Hydrogel patch and preparation method thereof

A hydrogel patch and hydrogel technology, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as poor viscosity of hydrogels, and achieve the effect of meeting the requirements of adhesion

Active Publication Date: 2010-12-29
云南白药集团无锡药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned shortcomings of the existing hydrogel patch, the applicant provides another hydrogel patch and its preparation method after research and improvement, which solves

Method used

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  • Hydrogel patch and preparation method thereof
  • Hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0075] The preparation method of hydrogel patch of the present invention is:

[0076] (1) Disperse and dissolve the adhesive, chelating agent, and excipient with an appropriate amount of humectant, stir evenly, and set aside;

[0077] (2) disperse and dissolve the crosslinking agent with a dispersant, stir evenly, and set aside;

[0078] (3) Add the prepared part of step (2) into step (1), and stir evenly until there is no agglomerate, and it becomes a milky white suspension;

[0079] (4) Add liquid extract, transdermal accelerator, pH regulator, filler, thickener and deionized water, stir and knead evenly, and apply on the machine after vacuum defoaming.

Embodiment 1～6

[0082] See Table 1 for the weight of each ingredient required, unit: g

[0083] Table 1 Examples 1-6

[0084]

[0085] Preparation and test steps:

[0086] 1. Accurately weigh adhesive 1, adhesive 2, chelating agent (EDTA), excipient and humectant (glycerin) according to the formula, stir and disperse evenly, and this is part A. Adhesive 1, adhesive 2, chelating agent (EDTA) and excipients in part A are all insoluble in humectant (glycerin), but can be well dispersed in humectant (glycerin). Thick.

[0087] 2. Accurately weigh the cross-linking agent according to the formula, dissolve and disperse it with dispersant (ethanol) to form part B. The cross-linking agent in part B is also insoluble in ethanol, but is dispersed in ethanol as a slightly white suspension.

[0088] 3. Add the prepared part B into part A, and stir until there is no aggregate and uniform milky white suspension; the crosslinking agent in component B first reacts with the chelating agent in component...

Embodiment 7～12

[0098] See Table 2 for the weight of each ingredient required, unit: g

[0099] Table 2 Embodiment 7~12

[0100]

[0101] The preparation and test steps of Examples 7-12 are basically the same as those of Examples 1-6, except that Yunnan Baiyao liquid extract is not added in Step 4, so it is convenient to test the hydrogel matrix itself. The test results of its initial adhesion performance are shown in Table 3.

[0102] Table 3 The test of initial adhesion performance (30 degree slope rolling ball method)

[0103]

[0104] It can be seen from Table 3 that the addition of tackifiers has a significant effect on changing the initial adhesive properties of hydrogel matrix colloids. With the increase of the added amount of tackifier, its initial tack increases gradually, but when its content reaches 5%, the rise of colloid's initial tack is relatively gentle.

[0105] In addition, it is considered that with the increase of the added amount of tackifier and the increase of ...

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Abstract

The invention relates to a hydrogel patch and a preparation method thereof. The hydrogel patch consists of three parts: bidirectional flexible non-woven fabric, medicament-containing paste and a cover film layer, wherein the main part, namely the medicament-containing paste is prepared from fluid extract and proper hydrogel matrixes such as an adhesive, a humectant, an excipient, a pH modifying agent, a cross-linking agent, a transdermal enhancer, a filler, a dispersant, a chelating agent, a tackifier and deionized water according to a proportion, wherein the tackifier is at least one of polyvinyl alcohol, povidone, gelatin, carboxymethyl cellulose, collagen, modified starch and plant polysaccharide, or is emulsion formed by polymerizing free radicals of 0-30 percent acrylic acid, 0 to 50 percent vinyl pyrrolidone and 0 to 50 percent 2-acrylamido-2-methylpropanesulfonic acid, and is added in an amount which is 5 to 15 percent based on the total weight. The hydrogel patch solves the common problem of poor viscosity of common hydrogel, and has the characteristics of high adhesion, high compliance with skin, quick response, reusability, moisture retention, permeability and comfortable use.

Description

technical field [0001] The invention relates to a hydrogel-based patch and a preparation method thereof. Background technique [0002] Hydrogel patch is a new type of external application agent with high technological content, wide application range and convenient use in the world today. In the early 1970s, countries such as Japan and Europe began to develop medical hydrogel patches. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. Compared with the traditional rubber-type external plaster, the hydrogel patch has the following advantages: it has good biocompatibility, affinity, air permeability and sweat resistance to the skin, and is not easy to be allergic; it adopts water-soluble macromolecular gel Gel matrix, no residue after use, no pollution to clothes; good moisturizing performance, can quickly hydrate skin keratinocytes, which is conducive to transdermal absorption of drugs, and has the...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/534A61K9/70A61K47/32A61K47/36A61K47/38A61K47/42A61P29/00A61K31/045A61K31/125A61K31/165
Inventor 黄嘉兰谢黄养刘跃罗文虎
Owner 云南白药集团无锡药业有限公司
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