Cream for treating pressure sores and diabetic feet and preparation method thereof

Abstract

The invention belongs to the field of medicine, and provides cream for treating pressure sores and diabetic feet and a preparation method thereof.The cream is prepared from a component A, a component B, a component C and a component D. The component A is prepared from, by mass, 10-40 parts of ligustrum sinense leaves, 10-40 parts of angelica sinensis, 10-40 parts of sanguisorba officinalis, 10-40 parts of golden cypress, 10-40 parts of liquorice, 10-40 parts of radix angelicae, 10-40 parts of polygonum cuspidatum and 10-40 parts of dried rehmannia glutinosa; the component B is prepared from the following components in parts by mass: 10 to 30 parts of rhizoma coptidis, 10 to 30 parts of radix et rhizoma rhei, 10 to 30 parts of radix paeoniae rubra, 10 to 30 parts of radix scrophulariae, 10 to 30 parts of cortex moutan, 10 to 30 parts of radix astragali seu hedysari and 10 to 30 parts of rhizoma chuanxiong; the component C is prepared from the following components in parts by weight: 10 to 15g of radix lithospermi, 3 to 10g of borneol and 5 to 10g of beewax; the component D is 500g of medical vaseline; through a specific traditional Chinese medicine composition, pressure sores and diabetic feet can be effectively treated, related symptoms can be remarkably relieved, and meanwhile animal experiments show that the traditional Chinese medicine cream is free of toxic and side effects.

Description

Technical Field

[0001] The invention belongs to the field of medicine, in particular to a cream for treating bedsores and diabetic foot and a preparation method thereof. Background Art

[0002] Pressure sores, also known as bedsores, are mainly caused by prolonged pressure or friction that causes damage to the skin and subcutaneous tissue. This condition is common in patients who are bedridden or in wheelchairs for a long time because their skin is constantly compressed by the weight of their body. The severity of pressure sores can range from erythema of the skin to deep tissue necrosis, and in severe cases may lead to infection, pain and other complications. Diabetic foot is a common complication in patients with diabetes, which is mainly caused by nerve and blood vessel damage caused by long-term high blood sugar. This damage reduces the patient's feet's perception of pain and temperature, making them susceptible to trauma and infection. If not treated in time, diabetic foot can lead to severe foot ulcers, gangrene, and may even require amputation. In summary, pressure sores and diabetic foot are both diseases that cause serious damage to the patient's skin and tissue;

[0003] Currently, there are creams for treating pressure ulcers and diabetic foot on the market or in the research field, but these products cannot fully meet clinical needs. Traditional creams have poor therapeutic effects and obvious side effects. These problems limit their wide application and effectiveness.

[0004] To this end, those skilled in the art have proposed a cream for treating pressure sores and diabetic foot and a preparation method thereof to solve the problems raised by the background art. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a cream for treating pressure sores and diabetic foot and a preparation method thereof, so as to solve the problems in the prior art.

[0006] A cream for treating bedsores and diabetic foot, comprising component A, component B, component C and component D, wherein component A comprises, by mass fraction, 10-40 parts of flaxseed oil leaves, 10-40 parts of angelica sinensis, 10-40 parts of sanguisorba officinalis, 10-40 parts of phellodendron amurense, 10-40 parts of liquorice, 10-40 parts of angelica dahurica, 10-40 parts of knotweed and 10-40 parts of dried rehmannia root;

[0007] Component B comprises, by mass fraction, 10-30 parts of coptis root, 10-30 parts of rhubarb, 10-30 parts of red peony root, 10-30 parts of figwort, 10-30 parts of peony bark, 10-30 parts of astragalus and 10-30 parts of ligusticum chuanxiong;

[0008] Component C comprises, by weight, 10-15 g of lithospermum officinale, 3-10 g of borneol and 5-10 g of beeswax;

[0009] Component D is 500g of medical vaseline.

[0010] A method for preparing a cream for treating bedsores and diabetic foot, comprising the following steps:

[0011] S1, mixing the raw materials in component A and component B, crushing them, putting them into soybean oil and stirring to obtain a mixture 1;

[0012] S2, putting the mixture in step S1 into a thermostatic box to extract the fat-soluble components in the traditional Chinese medicine, leaving it for 48 hours, removing it, filtering out the medicine residue, and obtaining the AB component medicine oil for standby use;

[0013] S3, mixing the raw materials of component C according to the prescribed amount, crushing them, putting them into soybean oil and stirring, to obtain a mixture II;

[0014] S4, putting the mixture 2 into a thermostatic box for extraction and dissolution, taking it out after 48 hours, filtering out the drug residue to obtain the C component drug oil for standby use;

[0015] S5, mixing the AB component medicinal oil and the C component medicinal oil to prepare the Chinese medicinal oil;

[0016] S6, taking 500 g of medical vaseline, adding it into the traditional Chinese medicine oil, stirring and mixing, and preparing an ointment;

[0017] S7. Pack the cream.

