Preparation method and application of gastrodia elata yin-yang benefiting oral preparation

Abstract

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a preparation method and application of a Gastrodia elata Yin-boosting oral preparation. The oral preparation comprises the following raw materials in parts by weight: Gastrodia elata 20-25 parts, Rehmannia glutinosa 15-20 parts, Cornus officinalis 14-17 parts, Fructus Lycii 17-21 parts, Rubus corchorifolius 15-20 parts, Anoectochilus roxburghii 10-15 parts, Ophiopogon japonicus 10-20 parts, Polygonatum odoratum 10-14 parts, Panax ginseng 5-10 parts, Atractylodes macrocephala 7-12 parts, Poria cocos 5-10 parts, Ziziphus jujuba var. spinosa 10-15 parts, Schisandra chinensis 5-10 parts, Angelica dahurica 5-8 parts, Angelica sinensis 1-5 parts, and Glycyrrhiza uralensis 3-8 parts. Animal experiments prove that the oral preparation can prolong the exhaustive swimming time of mice, reduce the content of blood lactic acid and serum urea of mice after swimming, increase the storage of liver glycogen, and has a significant anti-fatigue effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a preparation method and application of an oral preparation of Gastrodia elata for nourishing Yin. Background Technology

[0002] With the increasingly fast pace of work and life in society, pressure from work, family, housing, medical care, interpersonal relationships and other aspects keeps people in a state of tension for a long time, which can easily lead to symptoms such as poor sleep quality, sleep deprivation, drowsiness, and forgetfulness, and subsequently cause a series of health problems such as decreased immunity, insufficient qi and blood, weak spleen and stomach, and aging.

[0003] Traditional Chinese medicine (TCM) believes that the human body is an organic whole, and that "when Yin and Yang are in balance, the spirit is healthy." In a healthy state, the body maintains a normal physiological state of Yin-Yang balance and Qi and blood circulation. When the body is invaded by external pathogens, and the immune system is insufficient to recognize and eliminate these "foreign" pathogens, it will lead to illness or a sub-healthy state. Globally, approximately 35-50% of the population is in a "sub-healthy" state, characterized by fatigue, decreased vitality, and weakened immunity. This condition is present to varying degrees in almost all adults. Furthermore, prolonged fatigue without relief can lead to illness. TCM classics state: "The spleen is the foundation of acquired constitution, the source of Qi and blood, governing muscles and limbs, and responsible for the transformation and transportation of food essence and dampness. Improper diet or excessive thinking damages the spleen and stomach. When the spleen fails to function properly, the production of Qi and blood is insufficient, clear Yang fails to ascend, and turbid Yin fails to descend. Consequently, the muscles and limbs are malnourished, resulting in symptoms such as weakness and soreness in the limbs, dizziness, headache, loss of appetite, abdominal distension, and diarrhea." Fatigue involves all five internal organs, primarily the spleen, liver, and kidneys.

[0004] Currently, there are various health-preserving Chinese herbal medicine preparations available on the market, but these products often contain numerous ingredients, have poor compatibility, and offer only limited and slow-acting effects. Therefore, by utilizing traditional Chinese medicine theories and through scientific formulation, a Chinese herbal medicine composition with calming, fatigue-relieving, liver-soothing, spleen-strengthening, and anti-aging properties can be researched and developed, and then formulated into an oral preparation. This would be of great significance in improving physical health. Summary of the Invention

[0005] The primary objective of this invention is to provide an oral preparation of Gastrodia elata for nourishing Yin, which has excellent anti-fatigue effects.

[0006] The second objective of this invention is to provide a simple method for preparing an oral preparation of Gastrodia elata for nourishing Yin.

[0007] The third objective of this invention is to provide an oral preparation of Gastrodia elata for nourishing Yin, which has broad application prospects.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] A gastrodia-invigorating oral preparation comprising the following raw materials in parts by weight: 20-25 parts gastrodia, 15-20 parts rehmannia, 14-17 parts cornus, 17-21 parts lycium, 15-20 parts red peony root, 10-15 parts silver thread grass, 10-20 parts ophiopogon, 10-14 parts polygonatum, 5-10 parts ginseng, 7-12 parts atractylodes macrocephala, 5-10 parts poria cocos, 10-15 parts jujube seed, 5-10 parts schisandra, 5-8 parts angelica dahurica, 1-5 parts angelica sinensis, and 3-8 parts licorice.

