Measurement method, system and related device
By using electrode sets implanted with subcutaneous tissue in the first electronic device, the problem of the existing electrocardiogram is large and cannot be carried around, and the electrocardiogram monitoring is realized anytime and anywhere and the detection of multiple physiological parameters is improved, and the efficiency of health monitoring is improved.
Patent Information
- Application Number
- CN202311865433.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-12-29
- Publication Date
- 2025-07-01
AI Technical Summary
The existing electrocardiogram is large in size and is not convenient for users to carry with them. It is impossible to achieve electrocardiogram monitoring anytime and anywhere.
The electrocardiogram signals and physiological parameters are determined by providing the first electrode set and the second electrode set in the first electronic device and implanting the electrode sets in the subcutaneous tissue.
It realizes the function of measuring ECG signals at any time and place, and can monitor a variety of physiological parameters, such as blood sugar, blood ketones, uric acid, etc., improving the efficiency of health monitoring.
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Figure CN120227022A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of electronic technologies, and in particular, to a measurement method, system, and related devices. Background Art
[0002] With the continuous development of electronic technologies, more and more electronic devices are equipped with health monitoring functions to facilitate users to understand their own health conditions in real time. Electrocardiogram (ECG) monitoring is an important part of health monitoring functions.
[0003] An electrocardiograph is a medical device with an ECG monitoring function. During the monitoring process, the electrocardiograph can obtain the user's ECG by contacting different positions of the user's skin with multiple wet electrodes.
[0004] However, the electrocardiograph is large in size and not convenient for users to carry around, so users cannot perform ECG monitoring anytime and anywhere. Summary of the Invention
[0005] This application provides a measurement method, system, and related devices, which can measure ECG signals anytime and anywhere, and can also measure one or more physiological parameters, improving the efficiency of health monitoring.
[0006] In a first aspect, this application provides a measurement method applied to a first electronic device. The first electronic device includes a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; when the first electrode group and the second electrode group are implanted into the subcutaneous tissue, the method includes: determining a first physiological parameter through the first electrode group; determining an ECG signal through the first electrode group and the second electrode group.
[0007] In this way, the user's ECG signal can be measured anytime and anywhere, and physiological parameters such as blood glucose, blood ketone, blood lactic acid, and uric acid can also be measured.
[0008] In a possible implementation, the first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode; the first pair of electrodes forms a loop with the first working electrode; determining the first physiological parameter through the first electrode group specifically includes: determining the first physiological parameter through the first working electrode and the first pair of electrodes; determining the ECG signal through the first electrode group and the second electrode group specifically includes: determining the ECG signal through the first working electrode and the second working electrode, or determining the ECG signal through the first pair of electrodes and the second working electrode.
[0009] In this way, the first electrode group can form a two-electrode system, and the first physiological parameter can be measured through this two-electrode system. Any electrode in the first working electrode (or the first pair of electrodes) of the first electrode group and the second electrode group can be used as the left arm LA electrode and the right arm RA electrode respectively to measure the ECG signal.
[0010] In a possible implementation, the first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode; the first pair of electrodes forms a loop with the first working electrode; the first working electrode or the first pair of electrodes is connected to the right leg drive circuit; determining the first physiological parameter through the first electrode group specifically includes: determining the first physiological parameter through the first working electrode and the first pair of electrodes; determining the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through the first working electrode, the first pair of electrodes and the second working electrode.
[0011] Among them, the electrode connected to the right leg drive circuit can be used as the right leg drive RLD electrode. The right leg drive circuit can be used to cancel the common mode signal.
[0012] In this way, the first electrode group can form a two-electrode system, and the first physiological parameter can be measured through this two-electrode system. Any one of the first working electrode, the first pair of electrodes in the first electrode group and any one electrode in the second electrode group can be used as the left arm LA electrode, the right leg drive RLD electrode and the right arm RA electrode respectively to measure the electrocardiogram signal.
[0013] In a possible implementation, the first electrode group includes a first working electrode, a first reference electrode and a first pair of electrodes; the first reference electrode is used to control the voltage of the first working electrode, and the first pair of electrodes forms a loop with the first working electrode; determining the first physiological parameter through the first electrode group specifically includes: generating a first current through the first working electrode; determining the first physiological parameter based on the first current.
[0014] In this way, the first electrode group can form a three-electrode system, and the first current is generated and conducted through this three-electrode system.
[0015] In a possible implementation, the second electrode group includes a second working electrode, a second reference electrode and a second pair of electrodes; the second reference electrode is used to control the voltage of the second working electrode, and the second pair of electrodes is used to form a loop with the second working electrode; the method further includes: generating a second current through the second working electrode; determining the second physiological parameter based on the second current.
[0016] In this way, the second electrode group can form a three-electrode system, and the second current is generated and conducted through this three-electrode system.
[0017] In a possible implementation, determining the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through any one electrode in the first electrode group and any one electrode in the second electrode group.
[0018] The left arm electrode and the right arm electrode can respectively select one electrode from the first electrode group and one electrode from the second electrode group. In this way, the electrocardiogram signal can be measured through the left arm electrode and the right arm electrode.
[0019] In a possible implementation, the electrocardiogram signal is determined by the first electrode group and the second electrode group, specifically including: determining the electrocardiogram signal by any two electrodes in the first electrode group and any one electrode in the second electrode group; or, determining the electrocardiogram signal by any one electrode in the first electrode group and any two electrodes in the second electrode group.
[0020] The left-arm electrode and the right-arm electrode can respectively select one electrode from the first electrode group and one electrode from the second electrode group. The right-leg drive electrode can be an electrode in the first electrode group or an electrode in the second electrode group. In this way, the electrocardiogram signal can be measured by the left-arm electrode, the right-arm electrode, and the right-leg drive electrode. Among them, the right-leg drive electrode is used to cancel the common-mode signal through the right-leg drive circuit.
[0021] In this way, the electrochemical electrode in the first electrode group can be used to measure both the first physiological parameter and the electrocardiogram signal.
[0022] In a possible implementation, the electrocardiogram signal is determined by any two electrodes in the first electrode group and any one electrode in the second electrode group, specifically including: when the first pair of electrodes is connected to a right-leg drive circuit, determining the electrocardiogram signal by the first pair of electrodes, the first working electrode, and the second reference electrode.
[0023] In a possible implementation, the electrocardiogram signal is determined by any one electrode in the first electrode group and any two electrodes in the second electrode group, specifically including: when the second pair of electrodes is connected to a right-leg drive circuit, determining the electrocardiogram signal by the second pair of electrodes, the second working electrode, and the first reference electrode.
[0024] It should be noted that the above two implementation manners are only two examples. In the present application, other electrodes in the first electrode group and the second electrode group can also be selected to measure the electrocardiogram signal, and the present application does not limit this here.
[0025] In a possible implementation, the first electrode group further includes a first electrocardiogram electrode and a second electrocardiogram electrode, the second electrode group further includes a third electrocardiogram electrode, and the second electrocardiogram electrode is connected to a right-leg drive circuit; determining the electrocardiogram signal by the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal by the first electrocardiogram electrode, the second electrocardiogram electrode, and the third electrocardiogram electrode.
[0026] In this way, the electrocardiogram signal can be measured by the separately provided electrocardiogram electrodes.
[0027] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second microneedle sensor. The first microneedle sensor includes the first electrode group, and the second microneedle sensor includes the second electrode group.
[0028] A microneedle sensor may refer to a sensor with a shape similar to that of a microneedle, and multiple electrodes may be provided inside the microneedle sensor.
[0029] In this way, the first electrode group and the second electrode group can be provided in the microneedle sensor.
[0030] In a possible implementation, the first electronic device further includes a first array sensor and a second array sensor. The first array sensor includes a first electrode group, and the second array sensor includes a second electrode group.
[0031] An array sensor may refer to a sensor including multiple electrodes arranged in an array. In a possible implementation, the array sensor may also be multiple electrodes arranged in an array.
[0032] In this way, the first electrode group and the second electrode group can be respectively provided in the array sensor in the form of an array.
[0033] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second array sensor. The first microneedle sensor includes a first electrode group, and the second array sensor includes a second electrode group.
[0034] In this way, the first electrode group can be provided in the microneedle sensor, and the second electrode group can be provided in the array sensor in the form of an array.
[0035] In a possible implementation, before determining the first physiological parameter through the first electrode group, the method further includes: determining that a first condition is satisfied, and the first condition includes any one or more of the following: receiving a first message sent by a second electronic device, where the first message is used to instruct the first electronic device to determine the first physiological parameter; detecting that the first electrode group and the second electrode group are implanted into the subcutaneous tissue; detecting that the electrocardiogram signal is abnormal.
[0036] In this way, the first condition can be a trigger condition for measuring the first physiological parameter.
[0037] In a possible implementation, before determining the electrocardiogram signal through the first electrode group and the second electrode group, the method further includes: determining that a second condition is satisfied, and the second condition includes any one or more of the following: receiving a second message sent by a second electronic device, where the second message is used to instruct the first electronic device to determine the electrocardiogram signal; detecting that the first electrode group and the second electrode group are implanted into the subcutaneous tissue; detecting that the first physiological parameter does not belong to a first interval.
[0038] In this way, the second condition can be a trigger condition for determining the electrocardiogram signal.
[0039] In a possible implementation, after determining the first physiological parameter through the first electrode group, the method further includes: outputting the first physiological parameter, or sending the first physiological parameter to a second electronic device.
[0040] In this way, the first physiological parameter can be output, or the first physiological parameter can be output through other electronic devices.
[0041] In a possible implementation, after determining the electrocardiogram signal through the first electrode group and the second electrode group, the method further includes: outputting the electrocardiogram signal, or sending the electrocardiogram signal to a second electronic device.
[0042] In this way, the electrocardiogram signal can be output, or the electrocardiogram signal can be output through other electronic devices.
[0043] In a possible implementation, the first physiological parameter may include, but is not limited to, any one or more of the following: blood glucose, blood ketone, uric acid, blood lactic acid, etc.
[0044] In a second aspect, the present application provides an electronic device, which is a first electronic device, including a first electrode group and a second electrode group. The distance between the first electrode group and the second electrode group is greater than a first distance; the first electrode group is used to determine a first physiological parameter when the first electrode group is implanted into subcutaneous tissue; the second electrode group is used to determine a second physiological parameter when the second electrode group is implanted into subcutaneous tissue; the first electrode group and the second electrode group are further used to determine an electrocardiogram signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
[0045] In a possible implementation, the first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode and a second pair of electrodes; the first pair of electrodes forms a loop with the first working electrode, and the second pair of electrodes forms a loop with the second working electrode; the first electrode group is used to determine the first physiological parameter when the first electrode group is implanted into subcutaneous tissue, specifically including: the first working electrode is used to determine the first physiological parameter when the first working electrode is implanted into subcutaneous tissue; the second electrode group is used to determine the second physiological parameter when the second electrode group is implanted into subcutaneous tissue, specifically including: the second working electrode is used to determine the second physiological parameter when the second working electrode is implanted into subcutaneous tissue; the first electrode group and the second electrode group are further used to determine the electrocardiogram signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: the first working electrode, the first pair of electrodes, and the second working electrode are further used to determine the electrocardiogram signal when the first working electrode, the first pair of electrodes, and the second working electrode are implanted into subcutaneous tissue.
[0046] In a possible implementation, the first electronic device further includes a microcontroller unit (MCU); the first electrode group includes a first working electrode, a first reference electrode, and a first counter electrode; the second electrode group includes a second working electrode, a second reference electrode, and a second counter electrode; the first electrode group is configured to determine a first physiological parameter when the first electrode group is implanted into subcutaneous tissue, specifically including: the first working electrode is configured to generate a first current when the first working electrode is implanted into subcutaneous tissue; the first reference electrode is configured to control the voltage of the first working electrode; the first counter electrode is configured to form a loop with the first working electrode; the MCU is configured to determine the first physiological parameter based on the first current; the second electrode group is configured to determine a second physiological parameter when the second electrode group is implanted into subcutaneous tissue, specifically including: the second working electrode is configured to generate a second current when the second working electrode is implanted into subcutaneous tissue; the second reference electrode is configured to control the voltage of the second working electrode; the second counter electrode is configured to form a loop with the second working electrode; the MCU is configured to determine the second physiological parameter based on the second current.
[0047] In a possible implementation, the first electrode group and the second electrode group are further configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: any two electrodes in the first electrode group and any one electrode in the second electrode group are configured to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue; or, any one electrode in the first electrode group and any two electrodes in the second electrode group are configured to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
[0048] The left-arm electrode and the right-arm electrode can respectively select one electrode from the first electrode group and one electrode from the second electrode group, and the right-leg drive electrode can be an electrode in the first electrode group or an electrode in the second electrode group. In this way, the ECG signal can be measured through the left-arm electrode, the right-arm electrode, and the right-leg drive electrode. Among them, the right-leg drive electrode is configured to cancel the common-mode signal through a right-leg drive circuit.
[0049] In a possible implementation, any two electrodes in the first electrode group and any one electrode in the second electrode group are configured to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: when the first counter electrode is connected to a right-leg drive circuit, the first counter electrode, the first working electrode, and the second reference electrode are configured to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
[0050] In a possible implementation, any one electrode in the first electrode group and any two electrodes in the second electrode group are used to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue. Specifically, when a right leg drive circuit is connected to the second pair of electrodes, the second pair of electrodes, the second working electrode, and the first reference electrode are used to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
[0051] It should be noted that the above two implementation manners are only two examples. In this application, other electrodes in the first electrode group and the second electrode group can also be selected to measure the ECG signal, and this application does not make any limitations here.
[0052] In a possible implementation, the first electrode group further includes a first ECG electrode and a second ECG electrode, and the second electrode group further includes a third ECG electrode. The second ECG electrode is connected to a right leg drive circuit. The first electrode group and the second electrode group are also used to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue. Specifically, the first ECG electrode, the second ECG electrode, and the third ECG electrode are used to determine an ECG signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
[0053] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second microneedle sensor. The first microneedle sensor includes the first electrode group, and the second microneedle sensor includes the second electrode group.
[0054] In a possible implementation, the first electronic device further includes a first array sensor and a second array sensor. The first array sensor includes the first electrode group, and the second array sensor includes the second electrode group.
[0055] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second array sensor. The first microneedle sensor includes the first electrode group, and the second array sensor includes the second electrode group.
[0056] In a possible implementation, the first electronic device further includes a communication module. The communication module is used to send a first physiological parameter to a second electronic device. The communication module is also used to send an ECG signal to the second electronic device.
[0057] In a possible implementation, the first electronic device further includes an output module. The output module is used to output the first physiological parameter. The output module is also used to output the ECG signal.
[0058] In a third aspect, the present application provides a measurement circuit, including a first electrode group, a second electrode group, a first electrochemical circuit module, a second electrochemical circuit module, an electrocardiogram (ECG) circuit module, and a microcontroller unit (MCU); the first electrode group is connected to the first electrochemical circuit module and is also connected to the ECG circuit module; the second electrode group is connected to the second electrochemical circuit module and is also connected to the ECG circuit module; the MCU is connected to the first electrochemical circuit module, the second electrochemical circuit module, and the ECG circuit module; the first electrode group is used to generate a first current signal; the first electrode group is further used to conduct the first current signal to the first electrochemical circuit module; the first electrochemical circuit module is used to determine a second current signal based on the first current signal; the first electrochemical circuit module is further used to conduct the second current signal to the MCU; the MCU is used to determine a first physiological parameter based on the second current signal; the second electrode group is used to generate a third current signal; the second electrode group is further used to conduct the third current signal to the second electrochemical circuit module; the second electrochemical circuit module is used to determine a fourth current signal based on the third current signal; the second electrochemical circuit module is further used to conduct the fourth current signal to the MCU; the MCU is used to determine a second physiological parameter based on the fourth current signal; the first electrode group and the second electrode group are used to acquire a first ECG signal; the first electrode group and the second electrode group are further used to conduct the first ECG signal to the ECG circuit module; the ECG circuit module is used to determine a second ECG signal based on the first ECG signal; the ECG circuit module is further used to conduct the second ECG signal to the MCU.
[0059] In a possible implementation, the first electrode group includes a first working electrode, a first reference electrode, and a first counter electrode; the first electrochemical circuit module includes a first potentiostat circuit and a first transimpedance circuit; the first potentiostat circuit is used to control the voltages of the first working electrode and the first reference electrode; the first transimpedance circuit is used to amplify the first current signal; the connection between the first electrode group and the first electrochemical circuit module specifically includes: the first working electrode, the first reference electrode, and the first counter electrode are connected to the first potentiostat circuit; the first working electrode is connected to the first transimpedance circuit.
[0060] In a possible implementation, the second electrode group includes a second working electrode, a second reference electrode, and a second counter electrode; the second electrochemical circuit module includes a second potentiostat circuit and a second transimpedance circuit; the second potentiostat circuit is used to control the voltages of the second working electrode and the second reference electrode; the second transimpedance circuit is used to amplify the third current signal; the connection between the second electrode group and the second electrochemical circuit module specifically includes: the second working electrode, the second reference electrode, and the second counter electrode are connected to the second potentiostat circuit, and the second working electrode is connected to the second transimpedance circuit.
[0061] In a possible implementation, the electrocardiogram (ECG) circuit module includes a right leg drive circuit, an amplification circuit, and a filtering circuit, and the amplification circuit is connected to the filtering circuit; the right leg drive circuit is used to cancel the common-mode signal, the amplification circuit is used to amplify the first ECG signal, and the filtering circuit is used for filtering; the first electrode group is connected to the ECG circuit module, specifically including: the first working electrode is connected to the amplification circuit, and the first pair of electrodes is connected to the right leg drive circuit; the second electrode group is connected to the ECG circuit module, specifically including: the second reference electrode is connected to the amplification circuit module; the first electrode group and the second electrode group are used to acquire the first ECG signal, specifically including: the first working electrode and the second reference electrode are used to acquire the first ECG signal; the first electrode group and the second electrode group are also used to conduct the first ECG signal to the ECG circuit module, specifically including: the first working electrode and the second reference electrode are used to conduct the first ECG signal to the amplification circuit; the ECG circuit module is used to determine the second ECG signal based on the first ECG signal, specifically including: the amplification circuit is used to amplify the first ECG signal and then conduct it to the filtering circuit; the filtering circuit is used to determine the second ECG signal based on the amplified first ECG signal; the ECG circuit module is also used to conduct the second ECG signal to the MCU, specifically including: the filtering circuit is also used to conduct the second ECG signal to the MCU.
[0062] In a possible implementation, the first electrode group further includes a first ECG electrode and a second ECG electrode, the second electrode group further includes a third ECG electrode, the ECG circuit module includes a right leg drive circuit, an amplification circuit, and a filtering circuit, and the amplification circuit is connected to the filtering circuit; the right leg drive circuit is used to cancel the common-mode signal, the amplification circuit is used to amplify the first ECG signal, and the filtering circuit is used for filtering; the first electrode group is connected to the ECG circuit module, specifically including: the first ECG electrode is connected to the amplification circuit, and the second ECG electrode is connected to the right leg drive circuit; the second electrode group is connected to the ECG circuit module, specifically including: the third ECG electrode is connected to the amplification circuit module; the first electrode group and the second electrode group are used to conduct the ECG signal to the ECG circuit module, specifically including: the first ECG electrode and the third ECG electrode are used to conduct the ECG signal to the amplification circuit; the ECG circuit module is used to determine the second ECG signal based on the first ECG signal, specifically including: the amplification circuit is used to amplify the first ECG signal and then conduct it to the filtering circuit; the filtering circuit is used to determine the second ECG signal based on the amplified first ECG signal; the ECG circuit module is also used to conduct the second ECG signal to the MCU, specifically including: the filtering circuit is also used to conduct the second ECG signal to the MCU.
[0063] Fourth aspect, the present application provides a measurement circuit, including a first electrode group, a second electrode group, a first switching switch, a first electrochemical circuit module, an electrocardiogram circuit module and a microcontroller unit MCU; the first switching switch includes a first group of input ports, a second group of input ports and a first group of output ports, and the first switching switch is used to connect the first group of input ports or the second group of input ports; the first electrode group is connected to the first group of input ports and is also connected to the electrocardiogram circuit module; the second electrode group is connected to the second group of input ports and is also connected to the electrocardiogram circuit module; the first group of output ports is connected to the first electrochemical circuit module; the MCU is connected to the first electrochemical circuit module and the electrocardiogram circuit module; the first electrode group is used to generate a first current signal; the first electrode group is also used to conduct the first current signal to the first switching switch; the first switching switch is used to conduct the first current signal to the first electrochemical circuit module when the first group of input ports is connected; the first electrochemical circuit module is used to determine a second current signal based on the first current signal; the first electrochemical circuit module is also used to send the second current signal to the MCU; the MCU is used to determine a first physiological parameter based on the second current signal; the second electrode group is used to generate a third current signal; the second electrode group is also used to conduct the third current signal to the first switching switch; the first switching switch is used to conduct the third current signal to the first electrochemical circuit module when the second group of input ports is connected; the first electrochemical circuit module is also used to determine a fourth current signal based on the third current signal; the first electrochemical circuit module is also used to conduct the fourth current signal to the MCU; the MCU is used to determine a second physiological parameter based on the fourth current signal; the first electrode group and the second electrode group are used to acquire a first electrocardiogram signal; the first electrode group and the second electrode group are also used to conduct the first electrocardiogram signal to the electrocardiogram circuit module; the electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal; the electrocardiogram circuit module is also used to conduct the second electrocardiogram signal to the MCU.
[0064] In a possible implementation manner, the first electrode group includes a first working electrode, a first reference electrode and a first counter electrode; the first group of input ports includes a first input port, a second input port and a third input port; the second electrode group includes a second working electrode, a second reference electrode and a second counter electrode; the second group of input ports includes a fourth input port, a fifth input port and a sixth input port; the first working electrode is connected to the first input port, the first reference electrode is connected to the second input port, and the first counter electrode is connected to the third input port; the second working electrode is connected to the fourth input port, the second reference electrode is connected to the fifth input port, and the second counter electrode is connected to the sixth input port.
[0065] In a possible implementation, the first set of output ports includes a first output port, a second output port, and a third output port; the first switching switch is used to connect to the first set of input ports, specifically including: the first output port is used to connect to the first input port, the second output port is used to connect to the second input port, and the third output port is used to connect to the third input port; the first switching switch is used to connect to the second set of input ports, specifically including: the first output port is used to connect to the fourth input port, the second output port is used to connect to the fifth input port, and the third output port is used to connect to the sixth input port.
[0066] In a possible implementation, the first electrochemical circuit module includes a first potentiostat circuit and a first transimpedance circuit; the first potentiostat circuit is used to control the voltages of the first working electrode and the first reference electrode; the first transimpedance circuit is used to amplify the first current signal; the first set of output ports is connected to the first electrochemical circuit module, specifically including: the first output port, the second output port, and the third output port are connected to the first potentiostat circuit; the first output port is connected to the first transimpedance circuit.
[0067] It can be understood that the measurement circuit provided in the fourth aspect can be combined with any possible implementation of the measurement circuit provided in the third aspect above.
[0068] Fifth aspect, the present application provides a measurement circuit, comprising a first electrode group, a second electrode group, a second switching switch, a third switching switch, a fourth switching switch, a first electrochemical circuit module, an electrocardiogram circuit module and a microcontroller unit MCU; the second switching switch comprises a third group of input ports, a fourth group of input ports and a second group of output ports, and the second switching switch is used to connect the third group of input ports or the fourth group of input ports; the first electrode group is connected to the third group of input ports and is also connected to the electrocardiogram circuit module; the second electrode group is connected to the fourth group of input ports and is also connected to the electrocardiogram circuit module; the second group of output ports is connected to the first electrochemical circuit module through the third switching switch and the fourth switching switch, and the second output port is connected to the electrocardiogram circuit module through the third switching switch and the fourth switching switch; the third switching switch and the fourth switching switch are used to control the second group of output ports to connect to the first electrochemical circuit module or the electrocardiogram circuit module; the MCU is connected to the first electrochemical circuit module and the electrocardiogram circuit module; the first electrode group is used to generate a first current signal; the first electrode group is also used to conduct the first current signal to the second switching switch; the second switching switch is used to conduct the first current signal to the first electrochemical circuit module when the second switching switch connects the third group of input ports and the third switching switch and the fourth switching switch control the second group of output ports to connect to the first electrochemical circuit module; the first electrochemical circuit module is used to determine a second current signal based on the first current signal; the first electrochemical circuit module is also used to send the second current signal to the MCU; the MCU is used to determine a first physiological parameter based on the second current signal; the second electrode group is used to generate a third current signal; the second electrode group is also used to conduct the third current signal to the first switching switch; the first switching switch is used to conduct the third current signal to the first electrochemical circuit module when the second switching switch connects the fourth group of input ports and the third switching switch and the fourth switching switch control the second group of output ports to connect to the first electrochemical circuit module; the first electrochemical circuit module is also used to determine a fourth current signal based on the third current signal; the first electrochemical circuit module is also used to conduct the fourth current signal to the MCU; the MCU is used to determine a second physiological parameter based on the fourth current signal; the first electrode group and the second electrode group are used to acquire a first electrocardiogram signal; the first electrode group and the second electrode group are also used to conduct the first electrocardiogram signal to the electrocardiogram circuit module when the third switching switch and the fourth switching switch control the second group of output ports to connect to the electrocardiogram circuit module; the electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal; the electrocardiogram circuit module is also used to conduct the second electrocardiogram signal to the MCU.
[0069] It can be understood that the measurement circuit provided in the fifth aspect can be combined with any possible implementation manner of the measurement circuits provided in the above third aspect and fourth aspect.
[0070] In a sixth aspect, the present application provides a chip system, which is applied to a first electronic device. The chip system includes: a processing circuit and an interface circuit. The interface circuit is configured to receive code instructions and transmit them to the processing circuit, and the processing circuit is configured to run the code instructions so that the chip system executes the measurement method in any possible implementation manner of any one of the above aspects.
[0071] In a seventh aspect, an embodiment of the present application provides a readable storage medium, including instructions that, when running on a first electronic device, cause the first electronic device to execute the measurement method in any possible implementation manner of any one of the above aspects.
[0072] In an eighth aspect, an embodiment of the present application provides a computer program product that, when running on a first electronic device, causes the first electronic device to execute the measurement method in any possible implementation manner of any one of the above aspects.
[0073] The beneficial effects of the second aspect to the eighth aspect can refer to the beneficial effects of the first aspect above. BRIEF DESCRIPTION OF THE DRAWINGS
[0074] Figure 1A FIG. is a schematic diagram of a scenario for measuring physiological parameters through a three-electrode system provided by an embodiment of the present application;
[0075] Figure 1B FIG. is a schematic diagram of the system architecture of a measurement system 10 provided by an embodiment of the present application;
[0076] Figure 2A FIG. is a schematic diagram of the hardware structure of an electronic device 100 provided by an embodiment of the present application;
[0077] Figure 2B FIG. is a schematic diagram of the hardware structure of an electronic device 200 provided by an embodiment of the present application;
[0078] Figure 3A FIG. is a schematic diagram of the device form of an electronic device 200 provided by an embodiment of the present application;
[0079] Figure 3B FIG. is a schematic diagram of the internal structure of an electronic device 200 provided by an embodiment of the present application;
[0080] Figure 3C FIG. is a schematic diagram of the distribution of electrodes on a microneedle sensor 303 provided by an embodiment of the present application;
[0081] Figure 3D FIG. is another schematic diagram of the device form of an electronic device 200 provided by an embodiment of the present application;
[0082] Figure 3EAnother internal structure schematic diagram of the electronic device 200 provided by the embodiment of the present application;
[0083] Figures 4A - 4B Schematic diagram of the connection relationship between two circuit modules and a processor provided by the embodiment of the present application;
[0084] Figures 4C - 4J Schematic diagram of a set of measurement circuits provided by the embodiment of the present application;
[0085] Figure 5A Flow schematic diagram of a measurement method provided by the embodiment of the present application;
[0086] Figure 5B Waveform schematic diagram of an electrocardiogram signal provided by the embodiment of the present application;
[0087] Figure 5C An electrocardiogram provided by the embodiment of the present application;
[0088] Figure 6 Flow schematic diagram of another measurement method provided by the embodiment of the present application;
[0089] Figures 7A - 7F Schematic diagram of the output interface of a set of physiological parameters provided by the embodiment of the present application;
[0090] Figures 7G - 7J Schematic diagram of the output interface of a set of electrocardiogram signals provided by the embodiment of the present application;
[0091] Figures 7K - 7L Schematic diagram of the interface for triggering electrocardiogram monitoring when a set of physiological parameters are abnormal provided by the embodiment of the present application;
[0092] Figures 7M - 7N Schematic diagram of the interface for executing the micro - physical examination function provided by the embodiment of the present application;
[0093] Figure 8 Functional module schematic diagram of the electronic device 200 provided by the embodiment of the present application;
[0094] Figure 9 Functional module schematic diagram of a measurement system 10 provided by the embodiment of the present application;
[0095] Figure 10 Physical entity device schematic diagram of an electronic device 300 provided by the embodiment of the present application;
[0096] Figure 11 Flow schematic diagram of a measurement method provided by the embodiment of the present application. Detailed implementation manners
[0097] The technical solutions in the embodiments of the present application will be clearly and elaborately described below with reference to the accompanying drawings. Among them, in the description of the embodiments of the present application, unless otherwise specified, " / " means "or". For example, A / B may mean A or B; "and / or" in the text is only a description of the association relationship between associated objects, indicating that there can be three relationships. For example, A and / or B may mean: A exists alone, A and B exist simultaneously, and B exists alone. In addition, in the description of the embodiments of the present application, "a plurality of" means two or more than two.