[0018] Preferably, in step S1, the amount of soybean oil is 1000 ml.

[0019] Preferably, in step S2, the temperature of the thermostat is controlled at 80-90°C.

[0020] Preferably, in step S3, the amount of soybean oil is 1000 ml.

[0021] Preferably, in step S4, the temperature of the thermostat is controlled at 80-100°C.

[0022] Preferably, in step S5, the mixing ratio of component AB medicinal oil and component C medicinal oil is 10:1.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The cream prepared by the present invention has a good effect of promoting the healing of damaged skin caused by pressure sores and diabetic foot, and damaged and infected wounds without scars.

[0025] 2. The cream prepared by the present invention has been shown to have no toxic or side effects through animal experiments. DETAILED DESCRIPTION

[0026] The following examples are used to illustrate the present invention, but they are not intended to limit the scope of the present invention.

[0027] Embodiment 1: The present invention provides a cream for treating bedsores and diabetic foot, comprising component A, component B, component C and component D, wherein component A comprises, by mass fraction, 10-40 parts of waxberry leaves, 10-40 parts of angelica, 10-40 parts of sanguisorba officinalis, 10-40 parts of phellodendron, 10-40 parts of liquorice, 10-40 parts of angelica dahurica, 10-40 parts of knotweed and 10-40 parts of dried rehmannia root;

[0028] Among them, in component A, the leaves of the wax tree have anti-inflammatory, antibacterial and antifungal, diuretic, anti-inflammatory and analgesic, and antioxidant effects, which help relieve skin inflammation and promote skin health;

[0029] Angelica can invigorate blood circulation and remove blood stasis, improve blood circulation, nourish blood and improve skin's antioxidant capacity; at the same time, Angelica can also help regulate immunity and improve symptoms such as insomnia and indigestion;

[0030] Sanguisorba officinalis has the effects of promoting diuresis and reducing swelling, clearing away heat and detoxifying, cooling blood and stopping bleeding. It can be used to treat various symptoms caused by internal heat, as well as to stop bleeding and reduce swelling and heal sores.

[0031] Phellodendron amurense has the effects of clearing away heat and dampness, antibacterial and anti-inflammatory, astringent and antidiarrheal, antioxidant, and anti-allergic, and has a good effect on the treatment of skin infections and inflammatory diseases.

[0032] Licorice has the functions of clearing away heat and detoxifying, reducing inflammation, removing phlegm and relieving cough, relieving pain and harmonizing various medicines. It can assist in the treatment of skin inflammation, relieve pain, and enhance the efficacy of other medicines.

[0033] Angelica dahurica has the effects of dispelling cold, dispelling wind and relieving pain, clearing the nasal passages, drying dampness and stopping leukorrhea, and beautifying and nourishing the skin. It improves local blood circulation and accelerates the metabolism of skin cells.

[0034] Polygonum cuspidatum has the effects of clearing away heat and detoxifying, dispersing blood stasis and relieving pain, resolving phlegm and relieving cough. It is mainly used to treat damp-heat jaundice, stranguria, leucorrhea and other symptoms. It can also calm and relieve pain, and is also beneficial to the cardiovascular system.

[0035] Dried Rehmannia root has the effects of clearing heat and cooling blood, nourishing yin and promoting body fluid. It can be used to treat symptoms such as fever, thirst, yin deficiency and internal heat. It helps to regulate the patient's internal environment and promote wound healing.

[0036] Component B comprises, by mass fraction, 10-30 parts of coptis root, 10-30 parts of rhubarb, 10-30 parts of red peony root, 10-30 parts of figwort, 10-30 parts of peony bark, 10-30 parts of astragalus and 10-30 parts of ligusticum chuanxiong;

[0037] Among them, in component B, coptis chinensis, rhubarb, red peony root, Scrophularia ningpoensis, peony bark, astragalus and chuanxiong are all traditional Chinese medicinal materials, which have the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, cooling blood and stopping bleeding, invigorating qi and nourishing blood, and can assist in the treatment of skin inflammation and infection, promote wound healing, and improve blood circulation.

