Instant gelling agent for treating allergic rhinitis

Abstract

The invention belongs to the field of western medicinal preparation, and relates to a preparation with suitable phase variation, detention time prolonging effects and topically administered in nasal cavity, and its preparation method. The method comprises dispersing momestasone furoate or budesonide in hydrophilic gel substrate prepared from acetyl-removed gellan gum and sodium alginate in micro powder form. the gel preparation is prepared and stored in solution from, and administered in solution spraying form; generates phase variation due to the change of environmental ionic strength, pH, or temperature after contacting with tunica mucosa of nasal cavity, and forms gel. The invention has the advantages of simple preparation and accurate administered dose; can prolong the contact time of medicine and schneiderian membrane; and improves therapeutic effect of the medicine to anaphylactic rhinitis.

Description

technical field

[0001] The invention belongs to the field of western medicine preparations, and relates to a novel nasal instant gel preparation containing glucocorticoids and a preparation method thereof. Background technique

[0002] Allergic rhinitis is an allergic inflammatory disease caused by a variety of allergens. It is prone to attack in spring and autumn and in cold climates. It is an allergic reaction that often occurs in the nasal mucosa. The incidence has increased in recent years. This disease can occur in men and women of any age, more common with 15-40 years old. Typical symptoms are nasal itching, nasal congestion, sneezing, a large amount of watery nasal discharge, and decreased sense of smell. When allergic rhinitis attacks, the patient is very painful and needs active treatment to relieve symptoms. For allergic rhinitis, we must first pay attention to remove the cause and incentives, such as keeping warm and cold, avoiding contact with pollen, preventin...

Images