[0010] Furthermore, the ingredients include the following parts by weight: 22 parts Gastrodia elata, 17 parts Rehmannia glutinosa, 16 parts Cornus officinalis, 20 parts Lycium barbarum, 18 parts Evodia rutaecarpa, 12 parts Lysimachia christinae, 15 parts Ophiopogon japonicus, 11 parts Polygonatum odoratum, 9 parts Panax ginseng, 8 parts Atractylodes macrocephala, 7 parts Poria cocos, 12 parts Ziziphus jujuba var. spinosa, 9 parts Schisandra chinensis, 6 parts Angelica dahurica, 3 parts Angelica sinensis, and 5 parts Glycyrrhiza uralensis.

[0011] The preparation method of the above-mentioned Gastrodia elata Yin-nourishing oral preparation includes the following steps:

[0012] (1) Weigh each raw material according to the weight ratio and add it to water, soak and boil it in sequence, and filter it to obtain the first filtrate and the first filter residue;

[0013] (2) Add water to the first filter residue from step (1) and boil it. After filtration, obtain the second filtrate and the second filter residue. Combine the first filtrate and the second filtrate and concentrate them into an extract. Then add pharmaceutically acceptable excipients to obtain the oral preparation of Gastrodia elata for nourishing yin.

[0014] Furthermore, the amount of water used in step (1) is 5-8 times the total mass of the raw materials.

[0015] Furthermore, the soaking time in step (1) is 2-3 hours; the decocting time is 1-2 hours.

[0016] Furthermore, the amount of water used in step (2) is 2-4 times the total mass of the first dregs; the decoction time is 0.5-1.5h.

[0017] Furthermore, the concentration temperature in step (2) is 50-60°C; the relative density of the extract is 1.3-1.4.

[0018] Furthermore, the oral preparation is one of tablets, granules, or capsules.

[0019] The above-mentioned Gastrodia elata Yin-nourishing oral preparation was used in the preparation of anti-fatigue drugs.

[0020] The pharmacological and medicinal properties analysis of the raw materials of this invention are as follows:

[0021] Gastrodia elata: [Properties and Channels Entered] Sweet and pungent in taste, neutral in nature. Enters the Liver channel. [Functions and Indications] It has the effects of extinguishing wind and stopping spasms, calming liver yang, dispelling wind and unblocking channels. It is mainly used to treat acute and chronic infantile convulsions, spasms and contractures, tetanus, dizziness, headache, hemiplegia, numbness of limbs, and rheumatic pain.

[0022] Rehmannia glutinosa: [Properties and Channels Entered] Sweet in taste, cold in nature. Enters the Heart, Liver, and Kidney channels. [Functions and Indications] It has the effects of clearing heat and cooling blood, nourishing Yin and generating fluids. It is mainly used to treat thirst and excessive drinking, internal heat and thirst, as well as nourishing Yin and moistening dryness, nourishing the kidneys and reducing fire, and treating Yin deficiency with internal heat, bone steaming fever and tidal fever.

[0023] Cornus officinalis: [Properties and Channels Entered] Sour and astringent in taste, slightly warm in nature. Enters the Liver and Kidney channels. [Functions and Indications] It has the effects of tonifying the Liver and Kidneys, astringing essence and consolidating the body. It is mainly used to treat dizziness, tinnitus, soreness and weakness of the lower back and knees, excessive sweating and collapse, etc.

[0024] Goji berries: [Properties and Channels Entered] Sweet in taste, neutral in nature. Enters the liver and kidney channels. [Functions and Indications] Nourishes the liver and kidneys, benefits essence and improves eyesight. Treats general weakness and deficiency of essence, lower back and knee pain, dizziness and tinnitus, internal heat and thirst, blood deficiency and chlorosis, and blurred vision.

