Traditional Chinese medicine composition for treating pulmonary nodule and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating pulmonary nodules, and belongs to the technical field of traditional Chinese medicine composition preparation. Comprising the following components in parts by weight: 10 parts of pericarpium citri reticulatae, 10 parts of rhizoma pinellinae praeparata, 10 parts of fructus aurantii immaturus, 10 parts of cortex magnoliae officinalis, 25 parts of angelica sinensis, 18 parts of ligusticum wallichii, 10 parts of rhizoma cyperi, 25 parts of honeysuckle, 12 parts of bletilla striata, 7 parts of folium artemisiae argyi, 7 parts of mint, 10 parts of radices stellariae dichotomae, 15 parts of exocarpium citri grandis, 15 parts of thunberg fritillary bulb, 15 parts of poria cocos, 15 parts of semen coicis, 10 parts of roasted rhizoma atractylodis macrocephalae, 10 parts of spina gleditsiae, 10 parts of hawthorn, 20 parts of selfheal, 20 parts of astragalus membranaceus, 12 parts of glossy privet fruit, 12 parts of fructus lycii and 4 parts of aspongopus. The invention further discloses a preparation method of the traditional Chinese medicine composition for treating pulmonary nodules. The traditional Chinese medicine has the effects of replenishing qi to invigorate the spleen, reducing phlegm and resolving masses, is mainly used for treating various types of pulmonary nodules, acute and chronic cough, chronic obstructive pulmonary disease and the like, and can be better suitable for different patients to take.

Description

Technical Field

[0001] The invention belongs to the technical field of preparation of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating pulmonary nodules and a preparation method thereof. Background Art

[0002] Pulmonary nodules are a common lung disease. Currently, the main methods for treating pulmonary nodules are surgery, radiotherapy, and chemotherapy. These methods have problems such as large side effects and high recurrence rates. In comparison, traditional Chinese medicine has the advantages of fewer side effects and stable efficacy in treating pulmonary nodules.

[0003] Chinese patent application No. 202210149593.2 discloses a Chinese medicine composition for treating pulmonary nodules and a preparation method thereof, comprising:

[0004] Take Cyperus rotundus, Curcuma aromatica, Tangerine peel, Sparganium, Curcuma zedoaria, Angelica sinensis and Ligusticum chuanxiong, perform steam distillation on them, extract volatile oil from them, and set aside;

[0005] The aqueous solution extracted by steam distillation of the above medicinal materials is filtered to obtain a distilled aqueous solution, and the distilled aqueous solution is heated and concentrated to obtain a distilled water concentrate for later use;

[0006] Keep the medicinal residue after steam distillation for later use;

[0007] The raw oysters are first boiled in water for one hour, and then the steam distilled drug residue obtained in the above step is added, mixed with the remaining medicinal materials, and extracted with water three times, the extracts are combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.20 at 70°C;

[0008] Add ethanol to make the alcohol content 40%, let stand for 24 hours, and filter;

[0009] Add the distilled water concentrate obtained above to concentrate into a fluid extract, add the volatile oil obtained above and purified water to a total weight that is three times the total weight of the medicinal materials, and fill it to obtain a mixture.

[0010] The above technology has the following problems: the above Chinese medicine composition for treating lung nodules is a pre-made product, the preparation process is complicated and cannot meet the needs of patients with different intolerance reactions.

[0011] In view of this, a Chinese medicine composition for treating pulmonary nodules and a preparation method thereof are designed to solve the above problems. Summary of the invention

[0012] To solve the problems raised in the above background technology. The present invention provides a Chinese medicine composition for treating lung nodules and a preparation method thereof, which has the effects of invigorating qi and strengthening spleen and resolving phlegm and dispersing nodules, and is mainly used to treat various types of lung nodules, acute and chronic coughs, and chronic obstructive pulmonary disease, etc., and can be better suitable for different patients to take.

[0013] Another object of the present invention is to provide a method for preparing a traditional Chinese medicine composition for treating pulmonary nodules.

