The invention pertains to the technical field of the copper clad laminate, which more particularly relates to a prepreg applied to a printing circuit multilayer board. The prepreg comprises reinforced materials and resin composite, wherein, the reinforced materials is glass fiber paper, and according to part by weight, the formulation of the resin composite is as follows: 20 to 84 portions of resin, 0 to 35 portions of filling materials, 0.01 to 0.3 portions of curing accelerator and 10 to 45 portions of solvent; the resin composite solvent is soaked in the glass fiber paper for 1 to 5 minutes, and is put in a 140 to 200 DEG C oven for baking for 2 to 10 minutes; after the solvent is removed, the prepreg applied to multilayer PCB processing materials is obtained; white flake and spot problems of base materials during the manufacturing procedures of the multilayer PCB are prevented, problems of de-lamination, shrink resin, holes and crack of the resin and white flake, etc. that come up after the multilayer PCB goes through cold and hot impact are improved, and the prepreg has good reliability and low cost.