Polyphenol substance hydrogen bond enhanced hydrogel

A technology of hydrogel and polyphenols, applied in aerosol delivery, bandage, emulsion delivery, etc., can solve problems such as poor mechanical properties, achieve enhanced mechanical properties, broad application prospects, and good comprehensive performance

Pending Publication Date: 2020-06-16
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the problems existing in the existing traditional chemically cross-linked hydrogels, one of the objectives of the present invention is to provide a polyphenolic substance hydrogen bond enhanced hydrogel, and the second objective of the present invention is to provide this polyphenolic substance The preparation method of hydrogen bond enhanced hydrogel, the third object of the present invention is to provide the application of this polyphenol hydrogen bond enhanced hydrogel
In order to overcome the problem of poor mechanical properties of traditional chemically cross-linked hydrogels, the present invention proposes a method for hydrogen bond-enhanced hydrogels of polyphenols

Method used

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  • Polyphenol substance hydrogen bond enhanced hydrogel
  • Polyphenol substance hydrogen bond enhanced hydrogel
  • Polyphenol substance hydrogen bond enhanced hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0035] 1. Preparation of double bond modified hyaluronic acid

[0036] 1 g of hyaluronic acid was stirred and dissolved in 100 mL of mixed solvent (DMF:water=1:2, v:v). After fully dissolving, cool down to 4°C in an ice-water bath, and adjust the pH to 8-9 with 5M (mol / L) sodium hydroxide solution. Slowly add 3.7 mL of methacrylic anhydride dropwise, and stir overnight at 4° C. to maintain a stable pH value between 8 and 9. The reacted solution was poured into 1L of absolute ethanol, and stood at 4° C. overnight to completely precipitate MA-HA (methacrylic anhydride-hyaluronic acid). Centrifuge, redissolve the precipitated product in ultrapure water, dialyze through a dialysis bag with a molecular weight of 14,000, change the water every 4 hours, freeze-dry after 5 days of dialysis, and obtain methacrylic anhydride-modified hyaluronic acid, that is, double-bond modified hyaluronic acid acid.

[0037] 2. Preparation of tannin-enhanced hyaluronic acid hydrogel

[0038] 2% (w...

Embodiment 2

[0042]1. Preparation of sodium alginate hydrogel

[0043] Prepare 5% (w / v) sodium alginate aqueous solution. Prepare a calcium chloride solution with a certain concentration (such as 10mmol / L), and add it dropwise to the sodium alginate aqueous solution until the gel is formed. Stand at room temperature for 2 hours for later use.

[0044] 2. Preparation method of tannic acid enhanced sodium alginate gel

[0045] Prepare a Tris buffer solution with a pH=8.5 and a concentration of 0.1M. A 10 mg / mL tannic acid / Tris solution was prepared, the prepared gel was soaked in it, and shaken at room temperature for 4 days in the dark. After taking out, rinse with phosphate buffered saline solution (PBS) of pH=7.4 for 3 times to obtain tannic acid enhanced sodium alginate gel.

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Abstract

The invention discloses polyphenol substance hydrogen bond enhanced hydrogel. The polyphenol substance hydrogen bond enhanced hydrogel is formed by hydrogen bond crosslinking of polyphenol substancesand hydroxyl-rich hydrogel. A preparation method of the polyphenol substance hydrogen bond enhanced hydrogel comprises the following steps: 1) crosslinking a hydroxyl-rich hydrogel matrix to obtain gel; and 2) soaking the gel in an alkaline solution of polyphenol substances, and carrying out a cross-linking reaction. The polyphenol substance hydrogen bond enhanced hydrogel can be used as a drug carrier or a tissue repair medical material. The mechanical strength of the polyphenol substance hydrogen bond enhanced hydrogel is remarkably improved, the degradation rate is greatly reduced, the comprehensive performance is remarkably improved, and the application prospect is wide.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a polyphenol hydrogen bond-enhanced hydrogel. Background technique [0002] Hydrogel is a network polymer that swells in water and retains water in the polymer voids, and has a wide range of applications in the field of biomaterials. However, traditional covalent chemically crosslinked hydrogels have weak mechanical properties, are prone to permanent rupture under external force, and their internal network crosslinking structure is single, which severely limits the application of hydrogels in tissue repair. [0003] The poor mechanical properties of traditional chemically crosslinked hydrogels are mainly due to the lack of corresponding energy dissipation mechanisms in the gel network, resulting in a low resistance to crack propagation in the network. Because under the external force loading, the cross-linked structure in the hydrogel network will be destroyed and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L5/04A61K9/06A61L26/00
CPCC08J3/075C08J3/243A61L26/008A61K9/06C08J2305/08C08J2305/04
Inventor 于珊耿志杰纪禹行刘群峰
Owner GUANGDONG PROV MEDICAL INSTR INST
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