The invention relates to a synthesis process of fluorinated nucleosides, comprising the following steps: step 1, refluxing cytosine and hexamethyldisilazane under the catalysis of ammonium sulfate, then adding isopropanol, and raising the temperature, Obtain a cytosine silyl ether protecting group solution; step 2, dissolve the glycosyl compound in isoamyl alcohol and stir, then add a catalyst and heat to obtain a glycosyl compound solution; step 3, drop the glycosyl compound into the cytosine silyl ether protecting group solution Add the glycosyl compound solution, after the dropwise addition, continue to keep warm for an hour, then filter with suction, add hydrochloric acid dropwise to the filtrate to precipitate a solid, and obtain an intermediate after drying; step 4, the intermediate Carry out the deprotection of the hydroxyl group to obtain the fluorinated nucleoside. The invention not only ensures the formation of the target intermediate configuration, but also greatly reduces the temperature, which not only reduces the requirements for equipment, improves the safety of operation, but also reduces energy consumption, which is beneficial to reduce costs, and is suitable for large-scale production applications .