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Polymer membranes for continuous analyte sensors

a technology of analyte sensor and polymer membrane, which is applied in the field of continuous measurement of analyte concentration, can solve the problems of many transcutaneous and intravascular sensors having problems in accurately sensing and reporting back glucose values continuously, and the complications of implantable glucose sensors within the body, so as to reduce the flux therethrough and reduce the effect of passage therethrough

Pending Publication Date: 2013-02-28
DEXCOM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes an implantable device that can continuously measure the concentration of an analyte in a host. The device includes a sensor that generates a signal based on the analyte concentration, and a membrane that reduces the flux of the analyte and passes the interferent. The membrane has alternating layers of a polycationic material and a polyanionic material, which help to selectively reduce the passage of interferents. The device can be made with a variety of different membrane materials and can have a different sensitivity to different interferents. The membrane layers can be cross-linked or self-assembled. The device can be used for continuous measurement of analyte concentrations in a host.

Problems solved by technology

Many implantable glucose sensors suffer from complications within the body and provide only short-term or less-than-accurate sensing of blood glucose.
Similarly, many transcutaneous and intravascular sensors have problems in accurately sensing and reporting back glucose values continuously over extended periods of time, for example, due to noise on the signal caused by interfering species or unknown noise-causing events.

Method used

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  • Polymer membranes for continuous analyte sensors
  • Polymer membranes for continuous analyte sensors
  • Polymer membranes for continuous analyte sensors

Examples

Experimental program
Comparison scheme
Effect test

example 1

General Preparation of Layered Interference Domains

[0249]Layered interference domains were prepared as follows. Nine poly(allylamine hydrochloride) (PAH) dip solutions were prepared by dissolving PAH having a molecular weight of approximately 100,000-200,000 g / mol in water to produce an aqueous solution with a concentration of approximately 50 mM of PAH. Each of the resulting nine solutions was then titrated with acetic acid or ammonium hydroxide to a pH of 10.0, 9.75, 9.5, 9.25, 9.0, 8.5, 8.0, 7.5, and 7.0, respectively.

[0250]Nine solutions for rinsing after PAH immersion were prepared by titrating water with ammonium hydroxide until a pH of 10.0, 9.75, 9.5, 9.25, 9.0, 8.5, 8.0, 7.5, and 7.0, respectively, was reached.

[0251]Five poly(acrylic acid) (PAA) dip solutions were prepared by dissolving PAA having a molecular weight of approximately 100,000 g / mol in water to produce an aqueous solution with a concentration of approximately 50 mM of PAA. Each of the resulting five solutions ...

example 2

Preparation of PAH / PVS Interference Domains

[0257]Layered interference domains were prepared using poly(allylamine hydrochloride) (PAH) and poly(vinyl sulfate) (PVS) as follows. Dipping solutions of PAH and corresponding rinse solutions were prepared according to Example 1.

[0258]Poly(vinyl sulfate) (PVS) dipping solutions and corresponding rinse solutions were prepared in a manner corresponding to the preparation of the PAA solutions described in Example 1.

[0259]Various interference domains were prepared by sequentially dipping a bare platinum wire into the PAH dip solution, followed by the corresponding rinse solution, followed by the PVS dip solution, and followed by the corresponding rinse solution. Interference domains were prepared with 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14 layers by sequentially dipping the wire into PAH dip / rinse solutions followed by PVS dip / rinse solutions.

[0260]For example, a four-layered interference domain was prepared by: (1) dipping a bare wire...

example 3

Effect of Different Numbers of PAH / PVS Layers

[0262]The number of PAH and PVS layers in interference domains was varied to determine the effect of the number of layers on the permeability of the resulting interference domain to H2O2, acetaminophen, ascorbic acid, and uric acid. Sensors were prepared comprising platinum electrodes coated with interference domains prepared according to the procedure described in Example 2. Specifically, an interference domain containing a single layer of PAH was prepared. Also, interference domains containing 2, 3, and 4 layers of alternating PAH and PVS layers were prepared. An enzyme domain was added according to methods known in the art. The resulting sensors were sequentially placed into solutions that contained either H2O2, acetaminophen, ascorbic acid, or uric acid. The average current response (pA) for each solution was measured. The sensitivity of the current response versus the concentration of H2O2 was determined. The selectivity of the inter...

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Abstract

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 13 / 594,602, filed Aug. 24, 2012, which claims the benefit of priority under 35 U.S.C. §119(e) of U.S. Provisional Application No. 61 / 527,856 filed Aug. 26, 2011, the disclosure of which is hereby expressly incorporated by reference in its entirety and is hereby expressly made a portion of this application.FIELD OF THE INVENTION[0002]Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has an interference domain that reduces permeation of one or more interferents into an electrochemically reactive surface. The interference domain can be configured to be more permeable or less permeable to one or more interferents than to a measured analyte species.BACKGROUND OF THE INVENTION[0003]Electrochemical sensors are useful in chemistry and medicine to determine the presence or concentration of a biological a...

Claims

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Application Information

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IPC IPC(8): A61B5/1473B05D7/00
CPCA61B5/686A61B2562/125A61B5/14865A61B5/14532A61B5/14503G01N27/333C12Q1/00A61B5/6846G01N27/3271A61B5/1486
Inventor HUGHES, JONATHANBOOCK, ROBERT J.DRING, CHRIS W.
Owner DEXCOM
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