[0014] To achieve the above object, the present invention provides the following technical solution: a Chinese medicine composition for treating pulmonary nodules, comprising the following components in weight ratio:

[0015] 10 parts of dried tangerine peel, 10 parts of French pinellia, 10 parts of immature bitter orange, 10 parts of magnolia bark, 25 parts of angelica, 18 parts of chuanxiong, 10 parts of cyperus, 25 parts of honeysuckle, 12 parts of bletilla striata, 7 parts of wormwood, 7 parts of mint, 10 parts of bupleurum, 15 parts of tangerine peel, 15 parts of thunbergia thunbergii, 15 parts of tuckahoe, 15 parts of tuckahoe, 10 parts of stir-fried atractylodes, 10 parts of gleditsia spinosa, 10 parts of hawthorn, 20 parts of selfheal, 20 parts of astragalus, 12 parts of glossy privet fruit, 12 parts of wolfberry fruit and 4 parts of nephroticum odoratum.

[0016] The method for preparing the Chinese medicine composition for treating pulmonary nodules comprises the following steps:

[0017] S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside;

[0018] S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials;

[0019] S3: placing the fished out Chinese medicinal materials in a decoction container, adding purified water to submerge the Chinese medicinal materials, decoct, and pour out the Chinese medicinal liquid;

[0020] S4: adding purified water into the decoction container, immersing the Chinese medicinal materials, decocts, and pours out the Chinese medicinal liquid;

[0021] S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition.

[0022] Furthermore, in step S3, the boiling temperature is 80-100° C. and the boiling time is 2 hours.

[0023] Furthermore, in step S4, the boiling temperature is 60-80° C., and the boiling time is 3 hours.

[0024] The Chinese medicine composition for treating pulmonary nodules and its application in preparing medicine for treating pulmonary nodules.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] The traditional Chinese medicine composition for treating lung nodules of the present invention only needs to purchase the Chinese medicinal materials of the composition for decoction and administration, the process is relatively simple, and the patient can decoct it by himself. After grabbing the Chinese medicinal materials, he can consult a doctor and reduce some of the Chinese medicinal materials for decoction and administration according to his own intolerance reaction. It has the effects of invigorating qi and strengthening the spleen and resolving phlegm and dispersing nodules, and is mainly used to treat various types of lung nodules, acute and chronic coughs, chronic obstructive pulmonary disease, etc., and can be better suitable for different patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A flowchart of a method for preparing a Chinese medicine composition for treating pulmonary nodules according to the present invention;

[0028] Figure 2 It is the CT scan image of the experimental mouse of the present invention;

[0029] Figure 3 This is a comparison diagram of CT scans of experimental mice of the present invention;

[0030] Figure 4 This is a comparison chart of CT scans of patients treated with the present invention. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] A Chinese medicine composition for treating pulmonary nodules, comprising the following components in weight ratio:

[0033] 5-15 parts of dried tangerine peel, 5-15 parts of French pinellia, 5-15 parts of immature bitter orange, 5-15 parts of magnolia bark, 15-25 parts of angelica, 10-20 parts of chuanxiong, 5-15 parts of cyperus, 15-25 parts of honeysuckle, 10-15 parts of bletilla striata, 5-10 parts of wormwood, 5-10 parts of mint, 5-15 parts of bupleurum, 10-20 parts of tangerine peel, 10-20 parts of fritillaria thunbergii, 10-20 parts of tuckahoe, 10-20 parts of coix seed, 5-15 parts of stir-fried atractylodes, 5-15 parts of gleditsia thorn, 5-15 parts of hawthorn, 10-20 parts of selfheal, 15-25 parts of astragalus, 10-15 parts of glossy privet fruit, 10-15 parts of wolfberry fruit and 1-5 parts of nine-scented insect.

[0034] See attached Figure 1 A method for preparing a Chinese medicine composition for treating pulmonary nodules comprises the following steps:

[0035] S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside;

[0036] S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials;

[0037] S3: placing the fished out Chinese medicinal materials in a decoction container, adding purified water to submerge the Chinese medicinal materials, decoct, and pour out the Chinese medicinal liquid;

[0038] S4: adding purified water into the decoction container, immersing the Chinese medicinal materials, decocts, and pours out the Chinese medicinal liquid;

[0039] S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition.

