Microcapsule sustained release agent and preparation method and application thereof

A technology for microcapsules and sustained-release agents, which is applied in the fields of microcapsules and sustained-release agents and their preparation and application fields, can solve the problems of short retention time of essences and the like, and achieve the effects of mild conditions, easy realization and prevention of volatilization

Inactive Publication Date: 2012-03-14
TIANJIN SINOSH NEW MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This application is also solving the problem that people can choose whether to release fragrance, but it does not solve the problem of short fragrance retention time

Method used

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  • Microcapsule sustained release agent and preparation method and application thereof
  • Microcapsule sustained release agent and preparation method and application thereof
  • Microcapsule sustained release agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve 5g of gelatin in 245ml of hot water at room temperature to prepare a 2% solution; dissolve 5g of gum arabic in 120ml of water to prepare a 4% aqueous solution of gum arabic, add 2ml of CO40 to the gum arabic solution and stir to dissolve, add 5g of essence , homogeneously emulsified at 3000rpm for 15min, add the gelatin solution prepared above to the emulsified emulsion, coagulate at 50°C, dropwise add acetic acid to adjust the pH to 4.0, stir for 30min, stop heating, let the temperature drop to room temperature, add 25% acetone 4ml of dialdehyde was solidified for 1h; adjusted the pH value of the system to 7, continued stirring for 30min, then stopped stirring, settled, and filtered to obtain a filter cake. Washed with ethanol and dried to obtain microcapsule sustained-release preparation. The encapsulation rate of the essence was 80%, and the drug loading was 20%.

[0028] Take the microcapsule sustained-release preparation prepared in Example 1 and carry ou...

Embodiment 2

[0059] Dissolve 5g of natural polymer gelatin in 120ml of hot water at room temperature to prepare a 4% solution; dissolve 5g of gum arabic in 245ml of water to prepare a 2% aqueous solution of gum arabic, add 2ml of Tween-20 to the gum arabic solution Stir to dissolve, add 5g of essence, homogeneously emulsify at 3000rpm for 15min, add the prepared natural polymer gelatin solution to the emulsified emulsion, coagulate at 50°C, adjust the pH to 4.0, stir for 30min, stop heating, and reduce the temperature to At room temperature, add 4 ml of 25% glutaraldehyde to solidify for 1 hour; adjust the pH of the system to 7, continue stirring for 30 minutes, then stop stirring, settle, and filter to obtain a filter cake, which is soaked in a 1% concentration of tannic acid solution for 12 After 1 hour, suction-filtered again, washed with ethanol, and dried to obtain microcapsule powder. The encapsulation rate of the essence was 90%, and the drug loading was 25%.

Embodiment 3

[0061] Dissolve 5g of gelatin in 120ml of hot water at room temperature to prepare a 4% solution; dissolve 5g of gum arabic in 245ml of water to prepare a 2% aqueous solution of gum arabic, add 2ml of CO40 to the gum arabic solution and stir to dissolve, add 5g of essence , homogeneously emulsified at 3000rpm for 15min, add the prepared gelatin solution to the emulsified emulsion, coagulate at 50°C, adjust the pH value to 4.0, stir for 30min, stop heating, make the temperature drop to room temperature, add 4ml of 25% glutaraldehyde Solidify for 1 hour; adjust the pH value of the system to 7, continue stirring for 30 minutes, then stop stirring, settle, and suction filter to obtain a filter cake, soak the filter cake in a 1% concentration of tannic acid solution for 12 hours, then suction filter, wash with ethanol , microcapsule powder is obtained after drying. The encapsulation rate of the essence was 50%, and the drug loading was 10%.

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Abstract

The invention provides a microcapsule sustained release agent and a preparation method and application thereof. The microcapsule sustained release agent is prepared by embedding essence with gelatin and Arabic gum, and is applied to sanitary towels or sanitary cushions or panty-shape diapers or pet cushions. The microcapsule sustained release agent consists of a core material and a wall material, wherein the wall material consists of natural high molecular gelatin, Arabic gum and a curing agent; the core material consists of essence and essential oil; the curing agent consists of tannic acid and glutaraldehyde; and microencapsulation is performed on the core material and the wall material in the ratio 1:2. The invention further provides a preparation method of the microcapsule sustained release agent. The preparation method comprises the following steps of: adding an emulsifier into Arabic gum for mixing; adding essence or essential oil into an emulsion for homogenizing and emulsifying; adding a gelatin solution into the emulsified emulsion; agglomerating into a capsule; curing with a curing agent; and drying to obtain a high-dispersity microcapsule sustained release agent. By adding the microcapsule sustained release agent into the space between a skin contact layer and a water-absorbing layer of a sanitary towel or sanitary cushion or panty-shape diaper or pet cushion, the effect of keeping fragrance for a long time can be achieved.

Description

technical field [0001] The present invention relates to a microcapsule sustained-release preparation, a preparation method and application thereof, in particular to a microcapsule sustained-release preparation with fragrance which can be used for sanitary napkins or sanitary pads, diapers or pet pads. Background technique [0002] With the development of the economy and the improvement of living standards, people's requirements for sanitary products have undergone great changes. From the past practical type to the enjoyment and health care type, the fragrance of sanitary napkins conforms to this trend. Because scented sanitary napkins have the functions of inhibiting bacteria and repelling insects, covering up odors, and making body and mind comfortable, they have been widely loved by people. [0003] Sanitary napkins have been scented for a long time, but currently on the market, fragrances are usually diluted with essence and then sprayed directly on the surface of the san...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/00B01J13/02A61L15/46A01K1/015
Inventor 韩海星王丽华孙玉琢
Owner TIANJIN SINOSH NEW MATERIAL TECH
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