[0098] Hereinafter, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as implying or suggesting relative importance or implicitly indicating the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the embodiments of the present application, unless otherwise specified, the meaning of "a plurality of" is two or more.
[0099] The term "user interface (UI)" in the following embodiments of the present application is a media interface for interaction and information exchange between an application program or an operating system and a user, which realizes the conversion between the internal form of information and the form acceptable to the user. The user interface is source code written in a specific computer language such as Java and Extensible Markup Language (XML). The interface source code is parsed and rendered on an electronic device and finally presented as content recognizable by the user. The common manifestation form of the user interface is the graphical user interface (GUI), which refers to the user interface related to computer operations displayed in a graphical manner. It can be visible interface elements such as text, icons, buttons, menus, tabs, text boxes, dialog boxes, status bars, navigation bars, and Widgets displayed on the display screen of an electronic device.
[0100] Some terms related to the embodiments of the present application are introduced below.
[0101] Electrocardiogram: An electrocardiogram (ECG) is a curve of biopotential changes generated during the beating of the heart and is an important physiological index characterizing the occurrence, propagation, and recovery process of cardiac electrical excitation.
[0102] Electrocardiogram: During each cardiac cycle, the pacemaker, atria, and ventricles of the heart are successively excited, accompanied by changes in bioelectricity. These changes in bioelectricity are called electrocardiogram. The heart pumps blood rhythmically, and its contraction and relaxation rhythms are controlled by electrocardiogram activities. Under normal circumstances, the sinoatrial node regularly emits impulses, which cause all myocardial tissues to generate electrical impulses through a special conduction system. The electric field generated by these electrical impulses spreads throughout the body, and the tiny currents generated are conducted through body tissues to different positions of the human body, resulting in different potentials at different parts of the human body. Therefore, by placing electrodes at different positions on the body surface, the potential differences at different positions on the body surface can be measured, and thus the electrocardiogram can be determined.
[0103] Electrode lead system: The electrode lead system is used to indicate the number and arrangement of multiple electrodes for measuring electrocardiogram. The electrode lead system can include, but is not limited to, any one or more of the following: the international standard twelve-lead system, the bipolar lead system, etc.
[0104] International standard twelve-lead system: In the international standard twelve-lead system, ten electrodes need to be placed on the body surface. These ten electrodes are located on the left arm (LA), right arm (RA), left leg (LL), right leg (RL), and the remaining six electrodes are located on the chest. Among them, the electrode on the right leg can be used as a reference electrode, and the remaining nine electrodes can be used as electrocardiogram detection electrodes to measure the electrocardiogram signals on the body surface of the human body (such as the potential difference between different parts of the body surface), and determine the electrocardiogram based on the measured electrocardiogram signals.
[0105] Bipolar lead system: The bipolar lead system can include three electrodes, namely the left arm (LA) electrode, the right arm (RA) electrode, and the right leg (RL) electrode. Generally, the left arm electrode is set on the left arm, the right arm electrode is set on the right arm, and the right leg electrode is set on the right leg. It should be noted that the above three electrodes can also be set at other positions on the human body respectively. The bipolar lead system can obtain the electrocardiogram signals on the body surface by measuring the potential difference between two limbs, and determine the electrocardiogram based on the measured electrocardiogram signals. Among them, the left arm electrode and the right arm electrode are used to obtain the electrocardiogram signals on the body surface (such as the potential difference between the left arm and the right arm, etc.), and the right leg electrode can be used as a reference electrode.
[0106] Common-mode interference: During the process of measuring electrocardiogram, the right leg can be regarded as grounded. At this time, the electrocardiogram signals measured by the LA electrode and the RA electrode are based on the ground. However, there is a grounding impedance when the human body is grounded, and the grounding impedance will introduce common-mode interference and generate common-mode signals. The right leg drive (RLD) circuit can cancel the common-mode signals. The RLD circuit can be connected to the RL electrode to eliminate signals and improve the measurement accuracy.
[0107] Right leg drive electrode: The right leg drive (RLD) electrode refers to the RL electrode connected to the RLD circuit. The RLD electrode, LA electrode, and RA electrode can form a bipolar lead system for measuring electrocardiogram signals. In the embodiments of the present application, the electrodes used to measure electrocardiogram signals can also be referred to as electrocardiogram electrodes. When measuring electrocardiogram signals using a bipolar lead system, the electrocardiogram electrodes can include the LA electrode, RA electrode, and RLD electrode.
[0108] Blood glucose: Blood glucose refers to glucose in the blood. Glucose is an important component of the human body and also an important source of energy. The normal human body needs a lot of sugar every day to provide energy for the normal operation of various tissues and organs. Blood glucose must be maintained within a certain range to meet the needs of various organs and tissues in the body. High blood glucose is likely to induce diabetes, and low blood glucose is likely to cause insufficient energy in human organs, resulting in serious consequences.
[0109] Blood ketone: Blood ketone refers to the content of ketone bodies in the blood. Muscle and fat produce ketone bodies through exercise metabolism, and these ketone bodies enter the blood. When blood ketone is within the normal range, it will not have a negative impact on the human body. When blood ketone is too high (for example, greater than a specific value), the human body is at risk of acidosis.
[0110] Blood lactic acid: Blood lactic acid refers to the concentration of lactic acid in the blood. Blood lactic acid is an intermediate product of sugar metabolism in the body, mainly produced by red blood cells, striated muscle, and brain tissue. The concentration of lactic acid in the blood mainly depends on the synthesis rate and metabolic rate of the liver and kidneys. Lactic acid monitoring refers to measuring the concentration of lactic acid in the blood, and lactic acid monitoring helps to determine whether the user's liver and kidney functions are normal.
[0111] Uric acid: Uric acid is the end product of purine metabolism, which is trioxypurine, and its alcohol form is weakly acidic. The human body contains uric acid, and uric acid can be excreted from the body through urine. Imbalance between the production amount and excretion amount of uric acid in the body is likely to lead to an increase in blood uric acid, thus causing diseases. Uric acid is mainly produced in the liver and most of it is excreted from the body through glomerular filtration with urine. Therefore, uric acid monitoring helps to determine whether the user's liver and kidney functions are normal.
[0112] Electrochemical electrode: The electrochemical electrode reacts with a specific substance to form an electric current or voltage. In the embodiments of the present application, the electrochemical electrode can be used to measure one or more physiological parameters, such as blood glucose, blood ketone, uric acid, blood lactic acid, etc. According to different functions, the electrochemical electrode can include the following multiple types: working electrode, counter electrode, and reference electrode. Multiple electrochemical electrodes with different functions can form an electrochemical system for measuring physiological parameters. Common electrochemical systems include two-electrode systems and three-electrode systems.
[0113] Two - electrode system: The two - electrode system can include a working electrode and a counter electrode, or a working electrode and a reference electrode. Under the two - electrode system, the working electrode can be used to carry out the reaction under study, and the counter electrode (or reference electrode) can form a circuit with the working electrode and can also control the voltage of the working electrode.
[0114] Three - electrode system: The three - electrode system can include a working electrode, a reference electrode and a counter electrode. Under the three - electrode system, the working electrode can be used to carry out the reaction under study, the counter electrode can form a circuit with the working electrode, and the reference electrode can control the voltage of the working electrode. Specific examples of the three - electrode system can refer to the relevant content in the following Figure 1A illustrated embodiments.
[0115] Continuous glucose monitoring device: A continuous glucose monitoring (CGM) device is an electronic device used to measure blood glucose. The CGM device can include an electrochemical electrode, and a glucose enzyme (such as glucose oxidase, etc.) can be arranged in the electrochemical electrode. After the CGM device is implanted subcutaneously into a user, the glucose enzyme in the electrochemical electrode can react with glucose in the interstitial fluid to generate an electric current. The CGM device can measure the electric current generated by the reaction of the glucose enzyme and glucose, determine the glucose concentration in the user's interstitial fluid based on the magnitude of the current, and determine the glucose concentration in the user's blood, that is, the user's blood glucose value, based on the glucose concentration in the interstitial fluid.
[0116] Enzyme: An enzyme is a protein or ribonucleic acid (RNA) produced by living cells, which has high specificity for its substrate and high catalytic efficiency. The ability of an enzyme to catalyze a chemical reaction is called enzyme activity (also known as enzyme vigor). The activity of an enzyme is related to temperature. Different types of enzymes correspond to different optimal temperatures. When the temperature of the environment where the enzyme is located is the optimal temperature, the activity of the enzyme is the highest and the catalytic ability is the strongest.
[0117] Exemplarily, Figure 1A shows a schematic diagram of a scenario for measuring physiological parameters through a three - electrode system provided by an embodiment of the present application.
[0118] As Figure 1AAs shown, the three - electrode system may include a working electrode, a reference electrode, and a counter electrode. Among them, the working electrode (WE) is also called the research electrode. The working electrode refers to the electrode used for the reaction under study. Taking the electrochemical electrode for measuring blood glucose as an example, the working electrode may have a substance capable of reacting with glucose (such as glucose oxidase), and the working electrode can be used to react with glucose to generate a reaction current. The counter electrode (CE), also known as the auxiliary electrode, can form a circuit with the working electrode to make the working electrode current smooth, so as to ensure that the reaction under study occurs on the working electrode. The reference electrode (RE) is an electrode with a known potential and close to an ideal non - polarized electrode. There is basically no current passing through the reference electrode, which is used to control the voltage of the working electrode.
[0119] When the working electrode, reference electrode, and counter electrode are implanted into the subcutaneous tissue, the working electrode can react with the target substances (such as glucose, ketone bodies, uric acid, lactic acid, etc.) to generate a reaction current. By measuring the magnitude of this reaction current, the value of the physiological parameter can be determined.
[0120] The following introduces the system architecture of a measurement system 10 provided by an embodiment of the present application.
[0121] As Figure 1B shown, the measurement system 10 may include an electronic device 100 and an electronic device 200. A communication connection may be established between the electronic device 100 and the electronic device 200. The above - mentioned communication connection may be a wired connection or a wireless connection. The wireless communication connection may be a wireless communication connection established by the electronic device 100 and the electronic device 200 using any one of wireless communication technologies such as wireless local area networks (WLAN) (such as wireless fidelity (Wi - Fi) networks), Bluetooth (BT), global navigation satellite system (GNSS), frequency modulation (FM), near field communication (NFC), infrared technology (IR), NearLink, intrabody communication (IBC), etc.
[0122] In some embodiments, when the electronic device 100 detects that the monitoring condition 3 is met, it may send information 3 to the electronic device 200. The information 3 is used to request the electronic device 200 to send the physiological data 1 to the electronic device 100. The physiological data 1 is used to determine the user's physiological parameter 1 (such as blood glucose, blood ketone, uric acid, blood lactic acid, etc.). In some embodiments, when the electronic device 100 detects that the monitoring condition 4 is met, it may also send information 4 to the electronic device 200. The information 4 is used to request the electronic device 200 to send the electrocardiogram signal to the electronic device 100. The specific content of the monitoring condition 3 and the monitoring condition 4 can refer to the relevant descriptions in the following Figure 6 illustrated embodiments, which will not be elaborated here for the time being. In some embodiments, the electronic device 100 may also send information 5 to the electronic device 200. The information 5 is used to request the electronic device 200 to send the electrocardiogram signal and the physiological data 1 to the electronic device 100.
[0123] The electronic device 100 may receive the physiological data sent by the electronic device 200 and determine and output the user's physiological parameters based on the physiological data. The electronic device 100 may also receive and output the electrocardiogram signal sent by the electronic device 200.
[0124] The electronic device 200 may include a plurality of electrochemical electrodes. The electrochemical electrodes may react with specific chemical substances to generate a reaction current. The electronic device 200 may acquire the user's physiological data, and the physiological data can be used to determine any one or more of the physiological parameters such as blood glucose, blood ketone, uric acid, blood lactic acid, etc. The electronic device 200 may also acquire the user's electrocardiogram signal through a plurality of electrocardiogram electrodes. It should be noted that in some embodiments, the plurality of electrocardiogram electrodes may be some of the above-mentioned plurality of electrochemical electrodes, or may be electrodes different from the above-mentioned plurality of electrochemical electrodes. In other embodiments, one or more of the plurality of electrocardiogram electrodes may also be the same as one or more of the above-mentioned plurality of electrochemical electrodes.
[0125] In some embodiments, the electronic device 200 may receive and respond to the information 3 and send the user's physiological data to the electronic device 100. The electronic device 200 may also receive and respond to the information 4 and send the electrocardiogram signal to the electronic device 100.
[0126] In other embodiments, when the electronic device 200 detects that the monitoring condition 1 is met, it may determine and output the user's physiological parameter 1 (such as sending the physiological parameter 1 to the electronic device 100). When the electronic device 200 detects that the monitoring condition 2 is met, it may acquire and output the user's electrocardiogram signal (such as sending the electrocardiogram signal to the electronic device 100). The specific content of the monitoring condition 1 and the monitoring condition 2 can also refer to the relevant descriptions in the following Figure 5A illustrated embodiments, which will not be elaborated here for the time being.
[0127] In the embodiments of the present application, the electronic device 100 may be a wearable device such as a watch or a bracelet, or may be a mobile phone, a display screen, a tablet computer, a computer, etc. The electronic device 200 may be used to measure one or more physiological parameters, and may also be used to measure an electrocardiogram signal. The present application does not limit the device types of the electronic device 100 and the electronic device 200.
[0128] It can be understood that Figure 1B The measurement system 10 shown is only an example. In the embodiments of the present application, the measurement system 10 may also include more, fewer, or electronic devices with different device forms from those in the above embodiments. The present application does not make any limitations here.
[0129] The following introduces the hardware structure of an electronic device 100 provided by the embodiments of the present application.
[0130] Figure 2A FIG. shows a schematic diagram of the hardware structure of an electronic device 100 provided by the embodiments of the present application.
[0131] The electronic device 100 may be a mobile phone, a tablet computer, a desktop computer, a laptop computer, a handheld computer, a notebook computer, an ultra-mobile personal computer (UMPC), a netbook, a cellular phone, a personal digital assistant (PDA), an augmented reality (AR) device, a virtual reality (VR) device, an artificial intelligence (AI) device, a wearable device, a vehicle-mounted device, a smart home device, and / or a smart city device. The embodiments of the present application do not impose any special restrictions on the specific type of the electronic device.
[0132] The electronic device 100 may include a processor 110, an internal memory 121, a charging management module 140, a power management module 141, a battery 142, a sensor module 180, a display screen 194, etc. Optionally, the electronic device 100 may further include any one or more of the following: a wireless communication module 160, an audio module 170, a key 190, a motor 191, an indicator 192, a photoplethysmography (PPG) module 195, and an airbag. Among them, the audio module 170 may include any one or more of the following: a speaker 170A, a receiver 170B, and a microphone 170C. The sensor module 180 may include a touch sensor 180K.
[0133] It can be understood that the structure illustrated in the embodiments of the present invention does not constitute a specific limitation on the electronic device 100. In other embodiments of the present application, the electronic device 100 may include more or fewer components than those illustrated, or combine certain components, or split certain components, or have different component arrangements. The illustrated components may be implemented in hardware, software, or a combination of software and hardware.
[0134] The processor 110 may include one or more processing units. For example, the processor 110 may include an application processor (AP), a modem processor, a graphics processing unit (GPU), an image signal processor (ISP), a controller, a video codec, a digital signal processor (DSP), a baseband processor, and / or a neural-network processing unit (NPU), etc. Among them, different processing units may be independent devices or integrated in one or more processors.
[0135] The controller may generate operation control signals according to the instruction operation code and timing signals to complete the control of fetching and executing instructions.
[0136] A memory may also be provided in the processor 110 for storing instructions and data. In some embodiments, the memory in the processor 110 is a cache memory. This memory may store the instructions or data that the processor 110 has just used or recycled. If the processor 110 needs to use the instruction or data again, it can directly call it from the memory. This avoids repeated accesses, reduces the waiting time of the processor 110, and thus improves the efficiency of the system.
[0137] In some embodiments, the processor 110 may include one or more interfaces. The interfaces may include an inter-integrated circuit (I2C) interface, an inter-integrated circuit sound (I2S) interface, a pulse code modulation (PCM) interface, a universal asynchronous receiver / transmitter (UART) interface, a mobile industry processor interface (MIPI), a general-purpose input / output (GPIO) interface, a subscriber identity module (SIM) interface, and / or a universal serial bus (USB) interface, etc.
[0138] The charging management module 140 is configured to receive a charging input from a charger. The charger may be a wireless charger or a wired charger. In some embodiments of wired charging, the charging management module 140 may receive the charging input from a wired charger. In some embodiments of wireless charging, the charging management module 140 may receive the wireless charging input through the wireless charging coil of the electronic device 100. While charging the battery 142, the charging management module 140 may also supply power to the electronic device through the power management module 141.
[0139] The power management module 141 is used to connect the battery 142, the charging management module 140, and the processor 110. The power management module 141 receives the inputs from the battery 142 and / or the charging management module 140, and supplies power to the processor 110, the internal memory 121, the display screen 194, the wireless communication module 160, etc. The power management module 141 may also be used to monitor parameters such as the battery capacity, the number of battery cycles, and the battery health status (leakage, impedance). In some other embodiments, the power management module 141 may also be disposed in the processor 110. In some other embodiments, the power management module 141 and the charging management module 140 may also be disposed in the same device.
[0140] The wireless communication module 160 may provide solutions for wireless communications applied to the electronic device 100, including wireless local area networks (WLANs) (such as wireless fidelity (Wi-Fi) networks), Bluetooth (BT), global navigation satellite system (GNSS), frequency modulation (FM), near field communication (NFC), infrared (IR), NearLink, and intrabody communication (IBC). Exemplarily, when two electronic devices communicate using the intrabody communication solution, both of the two electronic devices are equipped with at least one electrode in contact with the skin, and through the above-mentioned electrodes in contact with the skin, the two electronic devices mutually transmit and receive information through the human body. The wireless communication module 160 may be one or more devices integrating at least one communication processing module.
[0141] The electronic device 100 realizes the display function through the GPU, the display screen 194, and the application processor, etc. The GPU is a microprocessor for image processing, which is connected to the display screen 194 and the application processor. The GPU is used to perform mathematical and geometric calculations for graphics rendering. The processor 110 may include one or more GPUs, which execute program instructions to generate or change display information.
[0142] The display screen 194 is used to display images, videos, etc. The display screen 194 includes a display panel. The display panel may be made of a liquid crystal display (LCD), and the display panel may also be made of an organic light-emitting diode (OLED), an active-matrix organic light-emitting diode (AMOLED), a flexible light-emitting diode (FLED), a MiniLED, a MicroLED, a Micro-OLED, a quantum dot light-emitting diode (QLED), etc. In some embodiments, the electronic device 100 may include 1 or N display screens 194, where N is a positive integer greater than 1.
[0143] The internal memory 121 may include one or more random access memories (RAM) and one or more non-volatile memories (NVM). The random access memory can be directly read and written by the processor 110, and can be used to store the operating system or executable programs of other running programs (such as machine instructions), and can also be used to store data of users and application programs, etc. The non-volatile memory can also store executable programs and store data of users and application programs, etc., and can be pre-loaded into the random access memory for the processor 110 to directly read and write.
[0144] The electronic device 100 can implement audio functions through the audio module 170, the speaker 170A, the receiver 170B, the microphone 170C, and the application processor, etc. For example, music playback, recording, etc.
[0145] The audio module 170 is used to convert digital audio information into an analog audio signal for output, and is also used to convert analog audio input into a digital audio signal. The audio module 170 can also be used for encoding and decoding audio signals. In some embodiments, the audio module 170 can be disposed in the processor 110, or some functional modules of the audio module 170 can be disposed in the processor 110.
[0146] The speaker 170A, also known as the "loudspeaker", is used to convert an audio electrical signal into a sound signal. The electronic device 100 can listen to music or hands-free calls through the speaker 170A.
[0147] The receiver 170B, also known as the "earpiece", is used to convert an audio electrical signal into a sound signal. When the electronic device 100 answers a call or a voice message, the voice can be listened to by placing the receiver 170B close to the human ear.
[0148] The microphone 170C, also known as the "microphone" or "transmitter", is used to convert a sound signal into an electrical signal. When making a call or sending a voice message, the user can speak with the mouth close to the microphone 170C to input the sound signal into the microphone 170C. The electronic device 100 can be provided with at least one microphone 170C. In some other embodiments, the electronic device 100 can be provided with two microphones 170C, which can not only collect sound signals but also implement a noise reduction function. In some other embodiments, the electronic device 100 can also be provided with three, four or more microphones 170C to implement sound signal collection, noise reduction, and can also identify the sound source to implement functions such as directional recording.
[0149] The touch sensor 180K, also known as the "touch control device". The touch sensor 180K can be disposed on the display screen 194, and the touch sensor 180K and the display screen 194 form a touch screen, also known as the "touch control screen". The touch sensor 180K is used to detect touch operations acting on it or nearby. The touch sensor can transmit the detected touch operation to the application processor to determine the type of touch event. Visual output related to the touch operation can be provided through the display screen 194. In some other embodiments, the touch sensor 180K can also be disposed on the surface of the electronic device 100, at a different position from the display screen 194.
[0150] The button 190 includes a power-on button, volume buttons, etc. The button 190 can be a mechanical button or a touch button. The electronic device 100 can receive button inputs and generate key signal inputs related to the user settings and function control of the electronic device 100.
[0151] The motor 191 can generate vibration prompts. The motor 191 can be used for incoming call vibration prompts and also for touch vibration feedback. For example, touch operations acting on different applications (such as taking pictures, audio playing, etc.) can correspond to different vibration feedback effects. For touch operations acting on different regions of the display screen 194, the motor 191 can also correspond to different vibration feedback effects. Different application scenarios (such as time reminder, receiving messages, alarm clock, games, etc.) can also correspond to different vibration feedback effects. The touch vibration feedback effect can also support customization.
[0152] The indicator 192 can be an indicator light and can be used to indicate the charging state, power change, and can also be used to indicate messages, missed calls, notifications, etc.
[0153] The PPG module 195 is an optional device. The PPG module 195 can include a transmitter and a receiver. The transmitter can be used to emit infrared light or green light, and the receiver can be used to receive infrared light or green light reflected by biological tissues (such as skin, blood, etc.). In some embodiments, the PPG module 195 can measure any one or more of the following physiological information: blood oxygen concentration, heart rate, blood pressure, respiratory rate, etc.
[0154] In some embodiments, the sensor module 180 of the electronic device 100 can also include any one or more of the following sensors: acceleration sensor, barometric pressure sensor, temperature sensor, gyroscope sensor, etc. Among them:
[0155] The acceleration sensor can detect the magnitude of the acceleration of the electronic device 100 in various directions (generally three axes). When the electronic device 100 is stationary, the magnitude and direction of gravity can be detected. It can also be used to identify the posture of the electronic device and is applied to applications such as horizontal and vertical screen switching, pedometer, etc.
[0156] A barometric pressure sensor can be used to measure barometric pressure. In some embodiments, the barometric pressure sensor can also be used to measure water pressure.
[0157] A temperature sensor can be used to measure the user's body temperature and also the temperature of the environment where the user is located.
[0158] A gyroscope sensor can be used to determine the motion posture of the electronic device 100. In some embodiments, the angular velocity of the electronic device 100 around three axes (i.e., the x, y, and z axes) can be determined by the gyroscope sensor.
[0159] In some embodiments, the electronic device 100 may further include an airbag, which can be used to measure blood pressure.
[0160] Figure 2B This is a schematic diagram of the hardware structure of an electronic device 200 provided by an embodiment of the present application.
[0161] As Figure 2B shown, the electronic device 200 includes a processor 201, a memory 202, a sensor 203, a wireless communication module 204, a power module 205, an electrocardiogram module 206, etc.
[0162] It can be understood that the structure schematically shown in the embodiments of the present invention does not constitute a specific limitation on the electronic device. In other embodiments of the present application, the electronic device may include more or fewer components than shown, or combine certain components, or split certain components, or have different component arrangements. The illustrated components can be implemented in hardware, software, or a combination of software and hardware.
[0163] The processor 201 may include one or more processing units. For example, the processor 201 may be a modulation and demodulation processor, a digital signal processor, a controller, a baseband processor, and / or a neural network processor, etc. Among them, different processing units may be independent devices or integrated in one or more processors. The processor 201 may also be referred to as a microcontroller unit (MCU).
[0164] The controller can generate operation control signals according to the instruction operation code and timing signals to complete the control of fetching instructions and executing instructions.
[0165] A memory may also be provided in the processor 201 for storing instructions and data. In some embodiments, the memory in the processor 201 is a cache memory. This memory can save the instructions or data that the processor 201 has just used or recycled. If the processor 201 needs to use the instruction or data again, it can directly call it from the memory. This avoids repeated accesses, reduces the waiting time of the processor 201, and thus improves the efficiency of the system.
[0166] The wireless communication module 204 can provide wireless communication solutions applied to electronic devices, including wireless local area networks (WLANs) (such as wireless fidelity (Wi-Fi) networks), Bluetooth (BT), global navigation satellite systems (GNSS), frequency modulation (FM), near field communication (NFC), infrared technology (IR), NearLink, and intrabody communication (IBC). Exemplarily, when two electronic devices communicate using the intrabody communication solution, both of the two electronic devices are equipped with at least one electrode in contact with the skin. Through the above-mentioned electrodes in contact with the skin, the two electronic devices can mutually transmit and receive information through the human body. The wireless communication module 204 can be one or more devices integrating at least one communication processing module. The wireless communication module 204 receives electromagnetic waves via an antenna, performs frequency modulation and filtering processing on the electromagnetic wave signals, and sends the processed signals to the processor 201. The wireless communication module 204 can also receive signals to be sent from the processor 201, perform frequency modulation and amplification on them, and convert them into electromagnetic waves through the antenna for radiation.
[0167] The memory 202 can include one or more random access memories and one or more non-volatile memories.
[0168] The non-volatile memory can include disk storage devices and flash memories.
[0169] The random access memory can be directly read and written by the processor 201. It can be used to store the operating system or executable programs of other running programs (such as machine instructions), and can also be used to store data of users and application programs, etc.
[0170] The non-volatile memory can also store executable programs and store data of users and application programs, etc. It can be pre-loaded into the random access memory for the processor 201 to directly read and write.
[0171] The sensor 203 can also include, but is not limited to, any one or more of the following: a glucose detection sensor 2032, a blood ketone detection sensor 2033, a uric acid detection sensor 2034, a lactic acid detection sensor 2035, etc. Optionally, the sensor 203 can also include a temperature sensor 2031.
[0172] The temperature sensor 2031 is used to detect temperature. In some embodiments, the electronic device 100 determines the user's skin temperature and / or ambient temperature based on the temperature detected by the temperature sensor 2031.
[0173] In some embodiments, the electronic device 200 can measure the user's blood glucose. In a specific implementation, the electronic device 200 can measure the glucose concentration in interstitial fluid (interstitial glucose) through the glucose detection sensor 2032, and then calculate the glucose concentration in plasma (blood) (blood glucose).
[0174] The glucose detection sensor 2032 is used to detect the concentration of glucose. In some embodiments, the glucose detection sensor 2032 can determine the glucose concentration by detecting the consumption of oxygen under the catalysis of glucose oxidase or the H2O2 generated by the glucose oxidation reaction in interstitial fluid. In some embodiments, the glucose detection sensor 2032 connects glucose oxidase to the electrode surface by using an electron mediator, such as nanomaterials, osmium metal, ferrocene, benzoquinones, etc., and then realizes the transfer of electrons through a series of redox reactions, thereby determining the glucose concentration.
[0175] During the process of the user using the electronic device 200 to measure blood glucose, the user can implant the electronic device 200 into the subcutaneous tissue. The electronic device 200 measures the glucose concentration in interstitial fluid through the electrode of the glucose detection sensor 2032, and then determines the user's blood glucose concentration.
[0176] In some embodiments, the electronic device 200 can measure the user's blood ketone. In a specific implementation, the electronic device 200 can measure the ketone body concentration in interstitial fluid through the blood ketone detection sensor 2033, and then calculate the blood ketone concentration (blood ketone) in plasma (blood). Alternatively, the electronic device 200 can also measure the blood ketone concentration in blood.
[0177] The blood ketone detection sensor 2033 is used to detect the concentration of blood ketone. During the process of the user using the electronic device 200 to measure blood ketone, the user can implant the electronic device 200 into the subcutaneous tissue. The electronic device 200 measures the blood ketone concentration in interstitial fluid through the electrode of the blood ketone detection sensor 2033, and then determines the user's blood ketone concentration. In some other embodiments, the user can also drop the sampled blood into the electronic device 200, and the electronic device 200 measures the blood ketone concentration in blood through the electrode of the blood ketone detection sensor 2033.
[0178] In some embodiments, the electronic device 200 may measure uric acid in a user's body. Specifically, in a specific implementation, the electronic device 200 may measure the concentration of ketone bodies in interstitial fluid through the uric acid detection sensor 2034 and then calculate the uric acid concentration (uric acid) in plasma (blood). Alternatively, the electronic device 200 may also measure the uric acid concentration in blood, or measure the uric acid concentration in the user's urine.