[0038] Component C comprises, by weight, 10-15 g of lithospermum officinale, 3-10 g of borneol and 5-10 g of beeswax;

[0039] Among them, in component C, Lithospermum officinale has the effects of cooling blood, activating blood circulation, detoxifying and clearing rashes, and can be used to treat symptoms such as excessive blood heat and toxicity, purple and black macules, and helps to relieve skin inflammation and infection;

[0040] Borneol has the effects of invigorating the mind, clearing away heat and relieving pain, and can relieve pain and discomfort;

[0041] Beeswax has the effects of detoxification, tissue regeneration and analgesia. It is often used to treat ulcers, trauma and other symptoms, and helps promote wound healing.

[0042] Component D is 500 g of medical vaseline, wherein the medical vaseline, as a base of the cream, has good moisturizing and lubricating effects, can protect the skin, and promote the absorption and penetration of drug ingredients.

[0043] From the above, we can see that by combining the above components together, this cream can give full play to the efficacy of each medicinal material, and has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, cooling blood and stopping bleeding, antibacterial and anti-inflammatory, and reducing swelling and relieving pain, thereby effectively treating pressure sores and diabetic foot diseases. At the same time, the interaction and synergistic enhancement between the components make the therapeutic effect of the cream more significant.

[0044] Embodiment 2: This embodiment is basically the same as the previous embodiment, except that a method for preparing a cream for treating pressure sores and diabetic foot comprises the following steps:

[0045] S1, mixing the raw materials in component A and component B, crushing them, putting them into soybean oil and stirring to obtain a mixture 1;

[0046] Among them, the crushing process helps to increase the surface area of ​​the raw materials and improve the subsequent extraction efficiency. The raw materials in component A and component B are placed in soybean oil and stirred. Soybean oil, as an extraction solvent for fat-soluble components, helps to dissolve the effective ingredients of traditional Chinese medicine.

[0047] S2, putting the mixture in step S1 into a thermostatic box to extract the fat-soluble components in the traditional Chinese medicine, leaving it for 48 hours, removing it, filtering out the medicine residue, and obtaining the AB component medicine oil for standby use;

[0048] Among them, controlling the temperature helps to accelerate the dissolution of the effective ingredients of traditional Chinese medicine and improve the extraction efficiency. The 48-hour extraction time ensures that the fat-soluble components in the traditional Chinese medicine are fully dissolved. The medicinal oil obtained after removing the residue is purer and convenient for subsequent use.

[0049] S3, mixing the raw materials of component C according to the prescribed amount, crushing them, putting them into soybean oil and stirring, to obtain a mixture II;

[0050] Among them, putting component C into soybean oil and stirring it is helpful for the full dissolution of the raw materials and subsequent extraction.

[0051] S4, putting the mixture 2 into a thermostatic box for extraction and dissolution, taking it out after 48 hours, filtering out the drug residue to obtain the C component drug oil for standby use;

[0052] Among them, putting the mixture into a constant temperature box for extraction is helpful for the API in the mixture to fully dissolve and react. Long-term extraction can ensure the purity and effectiveness of the drug oil.

[0053] S5, mixing the AB component medicinal oil and the C component medicinal oil to prepare the Chinese medicinal oil;

[0054] Among them, traditional Chinese medicine oil with multiple medicinal effects is obtained through mixing, which lays the foundation for the preparation of cream.

[0055] S6, taking 500 g of medical vaseline, adding it into the traditional Chinese medicine oil, stirring and mixing, and preparing an ointment;

[0056] Among them, by adding medical vaseline to the traditional Chinese medicine oil, the medical vaseline serves as the base of the cream and has good moisturizing, lubricating and skin protection effects. Stirring and mixing can ensure that the traditional Chinese medicine oil and vaseline are fully and evenly mixed to form a stable cream system.

[0057] S7. Pack the cream.

[0058] Among them, packaging can prevent the cream from being contaminated and deteriorating during storage and transportation, and at the same time, it is also convenient for patients to carry and use the cream.

[0059] Furthermore, in step S1, the amount of soybean oil is 1000 ml.

[0060] Furthermore, in step S2, the temperature of the thermostat is controlled at 80-90°C.

[0061] Furthermore, in step S3, the amount of soybean oil is 1000 ml.

[0062] Furthermore, in step S4, the temperature of the thermostat is controlled at 80-100°C.

[0063] Furthermore, in step S5, the mixing ratio of the AB component medicinal oil and the C component medicinal oil is 10:1, wherein the control of the ratio can avoid mutual influence and offset of the medicinal effects.

[0064] As can be seen from the above, the preparation method of the cream of the present invention ensures the stability and effectiveness of the cream through accurate raw material ratio, scientific extraction process and reasonable mixing and stirring steps.