[0025] Red Hail: [Properties and Channels Entered] Sour and bitter in taste, neutral in nature. [Functions and Indications] It has the effects of regulating qi, promoting blood circulation, eliminating phlegm, and promoting diuresis. It is mainly used to treat traumatic injuries, belching and acid reflux, jaundice, enteritis, dysentery, and hemoptysis due to pulmonary tuberculosis.

[0026] Silver Thread Grass: [Properties and Channels Entered] Bitter and pungent in taste, cool in nature. Enters the Liver, Spleen, and Kidney channels. [Functions and Indications] It has the effects of clearing heat and promoting diuresis. It is mainly used to treat jaundice, dysentery, urinary tract infections, leukorrhea, boils, and scabies.

[0027] Ophiopogon japonicus: [Properties and Channels Entered] Sweet and slightly bitter in taste, slightly cold in nature. Enters the Heart, Lung, and Stomach channels. [Functions and Indications] Nourishes Yin and generates fluids, moistens the lungs and clears the heart. Primarily treats insomnia and restlessness caused by internal heat and fluid depletion.

[0028] Polygonatum odoratum: [Properties and Channels Entered] Sweet in taste, neutral in nature. Enters the Lung and Stomach channels. [Functions and Indications] Nourishes Yin and moistens dryness, promotes body fluid production and quenches thirst. Primarily treats Lung and Stomach Yin deficiency, dry cough due to heat, dry throat and thirst, and internal heat with thirst.

[0029] Ginseng: [Properties and Channels Entered] Sweet and slightly bitter in taste, warm in nature. Enters the spleen, lung, and heart channels. [Functions and Indications] It has the effects of greatly replenishing vital energy, tonifying the spleen and lungs, promoting body fluid production, and calming the mind. It is mainly used to treat symptoms such as physical weakness and exhaustion, spleen deficiency with poor appetite, lung deficiency with cough and asthma, and thirst due to fluid depletion.

[0030] Atractylodes macrocephala: [Properties and Channels Entered] Sweet in taste, warm in nature. Enters the spleen and stomach channels. [Functions and Indications] It has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It is mainly used to treat symptoms such as loss of appetite, abdominal distension and diarrhea caused by spleen deficiency, dizziness, spontaneous sweating, edema, and threatened abortion caused by phlegm retention.

[0031] Poria cocos: [Properties and Channels Entered] Sweet and bland in taste, neutral in nature. Enters the Heart, Lung, Spleen, and Kidney channels. [Functions and Indications] It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind. It is mainly used to treat edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0032] Sour jujube seed: [Properties and Channels Entered] Sweet in taste, neutral in nature. Enters the heart, spleen, liver, and gallbladder channels. [Functions and Indications] Nourishes the liver, calms the mind, soothes the nerves, and astringes sweat. Primarily used to treat insomnia due to deficiency and restlessness, palpitations, thirst, and night sweats.

[0033] Schisandra chinensis: [Properties and Channels Entered] Sour and sweet in taste, warm in nature. Enters the Lung, Heart, and Kidney channels. [Functions and Indications] It has the effects of astringing the lungs and relieving cough, nourishing and astringing essence, stopping diarrhea and sweating. It is mainly used to treat cough and asthma due to lung deficiency, dry mouth and thirst, spontaneous sweating, night sweats, emaciation due to overwork, nocturnal emission and spermatorrhea, and chronic diarrhea and dysentery.

[0034] Angelica dahurica: [Properties and Channels Entered] Sweet and pungent in taste, warm in nature. Enters the Lung, Spleen, and Stomach channels. [Functions and Indications] It has the effects of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing nasal passages, drying dampness and stopping leukorrhea, reducing swelling and draining pus, and dispelling wind and relieving itching. It is mainly used to treat common cold due to wind-cold, headache, toothache, rheumatic pain, sinusitis, leukorrhea, carbuncles, and boils.