[0179] The uric acid detection sensor 2034 is used to detect the concentration of uric acid. During the process of the user using the electronic device 200 to measure uric acid, the user may implant the electronic device 200 into the subcutaneous tissue. The electronic device 200 measures the uric acid concentration in interstitial fluid through the electrodes of the uric acid detection sensor 2034, and then determines the user's uric acid concentration. In some other embodiments, the user may also drop the sampled blood (or urine) into the electronic device 200, and the electronic device 200 measures the uric acid concentration in the blood (or urine) through the electrodes of the uric acid detection sensor 2034.
[0180] The lactic acid detection sensor 2035 is used to detect the blood lactic acid concentration. During the process of the user using the electronic device 200 to measure blood lactic acid, the user may implant the electronic device 200 into the subcutaneous tissue. The electronic device 200 measures the lactic acid concentration in interstitial fluid through the electrodes of the lactic acid detection sensor 2035, and then determines the user's blood lactic acid concentration. In some other embodiments, the user may also drop the sampled blood (or interstitial fluid) into the electronic device 200, and the electronic device 200 measures the lactic acid concentration in the blood (or interstitial fluid) through the electrodes of the lactic acid detection sensor 2035.
[0181] In some embodiments, the electronic device 200 may send the collected physiological data to other devices through the wireless communication module 204, such as the electronic device 100, etc.
[0182] The memory 202 may be used to store the physiological data collected by the electronic device 200. Optionally, it may also be used to store the user's body temperature.
[0183] The power module 205 may include a battery 2051 and a power management module 2052. Optionally, the power module 205 may also include a charging management module 2053, etc.
[0184] The charging management module 2053 is used to receive a charging input from a charger. Among them, the charger may be a wireless charger or a wired charger. In some embodiments of wired charging, the charging management module 2053 may receive the charging input from a wired charger. In some embodiments of wireless charging, the charging management module 2053 may receive a wireless charging input through the wireless charging coil of the electronic device 100. While charging the battery 2051, the charging management module 2053 may also supply power to the electronic device through the power management module 2052.
[0185] The power management module 2052 is used to connect to the battery 2051, and the charging management module 2053 is connected to the processor 110. The power management module 2052 receives the inputs from the battery 2051 and / or the charging management module 2053 to supply power to the processor 201, the memory 202, the wireless communication module 204, etc. The power management module 2052 can also be used to monitor parameters such as the battery capacity, the number of battery cycles, and the battery health status (leakage, impedance). In some other embodiments, the power management module 2052 can also be disposed in the processor 201. In some other embodiments, the power management module 2052 and the charging management module 2053 can also be disposed in the same device.
[0186] The electrocardiogram module 206 can have the function of electrocardiogram monitoring, used to measure the electrocardiogram signal of the user and obtain the electrocardiogram of the user.
[0187] It should be understood that Figure 2B only the hardware structure of the electronic device 200 is exemplarily shown. In other embodiments of the present application, the electronic device 200 may include more or fewer components, and the embodiments of the present application do not limit this.
[0188] The embodiment of the present application provides a measurement method, which is applied to a first electronic device (also referred to as the electronic device 200). The first electronic device includes a first electrode group (also referred to as the electrode group 1) and a second electrode group (also referred to as the electrode group 2), and the distance between the first electrode group and the second electrode group is greater than a first distance; when the first electrode group and the second electrode group are implanted into the subcutaneous tissue, the method includes: determining a first physiological parameter through the first electrode group; determining an electrocardiogram signal through the first electrode group and the second electrode group.
[0189] In this way, the electrocardiogram signal of the user can be obtained at any time and anywhere through the electronic device 200, and moreover, one or more other physiological parameters of the user (such as blood glucose, blood ketone, blood lactic acid, uric acid, etc.) can be measured simultaneously, improving the efficiency of health monitoring.
[0190] Next, the device form and internal structure of the electronic device 200 provided by the embodiment of the present application will be introduced.
[0191] Figure 3A A schematic diagram of the device form of an electronic device 200 provided by the embodiment of the present application is shown.
[0192] As Figure 3A shown, the electronic device 200 may include a bottom case 301, a plurality of microneedle sensors, such as the microneedle sensor 303 and the microneedle sensor 304. Optionally, the electronic device 200 may further include a temperature-measuring and heat-conducting column 302. Among them:
[0193] In some embodiments, the bottom case 301 can be connected to the temperature-measuring and heat-conducting column 302, and the bottom case 301 can also be connected to the plurality of microneedle sensors. In some embodiments, the temperature-measuring and heat-conducting column 302 and the plurality of microneedle sensors can be embedded in the bottom case 301 or welded to the bottom case 301. The present application does not limit the specific connection method.
[0194] The temperature-measuring and heat-conducting column 302 can be used to measure the body temperature of a user, such as measuring the surface temperature of the user or the temperature of the subcutaneous tissue of the user, etc. In some embodiments, the temperature-measuring and heat-conducting column 302 can be in contact with the user's skin to measure the surface temperature of the user. In some embodiments, the temperature-measuring and heat-conducting column 302 can also be implanted into the subcutaneous tissue. In other embodiments, the temperature-measuring and heat-conducting column 302 can also be replaced by one or more temperature electrodes, and the one or more temperature electrodes can also be arranged in the plurality of microneedle sensors and implanted into the subcutaneous tissue.
[0195] The microneedle sensors can be used to be implanted into the subcutaneous tissue of a user. An electrode group can be arranged in each microneedle sensor, and each electrode group can be used to measure one or more physiological parameters. Each electrode group can include two or more electrochemical electrodes. In some embodiments, the electrode group can include one or more working electrodes and one or more counter electrodes (or reference electrodes), and the two types of electrochemical electrodes can form one or more two-electrode systems, and one or more physiological parameters can be measured through the one or more two-electrode systems. In other embodiments, the electrode group can include one or more working electrodes, one or more counter electrodes and one or more reference electrodes, and the three types of electrochemical electrodes can form one or more three-electrode systems, and one or more physiological parameters can be measured through the one or more three-electrode systems. In other embodiments, optionally, one or more electrocardiogram electrodes can be separately arranged in the electrode group, such as one or more of electrodes such as LA electrode, RA electrode and RLD electrode, etc.
[0196] Exemplarily, the multiple microneedle sensors may include a microneedle sensor 303 and a microneedle sensor 304. The microneedle sensor 303 may include an electrode group 1, and the microneedle sensor 304 may include an electrode group 2. The electrode group 1 may include at least one working electrode and at least one counter electrode. Optionally, the electrode group 1 may further include one or more reference electrodes. Further optionally, the electrode group 1 may further include one or more electrocardiogram electrodes. Similarly, the electrode group 2 may include at least one working electrode and at least one counter electrode. Optionally, the electrode group 2 may further include one or more reference electrodes. Further optionally, the electrode group 2 may further include one or more electrocardiogram electrodes. The electrode group 1 may be used to measure the physiological parameters of a user, and the electrode group 2 may also be used to measure the physiological parameters of the user. The physiological parameters may include, but are not limited to, any one or more of the following: blood glucose, blood ketone, uric acid, blood lactic acid, etc. The physiological parameters measured by the electrode group 1 and the electrode group 2 may be the same or different.
[0197] For example, the electrode group 1 in the microneedle sensor 303 may be used to measure the blood glucose of a user, and the electrode group 2 in the microneedle sensor 304 may be used to measure the blood ketone of the user. It can be understood that the embodiments herein are only exemplary illustrations that each microneedle sensor can be used to measure one or more physiological parameters. In the embodiments of the present application, the microneedle sensor 303 and the microneedle sensor 304 may also be used to measure physiological parameters different from those in the above embodiments, and the present application does not make any limitations herein.
[0198] It should be noted that the distance between the microneedle sensor 303 and the microneedle sensor 304 is greater than or equal to a preset distance (such as 3 cm), so that the electrocardiogram signal of the user can be ensured to be acquired by the two microneedle sensors.
[0199] It can be understood that Figure 3A the illustrated embodiments are only examples. In the embodiments of the present application, the electronic device 200 may also adopt a device form different from that in the above embodiments, such as including more microneedle sensors than those in the above embodiments, or including more, fewer, or different elements from those in the above embodiments, and the present application does not make any limitations herein.
[0200] Figure 3B FIG. shows an internal structural schematic diagram of an electronic device 200 provided by an embodiment of the present application.
[0201] As Figure 3B shown, the electronic device 200 may include a microneedle sensor 303, a microneedle sensor 304, a printed circuit board (PCB) 305, and a battery 306. Optionally, the electronic device 200 may further include a temperature measuring and heat conducting post 302. Among them:
[0202] The temperature-measuring and heat-conducting column 302 can be connected to the PCB 305 to transmit the measured temperature to the PCB 305. For other specific details of the temperature-measuring and heat-conducting column 302, reference can be made to the relevant descriptions in the Figure 3A embodiments shown above, which will not be elaborated here.
[0203] In the microneedle sensor 303, an electrode group 1 can be provided. The electrode group 1 can include a plurality of electrochemical electrodes. For example, a working electrode (WE) 3031 and a counter electrode (CE) 3033. Optionally, the electrode group 1 can further include a reference electrode (RE) 3032. The electrode group 1 is used to measure physiological parameter 1 (such as blood glucose, blood ketone, uric acid, blood lactic acid, etc.). In the electrode group 1, the working electrode 3031 can react with the target substance 1 corresponding to the physiological parameter 1 to generate a reaction current. For example, if the physiological parameter 1 is blood glucose, the target substance 1 can be glucose; or if the physiological parameter 1 is blood ketone, the target substance can be ketone body, etc. The reference electrode 3032 can be used to control the voltage of the working electrode 3031. The counter electrode 3033 can be used to form a circuit with the working electrode 3031 to ensure the generation and conduction of the reaction current. In some embodiments, the electrode group 1 can form a two-electrode system through the working electrode 3031 and the counter electrode 3033, and form a circuit through this two-electrode system to ensure the generation and conduction of the reaction current. In other embodiments, the electrode group 1 can form a three-electrode system through the working electrode 3031, the counter electrode 3033 and the reference electrode 3032, and form a circuit through this three-electrode system to ensure the generation and conduction of the reaction current. The two-electrode system and the three-electrode system can be used to measure physiological parameter 1.
[0204] In the microneedle sensor 304, an electrode group 2 can be provided. The electrode group 2 can include a plurality of electrochemical electrodes. For example, a working electrode (WE) 3041 and a counter electrode (CE) 3043. Optionally, the electrode group 2 can further include a reference electrode (RE) 3042. The electrode group 2 is used to measure physiological parameter 2 (such as blood glucose, blood ketone, uric acid, blood lactic acid, etc.). It should be noted that the physiological parameter 1 can be different from the physiological parameter 2. In some embodiments, the physiological parameter 1 can also be the same as the physiological parameter 2. The functions of the respective electrodes in the electrode group 2 can be analogously referred to the functions of the respective electrodes in the above electrode group 1. The electrode group 2 can also form a two-electrode system or a three-electrode system based on the types and numbers of the electrochemical electrodes, and measure the physiological parameter 2 through the two-electrode system or the three-electrode system.
[0205] The electrode group 1 and the electrode group 2 can also be used to measure the electrocardiogram signal of the user.
[0206] In some embodiments, the electrochemical electrodes in electrode group 1 and the electrochemical electrodes in electrode group 2 can be used as electrocardiogram (ECG) electrodes to measure ECG signals. Any electrode in electrode group 1 and any electrode in electrode group 2 can be used as the LA electrode and the RA electrode respectively. The RLD electrode can be an electrode in electrode group 1 or an electrode in electrode group 2, and the RLD electrode is connected to a right leg drive circuit for canceling the common mode signal. For example, RE3032 in the microneedle sensor 303 can be used as the LA electrode, WE3041 in the microneedle sensor 304 can be used as the RA electrode, and CE3043 can be used as the RLD electrode. It can be understood that the embodiments herein are only examples. In the embodiments of the present application, other electrodes in electrode group 1 and electrode group 2 can also be selected as ECG electrodes to measure ECG signals, and the present application does not make any limitations here. In the above cases, some of the electrochemical electrodes in electrode group 1 and electrode group 2 can be used to measure both the physiological parameters of the user and the ECG signals of the user.
[0207] In some other embodiments, dedicated ECG electrodes can be provided in electrode group 1 and electrode group 2 for measuring ECG signals. Among them, the LA electrode and the RA electrode are respectively provided in different electrode groups, and the RLD electrode can be provided in any one of the electrode groups. In this case, the ECG signals can be measured by the ECG electrodes, and the above-mentioned ECG electrodes are only used for measuring ECG signals.
[0208] In some other embodiments, dedicated ECG electrodes can be provided in electrode group 1 and electrode group 2. At the same time, some of the electrochemical electrodes in electrode group 1 and electrode group 2 can also be used as ECG electrodes. For example, an RLD electrode can be provided in electrode group 1. At the same time, one of the electrochemical electrodes in electrode group 1 and electrode group 2 can be selected as the LA electrode and the RA electrode respectively. In this way, the ECG signals can also be measured by the RLD electrode and multiple electrochemical electrodes. It can be understood that this is only an exemplary illustration here. Some of the electrodes in the ECG electrodes can use the electrochemical electrodes in electrode group 1 and electrode group 2. In the embodiments of the present application, more, fewer or different ECG electrodes than the above embodiments can also be provided, or other electrochemical electrodes can be used as ECG electrodes to measure ECG signals, and the present application does not make any limitations here.
[0209] The PCB 305 can obtain the ECG signals of the user through the microneedle sensor 303 and the microneedle sensor 304, and can also obtain the physiological data 1 of the user through the microneedle sensor 303. The physiological data 1 is used to determine the physiological parameter 1. The PCB 305 can also obtain the physiological data 2 of the user through the microneedle sensor 304. The physiological data 2 can be used to determine the physiological parameter 2. The PCB 305 can include multiple circuit modules. The internal circuit composition of the multiple circuit modules and the connection relationship between the circuit modules can be referred to as follows Figures 4A - 4JThe relevant content in the illustrated embodiments will not be elaborated here for the time being.
[0210] The battery 306 can be used to supply power to multiple modules in the electronic device 200, such as powering the PCB 305, etc. In some embodiments, the battery 306 can be a lithium battery. In other embodiments, the battery 306 can also be a battery made of other materials, which is not limited in this application.
[0211] It can be understood that the above Figure 3B illustrated embodiments are just examples. In some embodiments, the electronic device 200 may further include more microneedle sensors than the above embodiments, and the microneedle sensors may also include more or fewer electrochemical electrodes than the above embodiments, which is not limited in this application.
[0212] Figure 3C Fig. shows a schematic diagram of the distribution of electrodes on a microneedle sensor 303 provided by an embodiment of the present application.
[0213] As Figure 3C shown, the microneedle sensor 303 can include an on-skin part and a subcutaneous part. The subcutaneous part is used to be implanted into the subcutaneous tissue of the user, and the on-skin part is used to connect to the PCB 305. Exemplarily, the microneedle sensor 303 can be an irregularly shaped thin sheet, and the thin sheet can include two opposite faces, namely face A and face B.
[0214] An electrode group 1 can be provided on the microneedle sensor 303. For a specific description of the electrode group 1, reference can be made to the relevant content in the above Figures 3A - 3B illustrated embodiments. Exemplarily, the electrode group 1 can include a working electrode 3031, a reference electrode 3032, and a counter electrode 3033. In some embodiments, all the electrochemical electrodes in the electrode group 1 can be provided on face A of the microneedle sensor 303. Each electrochemical electrode can include a measurement end, a conduction end, and a wire for connecting the measurement end and the conduction end. Among them, the measurement ends of the one or more electrochemical electrodes are all provided on face A of the subcutaneous part, and the conduction ends of the one or more electrochemical electrodes are all provided on face A of the on-skin part.
[0215] It can be understood that Figure 3A the illustrated embodiments are only exemplary illustrations that all the electrodes on the microneedle sensor 303 can be provided on the same face of the microneedle sensor 303. In other embodiments, the electrodes on the microneedle sensor 303 can also be provided on different faces of the microneedle sensor 303. For example, the working electrode 3031 is provided on face A, and the reference electrode 3032 and the counter electrode 3033 are provided on face B, which is not limited in this application. In addition, in other embodiments, the microneedle sensor 303 can also adopt the same as Figure 3CDifferent forms, such as needle-shaped, cylindrical, triangular prism, polyhedron, etc., are not limited to the specific form of the microneedle sensor 303 in this application.
[0216] In this way, when the subcutaneous part of the microneedle sensor 303 is implanted into the subcutaneous tissue of the user, the microneedle sensor 303 can obtain the physiological data 1 of the user through the one or more electrochemical electrodes.
[0217] In some other embodiments, the microneedle sensor 303 may also include a plurality of working electrodes. In one possible implementation, two or more working electrodes can share the same reference electrode and / or counter electrode to form different three-electrode systems (or two-electrode systems) to measure the same or different physiological parameters, such as measuring blood glucose and blood ketone. In another possible implementation, the microneedle sensor 303 may further include a plurality of reference electrodes and / or counter electrodes. The plurality of working electrodes can form different three-electrode systems (or two-electrode systems) with different reference electrodes and / or counter electrodes to measure the same or different physiological parameters.
[0218] It should be noted that the electrode distribution on the microneedle sensor 304 can also refer to the Figure 3C electrode distribution of the microneedle sensor 303 shown above. In addition, if the electronic device 200 further includes other microneedle sensors, the electrode distribution on this microneedle sensor can also refer to the Figure 3C relevant description in the embodiments shown above, and this application will not elaborate on this.
[0219] Figure 3D Fig. shows a schematic diagram of the device form of another electronic device 200 provided by the embodiments of this application.
[0220] As Figure 3D shown, the electronic device 200 may include a bottom case 301 and a plurality of array sensors. Each array sensor may include an electrode group, and the specific content of the electrode group can refer to the Figure 3A relevant description in the embodiments shown above, and will not be elaborated here. Optionally, the electronic device 200 may further include a temperature measurement and heat conduction column 302. The specific content of the temperature measurement and heat conduction column 302 can refer to the Figures 3A - 3B relevant description in the embodiments shown above, and will not be elaborated here. In some embodiments, the plurality of array sensors may be provided on the bottom case 301. Optionally, the temperature measurement and heat conduction column 302 may also be provided. In the embodiments of this application, a sensor may refer to an element for obtaining a specific signal (such as a current signal, a voltage signal, an optical signal, etc.). In some embodiments, an array sensor may also refer to a plurality of electrodes arranged in an array.
[0221] Exemplarily, the multiple array sensors may include array sensor 307 and array sensor 308. Array sensor 307 may include electrode group 1, and array sensor 308 may include electrode group 2.
[0222] Electrode group 1 may include multiple electrochemical electrodes, such as working electrode group 3073 and counter electrode group 3075. Optionally, it may further include a reference electrode group 3074. Further optionally, it may also include one or more electrocardiogram electrodes, such as right leg drive (RLD) electrode 3072 and right arm (RA) electrode 3071. Among them, each electrode group may include one or more electrochemical electrodes of the same type. In some embodiments, the working electrode group 3073 and the counter electrode group 3075 in electrode group 1 may form one or more two-electrode systems, and each two-electrode system may form a circuit to ensure the generation and conduction of reaction current. Through this two-electrode system, electrode group 1 can measure one or more physiological parameters. In other embodiments, the working electrode group 3073, the reference electrode group 3074, and the counter electrode group 3075 in electrode group 1 may form one or more three-electrode systems, and each three-electrode system may form a circuit to ensure the generation and conduction of reaction current. It should be noted that in some embodiments, multiple two-electrode systems (or three-electrode systems) may share a counter electrode and / or a reference electrode. Through the two-electrode system and / or the three-electrode system, electrode group 1 can measure physiological parameter 1.
[0223] Electrode group 2 may include multiple electrochemical electrodes, such as working electrode group 3082 and counter electrode group 3084. Optionally, it may further include a reference electrode group 3083. Further optionally, it may also include one or more electrocardiogram electrodes, such as left arm (LA) electrode 3081. Among them, each electrode group may include one or more electrochemical electrodes of the same type. In some embodiments, the working electrode group 3082 and the counter electrode group 3084 in electrode group 2 may form one or more two-electrode systems, and each two-electrode system may form a circuit to ensure the generation and conduction of reaction current. Through this two-electrode system, electrode group 2 can measure one or more physiological parameters. In other embodiments, the working electrode group 3082, the reference electrode group 3083, and the counter electrode group 3084 in electrode group 2 may form one or more three-electrode systems, and each three-electrode system may form a circuit to ensure the generation and conduction of reaction current. It should be noted that in some embodiments, multiple two-electrode systems (or three-electrode systems) may share a counter electrode and / or a reference electrode. Through the two-electrode system and / or the three-electrode system, electrode group 2 can measure physiological parameter 2.
[0224] It can be understood that in the above embodiments, it is only an exemplary illustration that the electrode group 1 and the electrode group 2 may include one or more electrocardiogram electrodes. In the embodiments of the present application, it is only necessary to ensure that the LA electrode and the RA electrode are located in different electrode groups, and the RLD electrode may be located in any electrode group. The present application does not limit the specific correspondence between the electrocardiogram electrodes and the electrode groups.
[0225] In some other embodiments, separate electrocardiogram electrodes may be provided in the electrode group 1 and the electrode group 2. For example, a left arm (LA) electrode 3081, a right leg drive (RLD) electrode 3072, and a right arm (RA) electrode 3071. In this case, the electrocardiogram signal can be measured by the electrocardiogram electrodes, and the above electrocardiogram electrodes are only used for measuring the electrocardiogram signal.
[0226] In some embodiments, the electrochemical electrodes in the electrode group 1 and the electrochemical electrodes in the electrode group 2 can be used as electrocardiogram electrodes to measure the electrocardiogram signal. Any one electrode in the electrode group 1 and any one electrode in the electrode group 2 can be used as the LA electrode and the RA electrode respectively. The RLD electrode can be an electrode in the electrode group 1 or an electrode in the electrode group 2, and the RLD electrode is connected to a right leg drive circuit for canceling the common mode signal. For example, one or more reference electrodes in the reference electrode group 3074 in the electrode group 1 can be used as the LA electrode, one or more working electrodes in the working electrode group 3082 in the electrode group 2 can be used as the RA electrode, and one or more counter electrodes in the counter electrode group 3084 can be used as the RLD electrode. It can be understood that this embodiment is only an example. In the embodiments of the present application, other electrodes in the electrode group 1 and the electrode group 2 can also be selected as electrocardiogram electrodes to measure the electrocardiogram signal, and the present application does not limit this here. In the above case, some of the electrochemical electrodes in the electrode group 1 and the electrode group 2 can measure both the physiological parameters and the electrocardiogram signal of the user.
[0227] In some other embodiments, separate electrocardiogram electrodes may be provided in the electrode group 1 and the electrode group 2. At the same time, some of the electrochemical electrodes in the electrode group 1 and the electrode group 2 can also be used as electrocardiogram electrodes. For example, an RLD electrode may be provided in the electrode group 1. At the same time, one electrochemical electrode can be selected from the electrode group 1 and the electrode group 2 respectively as the LA electrode and the RA electrode. In this way, the electrocardiogram signal can also be measured by the RLD electrode and multiple electrochemical electrodes. It can be understood that this is only an exemplary illustration here. Some of the electrodes in the electrocardiogram electrodes can use the electrochemical electrodes in the electrode group 1 and the electrode group 2. In the embodiments of the present application, other electrochemical electrodes can also be used as electrocardiogram electrodes to measure the electrocardiogram signal, and the present application does not limit this here.
[0228] In the above array sensors 307 and 308, the specific functions of the working electrodes, reference electrodes, and counter electrodes can be analogously referred to the aboveFigure 3B The functions of the electrodes in the illustrated embodiments are described above and will not be elaborated here.
[0229] It should be noted that the distance between the array sensor 307 and the array sensor 308 is greater than or equal to a preset distance (for example, 3 cm), so that the electrocardiogram signals of the user can be acquired by the two array sensors.
[0230] It can be understood that Figure 3D The illustrated embodiments are just examples. In the embodiments of the present application, the electronic device 200 may also adopt a device form different from the above embodiments. For example, it may include more array sensors than the above embodiments, or the array sensors may include more, fewer, or different electrodes (including electrocardiogram electrodes and electrochemical electrodes) than the above embodiments, or it may include more, fewer, or different components than the above embodiments. The present application does not make any limitations here.
[0231] It should be noted that the above Figure 3A 、 Figure 3D The illustrated embodiments are just two examples. In the embodiments of the present application, the electronic device 200 may also include one or more array sensors and one or more microneedle sensors. The microneedle sensors may include multiple electrodes, and the array sensors may also include multiple electrodes. The electronic device 200 may also determine one physiological parameter through an array sensor and another physiological parameter through a microneedle sensor, and may also acquire electrocardiogram signals through the microneedle sensors and the array sensors. The present application does not make any limitations here.
[0232] Figure 3E FIG. shows a schematic internal structure diagram of an electronic device 200 provided in an embodiment of the present application.
[0233] As Figure 3E shown, the electronic device 200 may include an array sensor 307, an array sensor 308, a printed circuit board (PCB) 305, and a battery 306. Optionally, the electronic device 200 may further include a temperature measurement and heat conduction column 302. Among them:
[0234] The temperature measurement and heat conduction column 302 may be connected to the PCB 305 to transmit the measured temperature to the PCB 305. Other specific contents of the temperature measurement and heat conduction column 302 may refer to the relevant descriptions in the above Figure 3D illustrated embodiments and will not be elaborated here.
[0235] The electrode composition in the array sensor 307 (i.e., the electrode composition in the electrode group 1) and the electrode composition in the array sensor 308 (i.e., the electrode composition in the electrode group 2) may refer to the above Figure 3DFor the relevant descriptions in the embodiments shown, they will not be elaborated here. It should be noted that the array sensors 307 and 308 can be disposed on the PCB 305 or connected to the PCB.
[0236] In some embodiments, the PCB 305 can obtain the electrocardiogram signal of the user through the array sensors 307 and 308, and can also obtain the physiological data 1 of the user through the array sensor 307. The physiological data 1 is used to determine the physiological parameter 1. The PCB 305 can also obtain the physiological data 2 of the user through the array sensor 308. The physiological data 2 can be used to determine the physiological parameter 2. The PCB 305 can include a plurality of circuit modules. The internal circuit composition of the plurality of circuit modules and the connection relationship between the circuit modules can refer to the relevant content in the following Figures 4A - 4J shown embodiments, which will not be elaborated here for the time being. It should be noted that the physiological parameter 1 can include one or more physiological parameters. In some embodiments, multiple working electrodes in the array sensor 307 can be used to obtain physiological data of different physiological parameters. At this time, based on the physiological data 1, multiple different physiological parameters can be determined, such as blood glucose and blood ketone, etc., which are not limited in this application. It can be understood that the physiological parameter 2 can also include one or more physiological parameters.
[0237] The battery 306 can be used to supply power to multiple modules in the electronic device 200, such as supplying power to the PCB 305, etc. In some embodiments, the battery 306 can be a lithium battery. In other embodiments, the battery 306 can also be a battery made of other materials, which is not limited in this application.
[0238] It can be understood that the above Figure 3E shown embodiments are just an example. In some embodiments, the electronic device 200 can further include more array sensors than the above embodiments, and the array sensor 307 and / or the array sensor 308 can also include more or fewer electrodes (including electrocardiogram electrodes and electrochemical electrodes) than the above embodiments, which are not limited in this application.
[0239] Next, the connection relationship between the circuit modules in the PCB 305 provided by the embodiments of the present application will be introduced.
[0240] Figure 4A Fig. shows a schematic diagram of the connection relationship between the circuit modules in a PCB 305 provided by the embodiments of the present application.
[0241] As Figure 4AAs shown, the PCB 305 may include a microcontroller unit (MCU) 401, an analog-to-digital converter (ADC) 402, an electrocardiogram circuit module 403, one or more electrochemical circuit modules (such as electrochemical circuit module 404 and electrochemical circuit module 405), one or more electrode interfaces (such as electrode interface 406, electrode interface 407), etc. Optionally, the PCB 305 may also include a temperature module 408, etc. In some embodiments, the ADC 402 may also be integrated in the MCU 401. Among them:
[0242] The electrocardiogram circuit module 403 can be connected to the electrocardiogram electrodes. In the case of measuring the electrocardiogram using a bipolar lead system, the electrocardiogram electrodes may include an LA electrode, an RA electrode, and an RLD electrode. The LA electrode and the RA electrode can measure the electrocardiogram signal 1 and transmit the electrocardiogram signal 1 to the electrocardiogram circuit module 403. The electrocardiogram circuit module 403 can amplify, filter, etc. the electrocardiogram signal 1 to obtain the electrocardiogram signal 2 and send the electrocardiogram signal 2 to the ADC 402. In some embodiments, the electrocardiogram circuit module 403 may include an amplifier circuit 4031, a filter circuit 4032, and a right leg drive (RLD) circuit 4033. The amplifier circuit 4031 can be connected to the LA electrode and the RA electrode, and the RLD circuit 4033 can be connected to the RLD electrode. Among them, the amplifier circuit 4031 can receive the electrocardiogram signal 1 and perform amplification processing on the electrocardiogram signal 1. The RLD circuit 4033 can cancel the common-mode signal, and the filter circuit 4032 can filter the amplified electrocardiogram signal 1 to obtain the electrocardiogram signal 2.