[0040] Specifically, in step S3, the boiling temperature is 80-100° C., and the boiling time is 2 hours.

[0041] Specifically, in step S4, the boiling temperature is 60-80° C., and the boiling time is 3 hours.

[0042] A traditional Chinese medicine composition for treating pulmonary nodules and application thereof in preparing medicine for treating pulmonary nodules. Specific embodiment 1

[0044] A Chinese medicine composition for treating pulmonary nodules, comprising the following components in weight ratio:

[0045] 5 parts of dried tangerine peel, 5 parts of French pinellia, 5 parts of immature bitter orange, 5 parts of magnolia bark, 15 parts of angelica, 10 parts of chuanxiong, 5 parts of cyperus, 15 parts of honeysuckle, 10 parts of bletilla striata, 5 parts of wormwood, 5 parts of mint, 5 parts of silver bupleurum, 10 parts of tangerine peel, 10 parts of thunbergia thunbergii, 10 parts of tuckahoe, 10 parts of tuckahoe, 10 parts of stir-fried atractylodes, 5 parts of gleditsia thorn, 5 parts of hawthorn, 10 parts of selfheal, 15 parts of astragalus, 10 parts of glossy privet fruit, 10 parts of wolfberry fruit, and 1 part of good man nine-scented insect.

[0046] Made by the following production method:

[0047] S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside;

[0048] S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials;

[0049] S3: Place the fished out Chinese medicinal materials in a decoction container, add purified water to submerge the Chinese medicinal materials, decoct at 100°C for 2h, and pour out the Chinese medicinal liquid;

[0050] S4: Add purified water into the decoction container, immerse the Chinese medicinal materials, decoct at 80°C for 3h, and pour out the Chinese medicinal liquid;

[0051] S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition. Specific embodiment 2

[0053] A Chinese medicine composition for treating pulmonary nodules, comprising the following components in weight ratio:

[0054] 10 parts of dried tangerine peel, 10 parts of French pinellia, 10 parts of immature bitter orange, 10 parts of magnolia bark, 25 parts of angelica, 18 parts of chuanxiong, 10 parts of cyperus, 25 parts of honeysuckle, 12 parts of bletilla striata, 7 parts of wormwood, 7 parts of mint, 10 parts of bupleurum, 15 parts of tangerine peel, 15 parts of thunbergia thunbergii, 15 parts of tuckahoe, 15 parts of tuckahoe, 10 parts of stir-fried atractylodes, 10 parts of gleditsia spinosa, 10 parts of hawthorn, 20 parts of selfheal, 20 parts of astragalus, 12 parts of glossy privet fruit, 12 parts of wolfberry fruit and 4 parts of nephroticum odoratum.

[0055] Made by the following production method:

[0056] S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside;

[0057] S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials;

[0058] S3: Place the fished out Chinese medicinal materials in a decoction container, add purified water to submerge the Chinese medicinal materials, decoct at 100°C for 2h, and pour out the Chinese medicinal liquid;

[0059] S4: Add purified water into the decoction container, immerse the Chinese medicinal materials, decoct at 60°C for 3h, and pour out the Chinese medicinal liquid;

[0060] S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition. Specific embodiment three

[0062] A Chinese medicine composition for treating pulmonary nodules, comprising the following components in weight ratio:

[0063] 15 parts of dried orange peel, 15 parts of French pinellia, 15 parts of immature bitter orange, 15 parts of magnolia bark, 25 parts of angelica, 20 parts of ligusticum chuanxiong, 15 parts of cyperus rotundus, 25 parts of honeysuckle, 15 parts of bletilla striata, 10 parts of wormwood, 10 parts of mint, 15 parts of bupleurum, 20 parts of tangerine peel, 20 parts of fritillaria thunbergii, 20 parts of tuckahoe, 20 parts of coix seed, 15 parts of stir-fried atractylodes, 15 parts of gleditsia spinosa, 15 parts of hawthorn, 20 parts of selfheal, 25 parts of astragalus, 15 parts of glossy privet fruit, 15 parts of wolfberry fruit and 5 parts of nephrodisiac.

