Preparation method for hydroxylapatite hydrogel used for bone regeneration
A technology of hydroxyapatite and hydrogel, which is applied in the fields of medical science and prostheses, can solve the problems of poor stability of hydroxyapatite hydrogel, difficulty in stable and uniform dispersion, and no formation of covalent bonds. The effect of large selection range, low cost, good biocompatibility and toughness
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Embodiment 1
[0026] (1) Add 4g of hydroxyapatite nanoparticles to 80g of petroleum ether, stir at 500 rpm for 30 minutes, add 0.8g of n-propylamine and 4g of vinyltrimethoxysilane, and react at 50°C for 240 minutes; after the reaction, cool to 10°C, wash with petroleum ether, and dry to obtain functional hydroxyapatite nanoparticle powder.
[0027] (2) Add 1g of functional hydroxyapatite nanoparticles obtained in step (1), 4g oligoethylene glycol methyl ether methacrylate, 0.04g potassium persulfate, 0.04g N,N,N',N' - Add tetramethylethylenediamine to 20 g of deionized water, stir and disperse evenly to obtain a hydrogel pre-polymerization solution, and then polymerize at 25° C. for 24 hours to prepare a hydroxyapatite hydrogel with biological activity.
Embodiment 2
[0029] (1) Add 2.5g of hydroxyapatite microparticles to 80g of petroleum ether, stir at 500 rpm for 60 minutes, add 0.5g of n-propylamine and 2.5g of vinyl tris(β-methoxyethoxy ) silane, reacted at 60°C for 210 minutes; after the reaction, cooled to 10°C, washed with petroleum ether, and dried to obtain functional hydroxyapatite micron particle powder.
[0030] (2) Add 1g of functional hydroxyapatite microparticles obtained in step (1), 6g of 2-methyl-2-acrylate-2-(2-methoxyethoxy)ethyl ester, 0.05g of potassium persulfate, Add 0.05g of N,N,N',N'-tetramethylethylenediamine to 20g of deionized water, stir well and disperse evenly to obtain a hydrogel pre-polymerization solution, and then polymerize at 25°C for 48 hours to prepare a bioactive Hydroxyapatite hydrogel.
Embodiment 3
[0032] (1) Add 5 g of hydroxyapatite nanorods to 80 g of cyclohexane, stir at 800 rpm for 45 minutes, add 0.4 g of n-propylamine and 2 g of γ-methacryloxypropyltrimethoxysilane , and reacted at 80° C. for 60 minutes; after the reaction, cooled to 25° C., washed with cyclohexane, and dried to obtain functional hydroxyapatite nanorod powder.
[0033] (2) Add 0.8g of the functional hydroxyapatite nanorods obtained in step (1), 8g of polyethylene glycol diacrylate, 0.03g of sodium persulfate, and 0.06g of sodium thiosulfate into 20g of deionized water, and stir well Disperse evenly to obtain a hydrogel pre-polymerization solution, and then polymerize at 37° C. for 24 hours to prepare a hydroxyapatite hydrogel with biological activity.
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