[0035] Angelica sinensis: [Properties and Channels Entered] Sweet and pungent in taste, warm in nature. Enters the Liver, Heart, and Spleen channels. [Functions and Indications] It has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements. It is mainly used to treat blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to intestinal dryness, rheumatic pain, traumatic injuries, carbuncles and sores.

[0036] Licorice: [Properties and Channels Entered] Sweet in taste, neutral in nature. Enters the Heart, Lung, Spleen, and Stomach channels. [Functions and Indications] It has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing other herbs. It is mainly used to treat fatigue, poor appetite, palpitations, shortness of breath, abdominal pain, loose stools, limb pain, cough and wheezing, sore throat, and drug and food poisoning.

[0037] Compared with the prior art, the main advantages of the present invention are as follows:

[0038] This invention follows the principle of "principal," "assistant," "adjuvant," and "guide" in its formulation. The principal herbs are Gastrodia elata, Rehmannia glutinosa, Cornus officinalis, and Lycium barbarum; the assistant herbs are Paeonia lactiflora, Lysimachia christinae, Ophiopogon japonicus, Polygonatum odoratum, and Panax ginseng; the adjuvant herbs are Atractylodes macrocephala, Poria cocos, Ziziphus jujuba var. spinosa, Schisandra chinensis, Angelica dahurica, and Angelica sinensis; and the guide herb is Glycyrrhiza uralensis. The combined effects of these herbs nourish the liver and replenish qi, calm the mind, and combat fatigue, effectively relieving symptoms of mental fatigue. Animal experiments have confirmed that the oral preparation of this invention can prolong the exhaustive swimming time of mice, reduce the levels of blood lactic acid and serum urea after swimming, and increase liver glycogen reserves, demonstrating a significant anti-fatigue effect. Detailed Implementation

[0039] The technical solution of the present invention will be further described below with reference to specific embodiments. However, those skilled in the art should understand that the following embodiments are only for illustrating the present invention and should not be regarded as limiting the present invention. Specific conditions not specified in the embodiments are performed according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the reagents or instruments used are all conventional products obtained through commercial channels.

[0040] Example 1

[0041] Example 1 provides an oral preparation of Gastrodia elata for nourishing Yin, which includes the following raw materials in parts by weight: 22 parts of Gastrodia elata, 17 parts of Rehmannia glutinosa, 16 parts of Cornus officinalis, 20 parts of Lycium barbarum, 18 parts of Evodia rutaecarpa, 12 parts of Lysimachia christinae, 15 parts of Ophiopogon japonicus, 11 parts of Polygonatum odoratum, 9 parts of Panax ginseng, 8 parts of Atractylodes macrocephala, 7 parts of Poria cocos, 12 parts of Ziziphus jujuba var. spinosa, 9 parts of Schisandra chinensis, 6 parts of Angelica dahurica, 3 parts of Angelica sinensis, and 5 parts of Glycyrrhiza uralensis.

[0042] Example 1 also provides the following method for preparing the above-mentioned Gastrodia elata Yin-nourishing oral preparation:

[0043] (1) Weigh each raw material according to the weight ratio; with the amount of water being 7 times the total mass of the raw materials, soak the raw materials in water for 2.5 hours, then boil for 1.5 hours, and filter to obtain the first filtrate and the first filter residue;

[0044] (2) With water amounting to 3 times the total mass of the first residue, add water to the first filter residue from step (1) and decoct for 1 hour. After filtration, obtain the second filtrate and the second filter residue. Combine the first filtrate and the second filtrate and concentrate at 55°C to an extract with a relative density of 1.3. Based on the mass of the extract, add 1% dextrin and 1% sucrose by the mass of the extract, and prepare granules according to conventional methods to obtain the oral preparation of Gastrodia elata for nourishing yin.