[0064] Made by the following production method:

[0065] S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside;

[0066] S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials;

[0067] S3: Place the fished out Chinese medicinal materials in a decoction container, add purified water to submerge the Chinese medicinal materials, decoct at 80°C for 2h, and pour out the Chinese medicinal liquid;

[0068] S4: Add purified water into the decoction container, immerse the Chinese medicinal materials, decoct at 60°C for 3h, and pour out the Chinese medicinal liquid;

[0069] S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition.

[0070] Toxicity experiment of Chinese medicine composition for treating pulmonary nodules:

[0071] 50 adult healthy mice were purchased and bred for one week in an environment with a room temperature of 18-20°C, a relative humidity of 60% and no convection wind. After the mice were adapted to the environment, the acute toxicity test was carried out;

[0072] Before the experiment, mice were fasted for 10–12 h and had normal drinking water;

[0073] During the experiment, the mice were randomly divided into five groups, A, B, C, D and E, with half males and half females in each group. Group A was gavaged with 500 mg / kg of the Chinese medicine composition, group B was gavaged with 600 mg / kg of the Chinese medicine composition, group C was gavaged with 700 mg / kg of the Chinese medicine composition, group D was gavaged with 800 mg / kg of the Chinese medicine composition, and group E was gavaged with normal saline. The mice ate normally 1 hour after administration, and were observed for 4 hours after administration. The remaining time was observed twice a day for 7 consecutive days, and the eating and drinking conditions, abnormal activities, abnormal muscle movements, reactions to external stimuli, and the death of the mice were recorded. The experimental results showed that after a period of administration according to the dosage of groups A, B, C, D and E, the mice did not show idleness, lethargy and the like, and their eating and drinking conditions were normal, without abnormal activities, and their reactions to external stimuli were normal. After a period of administration of a large dose according to group D, the mice showed a short rest adjustment behavior and then recovered to normal behavior. The death is shown in the following table:

[0074] Table 1: Death of mice after oral administration of the Chinese medicine composition

[0075]

[0076]

[0077] The mice were killed by dislocating the cervical vertebrae and weighed. The spleen, kidneys, liver and other organs were dissected and weighed, and the organ index of each organ was recorded and calculated. The calculation formula of the organ index is:

[0078] Organ index / % = organ mass / body weight × 100%

[0079] The experimental data were analyzed by ANOVA in SPSS22.0 statistical software. The results were expressed as mean ± error. P < 0.01 indicated a significant difference, and P > 0.05 indicated an insignificant difference. The organ indexes of the mouse organs are shown in the following table:

[0080] Table 2: Effects of Chinese medicine combination on organ indexes of mice

[0081]

[0082] It can be seen from the above table that the Chinese medicine composition in groups A, B, C and D has no obvious effect on the changes in cardiac index, liver index, spleen index and kidney index, but changes with the increase of dose. From the experimental results, it can be seen that the dosage of 600 mg / kg of the Chinese medicine composition in group B is the best.

[0083] Animal experiments on Chinese medicine composition for treating pulmonary nodules:

[0084] Before the experiment, SPF-grade C57BL / 6 female mice were purchased and adaptively raised in an environment with a room temperature of 18-20°C, a relative humidity of 60% and no convection wind for one week. After the mice adapted to the environment and were not infected with specific pathogens, the model was constructed. Bleomycin was dissolved in physiological saline as an inducing substance to prepare an induction solution with a concentration of 5 mg / kg. Sodium pentobarbital was injected into the abdominal cavity of the mouse by intraperitoneal injection to put it into an anesthetized state. The mouse was fixed on the experimental table in a supine position, the neck was depilated and disinfected, the skin of the mouse neck was incised, the trachea was separated layer by layer and exposed, the trachea was gently clamped with tweezers, the induction solution was pierced into the trachea through the gap of the tracheal cartilage ring through a microsyringe, and slowly injected. After the injection, the mouse was upright and rotated to evenly distribute the induction solution in the lungs, sutured, and after the operation, the mouse was returned to the breeding environment, given water and food to recover. Fifteen days later, CT scan was performed, and the CT images were obtained as shown in the attached figure. Figure 2 As shown, it can be seen that after fifteen days of inoculation with the induction solution, irregular consolidation shadows can be seen in the cross-section of the lungs of mice. Therefore, the mouse animal model of pulmonary nodules was successfully established.

