Hydrogel patch and preparation method thereof

Abstract

The invention relates to a hydrogel patch and a preparation method thereof. The hydrogel patch consists of three parts: bidirectional flexible non-woven fabric, medicament-containing paste and a cover film layer, wherein the main part, namely the medicament-containing paste is prepared from fluid extract and proper hydrogel matrixes such as an adhesive, a humectant, an excipient, a pH modifying agent, a cross-linking agent, a transdermal enhancer, a filler, a dispersant, a chelating agent, a tackifier and deionized water according to a proportion, wherein the tackifier is at least one of polyvinyl alcohol, povidone, gelatin, carboxymethyl cellulose, collagen, modified starch and plant polysaccharide, or is emulsion formed by polymerizing free radicals of 0-30 percent acrylic acid, 0 to 50 percent vinyl pyrrolidone and 0 to 50 percent 2-acrylamido-2-methylpropanesulfonic acid, and is added in an amount which is 5 to 15 percent based on the total weight. The hydrogel patch solves the common problem of poor viscosity of common hydrogel, and has the characteristics of high adhesion, high compliance with skin, quick response, reusability, moisture retention, permeability and comfortable use.

Description

technical field

[0001] The invention relates to a hydrogel-based patch and a preparation method thereof. Background technique

[0002] Hydrogel patch is a new type of external application agent with high technological content, wide application range and convenient use in the world today. In the early 1970s, countries such as Japan and Europe began to develop medical hydrogel patches. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. Compared with the traditional rubber-type external plaster, the hydrogel patch has the following advantages: it has good biocompatibility, affinity, air permeability and sweat resistance to the skin, and is not easy to be allergic; it adopts water-soluble macromolecular gel Gel matrix, no residue after use, no pollution to clothes; good moisturizing performance, can quickly hydrate skin keratinocytes, which is conducive to transdermal absorption of drugs, and has the...

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