[0065] Experimental Example 1:

[0066] Objective: To observe whether the traditional Chinese medicine cream prepared by the present invention has side effects on the skin.

[0067] Select 10 healthy guinea pigs, half male and half female, weighing 200 ± 20g, cut the left and right side hair of the back, with an area of ​​about 8cm2, apply vaseline on the left side of the back of each animal as a control, and apply the Chinese medicine cream prepared by the present invention on the right side, adopt the self-control observation method, apply continuously for 7 days, observe for 7 days after drug withdrawal, and find that during the application period and stop applying for one week, the right side skin of each guinea pig is the same as the left side, without any skin irritation reaction (no redness, swelling, no rash, ulceration). It shows that the Chinese medicine oil wound dressing has no irritation to normal skin.

[0068] Experimental Example 2:

[0069] Objective: To observe the healing effect of the traditional Chinese medicine cream prepared by the present invention on rabbit skin burns.

[0070] Eighteen healthy New Zealand rabbits weighing about 2kg, 9 males and 9 females, were selected. After light anesthesia was given by intravenous injection of 20% urethane at 2ml / kg at the ear margin, the hair on both sides of the animal's back spine was removed with 10% sodium sulfide, about 10×10cm2, and a homemade simple high-temperature scalding device (refer to Fan Caibin et al., Establishment of Deep II-degree Burn Model in Rabbits, Fuzhou General Hospital of Nanjing Military Region) was used. A tin bucket filled with castor oil was placed on an electric stove and heated to 150℃. The bottom of the tin bucket was placed on the right side of the rabbit's back for 10 seconds to create a deep II° burn model. The left side was used as a normal control. After each rabbit was scalded, it was randomly divided into three groups, namely, a vaseline control group, a compound tung leaf burn oil group, and a Chinese medicine oil cream group. The experiment used self-control to observe the healing effect of Chinese medicine cream on rabbit skin water soup injury. The three groups were smeared with vaseline, compound tung leaf burn oil, and Chinese medicine cream on the right side, respectively. Apply once a day for 3 consecutive weeks to observe the healing of burns in the three groups of animals. The results are shown in Table 1. Observation of wound healing: All cases in the treatment group healed, and scar hyperplasia was not obvious. Chinese medicine cream can significantly promote the healing of deep II° burns in rabbits and significantly shorten the healing time of burns.

[0071] Table 1 The therapeutic effect of Chinese herbal cream on deep second-degree burns in rabbits

[0072]

[0073]

[0074] Note: Compared with the saline group★★p﹤0.01

[0075] ★★p﹤0.01

[0076] Experimental Example 4:

[0077] Objective: To observe the healing effect of Chinese medicine cream on rabbit skin injury

[0078] Model 1: Trauma model test: 30 healthy New Zealand rabbits weighing about 2 kg, 15 males and 15 females, were selected. After light anesthesia was given by intravenous injection of 20% urethane at 2 ml / kg at the ear margin, the hair on both sides of the spine on the back of the animals was removed with 10% sodium sulfide, and the skin was disinfected with iodine and then an area of ​​2.45 cm was covered. 2 A steel puncher was used to cut 5 circular wounds from top to bottom at 2 cm on both sides of the rabbit's back spine, with a distance of 2.5 cm between holes, deep to the subcutaneous area, and used after hemostasis. The prepared models were randomly divided into 5 groups of 6 rabbits each: blank control group, vaseline group, positive control group (compound tung leaf burn oil group), treatment group (traditional Chinese medicine cream group) and large and small dose groups, with the left side as a normal control. Animals with simple trauma were given the drug for 7 consecutive days.

[0079] Model 2: Trauma infection model test: 30 healthy New Zealand rabbits, weighing about 2 kg, 15 males and 15 females, were selected. Immediately after the wound was cut, 0.1 ml of Staphylococcus aureus or Pseudomonas aeruginosa was dripped on the wound surface. The concentration was 1×1011L -1 and 5×1010L -1 . After 24 hours, the wounds of the animals became red, swollen and had purulent secretions. Staphylococcus aureus or Pseudomonas aeruginosa was isolated from the wound tissue, indicating that the infected wound was successfully prepared. After the model was successfully prepared, each large group was divided into 5 groups, with 6 rabbits in each group and 5 wounds in each rabbit. The blank control group did not apply the medicine; the pure vegetable oil group; the positive control group were all applied with compound tung leaf burn oil, and the Chinese medicine cream group was applied with Chinese medicine cream once and twice. The day when the wound was treated with bacterial drops was d0, and the medicine was given on d1 the next day. The medicine was applied once a day, and the high-dose group was applied twice a day. The bacterial infection group was given medicine for 14 consecutive days, and covered with a sterile dressing after applying the medicine. The right side was applied with the medicine and the left side was used as the control. The experiment used self-control to observe the healing effect of Chinese medicine oil wound dressing on the damaged skin of rabbits.