[0085] Before the experiment, 40 SPF-grade C57BL / 6 female mice were purchased and the pulmonary nodule mouse animal model was established according to the above method;

[0086] During the experiment, mice were randomly divided into four groups, A, B, C and D, with half male and half female in each group. Group A was administered with 600 mg / kg of the specific embodiment 1, group B was administered with 600 mg / kg of the specific embodiment 2, group C was administered with 600 mg / kg of the specific embodiment 3, and group D was administered with normal saline. After administration, they ate normally for 15 days.

[0087] During the experiment, after 15 days, one mouse from each group was scanned by CT, and the CT images were obtained as shown in the attached figure. Figure 3 As shown, it can be seen that irregular consolidation shadows can be seen in the cross-section of the CT of mice after administration, but the volume is smaller than the initial volume. Therefore, it can be seen that the Chinese medicine composition can treat the lung nodules of mice, and the treatment effect of the lung nodules in group B is the best;

[0088] During the experiment, 15 days later, one mouse from each group was killed by dislocating the cervical vertebrae, the chest cavity was cut open, the right lung lobe was taken and placed in a 4% paraformaldehyde solution for fixation for 48 hours, and then the slices were sliced, baked, stained, washed, and sealed after dehydration, transparency, and wax embedding. The pathological morphology of the lung tissue was observed under an inverted light microscope. It can be seen that the Chinese medicine composition can treat the lung nodules of mice, and the lung nodules of group B have the best treatment effect.

[0089] During the experiment, 15 days later, one mouse was taken from each group and fixed on the small animal operating table. The skin in the middle of the neck was cut open, the trachea was bluntly separated, an oblique incision was cut at the proximal end, a 24G intravenous indwelling needle was inserted and ligated, 0.5mL of pre-cooled PBS was slowly injected into the mouse lungs through the intravenous indwelling needle each time, and then slowly withdrawn with a 2mL syringe. After withdrawing and injecting 3 times, the bronchoalveolar lavage fluid was collected in an EP tube and placed on ice. The above operation was repeated 3 times, and the recovery rate must be no less than 80%. The collected bronchoalveolar lavage fluid was centrifuged at 1000×g and 4℃ for 10 minutes, and the supernatant was transferred to another clean EP tube. The recovery rate must be no less than 80%. TNF-α and IL-6 in the bronchoalveolar lavage fluid were detected, and the results are shown in the following table:

[0090] Table 3: Levels of TNF-α and IL-6 in bronchoalveolar lavage fluid of mice in each group

[0091] deal with quantity TNF-α IL-6 Group A 10 0.425±0.220 6.589±0.313 Group B 10 0.298±0.288 7.002±0.802 Group C 10 0.355±0.280 6.581±0.313 Group D 10 0.502±0.338 4.283±0.226

[0092] It can be seen from the above table that the Chinese medicine compositions of groups A, B and C all have the efficacy of treating pulmonary nodules, but the Chinese medicine composition of group B has the best efficacy in treating pulmonary nodules.

[0093] Clinical trials of Chinese medicine compositions for treating pulmonary nodules:

[0094] One hundred patients who were admitted to Hubei Provincial Hospital of Traditional Chinese Medicine and diagnosed with pulmonary nodules were selected as the research subjects. The diagnostic criteria were in accordance with the diagnostic criteria for pulmonary nodules in the "Chinese Expert Consensus on Diagnosis and Treatment of Pulmonary Nodules (2018 Edition)" compiled by the Lung Cancer Study Group of the Chinese Society of Respiratory Medicine and the Expert Group of the Chinese Lung Cancer Prevention and Control Alliance.

