A traditional Chinese medicine composition for treating constipation, a preparation method thereof and application thereof

By using a combination of traditional Chinese medicine to nourish kidney yin, moisten the intestines and promote bowel movements, and regulate lung qi, the drug dependence and fluid depletion problems of constipation caused by yin deficiency and intestinal dryness are resolved, achieving a safe and effective treatment.

CN122440735APending Publication Date: 2026-07-24THE SECOND AFFILIATED HOSPITAL OF NANJING UNIV OF TRADITIONAL CHINESE MEDICINE (JIANGSU SECOND HOSPITAL OF TRADITIONAL CHINESE MEDICINE JIANGSU TRAINING CENT FOR TRADITIONAL CHINESE MEDICINE MANAGEMENT CADRES)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-17
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing treatments for constipation due to yin deficiency and intestinal dryness have problems such as drug dependence, electrolyte imbalance, melanosis coli, and high relapse rates after drug withdrawal. Traditional Chinese medicine treatments, on the other hand, deplete body fluids or aggravate yin deficiency, and there is a lack of effective treatment methods.

Method used

A traditional Chinese medicine composition is used, consisting of Rehmannia glutinosa, Cornus officinalis, Scrophularia ningpoensis, Ophiopogon japonicus, Prunus japonica seed, Platycladus orientalis seed, Cannabis sativa seed, Leonurus japonicus seed, Bombyx batryticatus, Angelica sinensis, Salvia miltiorrhiza, Prunus armeniaca seed, Platycodon grandiflorus, Citrus aurantium, Citrus reticulata peel, and Glycyrrhiza uralensis. The volatile oil is extracted by supercritical fluid extraction and ethanol entrainer method, and then encapsulated with β-cyclodextrin to prepare granules, tablets or capsules. It nourishes kidney yin, nourishes heart yin, moistens the intestines and promotes bowel movement, promotes lung qi and regulates spleen and stomach function.

Benefits of technology

It significantly shortens the time to expel the first black stool, increases fecal water content and intestinal propulsion rate, improves symptoms of constipation and difficulty in defecation, improves quality of life, and has high safety in clinical use.

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Abstract

The application discloses a traditional Chinese medicine composition for treating constipation, which is prepared from the following traditional Chinese medicine extracts: 20-30 parts of radix rehmanniae preparata, 15-25 parts of fructus corni, 10-20 parts of radix scrophulariae, 10-20 parts of radix ophiopogonis, 10-20 parts of prunus domestica, 9-15 parts of semen platycladi, 10-20 parts of semen cannabis, 4-6 parts of semen abri, 10-20 parts of bombyx batryticatus, 8-12 parts of angelica sinensis, 8-12 parts of salvia miltiorrhiza, 3-8 parts of prunus armeniaca, 8-12 parts of platycodon grandiflorum, 8-12 parts of fructus aurantii, 9-12 parts of pericarpium citri reticulatae, 4-8 parts of glycyrrhiza uralensis, and a preparation method thereof is disclosed. The application is used for treating constipation of the type of dry intestine due to yin deficiency by the treatment principles of tonifying kidney yin, tonifying heart yin, moistening the intestines, moistening the intestines with pungent flavor, promoting lung and regulating qi, lifting the cover of the pot, regulating qi and invigorating the spleen, and regulating and protecting the spleen and stomach.
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