[0243] The one or more electrochemical circuit modules may include an electrochemical circuit module 404 and an electrochemical circuit module 405. Each electrochemical circuit can measure a physiological parameter, such as blood glucose, blood ketone, uric acid, blood lactic acid, etc. The physiological parameters measured by the electrochemical circuit module 404 and the electrochemical circuit module 405 may be the same or different.
[0244] The electrochemistry circuit module 404 can be connected to one or more electrochemistry electrodes. In the case of measuring physiological parameters using a three - electrode system, the electrochemistry circuit module 404 can be connected with one or more working electrodes, one or more reference electrodes, and one or more counter electrodes. The one or more electrochemistry electrodes can react with the target substance 1 to generate a current signal 1 and conduct the current signal 1 to the electrochemistry circuit module 404. The electrochemistry circuit module 404 can perform processing such as amplifying the current signal 1 to obtain a current signal 2 and send the current signal 2 to the ADC 402. In some embodiments, the electrochemistry circuit module 404 can include a potentiostat circuit 4041 and a transimpedance circuit 4042. The potentiostat circuit 4041 can control the voltage difference between the reference electrode and the working electrode. The transimpedance circuit 4042 can amplify the current signal 1 to obtain a current signal 2. In some embodiments, there may be an overlapping part between the potentiostat circuit 4041 and the transimpedance circuit 4042, for example, there are one or more components shared by the potentiostat circuit 4041 and the transimpedance circuit 4042. Specific examples can refer to the relevant content in the following Figures 4C - 4D , Figures 4F - 4J illustrated embodiments, which will not be elaborated here for the time being.
[0245] The electrochemistry circuit module 405 can be connected to one or more electrochemistry electrodes. In the case of measuring physiological parameters using a three - electrode system, the electrochemistry circuit module 405 can be connected with one or more working electrodes, one or more reference electrodes, and one or more counter electrodes. The one or more electrochemistry electrodes can react with the target substance 2 to generate a current signal 3 and conduct the current signal 3 to the electrochemistry circuit module 405. The electrochemistry circuit module 405 can perform processing such as amplifying the current signal 3 to obtain a current signal 4 and send the current signal 4 to the ADC 402. In some embodiments, the electrochemistry circuit module 405 can include a potentiostat circuit 4051 and a transimpedance circuit 4052. The potentiostat circuit 4051 can control the voltage difference between the reference electrode and the working electrode. The transimpedance circuit 4052 can amplify the current signal 3 to obtain a current signal 4. In some embodiments, there may be an overlapping part between the potentiostat circuit 4051 and the transimpedance circuit 4052, for example, there are one or more components shared by the potentiostat circuit 4051 and the transimpedance circuit 4052. Specific examples can refer to the relevant content in the following Figures 4C - 4D , Figures 4F - 4J illustrated embodiments, which will not be elaborated here for the time being.
[0246] The one or more electrode interfaces can include an electrode interface 406 and an electrode interface 407. The electrode interface can connect the electrochemistry circuit module to one or more electrochemistry electrodes and can also connect the electrocardiogram circuit module 403 and the electrocardiogram electrodes.
[0247] In some embodiments, the electrode interface 406 can connect the electrochemistry circuit module 404 to one or more electrochemistry electrodes. The electrode interface 406 can also connect the electrocardiogram circuit module 403 and the LA electrode. The electrode interface 407 can connect the electrochemistry circuit module 405 to one or more electrochemistry electrodes, and the electrode interface 407 can also connect the electrocardiogram circuit module 403 and the RA electrode and the RLD electrode.
[0248] Exemplarily, if the electronic device 200 is the above-mentioned Figures 3A - 3B shown electronic device 200, the electrochemistry electrodes connected by the electrode interface 406 can include the working electrode 3031, the reference electrode 3032, and the counter electrode 3033 in the above Figure 3B shown embodiment, and the LA electrode connected by the electrode interface 406 can be the reference electrode 3032; the electrochemistry electrodes connected by the electrode interface 407 can include the working electrode 3041, the reference electrode 3042, and the counter electrode 3043 in the above Figure 3B shown embodiment, the RA electrode connected by the electrode interface 407 can be the working electrode 3041, and the RLD electrode can be the counter electrode 3043.
[0249] Another exemplarily, if the electronic device 200 is the above-mentioned Figures 3D - 3E shown electronic device 200, the electrochemistry electrodes connected by the electrode interface 406 can include the working electrode group 3082, the reference electrode group 3083, and the counter electrode group 3084 in the above Figure 3D shown embodiment, and the LA electrode connected by the electrode interface 406 can be the LA electrode 3081; the electrochemistry electrodes connected by the electrode interface 407 can include the working electrode group 3073, the reference electrode group 3074, and the counter electrode group 3075 in the above Figure 3D shown embodiment, the RA electrode connected by the electrode interface 407 can be the RA electrode 3071, and the RLD electrode can be the RLD electrode 3072. It can be understood that the above two embodiments are only examples. In the embodiments of the present application, the connection relationship between the electrode interface and the electrodes (including electrochemistry electrodes and electrocardiogram electrodes) can also be different from the above embodiments, and the present application does not limit this here.
[0250] The ADC402 can receive the current signals (such as current signal 2, current signal 4, etc.) sent by the one or more electrochemical circuit modules. The ADC402 can also receive the analog electrocardiogram signal 2 sent by the electrocardiogram circuit module 403. The ADC402 can perform analog-to-digital conversion on the received analog signals (such as current signal 2, current signal 4, electrocardiogram signal 2, etc.) to obtain corresponding digital signals. Exemplarily, the ADC402 can perform analog-to-digital conversion on current signal 2 to obtain current signal 5. The ADC402 can perform analog-to-digital conversion on current signal 4 to obtain current signal 6. The ADC402 can also perform analog-to-digital conversion on electrocardiogram signal 2 to obtain electrocardiogram signal 3. The above-mentioned current signal 5, current signal 6, and electrocardiogram signal 3 are all digital signals.
[0251] The MCU401 can receive the digital signals (such as current signal 5, current signal 6, and electrocardiogram signal 3) sent by the ADC402, and can also receive the temperature signal sent by the temperature module 408. The MCU401 can determine the electrocardiogram of the user based on the electrocardiogram signal 3 sent by the ADC402. The MCU401 can determine the physiological parameter 1 of the user based on the current signal 5 sent by the ADC02, and the MCU401 can also determine the physiological parameter 2 of the user based on the current signal 6. Optionally, the MCU401 can also determine the body temperature of the user based on the temperature signal.
[0252] The temperature module 408 can detect the temperature signal and send the temperature signal to the MCU401.
[0253] In some embodiments, the PCB305 may further include a charging circuit module 409, and the charging circuit module 409 can supply power to other modules in the PCB305.
[0254] The charging circuit module 409 may include a charging management chip 4092 and a voltage stabilizing circuit 4094. Optionally, the charging circuit module 409 may further include a battery 4093 and a charging interface 4091. In some embodiments, the battery 4093 may not be disposed in the PCB305, but is connected to the charging circuit module 409 in the PCB305.
[0255] The charging interface 4091 can receive a charging input (such as the charging input of a wired charger, wireless charging input, etc.). The charging interface 4091 can charge the battery 4093 through the charging management chip 4092, or can also transmit electrical energy to the voltage stabilizing circuit 4094 through the charging management chip 4092.
[0256] The voltage stabilizing circuit 4094 can provide voltage-stabilized electrical energy for other circuit modules in the PCB305. The voltage stabilizing circuit 4094 can receive the electrical energy transmitted by the charging management chip 4092, or can also receive the electrical energy transmitted by the battery 4093.
[0257] It can be understood that Figure 4A the illustrated embodiments are merely examples. In the embodiments of the present application, the PCB 305 may further include more, fewer, or different circuit modules (such as an electrochemical circuit module, an electrode interface, etc.) than those in the above embodiments. Moreover, the connection relationships between the various circuit modules in the PCB 305 may also be different from those in the above embodiments, and the present application does not make any limitations here.
[0258] In some embodiments, the same electrochemical circuit module in the PCB 305 can be used to measure multiple physiological parameters, and the PCB 305 can control the physiological parameters measured by the electrochemical circuit module through one or more switching switches.
[0259] Exemplarily, Figure 4B FIG. shows a schematic diagram of the connection relationships between the various circuit modules in another PCB 305 provided by the embodiments of the present application.
[0260] As Figure 4B shown, the PCB 305 may include a microcontroller unit (MCU), an analog-to-digital converter (ADC) 402, an electrocardiogram circuit module 403, a switching switch MUX0, one or more electrochemical circuit modules (such as an electrochemical circuit module 404), one or more electrode interfaces (such as electrode interfaces 406 and 407), etc. Optionally, the PCB 305 may further include, but is not limited to, any one or more of the following: a temperature module 408, a charging circuit module 409, etc. Among them:
[0261] The input end of the switching switch MUX0 may be connected to the electrode interface 406 and the electrode interface 407. The output end of the switching switch MUX0 may be connected to the electrochemical circuit module 404. The switching switch MUX0 can connect to the electrode interface 406 or the electrode interface 407.
[0262] The electrochemical circuit module 404 can be connected to multiple electrochemical electrodes through the switching switch MUX0.
[0263] When MUX0 connects to the electrode interface 406, the electrochemistry circuit module 404 can connect one or more electrochemistry electrodes through MUX0 and the electrode interface 406. In the case of measuring physiological parameters using a three - electrode system, the one or more electrochemistry electrodes can include one or more working electrodes, one or more reference electrodes, and one or more counter electrodes. The one or more electrochemistry electrodes can react with the target substance 1 to generate a current signal 1 and conduct the current signal 1 to the electrochemistry circuit module 404. The electrochemistry circuit module 404 can perform processing such as amplifying the current signal 1 to obtain a current signal 2 and send the current signal 2 to the ADC 402.
[0264] When MUX0 connects to the electrode interface 407, the electrochemistry circuit module 404 can connect one or more electrochemistry electrodes through MUX0 and the electrode interface 407. In the case of measuring physiological parameters using a three - electrode system, the one or more electrochemistry electrodes can include one or more working electrodes, one or more reference electrodes, and one or more counter electrodes. The one or more electrochemistry electrodes can react with the target substance 2 to generate a current signal 3 and conduct the current signal 3 to the electrochemistry circuit module 404. The electrochemistry circuit module 404 can perform processing such as amplifying the current signal 3 to obtain a current signal 4 and send the current signal 4 to the ADC 402.
[0265] In some embodiments, the electrochemistry circuit module 404 can include a potentiostat circuit 4041 and a transimpedance circuit 4042. The potentiostat circuit 4041 can control the voltage difference between the reference electrode and the working electrode. The transimpedance circuit 4042 can amplify the current signal. For example, it can amplify the current signal 1 to obtain the current signal 2, or amplify the current signal 3 to obtain the current signal 4. In some embodiments, there may be an overlapping part between the potentiostat circuit 4041 and the transimpedance circuit 4042. For example, there are one or more components shared by the potentiostat circuit 4041 and the transimpedance circuit 4042. For specific examples, reference can be made to the relevant content in the following Figures 4C - 4D , Figures 4F - 4J illustrated embodiments, which will not be elaborated here for the time being.
[0266] The one or more electrode interfaces may include electrode interface 406 and electrode interface 407. The electrode interfaces can connect the electrochemical circuit module to one or more electrochemical electrodes, and can also connect the electrocardiogram circuit module 403 and the electrocardiogram electrodes. In some embodiments, electrode interface 406 can connect the switching switch MUX0 to one or more electrochemical electrodes. Electrode interface 406 can also connect the electrocardiogram circuit module 403 and the LA electrode. Electrode interface 407 can connect the switching switch MUX0 to one or more electrochemical electrodes, and electrode interface 407 can also connect the electrocardiogram circuit module 403 and the RA electrode and the RLD electrode. The connection relationships between electrode interface 406, electrode interface 407 and each electrode can refer to the relevant descriptions in the Figure 4A corresponding embodiments shown above, and will not be elaborated here.
[0267] In addition, the specific contents of MCU401, ADC402, electrocardiogram circuit module 403, temperature module 408, and charging circuit module 409 can refer to the relevant descriptions in the Figure 4A corresponding embodiments shown above, and will not be elaborated here.
[0268] It can be understood that Figure 4B the embodiments shown above are only examples. In the embodiments of the present application, PCB305 may also include more, fewer, or different circuit modules (such as electrochemical circuit modules, electrode interfaces, etc.) than those in the above embodiments. Moreover, the connection relationships between the circuit modules in PCB305 can also be different from those in the above embodiments, and the present application does not make any limitations here. In addition, in some embodiments, a single electrochemical module can also be used to measure more than two physiological parameters, and the present application does not make any limitations here either.
[0269] In other embodiments, more or fewer switching switches may be provided in PCB305, or switching switches may be provided at different positions from the Figure 4B corresponding embodiments shown above. These switching switches can be used to control PCB305 to measure the current signal / electrocardiogram signal of a specified physiological parameter at the same time, or to measure the electrocardiogram signal and the current signals of one or more physiological parameters simultaneously.
[0270] Taking the example that both electrode group 1 and electrode group 2 can form a three-electrode system, the multiple measurement circuits provided by the embodiments of the present application will be introduced below.
[0271] Figure 4C The circuit diagram of a measurement circuit provided by the embodiments of the present application is shown.
[0272] As Figure 4CAs shown, the measurement circuit may include a potentiostat circuit 1, a transimpedance circuit 1, a potentiostat circuit 2, a transimpedance circuit 2, a right leg drive circuit, an amplification circuit, a filtering circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit may also include multiple electrode groups, such as electrode group 1 and electrode group 2. Exemplarily, electrode group 1 may include a working electrode W1, a reference electrode R1, and a counter electrode C1; electrode group 2 may include a working electrode W2, a reference electrode R2, and a counter electrode C2.
[0273] The components in each circuit module and the connection manner of the components will be introduced separately below.
[0274] The potentiostat circuit 1 may include a digital-to-analog conversion module DAC1, an operational amplifier AMP_1, and an operational amplifier AMP_2. Each operational amplifier may include a non-inverting input terminal, an inverting input terminal, and an output terminal. Among them, DAC1 can generate a stable voltage signal. DAC1 can be connected to the non-inverting input terminal of operational amplifier AMP_1 and can also be connected to the non-inverting input terminal of operational amplifier AMP_2 to provide the same voltage input for operational amplifier AMP_1 and operational amplifier AMP_2. The output terminal of operational amplifier AMP_1 can be connected to the counter electrode C1 in electrode group 1, and the inverting input terminal of operational amplifier AMP_1 can be connected to the reference electrode R1 in electrode group 1. The inverting input terminal of operational amplifier AMP_2 can be connected to the working electrode W1 in electrode group 1, and the output terminal of operational amplifier AMP_2 can be connected to ADC. In this way, by applying the same voltage to the non-inverting input terminals of operational amplifier AMP_1 and operational amplifier AMP_2, the voltage difference between the reference electrode R1 and the working electrode W1 can be controlled, so that the voltage on the working electrode W1 is approximately equal to the voltage on the reference electrode R1.
[0275] The transimpedance circuit 1 may include an operational amplifier AMP_2 and a resistor RTIA_1. Both ends of the resistor RTIA_1 are respectively connected to the inverting input terminal and the output terminal of the operational amplifier AMP_2. In this way, when there is a stable voltage input at the non-inverting input terminal of the operational amplifier AMP_2, the transimpedance circuit 1 can amplify the current signal input to the inverting input terminal of the operational amplifier AMP_2. Since the inverting input terminal of the operational amplifier AMP_2 is connected to the working electrode W1 in electrode group 1 and the output terminal of the operational amplifier AMP_2 is connected to ADC, the transimpedance circuit 1 can amplify the current signal conducted by the working electrode W1 and transmit the amplified current signal to ADC.
[0276] The potentiostat circuit 2 may include a digital-to-analog conversion module DAC2, an operational amplifier AMP_5, and an operational amplifier AMP_6. Among them, DAC2 can generate a stable voltage signal. DAC2 can be connected to the non-inverting input terminal of operational amplifier AMP_5 and also to the non-inverting input terminal of operational amplifier AMP_6, providing the same voltage input for operational amplifier AMP_5 and operational amplifier AMP_6. The output terminal of operational amplifier AMP_5 can be connected to the counter electrode C2 in electrode group 2, and the inverting input terminal of operational amplifier AMP_5 can be connected to the reference electrode R2 in electrode group 2. The inverting input terminal of operational amplifier AMP_6 can be connected to the working electrode W2 in electrode group 2, and the output terminal of operational amplifier AMP_6 can be connected to the ADC. In this way, by applying the same voltage to the non-inverting input terminals of operational amplifier AMP_5 and operational amplifier AMP_6, the voltage difference between the reference electrode R2 and the working electrode W2 can be controlled, making the voltage on the working electrode W2 approximately equal to the voltage on the reference electrode R2. It should be noted that in some embodiments, the potentiostat circuit 2 may also share a digital-to-analog conversion module DAC1 with the potentiostat circuit 1. In this case, the digital-to-analog conversion module DAC2 in the potentiostat circuit 2 can also be replaced by the digital-to-analog conversion module DAC1, and the present application does not make any limitations here.
[0277] The transimpedance circuit 2 may include an operational amplifier AMP_6 and a resistor RTIA_2. Both ends of the resistor RTIA_2 are respectively connected to the inverting input terminal and the output terminal of the operational amplifier AMP_6. In this way, when there is a stable voltage input at the non-inverting input terminal of the operational amplifier AMP_6, the transimpedance circuit 2 can amplify the current signal input to the inverting input terminal of the operational amplifier AMP_6. Since the inverting input terminal of the operational amplifier AMP_6 is connected to the working electrode W2 in electrode group 2 and the output terminal of the operational amplifier AMP_6 is connected to the ADC, the transimpedance circuit 2 can amplify the current signal conducted by the working electrode W2 and transmit the amplified current signal to the ADC.
[0278] The amplification module may include an instrumentation amplifier IA, which may be a component integrated by multiple operational amplifiers. The instrumentation amplifier IA may include a non-inverting input terminal, an inverting input terminal, and an output terminal. The instrumentation amplifier IA may perform a differential operation on the signals at the non-inverting input terminal and the inverting input terminal, and amplify the differential-mode signal between the non-inverting input terminal and the inverting input terminal. At the same time, the instrumentation amplifier IA only plays a following role for the common-mode signal, thereby increasing the ratio between the amplitudes of the differential-mode signal and the common-mode signal and achieving the effect of suppressing the common-mode signal. The non-inverting input terminal of the instrumentation amplifier IA may be connected to the reference electrode R1 in the electrode group 1, and the inverting input terminal may be connected to the working electrode W2 in the electrode group 2. At this time, the reference electrode R1 may be regarded as the LA electrode, and the working electrode W2 may be regarded as the RA electrode. In this way, the instrumentation amplifier IA may amplify the potential difference between the LA electrode and the RA electrode and transmit the amplified electrocardiogram signal to the filtering circuit.
[0279] In some embodiments, the right leg drive circuit may include an operational amplifier AMP_3, multiple resistors, and a capacitor C1. The multiple resistors may include a resistor R1, a resistor R2, a resistor R3, and a resistor R4. Among them, the non-inverting input terminal of the operational amplifier AMP_3 may be connected to the voltage source VCM_REF, and the voltage source VCM_REF may apply a stable voltage to the operational amplifier AMP_3. The inverting input terminal of the operational amplifier AMP_3 may be connected to the instrumentation amplifier IA through the resistor R2 to receive the common-mode signal output by the instrumentation amplifier IA. In addition, the output terminal of the operational amplifier AMP_3 may be connected to the counter electrode C2 in the electrode group 2 through the resistor R1. At this time, the counter electrode C2 may be regarded as the RLD electrode. Both ends of the resistor R3 may be respectively connected to the output terminal and the inverting input terminal of the operational amplifier AMP_3, both ends of the resistor R4 may be respectively connected to the capacitor C1 and the output terminal of the operational amplifier AMP_3, and both ends of the capacitor C1 may be respectively connected to the resistor R4 and the inverting input terminal of the operational amplifier AMP_3. That is, the resistor R4 and the capacitor C1 are in series, and the branch formed by the series connection of the resistor R4 and the capacitor C1 is in parallel with the resistor R3. The right leg drive circuit may apply an anti-phase signal of the common-mode signal through the RLD electrode, thereby canceling the common-mode signal.
[0280] The filtering circuit may include multiple filters, such as filter filter1 and filter filter2. Optionally, it may also include an operational amplifier AMP_4. In some embodiments, filter filter1 may be connected to the output terminal of the instrumentation amplifier IA and the input terminal of the operational amplifier AMP_4, and filter filter2 may be connected to the output terminal of the operational amplifier AMP_4 and the input terminal of the ADC. The filtering circuit may receive the amplified electrocardiogram signal sent by the amplification circuit, perform one or more operations such as filtering and amplification on the amplified electrocardiogram signal, and send the processed electrocardiogram signal to the ADC.
[0281] The DFT module is an optional module. The DFT can perform DFT processing on the digital signal transmitted by the ADC and then transmit it to the MCU.
[0282] The specific functions of the ADC, MCU, and temperature module temp can be referred to the relevant descriptions in the above Figure 4A or Figure 4B illustrated embodiments, and will not be elaborated here.
[0283] It should be noted that in the Figure 4C illustrated embodiment, electrode group 1 and electrode group 2 may be electrode group 1 and electrode group 2 in the above Figures 3A - 3B or Figures 3D - 3E illustrated embodiments.
[0284] It can be understood that the above Figure 4C illustrated embodiments are just examples. In the embodiments of the present application, the measurement circuit may also include more electrode groups, potentiostat circuits, and transimpedance circuits for measuring more physiological parameters, which are not limited herein. In addition, each circuit module of the measurement circuit may also include more, fewer, or different elements from those in the above embodiments, which are not limited herein.
[0285] Figure 4D shows the circuit diagram of another measurement circuit provided by the embodiments of the present application.
[0286] As Figure 4DAs shown, the measurement circuit may include a potentiostat circuit 1, a transimpedance circuit 1, a potentiostat circuit 2, a transimpedance circuit 2, a right leg drive circuit, an amplification circuit, a filtering circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit may further include a plurality of electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 may include one or more working electrodes W1, one or more reference electrodes R1, and one or more counter electrodes C1. In addition, electrode group 1 may further include an LA electrode; electrode group 2 may include one or more working electrodes W2, one or more reference electrodes R2, and one or more counter electrodes C2. In addition, electrode group 2 may further include an RA electrode and an RLD electrode.
[0287] The connection relationships between each electrode in electrode group 1 and electrode group 2 and other circuit elements will be introduced separately below.
[0288] In electrode group 1, the one or more counter electrodes C1 may be connected to the output terminal of operational amplifier AMP_1; the one or more reference electrodes R1 may be connected to the inverting input terminal of operational amplifier AMP_1; the one or more working electrodes W1 may be connected to the inverting input terminal of operational amplifier AMP_2; the LA electrode may be connected to the non-inverting input terminal of instrumentation amplifier IA. Among them, operational amplifier AMP_1 and operational amplifier AMP_2 belong to potentiostat circuit 1, and instrumentation amplifier IA belongs to the amplification circuit.
[0289] In electrode group 2, the one or more counter electrodes C2 may be connected to the output terminal of operational amplifier AMP_5; the one or more reference electrodes R2 may be connected to the inverting input terminal of operational amplifier AMP_5; the one or more working electrodes W2 may be connected to the inverting input terminal of operational amplifier AMP_6; the RA electrode may be connected to the inverting input terminal of instrumentation amplifier IA, and the RLD electrode may be connected to the output terminal of operational amplifier AMP_3 through resistor R1. Among them, operational amplifier AMP_5 and operational amplifier AMP_6 belong to potentiostat circuit 2, instrumentation amplifier IA belongs to the amplification circuit, and operational amplifier AMP_3 and resistor R1 belong to the right leg drive circuit.
[0290] It should be noted that in electrode group 1 or electrode group 2, the one or more electrodes with the same function may be connected to external components in parallel. The specific connection method may refer to the relevant content in the following Figure 4E illustrated embodiments and will not be elaborated here for the time being.
[0291] In addition, for the specific details of the potentiostat circuit 1, transimpedance circuit 1, potentiostat circuit 2, transimpedance circuit 2, right leg drive circuit, amplifier circuit, filter circuit, MCU, ADC, DFT, and temperature module temp, reference can be made to the relevant content in the above Figure 4C illustrated embodiments, which will not be elaborated here.
[0292] In Figure 4D the illustrated embodiments, electrode group 1 and electrode group 2 can be the electrode group 1 and electrode group 2 in the above Figures 3A - 3B , or Figures 3D - 3E the illustrated embodiments.
[0293] It can be understood that the above Figure 4D illustrated embodiments are just examples. In the embodiments of the present application, the measurement circuit can also include more electrode groups, potentiostat circuits, and transimpedance circuits for measuring more physiological parameters, which are not limited herein. In addition, each circuit module of the measurement circuit can also include more, fewer, or different elements from those in the above embodiments, which are not limited herein.
[0294] By using the above Figure 4C or Figure 4D illustrated measurement circuit, multiple physiological parameters and the user's electrocardiogram signal can be measured simultaneously.
[0295] Figure 4E shows a schematic diagram of the connection manner between one or more electrodes with the same function in an array sensor 1 provided in the embodiments of the present application and other elements in the circuit.
[0296] As Figure 4E shown, the array sensor 1 can include one or more working electrodes W1, one or more reference electrodes R1, one or more counter electrodes C1, and LA electrodes. Among them, the one or more working electrodes W1 can include working electrode W11, working electrode W12, and working electrode W13; the one or more reference electrodes R1 can include reference electrode R11, reference electrode R12, and reference electrode R13; the one or more counter electrodes C1 can include counter electrode C11, counter electrode C12, and counter electrode C13.
[0297] Taking the array sensor 1 including the above Figure 4D illustrated electrode group 1 as an example, the working electrodes W11, W12, and W13 can be connected to the same port in parallel, such as the inverting input terminal of the operational amplifier AMP_2 in the above Figure 4D illustrated embodiment. The reference electrodes R11, R12, and R13 can be connected to the same port in parallel, such as the above Figure 4DThe inverting input terminal of the operational amplifier AMP_1 in the illustrated embodiment. The counter electrodes C11, C12, and C13 can be connected to the same port in a parallel manner, such as the above Figure 4D The output terminal of the illustrated operational amplifier AMP_1.
[0298] It can be understood that the above Figure 4E The illustrated embodiment is only an exemplary illustration that electrodes with the same function in the array sensor can be connected to the same port of the same component in the measurement circuit in a parallel manner. In the embodiment of the present application, the number of electrodes with different functions in the array sensor 1 can also be different from that of the above embodiment, and other array sensors or microneedle sensors (such as microneedle sensors with multiple electrochemical electrodes of the same type) can also be connected to the components in the measurement circuit in the manner shown in the above embodiment, and the present application does not make any limitations here.
[0299] In a possible implementation manner, multiple electrode groups in the measurement circuit can share an electrochemical circuit module (including a potentiostat circuit and a transimpedance circuit). At this time, the measurement circuit can further include a switching switch, and the switching switch can be used to control the electrochemical circuit module to connect to electrode group 1 or electrode group 2.
[0300] Figure 4F Shows the circuit diagram of another measurement circuit provided by the embodiment of the present application.
[0301] As Figure 4F Shown, the measurement circuit can include a switching switch MUX0, a potentiostat circuit 1, a transimpedance circuit 1, a right leg drive circuit, an amplification circuit, a filtering circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit can further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit can further include multiple electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 can include a working electrode W1, a reference electrode R1, and a counter electrode C1; electrode group 2 can include a working electrode W2, a reference electrode R2, and a counter electrode C2.
[0302] The switching switch MUX0 may include multiple input terminals, such as input terminal A01, input terminal A02, input terminal A03, input terminal B01, input terminal B02, and input terminal B03; the switching switch MUX0 may also include multiple output terminals, such as output terminal Y01, output terminal Y02, and output terminal Y03. Each output terminal of the switching switch MUX0 may correspond to multiple input terminals. Among them, output terminal Y01 may correspond to input terminal A01 and input terminal B01, output terminal Y02 may correspond to input terminal A02 and input terminal B02, and output terminal Y03 may correspond to input terminal A03 and input terminal B03. MUX0 may control the output terminal to connect to one of the corresponding input terminals, for example, control output terminal Y01 to connect to input terminal A01 or input terminal B01, control output terminal Y02 to connect to input terminal A02 or input terminal B02, and control output terminal Y03 to connect to input terminal A03 or input terminal B03.
[0303] Output terminal Y01 may be connected to the output terminal of operational amplifier AMP_1, output terminal Y02 may be connected to the inverting input terminal of operational amplifier AMP_1, and output terminal Y03 may be connected to the inverting input terminal of operational amplifier AMP_2. Operational amplifier AMP_1 and operational amplifier AMP_2 belong to the potentiostat circuit 1.
[0304] Input terminal A01 may be connected to the counter electrode C2, input terminal A02 may be connected to the reference electrode R2, and input terminal A03 may be connected to the working electrode W2. Input terminal B01 may be connected to the counter electrode C1, input terminal B02 may be connected to the reference electrode R1, and input terminal B03 may be connected to the working electrode W1.
