Novel dosage form of sinomenine medicament or hydrochlorate thereof and preparation technique thereof

A technology of sinomenine and hydrochloride, which is applied in the field of sinomenine or its hydrochloride enteric-coated controlled-release tablet and its preparation technology, can solve the toxic and side effects, low bioavailability, and cannot meet clinical needs And other issues
CN101375849AActive Publication Date: 2009-03-04HUNAN ZHENGQING PHARM GRP CO LTD
0 Cites 17 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN ZHENGQING PHARM GRP CO LTD
Publication Date
2009-03-04

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a sinomenine or an enteric-coated controlled-release tablet of hydrochloride thereof. The prepared enteric-coated controlled-release tablet hardly releases the drug in artificial simulated gastric juice, but can slowly and smoothly release the drug in artificial simulated intestinal juice; the sustained release time of the drug can achieve more than 12 hours or even 24 hours; the enteric-coated controlled-release tablet is taken once or twice daily, the plasma drug concentration in vivo is smooth, and the peak-valley phenomenon of the plasma drug concentration is reduced; as the prepared enteric-coated controlled-release tablet hardly releases the drug in stomach, the contacted concentration of the drug with the gastric mucosa is small, the stimulation of the stomach caused by the drug is alleviated. As the prepared enteric-coated controlled-release tablet sustainedly slowly releases the drug in intestinal tract, the times of the drug administration are reduced, and the patient compliance is improved, thereby being applicable to the needs of the clinical development.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a new drug dosage form of sinomenine or its hydrochloride, in particular to a sinomenine or its hydrochloride enteric-coated controlled-release tablet and a preparation process thereof. Background technique

[0002] Sinomenine (sinomenine) is the main active ingredient in the rhizomes of Chinese medicine Fangjiaceae plants such as Qingfengteng and Xunfengteng. At present, its hydrochloride is mainly used clinically. Sinomenine hydrochloride is a long needle-like crystal with a melting point of 233°C , easily soluble in water and dilute sodium hydroxide, soluble in ethanol, insoluble in chloroform and ether, and the equilibrium solubility in water, 0.1mol / L hydrochloric acid, pH6.8 phosphate buffer solution is 42.57, 23.73, 58.84 mg / ml. Sinomenine has pharmacological effects such as anti-inflammation, immunosuppression, analgesia, lowering blood pressure, anti-arrhythmia, anti-allergy, releasing histamine, and affecting gastroi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More