The invention discloses a production technology of sucralose. The technology is characterized in that the technology comprises the steps of: an esterification step, a hydrolysis step, a translocation step, a chlorination step, an extraction step, a sucralose-6-acetate refining step, and a de-protection step. The technology has the advantages that: the production technology of sucralose is easy to realize, the product energy consumption is low, and the yield is high. With the technology, the prepared sucralose can be used for improving the life qualities of people, especially the life qualities of people required to avoid sugar. The sweet characteristic of sucralose is similar to that of cane sugar, and sucralose has no bitter after-taste. Sucralose has no calories, causes no dental caries, and has good stability. Sucralose is especially stable in water solutions. Currently, sucralose is already widely applied in industries such as beverages, foods, medicines, and cosmetics. Sucralose is a novel non-nutritional sweetening agent, and is an ideal food additive for patients of obesity, cardiovascular diseases and diabetes, such that the applications of sucralose in health-care foods and medicines are continuously improved.