[0045] Example 2

[0046] Example 2 provides an oral preparation of Gastrodia elata for nourishing Yin, which includes the following raw materials in parts by weight: 25 parts of Gastrodia elata, 20 parts of Rehmannia glutinosa, 17 parts of Cornus officinalis, 21 parts of Lycium barbarum, 20 parts of Carthamus tinctorius, 15 parts of Lysimachia christinae, 20 parts of Ophiopogon japonicus, 14 parts of Polygonatum odoratum, 10 parts of Panax ginseng, 12 parts of Atractylodes macrocephala, 10 parts of Poria cocos, 15 parts of Ziziphus jujuba var. spinosa, 10 parts of Schisandra chinensis, 8 parts of Angelica dahurica, 5 parts of Angelica sinensis, and 8 parts of Glycyrrhiza uralensis.

[0047] Example 2 also provides the following method for preparing the above-mentioned Gastrodia elata Yin-nourishing oral preparation:

[0048] (1) Weigh each raw material according to the weight ratio; with the amount of water being 8 times the total mass of the raw materials, soak the raw materials in water for 3 hours, then boil for 2 hours, and filter to obtain the first filtrate and the first filter residue;

[0049] (2) With water amounting to 4 times the total mass of the first residue, add water to the first filter residue from step (1) and decoct for 1.5 hours. After filtration, obtain the second filtrate and the second filter residue. Combine the first filtrate and the second filtrate and concentrate at 60°C to an extract with a relative density of 1.4. Add 1% starch by mass of the extract and prepare capsules according to conventional methods to obtain the oral preparation of Gastrodia elata for nourishing yin.

[0050] Example 3

[0051] Example 3 provides an oral preparation of Gastrodia elata for nourishing Yin, which includes the following raw materials in parts by weight: 20 parts of Gastrodia elata, 15 parts of Rehmannia glutinosa, 14 parts of Cornus officinalis, 17 parts of Lycium barbarum, 15 parts of Paeonia lactiflora, 10 parts of Lysimachia christinae, 10 parts of Ophiopogon japonicus, 10 parts of Polygonatum odoratum, 5 parts of Panax ginseng, 7 parts of Atractylodes macrocephala, 5 parts of Poria cocos, 10 parts of Ziziphus jujuba var. spinosa, 5 parts of Schisandra chinensis, 5 parts of Angelica dahurica, 1 part of Angelica sinensis, and 3 parts of Glycyrrhiza uralensis.

[0052] Example 3 also provides the following method for preparing the above-mentioned Gastrodia elata Yin-nourishing oral preparation:

[0053] (1) Weigh each raw material according to the weight ratio; with the amount of water being 5 times the total mass of the raw materials, soak the raw materials in water for 2 hours, then boil for 1 hour, and filter to obtain the first filtrate and the first filter residue;

[0054] (2) With water amounting to twice the total mass of the first residue, add water to the first filter residue from step (1) and decoct for 0.5 h. After filtration, obtain the second filtrate and the second filter residue. Combine the first filtrate and the second filtrate and concentrate at 50°C to an extract with a relative density of 1.3. Add 1% starch by mass of the extract and prepare tablets according to conventional methods to obtain the oral preparation of Gastrodia elata for nourishing yin.

[0055] Comparative Example 1

[0056] Comparative Example 1 provides an oral preparation comprising the following ingredients in parts by weight: 22 parts Gastrodia elata, 17 parts Rehmannia glutinosa, 16 parts Cornus officinalis, 20 parts Lycium barbarum, 12 parts Lysimachia christinae, 15 parts Ophiopogon japonicus, 11 parts Polygonatum odoratum, 9 parts Panax ginseng, 8 parts Atractylodes macrocephala, 7 parts Poria cocos, 12 parts Ziziphus jujuba var. spinosa, 9 parts Schisandra chinensis, 6 parts Angelica dahurica, 3 parts Angelica sinensis, and 5 parts Glycyrrhiza uralensis.

[0057] Comparative Example 2

[0058] Comparative Example 2 provides an oral preparation comprising the following ingredients in parts by weight: 22 parts Gastrodia elata, 17 parts Rehmannia glutinosa, 16 parts Cornus officinalis, 20 parts Lycium barbarum, 18 parts Paeonia lactiflora, 15 parts Ophiopogon japonicus, 11 parts Polygonatum odoratum, 9 parts Panax ginseng, 8 parts Atractylodes macrocephala, 7 parts Poria cocos, 12 parts Ziziphus jujuba var. spinosa, 9 parts Schisandra chinensis, 6 parts Angelica dahurica, 3 parts Angelica sinensis, and 5 parts Glycyrrhiza uralensis.

