mercaptolated polyvinyl alcohol, and 0.1 g of 1-hydroxycyclohexyl phenyl ketone, and add to 81.9 g of K with a pH of 7.4. 2 HPO 4 -KH 2 PO 4 In the b...

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Abstract

The invention relates to a method for preparing an aquogel matrix, in particular to a method for preparing the aquogel matrix for ultraviolet light three-dimensional (3D) printing and belongs to the technical field of preparation of biological materials. An alkenyl group is ingrafted on a chitosan molecular chain, a sulfydryl group is ingrafted on polyvinyl alcohol, and mixing is performed to obtain the aquogel matrix for ultraviolet light 3D printing. According to the aquogel matrix, sulfydryl-alkene 'click' reaction characteristic is fully utilized, gel forming is rapidly achieved under ultraviolet irradiation, inhibition of oxygen in air or a system can be fully overcome, 3D printing efficiency is greatly increased, cytocompatibility of the aquogel matrix is good, enough supporting environment is provided for cell growth, and cell adhesion, growth and proliferation can be facilitated. The preparation method is simple and low in costs, and industrial production is easy.

Description

technical field [0001] The invention relates to a method for preparing a hydrogel matrix, in particular to a method for preparing a hydrogel matrix for ultraviolet 3D printing, and belongs to the technical field of biomaterial preparation. Background technique [0002] Hydrogel is a kind of hydrophilic network polymer swelling body that can swell in water, absorb and retain a large amount of water without dissolving in water. Because of its high water content and structure similar to extracellular matrix, it is suitable for cell adhesion, growth and proliferation. It has become one of the preferred substrates for 3D tissue printing and artificial organ preparation, and has therefore become a major player in chemistry, materials and life medicine. research hotspots. [0003] As a traditional 3D printing solidification molding light source, laser has the advantages of accurate printing size, but when it is used for 3D biological tissue printing, its overheating problem will c...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L29/04C08G81/02C08B37/08C08F116/06C08F8/34
Inventor 周应山董齐杨硕硕殷先泽杨红军柏自奎顾绍金徐卫林
Owner WUHAN TEXTILE UNIV
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