[0305] When the switching switch MUX0 selects to connect to input terminals A01, A02, and A03, the potentiostat circuit 1 and the cross-group circuit 1 may be connected to the electrochemical electrodes in electrode group 2 through the switching switch MUX0; when the switching switch MUX0 selects to connect to input terminals B01, B02, and B03, the potentiostat circuit 1 and the cross-group circuit 1 may be connected to the electrochemical electrodes in electrode group 1 through the switching switch MUX0.
[0306] In addition, in electrode group 2, the counter electrode C2 may also be used as an RLD electrode and connected to the output terminal of operational amplifier AMP_3 through resistor R1, and the working electrode W2 may also be used as an RA electrode and connected to the inverting input terminal of instrumentation amplifier IA. In electrode group 1, the reference electrode R1 may also be used as an LA electrode and connected to the non-inverting input terminal of instrumentation amplifier IA. Instrumentation amplifier IA belongs to the amplification circuit, and resistor R1 and operational amplifier AMP_3 belong to the right leg drive circuit.
[0307] In addition, for the compositions of other components and the connection manners of components in circuits such as potentiostat circuit 1, transimpedance circuit 1, potentiostat circuit 2, transimpedance circuit 2, right leg drive circuit, amplifier circuit, and filter circuit, reference can be made to the relevant descriptions in the embodiments Figure 4C shown above, which will not be elaborated here. Moreover, for the specific contents of MCU, ADC, DFT, and temperature module temp, reference can be made to the relevant contents in the embodiments Figure 4C shown above, which will not be elaborated here.
[0308] It can be understood that the embodiments Figure 4F shown above are just examples. In the embodiments of the present application, the measurement circuit may further include more electrode groups, potentiostat circuits, and transimpedance circuits. The switching switch may also include more input terminals and output terminals, or may also include more switching switches for controlling the measurement of more physiological parameters, which are not limited in this application. In addition, each circuit module of the measurement circuit may further include more, fewer, or different components from those in the above embodiments, which are not limited in this application.
[0309] Figure 4G Fig. shows the circuit diagram of another measurement circuit provided by the embodiments of the present application.
[0310] As Figure 4G shown, the measurement circuit may include switching switch MUX0, potentiostat circuit 1, transimpedance circuit 1, right leg drive circuit, amplifier circuit, filter circuit, analog-to-digital conversion module ADC, and MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: discrete Fourier transform module DFT, temperature module temp, etc. Moreover, the measurement circuit may further include multiple electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 may include one or more working electrodes W1, one or more reference electrodes R1, and one or more counter electrodes C1, and electrode group 1 may further include LA electrode; electrode group 2 may include one or more working electrodes W2, one or more reference electrodes R2, and one or more counter electrodes C2, and electrode group 2 may further include RA electrode and RLD electrode.
[0311] Switching switch MUX0 may include multiple input terminals and output terminals, and each output terminal may correspond to multiple input terminals. For the corresponding relationship between the input terminals and output terminals in switching switch MUX0, and the connection relationships between the input terminals, output terminals and other components or electrodes, reference can be made to the relevant descriptions in the embodiments Figure 4F shown above, which will not be elaborated here. It should be noted that for the connection manners between each electrochemical electrode in electrode group 1 and electrode group 2 and switching switch MUX0, reference can be made to the relevant contents in the embodiments Figure 4E and Figure 4F shown above.
[0312] When the switching switch MUX0 selects to connect to input terminals A01, A02, and A03, the potentiostat circuit 1 and the cross-group circuit 1 can be connected to the electrochemical electrodes in the electrode group 2 through the switching switch MUX0; when the switching switch MUX0 selects to connect to input terminals B01, B02, and B03, the potentiostat circuit 1 and the cross-group circuit 1 can be connected to the electrochemical electrodes in the electrode group 1 through the switching switch MUX0.
[0313] In addition, in the electrode group 2, the RLD electrode is connected to the output terminal of the operational amplifier AMP_3 through the resistor R1, and the RA electrode can be connected to the inverting input terminal of the instrumentation amplifier IA. In the electrode group 1, the LA electrode can be connected to the non-inverting input terminal of the instrumentation amplifier IA. The instrumentation amplifier IA belongs to the amplification circuit, and the resistor R1 and the operational amplifier AMP_3 belong to the right leg drive circuit.
[0314] In addition, the component compositions and component connection manners of other components in circuits such as the potentiostat circuit 1, the transimpedance circuit 1, the potentiostat circuit 2, the transimpedance circuit 2, the right leg drive circuit, the amplification circuit, and the filtering circuit can refer to the relevant descriptions in the above Figure 4C illustrated embodiments and will not be elaborated here. Moreover, the specific contents of the MCU, ADC, DFT, and temperature module temp can refer to the relevant contents in the above Figure 4C illustrated embodiments and will not be elaborated here.
[0315] It can be understood that the above Figure 4G illustrated embodiments are only examples. In the embodiments of the present application, the measurement circuit may further include more electrode groups, potentiostat circuits, and transimpedance circuits. The switching switch may also include more input terminals and output terminals, or may also include more switching switches for controlling the measurement of more physiological parameters, which are not limited in the present application. In addition, each circuit module of the measurement circuit may further include more, fewer, or different components from those in the above embodiments, which are not limited in the present application.
[0316] Using Figure 4F or Figure 4G the illustrated measurement circuit, another physiological signal can be measured under the control of the switching switch while measuring the electrocardiogram signal.
[0317] In another possible implementation manner, the electrochemical circuit module and the electrocardiogram circuit module in the measurement circuit can share one or more components (such as operational amplifiers, filters, etc.). The measurement circuit may further include multiple switching switches, and the switching switches can be used to control the measurement of the electrocardiogram signal or other physiological parameters by the one or more components.
[0318] Figure 4HThe circuit diagram of a measurement circuit provided by an embodiment of the present application is shown.
[0319] As Figure 4H shown, the measurement circuit may include a plurality of switching switches, a potentiostat circuit 0, a transimpedance circuit 0, a right leg drive circuit, an amplification circuit, a filtering circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit may further include a plurality of electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 may include a working electrode W1, a reference electrode R1, and a counter electrode C1; electrode group 2 may include a working electrode W2, a reference electrode R2, and a counter electrode C2.
[0320] The plurality of switching switches may include a switching switch MUX1, a switching switch MUX2, and a switching switch MUX3. The switching switch MUX1 may be used to control the micro-needle sensor that connects the potentiostat circuit 0 and the transimpedance circuit 0. The switching switches MUX2 and MUX3 may be used to control the measurement circuit to measure electrocardiogram signals or other physiological parameters.
[0321] The ports of the plurality of switching switches and the connection manner of each port are introduced separately below.
[0322] The switching switch MUX1 may include a plurality of input terminals, such as input terminal A11, input terminal A12, input terminal A13, input terminal B11, input terminal B12, and input terminal B13; the switching switch MUX1 may further include a plurality of output terminals, such as output terminal Y11, output terminal Y12, and output terminal Y13. Each output terminal of the switching switch MUX1 may correspond to a plurality of input terminals, and MUX1 may control the output terminal to connect to one of the input terminals corresponding to the output terminal. Among them, the output terminal Y11 may correspond to the input terminals A11 and B11, the output terminal Y12 may correspond to the input terminals A12 and B12, and the output terminal Y13 may correspond to the input terminals A13 and B13.
[0323] The output terminal Y11 may be connected to the output terminal of the operational amplifier AMP_7, the output terminal Y12 may be connected to the input terminal B22 of the switching switch MUX2, the output terminal Y12 may also be connected to the input terminal A31 of the switching switch MUX3, the output terminal Y12 may also be connected to the non-inverting input terminal of the instrumentation amplifier IA through the resistor R6, the output terminal Y12 may also be connected to the LA electrode (such as the reference electrode R1 in electrode group 1), and the output terminal Y13 may be connected to the input terminal A32 of the switching switch MUX3.
[0324] The input terminal A11 can be connected to the counter electrode C2, the input terminal A12 can be connected to the reference electrode R2, and the input terminal A13 can be connected to the working electrode W2. The input terminal B11 can be connected to the counter electrode C1, the input terminal B12 can be connected to the reference electrode R1, and the input terminal B13 can be connected to the working electrode W1.
[0325] When the switching switch MUX1 selects to connect the input terminals A11, A12, and A13, the potentiostat circuit 0 and the cross-group circuit 0 can be connected to the electrochemical electrodes in the electrode group 2 through the switching switch MUX1; when the switching switch MUX1 selects to connect the input terminals B11, B12, and B13, the potentiostat circuit 0 and the cross-group circuit 0 can be connected to the electrochemical electrodes in the electrode group 1 through the switching switch MUX1.
[0326] The switching switch MUX2 can include multiple input terminals, such as the input terminals A21, A22, B21, and B22; the switching switch MUX2 can also include multiple output terminals, such as the output terminals Y21 and Y22. Each output terminal of the switching switch MUX2 can correspond to multiple input terminals, and MUX2 can control the output terminal to connect to one of the input terminals corresponding to the output terminal. Among them, the output terminal Y21 can correspond to the input terminals A21 and B21, and the output terminal Y22 can correspond to the input terminals A22 and B22.
[0327] The output terminal Y21 can be connected to the non-inverting input terminal of the operational amplifier AMP_7, and the output terminal Y22 can be connected to the non-inverting input terminal of the operational amplifier AMP_8.
[0328] The input terminal A21 can be connected to the digital-to-analog conversion module DAC0, and the input terminal A22 can be connected to the digital-to-analog conversion module DAC0. The input terminal B21 can be connected to the working electrode W2 in the electrode group 2, and the input terminal B21 can also be connected to the non-inverting input terminal of the instrumentation amplifier IA through the resistor R5. The input terminal B22 can be connected to the LA electrode (i.e., the reference electrode R1 in the electrode group 1), the input terminal B22 can also be connected to the output terminal Y12 of the switching switch MUX1 and the input terminal A31 of the switching switch MUX3. The input terminal B22 can also be connected to the non-inverting input terminal of the instrumentation amplifier IA through the resistor R6.
[0329] The switching switch MUX3 may include multiple input terminals, such as input terminal A31, input terminal A32, input terminal B31, and input terminal B32; the switching switch MUX3 may also include multiple output terminals, such as output terminal Y31 and output terminal Y32. Each output terminal of the switching switch MUX3 may correspond to multiple input terminals, and MUX3 may control the output terminal to connect to one of the input terminals corresponding to the output terminal. Among them, output terminal Y31 may correspond to input terminal A31 and input terminal B31, and output terminal Y32 may correspond to input terminal A32 and input terminal B32.
[0330] Output terminal Y31 may be connected to the inverting input terminal of operational amplifier AMP_7, and output terminal Y32 may be connected to the inverting input terminal of operational amplifier AMP_8. Operational amplifier AMP_7 and operational amplifier AMP_8 belong to the potentiostat circuit 0.
[0331] Input terminal A31 may be connected to the output terminal Y12 of switching switch MUX1 and the input terminal B22 of switching switch MUX2. Input terminal A32 may be switched to the output terminal Y13 of switching switch MUX1, and input terminal A32 may also be connected to the output terminal of operational amplifier AMP_8 through resistor RTIA_0. Input terminal B31 may be connected to the output terminal of instrumentation amplifier IA, and input terminal B31 may also be connected to the inverting input terminal of operational amplifier AMP_3 through resistor R2. Input terminal B32 may be connected to input terminal B31, that is, the inputs of input terminal B31 and input terminal B32 are the same.
[0332] When switching switch MUX2 selects to connect input terminals A21 and A22, and switching switch MUX3 selects to connect input terminals A31 and A32, the measurement circuit may measure the user's physiological parameters (such as blood glucose, blood ketone, etc.); when MUX2 selects to connect input terminals B21 and B22, and switching switch MUX3 selects to connect input terminals B31 and B32, the measurement circuit may measure the electrocardiogram signal.
[0333] The potentiostat circuit 0 may include a digital-to-analog conversion module DAC0, operational amplifier AMP_7, operational amplifier AMP_8, switching switch MUX2, and switching switch MUX3. Among them, the connection method of each component may refer to the relevant description of the above-mentioned switching switch MUX2 and switching switch MUX3, and the function description of other components may refer to the relevant description in the above-mentioned embodiments, which will not be elaborated here. In addition, the output terminal of operational amplifier AMP_7 may also be connected to filter filter1, and the output terminal of operational amplifier AMP_8 may also be connected to filter filter2.
[0334] The cross-group circuit 0 may include an operational amplifier AMP_8, a resistor RTIA_0, and a switching switch MUX3. Among them, the connection method of each component can refer to the relevant descriptions of the above-mentioned switching switch MUX2 and switching switch MUX3, and the function descriptions of other components can refer to the relevant descriptions in the above-mentioned embodiments, which will not be elaborated here.
[0335] The amplification circuit may include an instrumentation amplifier IA, and may also include a resistor R5 and a resistor R6. Among them, the resistor R6 can be connected to the LA electrode (i.e., the reference electrode R1) and the non-inverting input terminal of the instrumentation amplifier IA, and the resistor R5 can be connected to the RA electrode (i.e., the working electrode W2) and the non-inverting input terminal of the instrumentation amplifier IA. The inverting input terminal of the instrumentation amplifier IA can be connected to the output terminal of the instrumentation amplifier IA. The other connection relationships of the instrumentation amplifier IA can refer to the relevant descriptions of other components, which will not be elaborated here.
[0336] The component composition and the connection relationships between the components in the right leg drive circuit can refer to the relevant descriptions in the above Figure 4C illustrated embodiments. In addition, the inverting input terminal of the operational amplifier AMP_3 can also be connected to the output terminal of the instrumentation amplifier IA, as well as the input terminals B31 and B32 of the switching switch MUX3, through a resistor R2.
[0337] The filtering circuit may include a filter filter1 and a filter filter2. The filtering circuit can be used to filter the signals output by the operational amplifier AMP_7 and the operational amplifier AMP_8.
[0338] The specific function descriptions of each module in the measurement circuit can refer to the relevant descriptions in the above Figure 4C illustrated embodiments, which will not be elaborated here.
[0339] It can be understood that the above Figure 4H illustrated embodiments are only examples. In the embodiments of the present application, the measurement circuit may further include more electrode groups, potentiostat circuits, and transimpedance circuits. The switching switch may also include more input terminals and output terminals, or may also include more switching switches for controlling the measurement of more physiological parameters. The present application does not make any limitations here. In addition, each circuit module of the measurement circuit may further include more, fewer, or different components from those in the above embodiments. The present application does not make any limitations here.
[0340] Figure 4I The circuit diagram of another measurement circuit provided by the embodiments of the present application is shown.
[0341] As Figure 4IAs shown, the measurement circuit may include multiple switching switches, a potentiostat circuit 0, a transimpedance circuit 0, a right leg drive circuit, an amplifier circuit, a filter circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit may also include multiple electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 may include one or more working electrodes W1, one or more reference electrodes R1, and one or more counter electrodes C1. Electrode group 1 may also include an LA electrode; Electrode group 2 may include one or more working electrodes W2, one or more reference electrodes R2, and one or more counter electrodes C2. Electrode group 2 may also include an RA electrode and an RLD electrode.
[0342] The multiple switching switches may include a switching switch MUX1, a switching switch MUX2, and a switching switch MUX3. The switching switch MUX1 may be used to control the connection of the potentiostat circuit 0 and the transimpedance circuit 0 to electrode group 1 or electrode group 2. The switching switches MUX2 and MUX3 may be used to control the measurement circuit to measure electrocardiogram signals or other physiological parameters.
[0343] The connection relationship between each electrode in electrode group 1 and electrode group 2 and the measurement circuit is introduced below.
[0344] In electrode group 1, the one or more working electrodes W1 may be connected to the input terminal B13 of the switching switch MUX1, the one or more reference electrodes R1 may be connected to the input terminal B12 of the switching switch MUX1, the one or more counter electrodes C1 may be connected to the input terminal B11 of the switching switch MUX1. The LA electrode may be connected to the non-inverting input terminal of the instrumentation amplifier IA through a resistor R6. The LA electrode may also be connected to the output terminal Y12 of the switching switch MUX1.
[0345] In electrode group 2, the one or more working electrodes W2 may be connected to the input terminal A13 of the switching switch MUX1, the one or more reference electrodes R2 may be connected to the input terminal A12 of the switching switch MUX1, the one or more counter electrodes C2 may be connected to the input terminal A11 of the switching switch MUX1. The RA electrode may be connected to the non-inverting input terminal of the instrumentation amplifier IA through a resistor R5. The RA electrode may also be connected to the input terminal B21 of the switching switch MUX2. The RLD electrode may be connected to the output terminal of the operational amplifier AMP_3 through a resistor R1.
[0346] When the switching switch MUX1 selects to connect to input terminals A11, A12, and A13, the potentiostat circuit 0 and the cross-group circuit 0 can be connected to the electrochemical electrodes in electrode group 2 through the switching switch MUX1; when the switching switch MUX1 selects to connect to input terminals B11, B12, and B13, the potentiostat circuit 0 and the cross-group circuit 0 can be connected to the electrochemical electrodes in electrode group 1 through the switching switch MUX1.
[0347] When the switching switch MUX2 selects to connect to input terminals A21 and A22, and the switching switch MUX3 selects to connect to input terminals A31 and A32, the measurement circuit can measure the user's physiological parameters (such as blood glucose, blood ketone, etc.); when MUX2 selects to connect to input terminals B21 and B22, and the switching switch MUX3 selects to connect to input terminals B31, B32, and B33, the measurement circuit can measure the electrocardiogram signal.
[0348] For the specific function descriptions of each module in the measurement circuit, reference can be made to the relevant descriptions in the above Figure 4H illustrated embodiments, which will not be elaborated here.
[0349] It can be understood that the above Figure 4I illustrated embodiments are just examples. In the embodiments of the present application, the measurement circuit may further include more electrode groups, potentiostat circuits, and transimpedance circuits. The switching switch may also include more input terminals and output terminals, or may include more switching switches for controlling the measurement of more physiological parameters, which are not limited in this application. In addition, each circuit module of the measurement circuit may further include more, fewer, or different elements from those in the above embodiments, which are not limited in this application.
[0350] Using Figure 4H or Figure 4I the illustrated measurement circuit, the electrocardiogram signal can be controlled to be measured through the switching switch or the physiological parameters can be measured through the electrochemical electrodes.
[0351] In another possible implementation, three or more electrochemical circuit modules may be included in the measurement circuit. Multiple working electrodes in the electrode group can be respectively connected to different electrochemical circuit modules for measuring different physiological parameters. In this way, three or more physiological parameters can be measured simultaneously by the measurement circuit, and the electrocardiogram signal can also be measured simultaneously.
[0352] Exemplarily, such as Figure 4JAs shown, the measurement circuit may include a potentiostat circuit 1, a transimpedance circuit 1, a potentiostat circuit 2, a transimpedance circuit 2, a potentiostat circuit 3, a transimpedance circuit 3, a right leg drive circuit, an amplifier circuit, a filter circuit, an analog-to-digital conversion module ADC, and an MCU, etc. Optionally, the measurement circuit may further include any one or more of the following: a discrete Fourier transform module DFT and a temperature module temp, etc. Moreover, the measurement circuit may also include a plurality of electrode groups, such as electrode group 1 and electrode group 2. Electrode group 1 may include one or more working electrodes W1, one or more reference electrodes R1, and one or more counter electrodes C1. In addition, electrode group 1 may further include an LA electrode; Electrode group 2 may include working electrodes W21 and W22, reference electrodes R21 and R22, counter electrodes C21 and C22. In addition, electrode group 2 may further include an RA electrode and an RLD electrode.
[0353] Among them, the internal components and the connection relationships between the components of the potentiostat circuit 1, the transimpedance circuit 1, the potentiostat circuit 2, the transimpedance circuit 2, the right leg drive circuit, the amplifier circuit, the filter circuit, etc. may refer to the relevant descriptions in the above Figure 4D illustrated embodiment, and will not be elaborated here. The function descriptions of the analog-to-digital conversion module ADC, the discrete Fourier transform module DFT, and the MCU may also refer to the relevant descriptions in the above Figure 4D illustrated embodiment.
[0354] The potentiostat circuit 3 may include an operational amplifier AMP_9, an operational amplifier AMP_10, and a digital-to-analog conversion module DAC3. In some embodiments, the digital-to-analog conversion module DAC3 may also be replaced by the digital-to-analog conversion module DAC1 in the potentiostat circuit 1, or replaced by the digital-to-analog conversion module DAC2 in the potentiostat circuit 2. This application does not make a limitation here. Among them, DAC3 can generate a stable voltage signal. DAC3 can be connected to the non-inverting input terminal of the operational amplifier AMP_9, and can also be connected to the non-inverting input terminal of the operational amplifier AMP_10, providing the same voltage input for the operational amplifier AMP_9 and the operational amplifier AMP_10. The output terminal of the operational amplifier AMP_9 can be connected to the counter electrode C21 in the electrode group 2, and the inverting input terminal of the operational amplifier AMP_9 can be connected to the reference electrode R21 in the electrode group 2. The inverting input terminal of the operational amplifier AMP_10 can be connected to the working electrode W21 in the electrode group 2, and the output terminal of the operational amplifier AMP_10 can be connected to the ADC. In this way, by applying the same voltage to the non-inverting input terminals of the operational amplifier AMP_9 and the operational amplifier AMP_10, the voltage difference between the reference electrode R21 and the working electrode W21 can be controlled, so that the voltage on the working electrode W21 is approximately equal to the voltage on the reference electrode R21.
[0355] The transimpedance circuit 3 may include an operational amplifier AMP_10 and a resistor RTIA_3. Two ends of the resistor RTIA_3 may be respectively connected to the inverting input terminal and the output terminal of the operational amplifier AMP_10. The inverting input terminal of the operational amplifier AMP_10 may also be connected to the working electrode W21 in the electrode group 2.
[0356] The components and the connection relationships between the components in the potentiostat circuit 2 and the transimpedance circuit 2 may refer to the relevant descriptions in the above Figure 4D illustrated embodiments.
[0357] The connection relationships between the potentiostat circuit 2 and multiple electrodes in the electrode group 2 are as follows: The output terminal of the operational amplifier AMP_5 may be connected to the counter electrode C22 in the electrode group 2, and the inverting input terminal of the operational amplifier AMP_5 may be connected to the reference electrode R22 in the electrode group 2. The inverting input terminal of the operational amplifier AMP_6 may be connected to the working electrode W22 in the electrode group 2, and the output terminal of the operational amplifier AMP_6 may be connected to the ADC. In this way, by applying the same voltage to the non-inverting input terminals of the operational amplifier AMP_5 and the operational amplifier AMP_6, the voltage difference between the reference electrode R22 and the working electrode W22 can be controlled, so that the voltage on the working electrode W22 is approximately equal to the voltage on the reference electrode R22.
[0358] The connection relationships between the transimpedance circuit 2 and multiple electrodes in the electrode group 2 are as follows: The inverting input terminal of the operational amplifier AMP_6 may also be connected to the working electrode W22 in the electrode group 2.
[0359] The component compositions and the connection relationships between the components of other modules in the measurement circuit may all refer to the relevant content in the above Figure 4D illustrated embodiments, and will not be elaborated here.
[0360] It can be understood that the above Figure 4J illustrated embodiments are only exemplary. Different working electrodes in the electrode group may be connected to different electrochemical circuit modules. In the embodiments of the present application, the measurement circuit may further include more or fewer electrochemical circuit modules than the above embodiments. Multiple working electrodes in the electrode group 2 (or the electrode group 1) may also be respectively connected to different electrochemical circuit modules to measure different physiological parameters, and the present application does not make any limitations here.
[0361] In some other embodiments, the same reference electrode and / or counter electrode may be connected to different electrochemical circuit modules (such as different potentiostat circuits) for measuring multiple different physiological parameters, and the present application does not make any limitations here either.
[0362] It can be understood that the above Figures 4C - 4JThe illustrated embodiments are merely examples. In the embodiments of the present application, the measurement circuit may further include more, fewer, or different circuit modules and components than those in the above embodiments, or the connection manners between the respective components in the measurement circuit may also be different from those in the above embodiments, and the present application does not make any limitation here. For example, one or more circuit switches may further be provided in the measurement circuit (or in the circuit module of the measurement circuit) shown in any of the above embodiments, and the one or more circuit switches may also be used for the measurement circuit to measure one or more physiological parameters (or electrocardiogram signals), and the present application does not make any limitation here.
[0363] It should be noted that Figures 4C - 4J the electrode group 1 and the electrode group 2 in the illustrated embodiments above may be provided in the microneedle sensor or in the array sensor. In addition, Figures 4C - 4J the electrode group 1 and the electrode group 2 in the illustrated embodiments above may also adopt a two-electrode system. In the two-electrode system, the connection manner between the counter electrode and the working electrode may be the same as that in the above embodiments, and the counter electrode may also be used as the reference electrode to connect to the port to which the reference electrode in the above embodiments is connected, and the present application does not make any limitation here.
[0364] The following introduces the measurement method provided by the embodiments of the present application.
[0365] Figure 5A FIG. shows a schematic flowchart of a measurement method provided by the embodiments of the present application.
[0366] As Figure 5A shown, the specific process of the measurement method may include the following steps:
[0367] S501. The electronic device 200 determines that the monitoring condition 1 is satisfied and determines the physiological parameter 1.
[0368] The monitoring condition 1 may include but is not limited to any one or more of the following: receiving information 1 sent by other electronic devices for instructing the electronic device 200 to detect the physiological parameter 1; detecting that the user wears the electronic device 200 (i.e., the electrodes of the electronic device 200 are implanted into the subcutaneous tissue of the user), etc.; detecting that the electrocardiogram signal is abnormal.
[0369] Exemplarily, the electronic device 200 may determine whether the electronic device 200 is worn by the user based on whether the temperature detected by the temperature sensor belongs to a preset body temperature range. It can be understood that the embodiment here is merely an example. In the embodiments of the present application, the electronic device 200 may also adopt other methods to determine whether the electronic device 200 is worn, and the present application does not make any limitation here.
[0370] The physiological parameter 1 may include but is not limited to any one or more of the following: blood glucose, blood ketone, blood lactic acid, uric acid, etc.
[0371] In a possible implementation, when it is determined that monitoring condition 1 is met, the electronic device 200 can measure physiological parameter 1, and after determining physiological parameter 1, stop monitoring. In another possible implementation, when it is determined that monitoring condition 1 is met, the electronic device 200 can periodically detect physiological parameter 1, for example, determine the value of physiological parameter 1 at the current moment every 10 minutes (or 20 minutes, 30 minutes, etc.). It should be noted that in this case, different physiological parameters can correspond to different monitoring periods or the same monitoring period, which is not limited in this application.
[0372] The electronic device 200 can obtain the reaction current generated by the reaction with the target substance 1 through the electrochemical electrode corresponding to physiological parameter 1, and determine physiological parameter 1 based on the magnitude of the reaction current.
[0373] Exemplarily, if physiological parameter 1 is blood glucose, and the electrochemical electrode for measuring blood glucose includes the working electrode 3031, reference electrode 3032, and counter electrode 3033 in the micro-needle sensor 303 shown above. Figure 3B Then, when the micro-needle sensor 303 is implanted into the subcutaneous tissue, the working electrode 3031 can react with glucose to generate a reaction current. The electronic device 200 can obtain the magnitude of the reaction current, and determine the value of blood glucose based on the magnitude of the reaction current through the blood glucose calculation model stored in the electronic device 200.
[0374] Another exemplarily, if physiological parameter 1 is blood glucose, and the electrochemical electrode for measuring blood glucose includes the working electrode group 3073, reference electrode group 3074, and counter electrode group 3075 in the array sensor 307 shown above. Figure 3D Then, when the array sensor 307 is implanted into the subcutaneous tissue, the working electrode group 3073 can react with glucose to generate a reaction current. The electronic device 200 can obtain the magnitude of the reaction current, and determine the value of blood glucose based on the magnitude of the reaction current through the blood glucose calculation model stored in the electronic device 200.
[0375] It can be understood that the examples here are just two examples. In the embodiments of this application, physiological parameter 1 can also be other physiological parameters different from blood glucose, or include multiple physiological parameters, which is not limited in this application.
[0376] Optionally, the electronic device 200 can also measure the user's body temperature. In this case, further optionally, the electronic device 200 can also calibrate the value of physiological parameter 1 based on the user's body temperature.
[0377] S502. The electronic device 200 outputs physiological parameter 1.
[0378] In some embodiments, the electronic device 200 may include (or be connected to) an audio module and / or a display screen. In this case, the electronic device 200 may output the physiological parameter 1 in the form of voice broadcast through the audio module, or may output the physiological parameter 1 in the form of display on the display screen through the display screen.
[0379] In some other embodiments, for the electronic device 200 to output the physiological parameter 1, it may also be to send output information 1 to another electronic device (such as the electronic device 100). The output information 1 may include the physiological parameter 1, and the output information 1 can be used to instruct the receiving end to output the physiological parameter 1.
[0380] In some embodiments, while (or after) the electronic device 200 outputs the physiological parameter 1 of the user, it may also output any one or more of the following: evaluation result, value range, user status, historical curve, reference suggestion, etc. The specific description and determination method of each item can refer to the relevant description in step S605 shown below. Details are not described here for the time being. Figure 6 Shown in the relevant description of step S605 below, details are not described here for the time being.