[0059] The efficacy of the oral formulations obtained in Examples 1-3 and Comparative Examples 1-2 is described below in detail:

[0060] 1. Laboratory animals

[0061] 120 healthy male SPF-grade Kunming mice, weighing 18-22g, were acclimatized for 7 days.

[0062] 2. Experimental Grouping

[0063] 120 mice were randomly divided into a model group, a low-medium-high dose group of Example 1, a low dose group of Comparative Example 1, and a low dose group of Comparative Example 2, with 20 mice in each group.

[0064] 3. Administration method

[0065] Example 1 Low-dose group: The oral preparation of Example 1 was administered by gavage at a dose of 1.4 g / kg (crude drug) once a day for 30 consecutive days;

[0066] In Example 1, the dosage group was administered the oral preparation of Example 1 by gavage at a dose of 2.8 g / kg (crude drug) once a day for 30 consecutive days.

[0067] Example 1 High-dose group: The oral preparation of Example 1 was administered by gavage at a dose of 5.6 g / kg (crude drug) once a day for 30 consecutive days;

[0068] Comparative Example 1 Low-dose group: The oral preparation of Comparative Example 1 was administered by gavage at a dose of 1.4 g / kg (crude drug) once a day for 30 consecutive days;

[0069] Comparative Example 2 Low-dose group: The oral preparation of Comparative Example 2 was administered by gavage at a dose of 1.4 g / kg (crude drug) once a day for 30 consecutive days;

[0070] Model group: The same volume of physiological saline was administered by gavage once a day for 30 consecutive days.

[0071] 4. Detection indicators

[0072] 4.1 Measure weight

[0073] Mice were weighed and their weights recorded before gavage administration on day 1 and day 30 of the experiment. The results are shown in Table 1.

[0074] 4.2 Testing the time spent swimming with added weight

[0075] 0.5 h after the last administration, 5 mice were randomly selected from each group. Each group of mice was loaded with lead at the base of their tails with 5% of their body weight and placed in a container with a water depth of 30 cm and a water temperature of 25 ± 1 ℃. Their swimming performance was observed. The time when the mice could not float to the surface for 10 seconds was defined as the time when they were exhausted from swimming. The results are shown in Table 2.

[0076] 4.3 Detection of blood lactate content

[0077] 0.5 h after the last administration, 5 mice in each group were randomly selected for the first blood collection. The mice were then placed in a container at 30 °C and swam without load for 10 min. Blood was collected for the second and third times after 0 min and 20 min of rest following the end of the swim. Blood lactate content was measured according to the kit instructions. The results are shown in Table 3.

[0078] 4.4 Detection of serum urea content

[0079] 0.5 h after the last administration, 5 mice from each group were randomly selected and placed in a container at 30 ℃ for 90 min of weightless swimming. After resting for 60 min, blood was collected from the eyeballs and the serum urea content was measured according to the kit instructions. The results are shown in Table 4.

[0080] 4.5 Detection of liver glycogen content

[0081] 0.5 h after the last administration, the remaining 5 mice in each group were sacrificed, and 100 mg of liver was accurately weighed. The liver glycogen content was measured according to the kit operation procedure. The results are shown in Table 5.

[0082] Table 1

[0083]

[0084] Table 2

[0085]

[0086] Table 3

[0087]

[0088] Table 4

[0089]

[0090] Table 5

[0091]

[0092] As shown in Table 1, there was no significant difference in the body weight of mice in each group before and after the experiment. These results indicate that the oral formulation of the present invention did not cause abnormal changes in mouse body weight, meaning that the oral formulation of the present invention has high safety.

[0093] As shown in Tables 2-5, compared with the model group, the oral formulations of Example 1 and Comparative Examples 1-2 can all increase the weight-bearing swimming time of mice, increase liver glycogen levels, reduce serum urea concentration and blood lactate content 20 minutes after swimming, and the effect of Example 1 is better than that of Comparative Examples 1-2.