[0080] Treatment method: The animals in each group were smeared with physiological saline, pure vegetable oil, compound tung leaf burn oil and Chinese medicine cream on the right side. The high-dose group was smeared once a day, and the high-dose group was smeared twice a day. The wound healing of the animals in each group was observed for 2 consecutive weeks. The results are shown in Table 2 and Table 3:

[0081] Table 2 Healing effect of Chinese medicine cream on damaged skin of rabbits

[0082]

[0083] Note: Compared with the saline group★★p﹤0.01

[0084] Table 3 The healing effect of Chinese medicine cream on infectious skin lesions in rabbits

[0085]

[0086]

[0087] Note: Compared with the saline group★★p﹤0.01

[0088] It can be seen from Tables 2 and 3 that the Chinese medicine cream can significantly shorten the healing time of damaged skin and infected damaged skin of rabbits, and there are significant differences compared with the control group (p < 0.01), and can reduce wound exudation, inhibit the growth of Staphylococcus aureus and Bacillus pyocyaneus in infected wounds, control infection, and promote rapid wound healing without scars. At the same time, the cream prepared by the present invention can also be used for conventional dressing changes.

[0089] As can be seen from the above, the cream prepared by the present invention has no toxic side effects through the above animal tests. At the same time, the cream has a good effect of promoting the healing of damaged skin caused by pressure sores and diabetic foot, and damaged and infected wounds, without leaving scars.

[0090] The embodiments of the present invention are provided for the purpose of illustration and description. Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A cream for treating bedsores and diabetic foot, characterized in that: The invention comprises component A, component B, component C and component D, wherein component A comprises, by mass fraction, 10-40 parts of waxberry leaves, 10-40 parts of angelica sinensis, 10-40 parts of sanguisorba officinalis, 10-40 parts of phellodendron amurense, 10-40 parts of liquorice, 10-40 parts of angelica dahurica, 10-40 parts of knotweed and 10-40 parts of dried rehmannia root; The component B comprises, by mass fraction, 10-30 parts of coptis root, 10-30 parts of rhubarb, 10-30 parts of red peony root, 10-30 parts of figwort, 10-30 parts of peony bark, 10-30 parts of astragalus and 10-30 parts of ligusticum chuanxiong; The component C comprises, by weight, 10-15 g of lithospermum officinale, 3-10 g of borneol and 5-10 g of beeswax; The component D is 500 g of medical vaseline.

2. A method for preparing a cream for treating pressure sores and diabetic foot, the cream for treating pressure sores and diabetic foot as claimed in claim 1, characterized in that: The steps include: S1, mixing the raw materials in component A and component B, crushing them, putting them into soybean oil and stirring to obtain a mixture 1; S2, putting the mixture in step S1 into a constant temperature box to extract the fat-soluble components in the traditional Chinese medicine, leaving it for 48 hours, removing it, filtering out the medicine residue, and obtaining the AB component medicine oil for standby use; S3, mixing the raw materials of component C according to the prescribed amount, crushing them, putting them into soybean oil and stirring, to obtain a mixture II; S4, putting the mixture 2 into a thermostatic box for extraction and dissolution, taking it out after 48 hours, filtering out the drug residue to obtain the C component drug oil for standby use; S5, mixing the AB component medicinal oil and the C component medicinal oil to prepare the Chinese medicinal oil; S6, taking 500 g of medical vaseline, adding it into the traditional Chinese medicine oil, stirring and mixing, and preparing an ointment; S7. Pack the cream.

3. A method for preparing a cream for treating pressure sores and diabetic foot as claimed in claim 2, characterized in that: In step S1, the amount of soybean oil is 1000 ml.

4. A method for preparing a cream for treating pressure sores and diabetic foot as claimed in claim 2, characterized in that: In step S2, the temperature of the thermostat is controlled at 80-90°C.

5. A method for preparing a cream for treating pressure sores and diabetic foot as claimed in claim 2, characterized in that: In step S3, the amount of soybean oil is 1000 ml.

6. A method for preparing a cream for treating pressure sores and diabetic foot as claimed in claim 2, characterized in that: In step S4, the temperature of the thermostat is controlled at 80-100°C.

7. A method for preparing a cream for treating pressure sores and diabetic foot as claimed in claim 2, characterized in that: In step S5, the AB component medicinal oil and the C component medicinal oil are mixed in a ratio of 10:1.

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