[0381] S503. The electronic device 200 determines that the monitoring condition 2 is satisfied and acquires an electrocardiogram signal.
[0382] It should be noted that there is no limitation on the execution order between step S503 and the above step S501. The electronic device 200 may execute step S501 and step S503 simultaneously, or may execute one of the steps first and then the other step. This application does not make a limitation here.
[0383] The monitoring condition 2 may include but is not limited to any one or more of the following: receiving information 2 sent by another electronic device for instructing the electronic device 200 to detect an electrocardiogram signal; detecting that a biological object wears the electronic device 200 (i.e., the electrodes of the electronic device 200 are implanted into the subcutaneous tissue); detecting that the physiological parameter 1 is abnormal, etc.
[0384] Among them, the abnormality of the physiological parameter 1 means that the value of the physiological parameter 1 does not belong to the preset value range of the physiological parameter 1, and this value range may be pre-stored in the electronic device 200. Exemplarily, the electronic device 200 may start acquiring an electrocardiogram signal when it detects that the user's blood glucose exceeds the preset blood glucose value range. It can be understood that the embodiments here are only exemplary illustrations of determining whether to acquire an electrocardiogram signal based on the value of the physiological parameter. In the embodiments of this application, the physiological parameter 1 may also be other physiological parameters different from blood glucose, or may include multiple physiological parameters. This application does not make a limitation here.
[0385] It should be noted that during the process of acquiring the electrocardiogram (ECG) signal, the ECG electrodes used to measure the ECG signal can be implanted into the subcutaneous tissue. In some embodiments, the ECG electrodes can be the electrochemical electrodes in the electronic device 200 for measuring other physiological parameters.
[0386] Exemplarily, if the electronic device 200 is the electronic device 200 in the above Figure 3B illustrated embodiment, the ECG electrodes can be some of the electrochemical electrodes in the microneedle sensors 303 and microneedle sensors 304. For example, the LA electrode can be the reference electrode 3032, the RA electrode can be the working electrode 3041, and the RLD electrode can be the counter electrode 3043. Another exemplarily, if the electronic device 200 is the electronic device 200 in the above Figure 3D illustrated embodiment, the ECG electrodes can be the ECG electrodes in the array sensors 307 and array sensors 308. For example, the LA electrode can be the LA electrode 3081, the RA electrode can be the RA electrode 3071, and the RLD electrode can be the RLD electrode 3072. It can be understood that the above embodiments are only two examples. In the embodiments of the present application, when the ECG electrodes and the electrochemical electrodes share the same electrode, the corresponding relationship between the ECG electrodes and the electrochemical electrodes can also be different from the above embodiments, and the present application does not make any limitation here.
[0387] In a bipolar lead system, the ECG signal can refer to the voltage difference between the LA electrode and the RA electrode within a preset time period (such as 1 minute, 3 minutes, etc.). When the electronic device 200 measures the ECG signal using other lead systems, the ECG signal can also be the voltage difference between other electrodes within a preset time period, and the present application does not make any limitation here.
[0388] Exemplarily, Figure 5B shows a waveform schematic diagram of an ECG signal provided by an embodiment of the present application.
[0389] As Figure 5B shown, the two-dimensional coordinate system can include a horizontal axis and a vertical axis. The horizontal axis can represent time, and the vertical axis can represent voltage. The ECG signal waveform can be the curve Q in this two-dimensional coordinate system. According to the curve Q, it can be known that the ECG signal waveform fluctuates periodically as the heart pumps blood periodically.
[0390] It can be understood that Figure 5B the illustrated embodiment is only one example. In the embodiments of the present application, the waveform of the ECG signal can also be a waveform different from the above embodiment, and the present application does not make any limitation here.
[0391] S504. The electronic device 200 outputs the ECG signal.
[0392] In some embodiments, the electronic device 200 may include (or be connected to) an audio module and / or a display screen. At this time, the electronic device 200 may output the electrocardiogram signal in the form of voice broadcast through the audio module, or may output the electrocardiogram signal in the form of display on the display screen through the display screen.
[0393] In some other embodiments, when the electronic device 200 outputs the electrocardiogram signal, it may also refer to sending output information 2 to other electronic devices (such as the electronic device 100). The output information 2 may include the electrocardiogram signal, and the output information 2 can be used for the receiving end to output the electrocardiogram signal.
[0394] In some embodiments, the electronic device 200 (or the electronic device 100) may output the electrocardiogram signal in one or more different forms, such as in the form of a waveform diagram (outputting an electrocardiogram) or in the form of electrocardiogram indicators, etc.
[0395] In some embodiments, the electronic device 200 (or the electronic device 100) may determine an electrocardiogram based on the electrocardiogram signal and display the electrocardiogram in the form of display on the display screen. The electrocardiogram may be a waveform diagram of the electrocardiogram signal, and the electrocardiogram is used to characterize the relationship between the amplitude and time of the electrocardiogram signal.
[0396] The electrocardiogram may include multiple different waves, such as P wave, QRS complex, T wave, U wave. The following will introduce each wave in the electrocardiogram in combination with Figure 5C the electrocardiogram shown below.
[0397] As Figure 5C shown, the two-dimensional coordinate system may include a horizontal axis and a vertical axis. The horizontal axis may represent time, and the vertical axis may represent voltage. The waveform of the electrocardiogram signal within a single cardiac cycle may be the curve Q0 in this two-dimensional coordinate system.
[0398] According to Figure 5C it can be known that in the curve Q0, the curve segment from time t1 to time t2 may be called the P wave; the curve segment from time t2 to time t3 may be called the QRS complex; the curve segment from time t3 to time t4 may be called the T wave; the curve segment from time t4 to time t5 may be called the U wave. The point of the curve Q0 at time t3 may be called the J point, and the J point represents the end of the QRS complex. In addition, the time period between time t1 and time t2 may be called the PR interval, and the time period between time t2 and time t4 may be called the QT interval.
[0399] Exemplarily, the amplitude of curve Q0 changes in each time period as follows: from time t0 to time t1, the amplitude of curve Q0 is stable; from time t1 to time t2, the amplitude of curve Q0 first rises to the first peak point and then decreases, and then returns to stability, and there is a downward trend at time t2; from time t2 to time t3, the amplitude of curve Q0 first decreases to the first trough point and then rises, rises to the second peak point and then decreases, and decreases to the second trough point and then rises again; from time t3 to time t4, the amplitude of curve Q0 gradually rises after being stable for a period of time, rises to the third peak point and then gradually decreases to the third trough point; from time t4 to time t5, the amplitude of curve Q0 rises from the third trough point to the fourth peak point again, then decreases again, and then returns to stability. Among them, the amplitude of the second peak point is much higher than that of other peak points.
[0400] It can be understood that Figure 5C The illustrated embodiment is only an example. In the embodiments of the present application, the electrocardiogram may also include more cycles than the above embodiments, and the waveforms in each cycle may also be different from those in the above embodiments. For example, in some cycles, the P wave may also include two peak points, etc. The present application does not make any limitations here.
[0401] Each wave and interval in the electrocardiogram can characterize the health status of the user's heart. The P wave represents the depolarization process of the two atria. Since the sinoatrial node is located at the junction of the right atrium and the superior vena cava, the excitation of the sinoatrial node is first conducted to the right atrium, and then transmitted to the left atrium through the interatrial bundle, forming the P wave on the electrocardiogram. The P wave represents the atrial excitation, the first half represents the right atrial excitation, and the second half represents the left atrial excitation. When the atria are enlarged and the conduction between the two atria is abnormal, the P wave shows a tall and pointed or biphasic P wave. The PR interval represents the time from the start of atrial depolarization to the start of ventricular depolarization, mainly reflecting the time of excitation conduction through the atrioventricular junction area. The slow conduction speed of the atrioventricular node forms the PR segment on the electrocardiogram. When there is a block in the conduction from the atria to the ventricles, it is manifested as an extension of the PR interval or the disappearance of the ventricular wave after the P wave. The QRS complex represents the depolarization process of the ventricles. When there are conduction blocks in the left and right bundle branches of the heart, ventricular enlargement or hypertrophy, etc., the QRS complex will show widening, deformation and prolonged duration. The J point represents the complete depolarization of ventricular muscle cells. The T wave represents the repolarization process of the two ventricles. The change of the T wave on the electrocardiogram is affected by various factors. For example, when myocardial ischemia occurs, it can be manifested as low and inverted T waves, while the towering of the T wave can be seen in hyperkalemia, the hyperacute phase of acute myocardial infarction, etc. The U wave can be the waveform after the T wave and is currently considered to be related to the repolarization of the ventricles. The QT interval represents the time required for the entire process of ventricular depolarization and repolarization. The prolongation of the QT interval is often related to the occurrence of malignant arrhythmias.
[0402] The electronic device 200 can determine one or more ECG indicators based on the ECG signal. While outputting the ECG signal (or after outputting the ECG signal), the electronic device 200 can also output the one or more ECG indicators. The ECG indicators may include, but are not limited to, any one or more of the following: heart rate, amplitude, PR interval, QT interval, and the duration of each wave (such as the P wave duration, etc.). Among them, the heart rate can be determined based on the number of cardiac cycles per minute in the ECG signal. The PR interval, QT interval, and P wave duration, etc. can all be determined based on the ECG (or ECG signal).
[0403] Figure 6 A schematic flow chart of another measurement method provided in an embodiment of the present application is shown.
[0404] like Figure 6 As shown, the specific process of the measurement method may include the following steps:
[0405] S601. The electronic device 100 determines that the monitoring condition 3 is satisfied, and sends information 3 to the electronic device 200. The information 3 is used to request the electronic device 200 to send the physiological data 1 to the electronic device 100.
[0406] In some embodiments, monitoring condition 3 may include but is not limited to any one or more of the following: receiving an operation by the user to turn on the physiological monitoring function, receiving a start instruction 1 sent by other electronic devices, detecting that the user's physiological state is abnormal (for example, the heart rate does not belong to the preset heart rate range, etc.), detecting that the user's psychological state is abnormal (for example, being frightened), detecting that the user is in motion, detecting that the user has insomnia, detecting that the user's body posture is abnormal (for example, falling), detecting that the user's sports equipment is abnormal, detecting that the user's location is within a preset area (for example, the user is in a high altitude area), etc.
[0407] The physiological data 1 can be used to determine the physiological parameter 1, which may include but is not limited to any one or more of the following: blood sugar, blood ketones, blood lactate, uric acid, etc.
[0408] Physiological data 1 may include, but is not limited to, any one or more of the following: current data, body temperature, measured value of physiological parameter 1, calibrated value of physiological parameter 1, etc. Among them, the current data is used to characterize the magnitude of the reaction current generated by the reaction between the electrochemical electrode in the electronic device 200 and the target substance 1. The body temperature may be the body temperature of the user (or other organism) wearing the electronic device 200. The measured value of the physiological parameter 1 may be the value of the physiological parameter 1 determined by the electronic device 200 through the calculation model of the physiological parameter 1 based on the current data. The calibrated value of the physiological parameter 1 may be the value of the physiological parameter 1 determined by the electronic device 200 based on the current data and the body temperature, that is, the value of the physiological parameter 1 after calibration based on the body temperature.
[0409] The following describes the specific manner in which the electronic device 100 determines whether the monitoring condition 3 is met.
[0410] In some embodiments, the electronic device 100 may obtain user information and determine whether the electronic device 100 meets the monitoring condition 3 based on the user information. The user information may include, but is not limited to, any one or more of the following: physiological information, psychological information, motion information, sports equipment information, posture information, location information, and interaction information, etc. Among them, the physiological information can be used to characterize the physiological state of the user, and the physiological information may include, but is not limited to, any one or more of the following: heart rate, body temperature, blood pressure, disease information, etc.; the psychological information can be used to characterize the psychological state of the user, and the psychological information may include, but is not limited to, any one or more of the following: stress value, depression, emotional stability, high spirits, being frightened, etc.; the motion information can be used to characterize the motion state of the user, and the motion information may include, but is not limited to, any one or more of the following: swimming, diving, cycling, running, mountain climbing, skipping rope, yoga, etc.; the sports equipment information can be used to characterize the state of the sports equipment, and the sports equipment information may include, but is not limited to, any one or more of the following: the remaining oxygen in the oxygen cylinder, the weight of the smart backpack, the traveling resistance of the bicycle, etc.; the posture information can be used to characterize the body posture of the user, and the posture information may include, but is not limited to, any one or more of the following: falling, stepping empty, standing still, etc.; the location information can be used to characterize the location of the user, and the location information may include, but is not limited to, any one or more of the following: the geographical location of the user, the longitude and latitude information of the location where the user is located, the altitude information of the location where the user is located, the depth information of the location where the user is located, etc.; the interaction information may include the interaction operations between the user and the electronic device 100, such as receiving the operation of the user to turn on the physiological monitoring function, etc.
[0411] It should be noted that in the embodiments of the present application, the manner in which the electronic device 100 obtains user information may include, but is not limited to, the following manners: the electronic device 100 detects user information, the electronic device 100 receives user information sent by other electronic devices, and the electronic device 100 receives and responds to the operation of the user to input user information (such as disease information) to obtain user information.
[0412] The following describes some manners in which the electronic device 100 provided in the embodiments of the present application detects user information.
[0413] Exemplarily, the electronic device 100 can detect the user's motion information and posture information through devices such as a gyroscope sensor and an acceleration sensor; the electronic device 100 can detect the user's physiological information such as heart rate and blood pressure through devices such as a PPG module; the electronic device 100 can also collect the user's facial expressions through a camera and determine the user's emotional state through algorithm models such as image analysis and facial expression analysis; the electronic device 100 can also determine the user's psychological information such as stress value based on the physiological information; the electronic device 100 can also detect the user's interaction information through a touch sensor; the electronic device 100 can detect the user's location information through a location sensor (such as a global positioning chip, etc.); the electronic device 100 can also detect the air pressure of the environment where the user is located based on a barometric pressure sensor and determine the altitude and other location information of the location where the user is located based on the air pressure value, and so on.
[0414] It can be understood that the embodiments herein are only some examples. In the embodiments of the present application, the electronic device 100 may include more, fewer, or different devices than those in the above embodiments. Moreover, the electronic device 100 may also collect user information through sensors or other devices different from those in the above embodiments, and the present application does not make any limitations here.
[0415] The following introduces some ways for the electronic device 100 provided in the embodiments of the present application to determine whether the monitoring condition 3 is satisfied based on user information.
[0416] If the electronic device 100 determines that any one of the physiological information is abnormal, it is determined that the monitoring condition is satisfied. Exemplarily, the abnormal physiological information may include, but is not limited to, any one or more of the following: the heart rate does not belong to the preset heart rate range, the blood pressure does not belong to the preset blood pressure range, the body temperature does not belong to the preset body temperature range, etc.
[0417] Another exemplarily, the electronic device 100 can determine whether the physiological information satisfies any one of the following: the heart rate does not belong to the preset heart rate range, the blood pressure does not belong to the preset blood pressure range, the body temperature does not belong to the preset body temperature range, etc.; if the physiological information satisfies any one of the above, the electronic device 100 can determine that the user's physiological state is abnormal, that is, it is determined that the monitoring condition is satisfied.
[0418] If the electronic device 100 determines that the motion information satisfies the preset motion state, it is determined that the monitoring condition is satisfied. Exemplarily, the preset motion state may include, but is not limited to, any one or more of the following: diving state, mountain climbing state, cycling state, yoga state, swimming state, running state, etc.
[0419] If the electronic device 100 determines that the user's psychological state is abnormal based on the psychological information, it is determined that the monitoring condition is satisfied. Exemplarily, the abnormal psychological state includes, but is not limited to, any one or more of the following: the user is frightened, the user is in a low mood, the user is in a high mood, etc.
[0420] If the electronic device 100 determines that the user is in a preset area based on the location information, it is determined that the monitoring condition is met. The preset area may include, but is not limited to, any one or more of the following: high altitude areas, deep water areas, etc.
[0421] If the electronic device 100 determines that the user's body posture is abnormal based on the posture information, it is determined that the monitoring condition is met. Exemplarily, the user's body posture being abnormal includes, but is not limited to, any one or more of the following situations: the user falls, the user steps into empty space, etc.
[0422] If the electronic device 100 determines that the user's sports equipment is abnormal based on the sports equipment information, it is determined that the monitoring condition is met. Exemplarily, the user's sports equipment being abnormal may include, but is not limited to, any one or more of the following: the oxygen remaining in the oxygen cylinder is lower than the preset oxygen amount, the resistance of the bicycle during travel is greater than the preset resistance, the weight of the intelligent backpack is greater than the preset weight, etc. It can be understood that the above embodiments only exemplarily illustrate various ways of determining whether the monitoring condition 3 is met based on user information. In the embodiments of the present application, the electronic device 100 can also determine whether the monitoring condition 3 is met based on various types of user information. The electronic device 100 can also determine whether the monitoring condition 3 is met based on other information in the user information, and the monitoring condition 3 can also include more, fewer, or different conditions than the above embodiments. The present application does not make any limitations here.
[0423] S602. The electronic device 200 acquires physiological data 1.
[0424] In some embodiments, the electronic device 200 can start acquiring physiological data 1 in response to information 3.
[0425] In some other embodiments, the electronic device 200 can also periodically acquire physiological data 1 before receiving information 3.
[0426] The manner in which the electronic device 200 acquires physiological data 1 can refer to the relevant content of step S501 shown above Figure 5A and will not be elaborated here.
[0427] S603. The electronic device 200 sends the physiological data 1 to the electronic device 100.
[0428] In some embodiments, the electronic device 200 can send the physiological data 1 to the electronic device 100 in response to information 3.
[0429] In some other embodiments, the electronic device 200 periodically sends the physiological data 1 to the electronic device 100 before receiving information 3. In this case, the above step S602 may not be executed; in addition, the monitoring condition 3 can be used to trigger the electronic device 100 to execute the following step S605.
[0430] The electronic device 100 determines physiological parameter 1 based on physiological data 1.
[0431] In some embodiments, if the physiological data 1 includes the measured value or calibration value of physiological parameter 1, the electronic device 100 may use the measured value or calibration value of physiological parameter 1 as the value of physiological parameter 1.
[0432] In some embodiments, if physiological parameter 1 includes the measured value of physiological parameter 1 and body temperature, the electronic device 100 may calibrate the measured value of physiological parameter 1 based on the body temperature, and determine the calibrated value as the value of physiological parameter 1.
[0433] In some embodiments, if the physiological data 1 includes current data, the electronic device 100 may determine the value of physiological parameter 1 based on the current data. Optionally, if the physiological data 1 further includes body temperature, the electronic device 100 may also determine the value of physiological parameter 1 based on the current data and body temperature.
[0434] S605. The electronic device 100 outputs physiological parameter 1.
[0435] In some embodiments, after determining the user's physiological parameter 1, the electronic device 100 may output physiological parameter 1. The ways for the electronic device 100 to output physiological parameter 1 may include, but are not limited to, any one or more of the following: display on the display screen, voice broadcast, vibration, indicator light flashing, etc. The schematic diagram of the interface for the electronic device 100 to output physiological parameter 1 may refer to the relevant description in the following Figures 7C to 7F illustrated embodiments, which will not be elaborated here for the time being.
[0436] In some embodiments, when (or after) outputting the user's physiological parameter 1, the electronic device 100 may also output any one or more of the following: evaluation result, value range, user status, historical curve, reference suggestion, etc. Among them, the evaluation result is used to characterize whether the user's physiological parameter is normal. The value range refers to the normal range of the user's physiological parameter. The user status refers to the current state of the user, such as fasting state, non-fasting state, exercise state, high altitude state, sleep state, etc. The historical curve is used to characterize the relationship between the physiological parameter and time for the user in the past period (such as 30 minutes, 3 hours, 24 hours, etc.). The reference suggestion can be used to guide the user to maintain or restore the physiological parameter to the normal range.
[0437] In some other embodiments, after determining the physiological parameter 1 of the user, the electronic device 100 may also send an output instruction to another electronic device. The output instruction may include the physiological parameter 1 of the user, and the output instruction can be used to instruct the electronic device to output the physiological parameter 1 of the user. Optionally, the output instruction may further include, but is not limited to, any one or more of the following: user status, value range, evaluation result, historical curve, reference suggestion, etc. The electronic device 100 may output any one or more of the above contents based on the output instruction.
[0438] The following separately introduces the determination methods of the evaluation result, value range, user status, historical curve, reference suggestion, etc.
[0439] The following introduces the determination method of the user status.
[0440] In some embodiments, the electronic device 100 may determine the user status based on the user information. For the specific content of the user information, reference may be made to the relevant description in step S501 above, which will not be elaborated here. For example, the electronic device 100 may receive and respond to the operation of the user setting the user status to determine the user status. For another example, the electronic device 100 may determine whether the user is in a motion state based on the user's motion information. For another example, the electronic device 100 may determine whether the user is in a high altitude state based on the user's location information, etc. It can be understood that the embodiments here are only exemplary descriptions that the electronic device 100 may determine the user status based on the user information. In the embodiments of the present application, the electronic device 100 may also determine the user status based on other information in the user information, and the present application does not make a limitation here.
[0441] The following introduces the determination method of the value range.
[0442] The value range may be the value range of the physiological parameter stored in the electronic device 100. Exemplarily, Table 1 shows the value range of the physiological parameter stored in an electronic device 100 provided by an embodiment of the present application.
[0443] Table 1
[0444] Physiological parameter Value range unit: millimole per liter (mmol / L) Blood glucose [3.9,6.1] Blood ketone [0.05,0.3] Uric acid [0.18,0.42]
[0445] As shown in Table 1, the electronic device 100 may store the value ranges of one or more physiological parameters. For example, the value range of blood glucose may be [3.9, 6.1], the value range of blood ketone may be [0.05, 0.3], and the value range of uric acid may be [0.18, 0.42]. The units of the above value ranges are all millimoles per liter (mmol / L).
[0446] It can be understood that the embodiments shown in Table 1 are just examples. In the embodiments of the present application, the electronic device 100 may also store value ranges of physiological parameters that are more, less, or different from those in the embodiments shown in Table 1, and the value ranges of physiological parameters may also be different from the above value ranges. The present application does not make any limitations here.
[0447] In some other embodiments, the electronic device 100 may also store value ranges of physiological parameters in different user states. Exemplarily, Table 2 shows value ranges of physiological parameters stored by another electronic device 100 provided in the embodiments of the present application in different user states.
[0448] Table 2
[0449] Physiological parameter User status Value range unit: millimole per liter (mmol / L) Blood glucose Fasting state [3.9,6.1] Blood glucose Non - fasting state [3.9,8.99] Blood ketone Fasting state [0.05,0.3] Blood ketone Non - fasting state [0.05,0.5] Uric acid Fasting state [0.18,0.42] Uric acid Non - fasting state [0.18,0.5]
[0450] As shown in Table 2, the electronic device 100 may store value ranges of one or more physiological parameters in different user states. For example, in a fasting state, the value range of blood glucose may be [3.9, 6.1]; in a non-fasting state, the value range of blood glucose may be [3.9, 8.99]; in a fasting state, the value range of blood ketone may be [0.05, 0.3]; in a non-fasting state, the value range of blood ketone may be [0.05, 0.5]; in a fasting state, the value range of uric acid may be [0.18, 0.42]; in a non-fasting state, the value range of uric acid may be [0.18, 0.5]. The units of the above value ranges are all millimoles per liter (mmol / L).
[0451] It can be understood that the embodiments shown in Table 2 are just examples. In the embodiments of the present application, the electronic device 100 may also store value ranges of physiological parameters that are more, less, or different from those in the embodiments shown in Table 2, and the value ranges of physiological parameters may also be different from the above value ranges. The present application does not make any limitations here. In addition, the user states may also include more, less, or different user states from those in the above embodiments. Moreover, in some other embodiments, the electronic device 100 may also store the corresponding relationships between factors such as user gender, age, and diseases and the value ranges. The present application does not make any limitations here.
[0452] The electronic device 100 may determine the value range based on any one or more factors such as user state, user age, and gender.
[0453] The following introduces the determination method of the evaluation result.
[0454] In a possible implementation, the electronic device 100 may store the value range of the user's physiological parameters, and determine an evaluation result based on the user's physiological parameter 1 and the value range of the corresponding physiological parameter. In another possible implementation, the electronic device 100 may also determine the value range of the user's current physiological parameter based on the corresponding relationship between one or more factors such as the user's gender, age, user status, etc. and the value range, and determine the evaluation result based on the calibration value of the physiological parameter.
[0455] In some embodiments, the evaluation result may include normal and abnormal. When the physiological parameter 1 belongs to the value range, the electronic device 100 may determine that the evaluation result of this physiological parameter is normal. When the physiological parameter 1 does not belong to the value range, the electronic device 100 may determine that the evaluation result of this physiological parameter is abnormal. Optionally, in the case where the evaluation result is abnormal, the evaluation result may be further subdivided into any one or more of the following: on the high side, on the low side, too high, too low, etc., which are not limited in this application.
[0456] In some embodiments, if it is determined that the evaluation result is abnormal (or it is determined that the evaluation result is too high or too low, etc. among the abnormal), then the electronic device 100 may output a warning, and the output manner of the warning may include but is not limited to any one or more of the following: display on the display screen, voice broadcast, vibration, indicator light flashing, etc.
[0457] The determination method of the historical curve is introduced below.
[0458] In some embodiments, the electronic device 100 may determine the historical curve of this physiological parameter based on the calibration value of the physiological parameter measured this time. In other embodiments, the electronic device 100 may also determine the historical curve of this physiological parameter based on the calibration value of the physiological parameter measured this time and the calibration values of the physiological parameters measured in the past. The electronic device 100 may store the measurement time of each physiological parameter calibration value, and the electronic device 100 may determine the historical curve of this physiological parameter based on the different calibration values corresponding to the different measurement times.
[0459] The determination method of the reference suggestion is introduced below.
[0460] In a possible implementation, the electronic device 100 may determine a reference suggestion based on the evaluation result. For example, if the evaluation result is normal, the reference suggestion may be to suggest that the user maintain the current living habits, or it may be to suggest that the user strengthen exercise and maintain good work and rest, etc. If the evaluation result is abnormal, the reference suggestion may be to suggest that the user correct bad living habits and reduce the intake of greasy foods, etc.
[0461] In another possible implementation, the electronic device 100 may also determine reference suggestions based on user information. For example, when the electronic device 100 determines based on user information that the user is in a high altitude area, the reference suggestion may include "the oxygen in the current area is thin, please pay attention to reduce strenuous exercise." For another example, when the electronic device 100 determines based on user information that the duration of the user's fasting state is greater than a certain period of time (for example, 4 hours, etc.), the reference suggestion may include "you are currently hungry, please eat as soon as possible", etc. It can be understood that the embodiment here is only an illustrative example of how the electronic device 100 can determine reference suggestions based on user information. In the embodiment of the present application, the electronic device 100 can also determine content different from the above reference suggestions based on user information, and the present application does not limit this.
[0462] S606 . The electronic device 100 determines that the monitoring condition 4 is satisfied, and sends information 4 to the electronic device 200 . The information 4 is used to request the electronic device 200 to send an electrocardiogram signal to the electronic device 100 .
[0463] In some embodiments, monitoring condition 4 may include but is not limited to any one or more of the following: receiving an operation by the user to turn on the ECG function, receiving a start instruction 2 sent by other electronic devices, detecting that the user's physiological state is abnormal (for example, blood sugar does not belong to the preset blood sugar value range, etc.), detecting that the user's psychological state is abnormal (for example, being frightened), detecting that the user is in motion, detecting that the user has insomnia, detecting that the user's body posture is abnormal (for example, falling), detecting that the user's sports equipment is abnormal, detecting that the user's location is within a preset area (for example, the user is in a high altitude area), etc.
[0464] The determination method of each condition in monitoring condition 4 can also refer to the relevant content in the above step S601, which will not be repeated here.
[0465] In other embodiments, monitoring condition 4 may be the same as monitoring condition 3, that is, when the electronic device 100 determines that monitoring condition 3 is satisfied, the electronic device 100 may execute the above step S602 and the following step S608.
[0466] S607. The electronic device 200 obtains an electrocardiogram signal.
[0467] In some embodiments, the electronic device 200 may start acquiring electrocardiographic signals in response to the information 4 .
[0468] In other embodiments, the electronic device 200 may also periodically acquire the ECG signal before receiving the information 4 .
[0469] The method for the electronic device 200 to obtain the ECG signal can refer to the above Figure 5A The relevant contents of step S503 are not repeated here.
[0470] S608. The electronic device 200 sends an electrocardiogram signal to the electronic device 100.
[0471] In some embodiments, the electronic device 200 may send an electrocardiogram signal to the electronic device 100 in response to Information 4.
[0472] In some other embodiments, the electronic device 200 periodically sends an electrocardiogram signal to the electronic device 100 before receiving Information 4. In this case, the above-mentioned step S608 may not be executed; in addition, in this case, Monitoring Condition 4 can be used to trigger the electronic device 100 to execute the following step S609.
[0473] S609. The electronic device 100 outputs an electrocardiogram signal.
[0474] The electronic device 100 may output the electrocardiogram signal in one or more ways such as display on a display screen, audio broadcast, vibration, and indicator light flashing.