[0095] According to the relevant content of the "Guidelines for Clinical Research of New Chinese Medicines", the "Symptom Score Assessment Scale for Patients with Pulmonary Nodules" was formulated, with a total of 12 symptoms, including: cough, sputum, wheezing, shortness of breath, susceptibility to colds, fatigue, dizziness, tinnitus, fear of wind and cold, cold back, cold hands and feet, pale red or dark tongue, teeth marks on the edges of the tongue, greasy tongue coating and slippery pulse. The symptoms were recorded as 0, 1, 2 and 3 points respectively according to the absence, mild, moderate and severe symptoms;

[0096] Collect patient symptom scores as a basis for quantitative symptom assessment;

[0097] 100 patients with pulmonary nodules were divided into 50 control groups and 50 treatment groups according to their voluntary choice, as shown in the following table:

[0098] Table 4: Situation of control group and treatment group

[0099] project Control group Treatment Group male 25 25 female 25 25 Single lobe 23 20 Both lungs 10 16 Single pulmonary nodule 22 12 Multiple pulmonary nodules 10 25 age 45±15 45±15 Maximum nodule diameter 1.12±0.51 0.88±0.2

[0100] According to the order of patient admission and the principle of voluntariness, the treatment group was treated with 600 mg / kg of group B, 3 times a day, and each 3 months was a course of treatment. A lung CT follow-up was performed in one course of treatment. The treatment cycle was 6 months. The symptom scores of the patients before treatment were used as the evaluation basis, and compared with the symptom scores of the patients after the treatment cycle, the efficacy of the Chinese medicine composition was judged. The results are shown in the following table:

[0101] Table 5: Treatment effects of different groups

[0102] project Ineffective / Aggravated Valid / Invalid Significantly effective / effective Cured / effective Control group 50 0 0 0 Treatment Group 2 4 39 5

[0103] As shown in the table above, the Chinese medicine composition of the present application has a good therapeutic effect in treating pulmonary nodules;

[0104] Among them, a specific description of the situation of a clinical experiment:

[0105] The patient was a male, aged 58. Before treatment, he underwent chest CT scan followed by enhancement + 3D reconstruction + tomography. The imaging showed that the two lungs had slightly more texture and the two lung fields had increased transparency. A single solid nodule was seen in the left lower lobe (IM471), about 1.6cm×1.5cm in size, with visible lobes and burrs, and mild enhancement on the enhanced scan. A single solid nodule was seen in the right lower lobe (IM454), about 0.6cm×0.4cm in size. A single calcified nodule was seen in the left upper lobe (IM168), about 0.5cm×0.4cm in size. Stripes and patchy density increased shadows were seen in the left lower lobe. The trachea and bronchi are normal in shape; the number of lymph nodes in the mediastinum is increased; the heart is not large; calcification is seen in the aortic wall and coronary artery wall; no effusion is seen in the thoracic cavity on both sides; localized thickening of the left chest wall, mild enhancement can be seen on enhanced scanning; the imaging diagnosis is: solid nodule foci in the left lower lobe (high risk), which are new compared with the previous (20231124), and the possibility of tumor lesions is considered, please combine clinical diagnosis and puncture biopsy; fibrous proliferation foci in the left lower lobe and localized hypertrophy and adhesion of the adjacent pleura, which are increased compared with the previous (20231124); tiny nodules in the right lower lung, which are slightly larger than before, and follow-up reexamination is recommended; emphysema in both lungs; sclerosis of the aorta and coronary arteries, and pulmonary nodules such as attached Figure 4 (a)