[0094] In summary, this invention follows the principle of "principal," "assistant," "adjuvant," and "guide" in its formulation. The principal herbs are Gastrodia elata, Rehmannia glutinosa, Cornus officinalis, and Lycium barbarum; the assistant herbs are Paeonia lactiflora, Lysimachia christinae, Ophiopogon japonicus, Polygonatum odoratum, and Panax ginseng; the adjuvant herbs are Atractylodes macrocephala, Poria cocos, Ziziphus jujuba var. spinosa, Schisandra chinensis, Angelica dahurica, and Angelica sinensis; and the guide herb is Glycyrrhiza uralensis. Animal experiments have confirmed that the oral preparation of this invention can prolong the exhaustive swimming time of mice, reduce the levels of blood lactate and serum urea after swimming, and increase liver glycogen reserves, exhibiting a significant anti-fatigue effect.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. The basic principles and main features of the present invention have been described above with specific implementation schemes. Based on the present invention, some modifications or substitutions can be made, but these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of protection claimed by the present invention.

Claims

1. A gastrodia elata-based oral preparation for relieving fatigue, characterized in that, It is composed of the following ingredients in parts by weight: Gastrodia elata 20-25 parts, Rehmannia glutinosa 15-20 parts, Cornus officinalis 14-17 parts, Lycium barbarum 17-21 parts, Citrus reticulata 15-20 parts, Lysimachia christinae 10-15 parts, Ophiopogon japonicus 10-20 parts, Polygonatum odoratum 10-14 parts, Panax ginseng 5-10 parts, Atractylodes macrocephala 7-12 parts, Poria cocos 5-10 parts, Ziziphus jujuba var. spinosa 10-15 parts, Schisandra chinensis 5-10 parts, Angelica dahurica 5-8 parts, Angelica sinensis 1-5 parts, and Glycyrrhiza uralensis 3-8 parts.

2. The oral preparation of Gastrodia elata for relieving fatigue according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: Gastrodia elata 22 parts, Rehmannia glutinosa 17 parts, Cornus officinalis 16 parts, Lycium barbarum 20 parts, Evodia rutaecarpa 18 parts, Lysimachia christinae 12 parts, Ophiopogon japonicus 15 parts, Polygonatum odoratum 11 parts, Panax ginseng 9 parts, Atractylodes macrocephala 8 parts, Poria cocos 7 parts, Ziziphus jujuba var. spinosa 12 parts, Schisandra chinensis 9 parts, Angelica dahurica 6 parts, Angelica sinensis 3 parts, and Glycyrrhiza uralensis 5 parts.

3. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 1 or 2, characterized in that, Includes the following steps: (1) Weigh each raw material according to the weight ratio and add it to water, soak and boil it in sequence, and filter it to obtain the first filtrate and the first filter residue; (2) Add water to the first filter residue from step (1) and boil it. After filtration, obtain the second filtrate and the second filter residue. Combine the first filtrate and the second filtrate and concentrate them into an extract. Then add pharmaceutically acceptable excipients to obtain the oral preparation of Gastrodia elata for nourishing yin.

4. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 3, characterized in that, The amount of water used in step (1) is 5-8 times the total mass of the raw materials.

5. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 3, characterized in that, The soaking time in step (1) is 2-3 hours; the decocting time is 1-2 hours.

6. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 3, characterized in that, The amount of water used in step (2) is 2-4 times the total mass of the first dregs; the decoction time is 0.5-1.5h.

7. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 3, characterized in that, The concentration temperature in step (2) is 50-60℃; the relative density of the extract is 1.3-1.

4.

8. The method for preparing the Gastrodia elata Yin-nourishing oral preparation for anti-fatigue according to claim 3, characterized in that, The oral preparation is one of tablets, granules, or capsules.

9. The oral preparation of Gastrodia elata for nourishing Yin according to claim 1 or 2 is used in the preparation of anti-fatigue drugs.

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