[0475] The electronic device 100 may also output the electrocardiogram signal in the form of an electrocardiogram. Optionally, after (or simultaneously with) outputting the electrocardiogram, the electronic device 100 may also output one or more of the following: one or more electrocardiogram indexes, evaluation results of electrocardiogram indexes, evaluation results of cardiac function, value ranges of electrocardiogram indexes, user status, etc. The value range of an electrocardiogram index refers to the normal range of the electrocardiogram index. The user status refers to the current state of the user, such as resting state, exercise state, high altitude state, sleep state, etc. The evaluation result of an electrocardiogram index is used to indicate whether the electrocardiogram index belongs to the preset value range of the electrocardiogram index. The evaluation result of cardiac function is used to indicate whether the user's cardiac function is normal.
[0476] Among them, the specific content and determination method of the electrocardiogram index can refer to the relevant description in the above-mentioned Figure 5A The relevant description in step S504 shown; the value range of the electrocardiogram index may be pre-stored in the electronic device 100; the evaluation result of the electrocardiogram index can be determined based on the electrocardiogram index and the value range of the electrocardiogram index, and the specific method can refer to the relevant description in the above-mentioned step S605; the evaluation result of cardiac function can be determined based on the evaluation results of one or more electrocardiogram indexes; the determination method of the user status can also refer to the relevant description in the above-mentioned step S605, which will not be elaborated here.
[0477] In some application scenarios, the physiological parameter 1 may be blood glucose, and the schematic diagram of the output interface of blood glucose can refer to the following Figures 7A - 7F .
[0478] Exemplarily, such as Figure 7AAs shown, the electronic device 100 displays a health application interface 700. The health application interface 700 may include one or more entries, such as a blood glucose entry 701, a blood pressure entry, an electrocardiogram entry 702, a blood oxygen entry, etc. Each entry can be used to trigger the electronic device 100 to display a corresponding physiological parameter monitoring interface.
[0479] The electronic device 100 can receive and respond to a user's click operation on the blood glucose entry 701, and display, as Figure 7B shown, the blood glucose monitoring interface 710.
[0480] As Figure 7B shown, the blood glucose monitoring interface 710 may include a measurement control 711 and a history record control 712. The measurement control 711 can be used to trigger the electronic device 100 to determine and output the user's blood glucose, and the history record control 712 is used to trigger the electronic device 100 to display past blood glucose measurement records (including the measurement time and the user's blood glucose).
[0481] The electronic device 100 can receive and respond to a user's click operation on the measurement control 711. After determining the user's blood glucose based on the physiological data sent by the electronic device 200, the electronic device 100 can display, as Figure 7C shown, the output interface 720.
[0482] As Figure 7C shown, the output interface 720 may include blood glucose 721, and the blood glucose 721 is used to indicate the user's blood glucose value. Optionally, the output interface 720 may further include, but is not limited to, any one or more of the following: an evaluation result 722, a value range 723, a user status 724, and a history curve control 725. Among them, the evaluation result 722 can be used to indicate whether the user's blood glucose is normal. According to Figure 7C it can be known that the evaluation result 722 is a horizontal line, which can represent that the user's blood glucose value belongs to a preset value range, that is, the user's blood glucose is normal. In some embodiments, if the user's blood glucose value is greater than the preset value range, the evaluation result can also be an upward arrow, and if the user's blood glucose value is less than the preset value range, the evaluation result can also be a downward arrow. It can be understood that Figure 7C the display manner of the evaluation result 722 shown is only an example. In the embodiments of the present application, the evaluation result can also be represented by different symbols, words, etc., and the present application does not make a limitation here. The value range 723 is used to characterize the reference range of the user's blood glucose, that is, the normal value range of the user's blood glucose in the current user status. The user status 724 can be used to indicate the user's current status, for example, a fasting state. In some embodiments, when the user status is different, the value range 723 can also be different. The history curve control 725 can be used to trigger the electronic device 100 to display the history curve of the blood glucose, and the history curve is used to characterize the relationship between the user's blood glucose value and time in the past period of time.
[0483] The electronic device 100 can receive and respond to a user's click operation on the historical curve control 725, and display the historical curve interface 730 as shown in Figure 7D Or, the electronic device 100 can also receive and respond to a user's upward sliding operation on the output interface 720, and display content such as the historical curve as shown in Figure 7D in the output interface 720.
[0484] As Figure 7D shown, the historical curve interface 730 may include a historical curve 731. Optionally, it may further include a reference suggestion 732. Among them, the historical curve 731 can be used to characterize the relationship between the blood glucose value and time of the user in the past period. The reference suggestion 732 can be used to guide the user to maintain or restore the blood glucose to the normal range. For example, the reference suggestion 732 may include the text "Blood glucose is stable, please keep it". It can be understood that Figure 7D the reference suggestion 732 shown is just an example. In the embodiments of the present application, the reference suggestion 732 may also adopt an output form different from the above embodiments, and may also include more, less or different content from the above embodiments. The present application does not make any limitations here.
[0485] In some other embodiments, the electronic device 100 can receive and respond to a user's click operation on the measurement control 711. After determining the user's blood glucose (i.e., blood glucose value) based on the physiological data, if the user's blood glucose is abnormal, optionally, the electronic device 100 can display the warning interface 740 as shown in Figure 7E or display the output interface 750 as shown in Figure 7F in the output interface 750.
[0486] As Figure 7E shown, the warning interface 740 may include a warning 741. Optionally, it may further include a view result control 742. Among them, the warning 741 can be used to prompt the user that the current blood glucose is abnormal. For example, the warning 741 may include the text "Blood glucose is too low, please eat as soon as possible!!". The view result control 742 can be used to trigger the electronic device 100 to display the blood glucose value.
[0487] The electronic device 100 can receive and respond to a user's click operation on the view result control 742, and display the output interface 750 as shown in Figure 7F In some embodiments, the electronic device 100 can also display the output interface 750 as shown in Figure 7F when it detects that the display duration of the warning interface 740 is greater than a preset duration (such as 10 seconds, 15 seconds, etc.).
[0488] As Figure 7FAs shown, the output interface 750 may include blood glucose 751, and the blood glucose 751 may be the user's blood glucose value. Optionally, the output interface 750 may further include, but is not limited to, any one or more of the following: an evaluation result 752, a value range 753, a user status 754, a reference suggestion 755, etc. Among them, the evaluation result 752 may be used to indicate whether the user's blood glucose is normal. According to Figure 7F As can be seen, the evaluation result 752 is a downward arrow, which may indicate that the user's blood glucose value is less than the preset value range, that is, the user's blood glucose is abnormal. The value range 753 is used to represent the reference range of the user's blood glucose, that is, the value range of the blood glucose when the user is in a healthy state. The user status 754 may be used to indicate the user's current status, for example, the fasting state. In some embodiments, when the user status is different, the value range 753 may also be different. The output interface 750 may further include a reference suggestion 755. For example, the reference suggestion 755 may include the text "Blood glucose is too low. Please eat as soon as possible!". It can be understood that in some other embodiments, a historical curve (or a historical curve control) of the blood glucose may also be displayed in the output interface 750, and the historical curve is used to represent the relationship between the blood glucose value and time of the user in the past period of time. This application does not make any limitations here.
[0489] It can be understood that the above Figures 7A to 7F illustrated embodiments are only two examples. In the embodiments of this application, the output physiological parameter may also be other physiological parameters (such as blood ketone, uric acid, etc.), the device for outputting the physiological parameter may also be the electronic device 200 or other electronic devices, and the content displayed in the output interface may further include more, less, or different content from the above embodiments. This application does not make any limitations here.
[0490] Figures 7G - 7J shows a schematic diagram of the output interface of a group of electrocardiogram signals provided by the embodiments of this application.
[0491] Exemplarily, as Figure 7G shown, the electronic device 100 may display a health application interface 700, and the health application interface 700 may include one or more items, such as a blood glucose item 701, a blood pressure item, an electrocardiogram item 702, a blood oxygen item, etc. Each item may be used to trigger the electronic device 100 to display the corresponding physiological parameter monitoring interface.
[0492] The electronic device 100 may receive and respond to the user's click operation on the electrocardiogram item 702, and display an electrocardiogram monitoring interface 760 as Figure 7H shown.
[0493] As Figure 7HAs shown, the electrocardiogram (ECG) monitoring interface 760 may include a measurement control 761 and a history control 762. The measurement control 761 can be used to trigger the electronic device 100 to determine and output the user's ECG signal, and the history control 762 is used to trigger the electronic device 100 to display the past ECG signal measurement records.
[0494] The electronic device 100 can receive and respond to the user's click operation on the measurement control 761. After determining the user's electrocardiogram based on the ECG signal sent by the electronic device 200, the electronic device 100 can display an output interface 770 as Figure 7I shown.
[0495] As Figure 7I shown, the output interface 770 may include an electrocardiogram 771, and the electrocardiogram 771 may be a waveform diagram of the ECG signal.
[0496] In some embodiments, the electronic device 100 can also receive and respond to the user's upward sliding operation on the output interface 770. As Figure 7J shown, the electronic device 100 can display any one or more of the following contents in the output interface 770: heart rate 772, heart rate assessment result 773, amplitude 774, amplitude assessment result 775, and user status 776, etc. Among them, the heart rate 772 is used to indicate the user's heart rate; the heart rate assessment result 773 is used to indicate whether the user's heart rate is normal; the amplitude 774 is used to indicate the amplitude of the ECG signal; the amplitude assessment result 775 is used to indicate whether the amplitude of the ECG signal is normal; the user status 776 is used to indicate the user's current status, such as the resting state (or the exercise state, etc.), and the user status may have a certain impact on the ECG signal. According to Figure 7J it can be known that both the heart rate assessment result 773 and the amplitude assessment result 775 are horizontal lines, which can represent that the user's electrocardiogram belongs to a preset value range, that is, the user's ECG is normal. For other specific contents of the heart rate assessment result 773 and the amplitude assessment result 775, reference can be made to the relevant content of the assessment result 722 in the above Figure 7C shown embodiments, which will not be elaborated here.
[0497] It can be understood that the above Figures 7G - 7J shown embodiments are only examples. In the embodiments of the present application, the output interface of the ECG signal may also include more, less, or different contents from the above embodiments, such as including ECG indexes such as P wave duration, QT interval, etc., and the present application does not make any limitations here.
[0498] In some application scenarios, the electronic device 100 can also prompt the user to perform ECG monitoring when detecting that the value of the physiological parameter 1 is abnormal.
[0499] Exemplarily, taking the physiological parameter 1 as blood glucose as an example,Figure 7K The prompt interface 780 of the electronic device 100 is shown in the case of abnormal blood glucose.
[0500] As Figure 7K shown, the prompt interface 780 may include a prompt 781, an approval control 782, and a rejection control 783. The prompt 781 can be used to prompt the user to perform electrocardiogram monitoring. The prompt 781 may include text, such as "Abnormal blood glucose detected. It is recommended to turn on the electrocardiogram monitoring function". The approval control 782 can be used to trigger the electronic device 100 to send a message 4 to the electronic device 200. The message 4 is used to request the electronic device 200 to send an electrocardiogram signal to the electronic device 100. Optionally, a countdown (such as 5 seconds, 3 seconds, etc.) can also be displayed on the approval control 782. When the countdown ends and the electronic device 100 does not receive the user's operation, the electronic device 100 can send the message 4 to the electronic device 200. The rejection control 783 can be used to trigger the electronic device 100 to stop displaying the prompt interface 780. Optionally, it can also trigger the electronic device 100 to output content such as blood glucose calibration values.
[0501] The electronic device 100 can receive and respond to the user's click operation on the approval control 782 and display the electrocardiogram monitoring interface 790 as Figure 7L shown. The electrocardiogram monitoring interface 790 is used to prompt the user that the electronic device 100 is acquiring an electrocardiogram signal. In some embodiments, after receiving the electrocardiogram signal sent by the electronic device 200, the electronic device 100 can display the output interface 770 as described above Figure 7I shown.
[0502] It can be understood that the above Figures 7K - 7L is only an exemplary illustration. When the value of the physiological parameter 1 is abnormal, it can trigger a prompt to the user to turn on electrocardiogram monitoring. In the embodiments of the present application, the electronic device 100 can also directly jump to the electrocardiogram monitoring interface when detecting that the value of the physiological parameter 1 (such as blood glucose, blood ketone, etc.) is abnormal, and display the electrocardiogram signal after acquiring the electrocardiogram signal. The present application does not make any limitations here.
[0503] In some other application scenarios, the electronic device 100 may have a micro physical examination function. When the electronic device 100 detects that the user turns on the micro physical examination function, after determining one or more physiological parameters and an electrocardiogram signal, it can output the one or more physiological parameters and the electrocardiogram signal.
[0504] Exemplarily, as Figure 7MAs shown, the electronic device 100 may display a micro physical examination interface 800. The micro physical examination interface 800 may include a physical examination control 801, and the physical examination control 801 can be used to trigger the electronic device 100 to output one or more physiological parameters and electrocardiogram signals. Optionally, the micro physical examination interface 800 may also display physical examination items, and the physical examination items can be used to prompt the user about the items that the micro physical examination function can monitor. For example, Figure 7M In the illustrated embodiment, the physical examination items may include electrocardiogram, blood glucose, and blood ketone. After the micro physical examination function is enabled, the electronic device 100 can output electrocardiogram, blood glucose, and blood ketone, etc.
[0505] Optionally, before displaying the micro physical examination interface 800, the electronic device 100 may also display an interface for the user to select physical examination items. The electronic device 100 can receive and respond to the user's operation of selecting physical examination items, and display the micro physical examination interface 800 as Figure 7M shown.
[0506] The electronic device 100 can receive and respond to the user's click operation on the physical examination control 801. After determining the blood glucose, blood ketone, and electrocardiogram signals, the electronic device 100 can display an output interface 810 as Figure 7N shown. The output interface 810 may include an electrocardiogram 811, and may also include a blood glucose value 812 and a blood ketone value 813. Optionally, the output interface 810 may also include, but is not limited to, any one or more of the following: electrocardiogram indicators, value ranges of blood glucose, value ranges of blood ketone, evaluation results of blood glucose, evaluation results of blood ketone, etc.
[0507] It can be understood that Figures 7M - 7N the illustrated embodiment is only an exemplary illustration. The electronic device 100 can output one or more physiological parameters and electrocardiogram signals at the same time. In the embodiments of the present application, the items monitored by the micro physical examination function may also be different from those in the above embodiments. The electronic device 100 can also output multiple physiological parameters at the same time. The present application does not make any limitations here.
[0508] Next, a functional module of an electronic device 200 provided in the embodiments of the present application will be introduced.
[0509] Figure 8 The following shows a schematic diagram of the functional modules of a measurement system 10 provided in the embodiments of the present application.
[0510] As Figure 8 shown, the electronic device 200 may include an electrochemistry module 2001, an electrocardiogram module 2002, a data processing module 2003, a communication module 2004, etc. Optionally, it may also include any one or more of the following: a temperature module 2005, a control module 2006, an output module 2007, etc.
[0511] Among them:
[0512] The electrochemistry module 2001 can acquire current data of one or more physiological parameters (such as blood glucose, blood ketone, blood lactic acid, uric acid, etc.). In some embodiments, the electrochemistry module 2001 can receive and respond to a message N1 sent by the control module 2006 or the communication module 2004, and start acquiring current data of one or more physiological parameters specified by the message N1. The electrochemistry module 2001 can send the current data to the data processing module 2003,
[0513] The electrocardiogram module 2002 can acquire an electrocardiogram signal and send the electrocardiogram signal to the data processing module 2003. In some embodiments, the electrocardiogram signal can also receive and respond to a message N2 sent by the control module 2006 or the communication module 2004 to acquire the electrocardiogram signal.
[0514] The data processing module 2003 can determine one or more physiological parameters based on the current data sent by the electrochemistry module 2001. In some embodiments, the data processing module 2003 can also determine an electrocardiogram index and / or an electrocardiogram based on the electrocardiogram signal sent by the electrocardiogram module 2002. In some embodiments, the data processing module 2003 can also calibrate the value of the physiological parameter based on the body temperature sent by the temperature module 2005. The data processing module 2003 can send any one or more of one or more physiological parameters, electrocardiogram index, electrocardiogram, etc. to the output module 2007 or the communication module 2004.
[0515] The communication module 2004 can receive data sent by the data processing module 2003 (such as any one or more of one or more physiological parameters, electrocardiogram index, electrocardiogram, etc.) and send the received data to the electronic device 100. In some embodiments, the communication module 2004 can receive and respond to information 1 sent by another electronic device (such as the electronic device 100), and send the message N1 to the electrochemistry module 2001. The message N1 is used to instruct the electrochemistry module 2001 to start acquiring current data of one or more physiological parameters specified by the message N1. The communication module 2004 can also receive and respond to information 2 sent by another electronic device (such as the electronic device 100), and send the message N2 to the electrocardiogram module 2002. The message N2 is used to instruct the electrocardiogram module 2002 to start acquiring an electrocardiogram signal. In other embodiments, the communication module 2004 can also receive information 1 sent by another electronic device (such as the electronic device 100) and send the information 1 to the control module 2006. The communication module 2004 can also receive information 2 sent by another electronic device (such as the electronic device 100) and send the information 2 to the control module 2006.
[0516] The control module 2006 can also determine whether monitoring condition 1 or monitoring condition 2 is met. When monitoring condition 1 is met, the control module 2006 can send message N1 to the electrochemistry module 2001, and message N1 is used to instruct the electrochemistry module 2001 to start acquiring current data of one or more physiological parameters specified by message N1. When monitoring condition 2 is met, the control module 2006 can send message N2 to the electrochemistry module 2001, and message N2 is used to instruct the electrocardiogram module 2002 to start acquiring electrocardiogram signals. In some embodiments, monitoring condition 1 can include receiving information 1 sent by the communication module 2004, and monitoring condition 2 can include receiving information 2 sent by the communication module 2004.
[0517] The temperature module 2005 can measure the body temperature of the user or organism and send the body temperature to the data processing module 2003.
[0518] The output module 2007 can receive the data sent by the data processing module 2003 (such as any one or more of one or more physiological parameters, electrocardiogram metrics, electrocardiograms, etc.), and output the received data in any one or more of the ways such as voice broadcast, display screen display, vibration, indicator light flashing, etc.
[0519] It can be understood that Figure 8 The illustrated embodiment is only an example. In the embodiments of the present application, the electronic device 200 may further include more, fewer or different functional modules than the above embodiments, or combine the above multiple functional modules into one functional module, or split any one of the above functional modules into multiple functional modules. The present application does not make any limitations here.
[0520] Next, a functional module of a measurement system 10 provided by an embodiment of the present application will be introduced.
[0521] Figure 9 A schematic diagram of a functional module of a measurement system 10 provided by an embodiment of the present application is shown.
[0522] As Figure 9 shown, the measurement system 10 may include an electronic device 100 and an electronic device 200. The electronic device 100 may include a communication module 1002, a data processing module 1003, an output module 1006, etc. Optionally, the electronic device 100 may further include, but is not limited to, any one or more of the following: an interaction module 1001, a user information module 1004, an evaluation module 1005. The electronic device 200 may include an electrochemistry module 2001, an electrocardiogram module 2002, and a communication module 2004. Optionally, the electronic device 200 may further include any one or more of the following: a temperature module 2005, a control module 2006, etc. Among them:
[0523] The interaction module 1001 can receive and respond to user operations, such as operations to enable physiological monitoring functions, operations to enable electrocardiogram functions, etc. The interaction module 1001 can respond to the user's operation of enabling the physiological monitoring function and send message N3 to the communication module 1002. Message N3 can be used to instruct the communication module 1002 to send information 3 to the electronic device 200, and information 3 is used to request physiological data of one or more specified physiological parameters.
[0524] The communication module 1002 can communicate with other electronic devices (such as the electronic device 200, etc.). In some embodiments, the communication module 1002 can receive and respond to message N3, send information 3 to the communication module 2004 in the electronic device 200, and information 3 is used to request physiological data. The communication module 1002 can also receive the physiological data sent by the communication module 2004 in the electronic device 200 and send the physiological data to the data processing module 1003. In some embodiments, the communication module 1002 can also receive the physiological parameters (i.e., the values of physiological parameters) sent by the data processing module 1003, as well as receive the evaluation results and / or reference suggestions sent by the evaluation module 1005, and send any one or more of the physiological parameters, evaluation results, and reference suggestions to other electronic devices.
[0525] The data processing module 1003 can determine physiological parameters, such as blood glucose, blood ketone, etc., based on the physiological data sent by the communication module 1002. After determining the physiological parameters, the data processing module 1003 can send the physiological parameters to the output module 1006 or the communication module 1002. In some embodiments, the data processing module 1003 can also send the physiological parameters to the evaluation module 1005.
[0526] The user information module 1004 can obtain user information. In some embodiments, the user information module 1004 can collect user information. In other embodiments, the user information module 1004 can receive the user information obtained by the communication module 1002 from other electronic devices. In some embodiments, the user information module 1004 can determine the user status based on the user information and send the user status to the evaluation module 1005. In some embodiments, the user information module 1004 can also determine whether the user information meets the monitoring conditions (such as monitoring condition 3, monitoring condition 4, etc.). When the monitoring condition 3 is met, the user information module 1004 can send message N4 to the communication module 1002, and message N4 can be used to instruct the communication module 1002 to send information 3 to the electronic device 200. When the monitoring condition 4 is met, the user information module 1004 can send message N5 to the communication module 1002, and message N5 can be used to instruct the communication module 1002 to send information 4 to the electronic device 200.
[0527] The evaluation module 1005 can store the value range of physiological parameters. The evaluation module 1005 can determine an evaluation result based on the value range of physiological parameters and the physiological parameters, and the evaluation result is used to indicate whether the physiological parameter is normal. In some embodiments, the evaluation module 1005 can also receive the user status sent by the user information module 1004, and determine an evaluation result based on the relationship between the user status and the value range of physiological parameters, as well as the physiological parameters. In other embodiments, the evaluation module 1005 can also determine a reference suggestion based on the user status and / or the evaluation result, etc., and the reference suggestion is used to guide the user to maintain (or restore) the physiological parameter to the normal range. The evaluation module 1005 can send the evaluation result and / or the reference suggestion to the output module 1006, or send them to other electronic devices through the communication module 1002.
[0528] The output module 1006 can receive and output the physiological parameters sent by the data processing module 1003, and can also receive and output the evaluation result and / or the reference suggestion sent by the evaluation module 1005, etc.
[0529] In the electronic device 200, the communication module 2004 can communicate with the electronic device 100. In some embodiments, the communication module 2004 can receive the information 3 sent by the communication module 1002, and send the information 3 to the control module 2006 or send the message N6 to the electrochemical module 2001, and the message N6 is used to instruct the electrochemical module 2001 to send the current data of one or more specified physiological parameters to the communication module 2004. In some embodiments, the communication module 2004 can receive the information 4 sent by the communication module 1002, and send the information 4 to the control module 2006 or send the message N7 to the electrocardiogram module 2002, and the message N7 is used to instruct the electrocardiogram module 2002 to send the electrocardiogram signal to the communication module 2004.
[0530] The electrochemical module 2001 can obtain the current data of one or more physiological parameters (such as blood glucose, blood ketone, blood lactic acid, uric acid, etc.). In some embodiments, the electrochemical module 2001 can receive and respond to the message N6 sent by the control module 2006 or the communication module 2004, and start to obtain the current data of one or more physiological parameters specified by the message N6. In other embodiments, the electrochemical module 2001 can respond to the message N6 sent by the control module 2006 or the communication module 2004, and send the current data of one or more physiological parameters to the communication module 2004.
[0531] The electrocardiogram (ECG) module 2002 can acquire ECG signals. In some embodiments, the ECG signals can also be received and, in response to a message N7 sent by the control module 2006 or the communication module 2004, start acquiring ECG signals. In other embodiments, the ECG module 2002 can, in response to a message N7 sent by the control module 2006 or the communication module 2004, send the ECG signals to the communication module 2004.
[0532] The control module 2006 can also determine whether monitoring condition 1 or monitoring condition 2 is met. When monitoring condition 1 is met, the control module 2006 can send a message N1 to the electrochemistry module 2001. The message N1 is used to instruct the electrochemistry module 2001 to start acquiring current data of one or more physiological parameters specified by the message N1. When monitoring condition 2 is met, the control module 2006 can send a message N2 to the electrochemistry module 2001. The message N2 is used to instruct the ECG module 2002 to start acquiring ECG signals. In some embodiments, monitoring condition 1 can include receiving information 3 sent by the communication module 2004, and monitoring condition 2 can include receiving information 4 sent by the communication module 2004.
[0533] The temperature module 2005 can measure the body temperature of a user or a living being and send the body temperature to the communication module 2004.
[0534] In other embodiments, the electronic device 200 can further include, but is not limited to, any one or more of the following: a data processing module, an evaluation module, an output module, etc. The functional descriptions of the one or more modules can refer to the functional descriptions of the relevant modules in the above Figure 8 or Figure 9 illustrated embodiments and will not be elaborated here. It should be noted that if the electronic device 200 includes a data processing module, the physiological data sent by the communication module 2004 to the electronic device 100 can also refer to the values of physiological parameters (such as the measured values or calibrated values of physiological parameters).
[0535] It can be understood that Figure 9 the illustrated embodiments are only examples. In the embodiments of the present application, the measurement system 10 can include more, fewer, or different functional modules than those in the above embodiments, or combine the above multiple functional modules into one functional module, or split any one of the above functional modules into multiple functional modules. The present application does not make any limitations here.
[0536] It should be noted that the measurement method provided in the embodiments of the present application can not only measure the physiological parameters and ECG signals of a user, but also measure the physiological parameters and ECG signals of other living beings (such as pets, poultry, livestock, endangered animals, etc.). The present application does not make any limitations here.
[0537] For ease of subsequent description, the above-mentioned electronic device 100 and electronic device 200 may be collectively referred to as a device. It should be understood that the division of each unit in the device is only a division of logical functions. In actual implementation, they can be fully or partially integrated into a physical entity, or physically separated. In addition, the units in the device can be implemented in the form of a processor calling software. For example, the device includes a processor, the processor is connected to a memory, and instructions are stored in the memory. The processor calls the instructions stored in the memory to implement any of the above methods or the functions of each unit of the device. The processor is, for example, a general-purpose processor, such as a central processing unit (CPU) or a microprocessor, and the memory is a memory inside or outside the device. Alternatively, the units in the device can be implemented in the form of hardware circuits, and the functions of some or all of the units can be implemented by designing the hardware circuits. The hardware circuits can be understood as one or more processors. For example, in one implementation, the hardware circuit is an application-specific integrated circuit (ASIC), and the functions of some or all of the above units are implemented by designing the logical relationships of the components in the circuit. Again, in another implementation, the hardware circuit can be implemented by a programmable logic device (PLD). Taking a field programmable gate array (FPGA) as an example, it can include a large number of logic gate circuits, and the connection relationships between the logic gate circuits are configured through a configuration file to implement the functions of some or all of the above units. All units of the above device can be fully implemented in the form of a processor calling software, or fully implemented in the form of hardware circuits, or partially implemented in the form of a processor calling software, and the remaining part is implemented in the form of hardware circuits.
[0538] In the embodiments of the present application, a processor is a circuit with data processing capabilities. In one implementation, the processor can be a circuit with instruction reading and running capabilities, such as a CPU, a microprocessor, a graphics processing unit (GPU) (which can be understood as a type of microprocessor), or a digital signal processor (DSP), etc.; in another implementation, the processor can achieve certain functions through the logical relationship of a hardware circuit, and the logical relationship of the hardware circuit is fixed or can be reconfigured. For example, the processor is a hardware circuit implemented by an ASIC or a PLD, such as an FPGA. In a reconfigurable hardware circuit, the process of the processor loading a configuration document to implement the configuration of the hardware circuit can be understood as the process of the processor loading instructions to implement the functions of some or all of the above units. In addition, it can also be a hardware circuit designed for artificial intelligence, which can be understood as a type of ASIC, such as a neural network processing unit (NPU), a tensor processing unit (TPU), a deep learning processing unit (DPU), etc.
[0539] It can be seen that each unit in the above device can be one or more processors (or processing circuits) configured to implement the above method. For example: CPU, GPU, NPU, TPU, DPU, microprocessor, DSP, ASIC, FPGA, or a combination of at least two of these processor forms.
[0540] In addition, each unit in the above device can be integrated in whole or in part, or can be independently implemented. In one implementation, these units are integrated together and implemented in the form of a system-on-a-chip (SOC). The SOC can include at least one processor for implementing any of the above methods or implementing the functions of each unit of the device. The types of the at least one processor can be different. For example, it includes a CPU and an FPGA, a CPU and an artificial intelligence processor, a CPU and a GPU, etc.
[0541] Next, a possible physical entity structure of the electronic device 300 provided in the embodiments of the present application is introduced.
[0542] Exemplarily, Figure 10 FIG. shows a schematic diagram of the physical entity structure of an electronic device 300 provided in the embodiments of the present application.
[0543] As Figure 10As shown, the electronic device 300 may be any one of the electronic devices 100 and 200 in the above embodiments. The electronic device 300 may include: a processor 1101 and a memory 1102. Optionally, it may further include a transmitter 1103 and a receiver 1104. Among them, the processor 1101, the memory 1102, the transmitter 1103, and the receiver 1104 may be connected to each other or connected to each other through a bus 1105.
[0544] Exemplarily, the memory 1102 is used to store the computer programs and data of the electronic device 300. The memory 1102 may include, but is not limited to, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM), or a compact disc read-only memory (CD-ROM), etc.