[0106] Male, 59 years old. After treatment, he underwent chest CT plain scan and enhanced scan, chest CT plain scan + three-dimensional reconstruction + X-ray computed tomography (CT). The imaging showed that there were slightly more textures in both lungs and increased brightness of both lung fields; a single solid nodule shadow was seen in the left lower lobe (1M90), with a size of about 1.1cm×0.7cm, and mild enhancement on enhanced scan; multiple solid nodules were seen in the right lower lobe (IM110) and left oblique fissure (IM92), with a long diameter range of about 0.4-0.5cm, and the larger one was about 0.5cm×0.4cm, located in the anterior basal extension segment of the right lower lobe; the left upper lobe (IM42 ) A single calcified nodule was seen, about 0.5cm×0.4cm in size; cords and patchy shadows of increased density were seen in the left lower lobe; the tracheobronchial shadows were normal; the number of intra-longitudinal lymph nodes increased; the heart was not large; calcification was seen in the aortic wall and coronary artery wall; effusion was seen in both thoracic cavities, localized thickening of the left cerebral wall, and mild atrium enhancement was seen in enhanced scanning; the imaging diagnosis was: solid nodule focus in the left lower lobe (high risk), which was smaller than before treatment, please combine with clinical data; fibrous proliferation focus in the left lower lobe and localized hypertrophy and adhesion of the adjacent pleura, which was reduced compared with before treatment; tiny nodules in the right lower lobe, which were similar to the previous ones, and follow-up examinations were recommended, emphysema in both lungs; sclerosis of the aorta and coronary arteries; as attached Figure 4 (b)

[0107] It can be seen that the Chinese medicine composition of the present application has a good therapeutic effect in the treatment of pulmonary nodules.

[0108] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating pulmonary nodules, characterized in that: The composition comprises the following components in weight ratio: 10 parts of dried tangerine peel, 10 parts of French pinellia, 10 parts of immature bitter orange, 10 parts of magnolia bark, 25 parts of angelica, 18 parts of chuanxiong, 10 parts of cyperus, 25 parts of honeysuckle, 12 parts of bletilla striata, 7 parts of wormwood, 7 parts of mint, 10 parts of bupleurum, 15 parts of tangerine peel, 15 parts of thunbergia thunbergii, 15 parts of tuckahoe, 15 parts of tuckahoe, 10 parts of stir-fried atractylodes, 10 parts of gleditsia spinosa, 10 parts of hawthorn, 20 parts of selfheal, 20 parts of astragalus, 12 parts of glossy privet fruit, 12 parts of wolfberry fruit and 4 parts of nephroticum odoratum.

2. The method for preparing a Chinese medicine composition for treating pulmonary nodules according to claim 1, characterized in that: The following steps are involved: S1: Weigh tangerine peel, French pinellia, immature bitter orange, Magnolia officinalis, Chinese angelica, Chuanxiong, Cyperus rotundus, honeysuckle, Bletilla striata, Artemisia argyi, mint, Bupleurum argyi, red tangerine peel, Fritillaria thunbergii, Poria, Coix seeds, stir-fried Atractylodes macrocephala, Gleditsia sinensis thorn, Crataegus pinnatifida, Prunella vulgaris, Astragalus, Ligustrum lucidum fruit, Lycium barbarum and Nine-scented Worm according to the formula amount and set aside; S2: placing the above Chinese medicinal materials in a cleaning container, adding purified water to submerge the Chinese medicinal materials, skimming off floating dust, and taking out the Chinese medicinal materials; S3: placing the fished out Chinese medicinal materials in a decoction container, adding purified water to submerge the Chinese medicinal materials, decoct, and pour out the Chinese medicinal liquid; S4: adding purified water into the decoction container, immersing the Chinese medicinal materials, decocts, and pours out the Chinese medicinal liquid; S5: Combine the two Chinese medicine solutions, filter twice with gauze, and obtain a pure Chinese medicine solution, i.e., a Chinese medicine composition.

3. A method for preparing a Chinese medicine composition for treating pulmonary nodules according to claim 2, characterized in that: In step S3, the boiling temperature is 80-100° C. and the boiling time is 2 hours.

4. The method for preparing a Chinese medicine composition for treating pulmonary nodules according to claim 2, characterized in that: In step S4, the boiling temperature is 60-80° C. and the boiling time is 3 hours.

5. A Chinese medicine composition for treating pulmonary nodules according to claim 1 and its use in preparing a medicine for treating pulmonary nodules.

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