[0545] The software or program code required for all or part of the functions of the electronic device 300 in the above method embodiments is stored in the memory 1102.
[0546] In a possible implementation manner, if the software or program code required for part of the functions is stored in the memory 1102, then in addition to calling the program code in the memory 1102 to implement part of the functions, the processor 1101 may also cooperate with other components (such as the transmitter 1103 and the receiver 1104, etc.) to jointly complete other functions described in the method embodiments (such as the functions of receiving or sending data).
[0547] The transmitter 1103 and the receiver 1104 are used to support the electronic device 300 to communicate, such as receiving or sending data or signals, etc.
[0548] Exemplarily, the processor 1101 may be the CPU, GPU, NPU, TPU, DPU, microprocessor, DSP, ASIC, FPGA introduced above, or a combination of at least two of these processor forms, etc. The processor 1101 may be used to read the programs stored in the above memory 1102 and execute the operations performed by the electronic device 300 in any of the above embodiments.
[0549] Figure 10 For the specific operations and beneficial effects of each unit in the shown electronic device 300, reference may be made to the corresponding descriptions in the above method embodiments, which will not be elaborated here.
[0550] It can be understood that Figure 10The illustrated embodiments are merely examples. In the embodiments of the present application, the electronic device 300 may further include more, fewer, or different devices than those in the Figure 10 illustrated embodiments, and the present application does not limit this here. Figure 10 Shown in the embodiment, the present application does not limit this here.
[0551] The following introduces a chip system provided by the embodiments of the present application.
[0552] The present application also provides a chip system, which includes at least one processor for implementing any function involved in any one of the electronic devices 100 or 200 on either side in the above embodiments.
[0553] In a possible design, the chip system further includes a memory for storing program instructions and data, and the memory is located inside or outside the processor.
[0554] The chip system may be composed of chips or may include chips and other discrete devices.
[0555] Optionally, the processor in the chip system may be one or more. The processor may be implemented by hardware or by software. When implemented by hardware, the processor may be a logic circuit, an integrated circuit, etc. When implemented by software, the processor may be a general-purpose processor that implements by reading software code stored in the memory.
[0556] Optionally, the memory in the chip system may also be one or more. The memory may be integrated with the processor or may be separately provided from the processor, and the embodiments of the present application do not limit this. Exemplarily, the memory may be a non-transitory processor, such as a read-only memory ROM, which may be integrated with the processor on the same chip or may be separately provided on different chips. The embodiments of the present application do not specifically limit the type of the memory and the setting manner of the memory and the processor.
[0557] Exemplarily, the chip system can be a field programmable gate array (FPGA), an application specific integrated circuit (ASIC), a system on chip (SoC), a central processor unit (CPU), a network processor (NP), a digital signal processor (DSP), a micro controller unit (MCU), a programmable logic device (PLD), or other integrated chips.
[0558] It can be understood that the above chip system is only an example. In the embodiments of the present application, the chip system may also include more, fewer, or different devices from the above embodiments, and the present application does not make any limitations here.
[0559] Figure 11 The flowchart of a measurement method provided by an embodiment of the present application is shown.
[0560] As Figure 11 shown, the specific process of the measurement method may include the following steps:
[0561] S1101. When the first electrode group and the second electrode group are implanted into the subcutaneous tissue, the first electronic device determines a first physiological parameter through the first electrode group; the first electronic device includes the first electrode group and the second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance.
[0562] The first electronic device may be the electronic device 200 in the above embodiment. The first electrode group may be the electrode group 1 in the above embodiment, and the second electrode group may be the electrode group 2 in the above embodiment.
[0563] The first distance may be a preset distance, such as three centimeters. When the distance between the first electrode group and the second electrode group is greater than the first distance, the first electrode group and the second electrode group can measure the electrocardiogram signal.
[0564] In a possible implementation manner, the first physiological parameter may include, but is not limited to, any one or more of the following: blood glucose, blood ketone, uric acid, blood lactic acid, etc.
[0565] The specific manner in which the first electronic device determines the first physiological parameter through the first electrode group may refer to the aboveFigure 5A The relevant descriptions in the illustrated embodiments will not be elaborated herein.
[0566] In a possible implementation, the first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode; the first pair of electrodes forms a loop with the first working electrode; determining a first physiological parameter through the first electrode group specifically includes: determining the first physiological parameter through the first working electrode and the first pair of electrodes; determining an electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through the first working electrode and the second working electrode, or determining the electrocardiogram signal through the first pair of electrodes and the second working electrode.
[0567] In this way, the first electrode group can form a two - electrode system, and the first physiological parameter can be measured through this two - electrode system. Any one of the first working electrode (or the first pair of electrodes) in the first electrode group and the electrodes in the second electrode group can be used as the LA electrode and the RA electrode respectively to measure the electrocardiogram signal.
[0568] In a possible implementation, the first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode; the first pair of electrodes forms a loop with the first working electrode; the first working electrode or the first pair of electrodes is connected to a right - leg drive circuit; determining a first physiological parameter through the first electrode group specifically includes: determining the first physiological parameter through the first working electrode and the first pair of electrodes; determining an electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through the first working electrode, the first pair of electrodes and the second working electrode.
[0569] Among them, the electrode connected to the right - leg drive circuit can be used as the right - leg drive RLD electrode. The right - leg drive circuit can be used to cancel the common - mode signal. The specific circuit composition of the right - leg drive circuit can refer to the relevant content in the above Figure 4C and other embodiments, which will not be elaborated herein.
[0570] In this way, the first electrode group can form a two - electrode system, and the first physiological parameter can be measured through this two - electrode system. The first working electrode, the first pair of electrodes in the first electrode group and any one of the electrodes in the second electrode group can be used as the LA electrode, the RLD electrode and the RA electrode respectively to measure the electrocardiogram signal.
[0571] In a possible implementation, the first electrode group includes a first working electrode, a first reference electrode and a first pair of electrodes; the first reference electrode is used to control the voltage of the first working electrode, and the first pair of electrodes forms a loop with the first working electrode; determining a first physiological parameter through the first electrode group specifically includes: generating a first current through the first working electrode; determining the first physiological parameter based on the first current.
[0572] In this way, the first electrode group can form a three-electrode system, and a first current is generated and conducted through this three-electrode system.
[0573] In a possible implementation, the second electrode group includes a second working electrode, a second reference electrode, and a second counter electrode; the second reference electrode is used to control the voltage of the second working electrode, and the second counter electrode is used to form a loop with the second working electrode; the method further includes: generating a second current through the second working electrode; determining a second physiological parameter based on the second current.
[0574] In this way, the second electrode group can form a three-electrode system, and a second current is generated and conducted through this three-electrode system.
[0575] Exemplarily, taking the above Figures 4C - 4J illustrated embodiment as an example, in the above embodiment, the first working electrode can be the working electrode W1, the second working electrode can be the working electrode W2, the first counter electrode can be the counter electrode C1, the second counter electrode can be the counter electrode C2, the first reference electrode can be the reference electrode R1, and the second reference electrode can be the reference electrode R2.
[0576] S1102. The first electronic device determines an electrocardiogram signal through the first electrode group and the second electrode group.
[0577] In a possible implementation, determining the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through any one electrode in the first electrode group and any one electrode in the second electrode group.
[0578] The left arm electrode and the right arm electrode can respectively select one electrode from the first electrode group and one electrode from the second electrode group. In this way, the electrocardiogram signal can be measured through the left arm electrode and the right arm electrode.
[0579] In a possible implementation, determining the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal through any two electrodes in the first electrode group and any one electrode in the second electrode group; or, determining the electrocardiogram signal through any one electrode in the first electrode group and any two electrodes in the second electrode group.
[0580] The left arm electrode and the right arm electrode can respectively select one electrode from the first electrode group and one electrode from the second electrode group, and the right leg drive electrode can be an electrode in the first electrode group or an electrode in the second electrode group. In this way, the electrocardiogram signal can be measured through the left arm electrode, the right arm electrode, and the right leg drive electrode. Among them, the right leg drive electrode is used to cancel the common-mode signal through the right leg drive circuit.
[0581] In this way, the electrochemical electrode in the first electrode group can be used to measure both the first physiological parameter and the electrocardiogram signal.
[0582] In a possible implementation, an electrocardiogram signal is determined by any two electrodes in the first electrode group and any one electrode in the second electrode group. Specifically, when a right leg drive circuit is connected to the first pair of electrodes, the electrocardiogram signal is determined by the first pair of electrodes, the first working electrode, and the second reference electrode.
[0583] In a possible implementation, an electrocardiogram signal is determined by any one electrode in the first electrode group and any two electrodes in the second electrode group. Specifically, when a right leg drive circuit is connected to the second pair of electrodes, the electrocardiogram signal is determined by the second pair of electrodes, the second working electrode, and the first reference electrode.
[0584] It should be noted that the above two implementation manners are only two examples. In this application, other electrodes in the first electrode group and the second electrode group can also be selected to measure the electrocardiogram signal, and this application does not make any limitations here.
[0585] In a possible implementation, the first electrode group further includes a first electrocardiogram electrode and a second electrocardiogram electrode, the second electrode group further includes a third electrocardiogram electrode, and the second electrocardiogram electrode is connected to a right leg drive circuit; determining the electrocardiogram signal by the first electrode group and the second electrode group specifically includes: determining the electrocardiogram signal by the first electrocardiogram electrode, the second electrocardiogram electrode, and the third electrocardiogram electrode.
[0586] In this way, the electrocardiogram signal can be measured by the separately provided electrocardiogram electrodes.
[0587] By using the measurement method provided in the embodiments of this application, the electrocardiogram signal of the user can be measured anytime and anywhere, and physiological parameters such as blood glucose, blood ketone, blood lactic acid, and uric acid can also be measured.
[0588] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second microneedle sensor. The first microneedle sensor includes a first electrode group, and the second microneedle sensor includes a second electrode group.
[0589] Exemplarily, the first microneedle sensor can be the microneedle sensor 303 shown above Figures 3A - 3B and the second microneedle sensor can be the microneedle sensor 304 shown above Figures 3A - 3B and the second microneedle sensor can be the microneedle sensor 304 shown above.
[0590] In some embodiments, the microneedle sensor can refer to a sensor with a shape similar to that of a microneedle, and multiple electrodes can be arranged inside the microneedle sensor. In this way, the first electrode group and the second electrode group can be arranged in the microneedle sensor.
[0591] In a possible implementation, the first electronic device further includes a first array sensor and a second array sensor, the first array sensor includes a first electrode group, and the second array sensor includes a second electrode group.
[0592] In some embodiments, an array sensor may refer to a sensor including a plurality of electrodes arranged in an array.
[0593] Exemplarily, the first array sensor may be the above Figures 3D - 3E The array sensor 307 shown, the second array sensor can be the above Figures 3D - 3E Array sensor 308 is shown.
[0594] In this way, the first electrode group and the second electrode group can be respectively arranged in the array sensor in the form of an array.
[0595] In a possible implementation, the first electronic device further includes a first microneedle sensor and a second array sensor, the first microneedle sensor includes a first electrode group, and the second array sensor includes a second electrode group.
[0596] In this way, the first electrode group can be arranged in the microneedle sensor, and the second electrode group can be arranged in the array sensor in the form of an array.
[0597] In one possible implementation, before determining the first physiological parameter through the first electrode group, the method also includes: determining that a first condition is satisfied, the first condition including any one or more of the following: receiving first information sent by a second electronic device, the first information being used to instruct the first electronic device to determine the first physiological parameter; detecting that the first electrode group and the second electrode group are implanted in subcutaneous tissue; detecting an abnormal electrocardiogram signal.
[0598] Thus, the first condition may be a trigger condition for measuring the first physiological parameter. ...
Claims
1. A measurement method, characterized in that, Applied to a first electronic device, the first electronic device includes a first electrode group and a second electrode group, and the distance between the first electrode group and the second electrode group is greater than a first distance; When the first electrode group and the second electrode group are implanted into subcutaneous tissue, the method includes: Determining a first physiological parameter through the first electrode group; Determining an electrocardiogram signal through the first electrode group and the second electrode group.
2. The method according to claim 1, wherein The first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode; the first pair of electrodes forms a loop with the first working electrode; the first working electrode or the first pair of electrodes is connected to a right leg drive circuit; The determining of the first physiological parameter through the first electrode group specifically includes: Determining the first physiological parameter through the first working electrode and the first pair of electrodes; The determining of the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: Determining the electrocardiogram signal through the first working electrode, the first pair of electrodes, and the second working electrode.
3. The method according to claim 1, wherein The first electrode group includes a first working electrode, a first reference electrode, and a first pair of electrodes; the first reference electrode is used to control the voltage of the first working electrode, and the first pair of electrodes forms a loop with the first working electrode; The determining of the first physiological parameter through the first electrode group specifically includes: Generating a first current through the first working electrode; Determining the first physiological parameter based on the first current.
4. The method according to claim 3, wherein The second electrode group includes a second working electrode, a second reference electrode, and a second pair of electrodes; The second reference electrode is used to control the voltage of the second working electrode, and the second pair of electrodes is used to form a loop with the second working electrode; the method further includes: Generating a second current through the second working electrode; Determining a second physiological parameter based on the second current.
5. The method according to claim 4, characterized in that The determining of the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: Determining the electrocardiogram signal through any two electrodes in the first electrode group and any one electrode in the second electrode group; Or, Determining the electrocardiogram signal through any one electrode in the first electrode group and any two electrodes in the second electrode group.
6. The method according to claim 5, characterized in that, The determining of the electrocardiogram signal through any two electrodes in the first electrode group and any one electrode in the second electrode group specifically includes: When the first pair of electrodes is connected to a right leg drive circuit, determining the electrocardiogram signal through the first pair of electrodes, the first working electrode, and the second reference electrode.
7. The method according to claim 3 or 4, characterized in that, The first electrode group further includes a first electrocardiogram electrode and a second electrocardiogram electrode, and the second electrode group further includes a third electrocardiogram electrode, and the second electrocardiogram electrode is connected to a right leg drive circuit; The determining of the electrocardiogram signal through the first electrode group and the second electrode group specifically includes: Determining the electrocardiogram signal through the first electrocardiogram electrode, the second electrocardiogram electrode, and the third electrocardiogram electrode.
8. The method according to any one of claims 1 to 7, characterized in that The first electronic device further includes a first microneedle sensor and a second microneedle sensor, the first microneedle sensor includes the first electrode group, and the second microneedle sensor includes the second electrode group.
9. The method according to any one of claims 1-7, characterized in that, The first electronic device further includes a first array sensor and a second array sensor. The first array sensor includes the first electrode group, and the second array sensor includes the second electrode group.
10. The method according to any one of claims 1-9, characterized in that, Before determining the first physiological parameter through the first electrode group, the method further includes: Determining that a first condition is met, where the first condition includes any one or more of the following: receiving a first message sent by a second electronic device, the first message being used to instruct the first electronic device to determine the first physiological parameter; detecting that the first electrode group and the second electrode group are implanted in subcutaneous tissue; detecting an abnormal electrocardiogram signal.
11. The method according to any one of claims 1-10, characterized in that, Before determining the electrocardiogram signal through the first electrode group and the second electrode group, the method further includes: Determining that a second condition is met, where the second condition includes any one or more of the following: receiving a second message sent by a second electronic device, the second message being used to instruct the first electronic device to determine the electrocardiogram signal; detecting that the first electrode group and the second electrode group are implanted in subcutaneous tissue; detecting that the first physiological parameter does not belong to a first interval.
12. The method according to any one of claims 1-11, characterized in that, After determining the first physiological parameter through the first electrode group, the method further includes: Outputting the first physiological parameter, or sending the first physiological parameter to a second electronic device.
13. The method according to any one of claims 1-12, characterized in that, After determining the electrocardiogram signal through the first electrode group and the second electrode group, the method further includes: Outputting the electrocardiogram signal, or sending the electrocardiogram signal to a second electronic device.
14. The method according to any one of claims 1 to 13, characterized in that, The first physiological parameter includes any one or more of the following: blood glucose, blood ketone, uric acid, blood lactic acid.
15. An electronic device, being a first electronic device, characterized in that, Including a first electrode group and a second electrode group, the distance between the first electrode group and the second electrode group is greater than a first distance; The first electrode group is used to determine a first physiological parameter when the first electrode group is implanted in subcutaneous tissue; The second electrode group is used to determine a second physiological parameter when the second electrode group is implanted in subcutaneous tissue; The first electrode group and the second electrode group are further used to determine an electrocardiogram signal when the first electrode group and the second electrode group are implanted in subcutaneous tissue.
16. The electronic device according to claim 15, characterized in that, The first electrode group includes a first working electrode and a first pair of electrodes, and the second electrode group includes a second working electrode and a second pair of electrodes; the first pair of electrodes forms a loop with the first working electrode, and the second pair of electrodes forms a loop with the second working electrode; The first electrode group is used to determine a first physiological parameter when the first electrode group is implanted in subcutaneous tissue, specifically including: The first working electrode is used to determine a first physiological parameter when the first working electrode is implanted in subcutaneous tissue; The second electrode group is used to determine a second physiological parameter when the second electrode group is implanted in subcutaneous tissue, specifically including: The second working electrode is used to determine a second physiological parameter when the second working electrode is implanted in subcutaneous tissue; The first electrode group and the second electrode group are further used to determine an electrocardiogram signal when the first electrode group and the second electrode group are implanted in subcutaneous tissue, specifically including: The first working electrode, the first pair of electrodes, and the second working electrode are further configured to determine an electrocardiogram (ECG) signal when the first working electrode, the first pair of electrodes, and the second working electrode are implanted into subcutaneous tissue.
17. The electronic device according to claim 15, characterized in that, The first electronic device further includes a microcontroller unit (MCU); the first electrode group includes a first working electrode, a first reference electrode, and a first pair of electrodes; the second electrode group includes a second working electrode, a second reference electrode, and a second pair of electrodes. The first electrode group is configured to determine a first physiological parameter when the first electrode group is implanted into subcutaneous tissue, specifically including: The first working electrode is configured to generate a first current when the first working electrode is implanted into subcutaneous tissue. The first reference electrode is configured to control the voltage of the first working electrode. The first pair of electrodes is configured to form a loop with the first working electrode. The MCU is configured to determine the first physiological parameter based on the first current. The second electrode group is configured to determine a second physiological parameter when the second electrode group is implanted into subcutaneous tissue, specifically including: The second working electrode is configured to generate a second current when the second working electrode is implanted into subcutaneous tissue. The second reference electrode is configured to control the voltage of the second working electrode. The second pair of electrodes is configured to form a loop with the second working electrode. The MCU is configured to determine the second physiological parameter based on the second current.
18. The electronic device according to claim 17, wherein The first electrode group and the second electrode group are further configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: Any two electrodes in the first electrode group and any one electrode in the second electrode group are configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue. Or, Any one electrode in the first electrode group and any two electrodes in the second electrode group are configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
19. The electronic device according to claim 18, wherein Any two electrodes in the first electrode group and any one electrode in the second electrode group are configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: When the first pair of electrodes is connected to a right leg drive circuit, the first pair of electrodes, the first working electrode, and the second reference electrode are configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
20. The electronic device according to claim 17, wherein The first electrode group further includes a first ECG electrode and a second ECG electrode, the second electrode group further includes a third ECG electrode, and the second ECG electrode is connected to a right leg drive circuit. The first electrode group and the second electrode group are further configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue, specifically including: The first ECG electrode, the second ECG electrode, and the third ECG electrode are configured to determine an electrocardiogram (ECG) signal when the first electrode group and the second electrode group are implanted into subcutaneous tissue.
21. The electronic device according to any one of claims 15-20, characterized in that, The first electronic device further includes a first microneedle sensor and a second microneedle sensor. The first microneedle sensor includes the first electrode group, and the second microneedle sensor includes the second electrode group.
22. The electronic device according to any one of claims 15-20, characterized in that, The first electronic device further includes a first array sensor and a second array sensor. The first array sensor includes the first electrode group, and the second array sensor includes the second electrode group.
23. The electronic device according to any one of claims 15-22, characterized in that, The first electronic device further includes a communication module; The communication module is configured to send the first physiological parameter to a second electronic device; The communication module is further configured to send the electrocardiogram signal to the second electronic device.
24. A measurement circuit, characterized in that, It includes a first electrode group, a second electrode group, a first electrochemical circuit module, a second electrochemical circuit module, an electrocardiogram circuit module, and a micro control processing unit MCU; The first electrode group is connected to the first electrochemical circuit module and is also connected to the electrocardiogram circuit module; The second electrode group is connected to the second electrochemical circuit module and is also connected to the electrocardiogram circuit module; The MCU is connected to the first electrochemical circuit module, the second electrochemical circuit module, and the electrocardiogram circuit module; The first electrode group is used to generate a first current signal; The first electrode group is further used to conduct the first current signal to the first electrochemical circuit module; The first electrochemical circuit module is used to determine a second current signal based on the first current signal; The first electrochemical circuit module is further used to conduct the second current signal to the MCU; The MCU is used to determine a first physiological parameter based on the second current signal; The second electrode group is used to generate a third current signal; The second electrode group is further used to conduct the third current signal to the second electrochemical circuit module; The second electrochemical circuit module is used to determine a fourth current signal based on the third current signal; The second electrochemical circuit module is further used to conduct the fourth current signal to the MCU; The MCU is used to determine a second physiological parameter based on the fourth current signal; The first electrode group and the second electrode group are used to acquire a first electrocardiogram signal; The first electrode group and the second electrode group are further used to conduct the first electrocardiogram signal to the electrocardiogram circuit module; The electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal; The electrocardiogram circuit module is further used to conduct the second electrocardiogram signal to the MCU.
25. The circuit according to claim 24, wherein, The first electrode group includes a first working electrode, a first reference electrode, and a first counter electrode; the first electrochemical circuit module includes a first potentiostat circuit and a first transimpedance circuit; the first potentiostat circuit is used to control the voltages of the first working electrode and the first reference electrode; the first transimpedance circuit is used to amplify the first current signal; The connection between the first electrode group and the first electrochemical circuit module specifically includes: The first working electrode, the first reference electrode, and the first counter electrode are connected to the first potentiostat circuit; The first working electrode is connected to the first transimpedance circuit.
26. The circuit according to claim 25, wherein The second electrode group includes a second working electrode, a second reference electrode, and a second counter electrode; the second electrochemical circuit module includes a second potentiostat circuit and a second transimpedance circuit; the second potentiostat circuit is used to control the voltages of the second working electrode and the second reference electrode; the second transimpedance circuit is used to amplify the third current signal; The second electrode group is connected to the second electrochemical circuit module, specifically including: The second working electrode, the second reference electrode, and the second counter electrode are connected to the second potentiostat circuit, The second working electrode is connected to the second transimpedance circuit.
27. The circuit according to claim 26, wherein The electrocardiogram circuit module includes a right leg drive circuit, an amplification circuit, and a filtering circuit, and the amplification circuit is connected to the filtering circuit; the right leg drive circuit is used to cancel the common mode signal, the amplification circuit is used to amplify the first electrocardiogram signal, and the filtering circuit is used for filtering; The first electrode group is connected to the electrocardiogram circuit module, specifically including: The first working electrode is connected to the amplification circuit, and the first counter electrode is connected to the right leg drive circuit; The second electrode group is connected to the electrocardiogram circuit module, specifically including: The second reference electrode is connected to the amplification circuit module; The first electrode group and the second electrode group are used to acquire a first electrocardiogram signal, specifically including: The first working electrode and the second reference electrode are used to acquire the first electrocardiogram signal; The first electrode group and the second electrode group are also used to conduct the first electrocardiogram signal to the electrocardiogram circuit module, specifically including: The first working electrode and the second reference electrode are used to conduct the first electrocardiogram signal to the amplification circuit; The electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal, specifically including: The amplification circuit is used to amplify the first electrocardiogram signal and then conduct it to the filtering circuit; The filtering circuit is used to determine the second electrocardiogram signal based on the amplified first electrocardiogram signal; The electrocardiogram circuit module is also used to conduct the second electrocardiogram signal to the MCU, specifically including: The filtering circuit is also used to conduct the second electrocardiogram signal to the MCU.
28. The circuit according to claim 26, wherein The first electrode group further includes a first electrocardiogram electrode and a second electrocardiogram electrode, the second electrode group further includes a third electrocardiogram electrode, the electrocardiogram circuit module includes a right leg drive circuit, an amplification circuit, and a filtering circuit, and the amplification circuit is connected to the filtering circuit; the right leg drive circuit is used to cancel the common mode signal, the amplification circuit is used to amplify the first electrocardiogram signal, and the filtering circuit is used for filtering; The first electrode group is connected to the electrocardiogram circuit module, specifically including: The first electrocardiogram electrode is connected to the amplification circuit, and the second electrocardiogram electrode is connected to the right leg drive circuit; The second electrode group is connected to the electrocardiogram circuit module, specifically including: The third electrocardiogram electrode is connected to the amplification circuit module; The first electrode group and the second electrode group are used to conduct an electrocardiogram signal to the electrocardiogram circuit module, specifically including: The first electrocardiogram electrode and the third electrocardiogram electrode are used to conduct the electrocardiogram signal to the amplifier circuit; The electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal, specifically including: The amplifier circuit is used to amplify the first electrocardiogram signal and then conduct it to the filter circuit; The filter circuit is used to determine the second electrocardiogram signal based on the amplified first electrocardiogram signal; The electrocardiogram circuit module is also used to conduct the second electrocardiogram signal to the MCU, specifically including: The filter circuit is also used to conduct the second electrocardiogram signal to the MCU.
29. A measurement circuit, characterized in that, It includes a first electrode group, a second electrode group, a first switching switch, a first electrochemical circuit module, an electrocardiogram circuit module and a micro control processing unit MCU; the first switching switch includes a first group of input ports, a second group of input ports and a first group of output ports, and the first switching switch is used to connect the first group of input ports or the second group of input ports; The first electrode group is connected to the first group of input ports, and the first electrode group is connected to the electrocardiogram circuit module; The second electrode group is connected to the second group of input ports, and the second electrode group is connected to the electrocardiogram circuit module; The first group of output ports is connected to the first electrochemical circuit module; The MCU is connected to the first electrochemical circuit module and the electrocardiogram circuit module; The first electrode group is used to generate a first current signal; The first electrode group is also used to conduct the first current signal to the first switching switch; The first switching switch is used to conduct the first current signal to the first electrochemical circuit module when the first group of input ports is connected; The first electrochemical circuit module is used to determine a second current signal based on the first current signal; The first electrochemical circuit module is also used to send the second current signal to the MCU; The MCU is used to determine a first physiological parameter based on the second current signal; The second electrode group is used to generate a third current signal; The second electrode group is also used to conduct the third current signal to the first switching switch; The first switching switch is used to conduct the third current signal to the first electrochemical circuit module when the second group of input ports is connected; The first electrochemical circuit module is also used to determine a fourth current signal based on the third current signal; The first electrochemical circuit module is also used to conduct the fourth current signal to the MCU; The MCU is used to determine a second physiological parameter based on the fourth current signal; The first electrode group and the second electrode group are used to acquire a first electrocardiogram signal; The first electrode group and the second electrode group are also used to conduct the first electrocardiogram signal to the electrocardiogram circuit module; The electrocardiogram circuit module is used to determine a second electrocardiogram signal based on the first electrocardiogram signal; The electrocardiogram circuit module is also used to conduct the second electrocardiogram signal to the MCU.
30. The circuit according to claim 29, characterized in that, The first electrode group includes a first working electrode, a first reference electrode, and a first counter electrode; the first set of input ports includes a first input port, a second input port, and a third input port; the second electrode group includes a second working electrode, a second reference electrode, and a second counter electrode; the second set of input ports includes a fourth input port, a fifth input port, and a sixth input port; The first working electrode is connected to the first input port, the first reference electrode is connected to the second input port, and the first counter electrode is connected to the third input port; The second working electrode is connected to the fourth input port, the second reference electrode is connected to the fifth input port, and the second counter electrode is connected to the sixth input port.
31. The circuit according to claim 30, characterized in that, The first set of output ports includes a first output port, a second output port, and a third output port; The first switching switch is used to connect the first set of input ports, specifically including: The first output port is used to connect to the first input port, the second output port is used to connect to the second input port, and the third output port is used to connect to the third input port; The first switching switch is used to connect the second set of input ports, specifically including: The first output port is used to connect to the fourth input port, the second output port is used to connect to the fifth input port, and the third output port is used to connect to the sixth input port.
32. The circuit according to claim 31, wherein The first electrochemical circuit module includes a first potentiostat circuit and a first transimpedance circuit; the first potentiostat circuit is used to control the voltages of the first working electrode and the first reference electrode; the first transimpedance circuit is used to amplify the first current signal; The first set of output ports is connected to the first electrochemical circuit module, specifically including: The first output port, the second output port, and the third output port are connected to the first potentiostat circuit; The first output port is connected to the first transimpedance circuit.
33. A chip system, characterized in that, Applied to a first electronic device, the chip system includes: a processing circuit and an interface circuit, the interface circuit is used to receive code instructions and transmit them to the processing circuit, and the processing circuit is used to run the code instructions so that the chip system executes the method described in any one of the above claims 1-14.
34. A readable storage medium, comprising instructions, characterized in that, When the instruction runs on the first electronic device, the first electronic device is caused to execute the method described in any one of the above claims 1-14.
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