Solanum dulcamara total-saponin extract and preparation method and use thereof

A technology of extracts and total saponins, applied in the field of traditional Chinese medicine, can solve problems such as inability to achieve healing effects

Active Publication Date: 2009-06-10
SUNDIA MEDITECH COMPANY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Psoriasis is a chronic skin disease characterized by hyperproliferation of the epidermis, accompanied by parakeratosis and lymphocyte infiltration in the dermis. In the link, the main therapeutic drugs include corticosteroids, retinoic acid, vitamin D derivatives, etc. Although they show a certain short-term curative effect, they cannot achieve a curative effect.

Method used

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  • Solanum dulcamara total-saponin extract and preparation method and use thereof
  • Solanum dulcamara total-saponin extract and preparation method and use thereof
  • Solanum dulcamara total-saponin extract and preparation method and use thereof

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Experimental program
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Effect test

Embodiment 1

[0081] Add 1000g of 75% ethanol to 1000g, add 6L of 75% ethanol, heat and reflux for extraction for 1 hour, and extract the filter residue twice with 75% ethanol, 6L each time, heat and reflux for 1 hour, filter, and combine the filtrates. The filtrate was concentrated to a certain extent, extracted with n-butanol (500ml×4), the n-butanol was washed with water, then concentrated and dried, and the obtained solid was washed with petroleum ether, filtered, and the solid was recovered to obtain the total glycosides of radix chinensis, with a yield of 3.6%. Its total glucoside content was measured to be 49.4%.

Embodiment 2

[0083] Add 1500g of Baiying, add 7L of 50% ethanol, heat and reflux for extraction for 1 hour, and extract the filter residue twice with 50% ethanol, 5 L each time, heat and reflux for 1 hour, filter, and combine the filtrates. The filtrate was concentrated to a certain extent, and extracted with petroleum ether. After the extraction, the D101 macroporous resin on the water phase was washed with water and 20% ethanol in turn, and then eluted with 50% ethanol. The eluate was concentrated and dried to obtain total glycosides of astragalus. Its total glucoside content measured is 65.3%

Embodiment 3

[0085] Add 1500g of Baiying, add 7L of pure water, heat and reflux for extraction for 1 hour, and extract the filter residue with pure water twice, 5L each time, heat and reflux for 1 hour, filter, and combine the filtrates. The filtrate was concentrated to a certain extent and extracted with petroleum ether. After extraction, the D101 macroporous resin on the water phase was eluted with water-20% ethanol-50% ethanol-95% ethanol in sequence, and the 50% ethanol eluted parts were collected and concentrated to It has no alcohol smell, is concentrated and dried to obtain the total saponin extract of Baiying, and the total glycoside content is 59%.

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Abstract

The invention provides a solanum dulcamara total saponins extract containing 10-90% of solanum dulcamara total saponins by weight, which is a total steroidal saponins made from traditional Chinese medicine solanum dulcamara by process of extracting, separating and refining. Animal tests shows that: the exact has substantial effects of anti-inflammatory, anti-tumor, helicobacter pylori inhibition, gastric mucosa protection and keratinocyte proliferation inhibition, can be used in the preparation of medicaments for treating gastritis, stomach and duodenal ulcer stomach cancer and psoriasis.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine, in particular to an extract of a traditional Chinese medicine, a preparation method thereof and an application in preparation of medicines for treating gastritis, gastric and duodenal ulcers and psoriasis. technical background: [0002] The traditional Chinese medicine Baiying was first recorded in "Shen Nong's Materia Medica" and listed as top grade. There are also other names: white hair rattan, Shuyang spring, Paifeng rattan, etc. Baiying has been included in the 1977 edition of "Pharmacopoeia of the People's Republic of China". Baiying is a Solanaceae plant, rich in resources, sweet in taste, bitter in taste, and cold in nature. It has the effects of clearing away heat, detoxifying, expelling wind, promoting dampness, and removing blood stasis. For the treatment of damp-heat jaundice, rheumatic joint pain, excessive leucorrhea, edema, gonorrhea, erysipelas, boils, cancer. Modern research...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81C07J71/00
Inventor 王作鹏王晓川胡斌左剑陈娜
Owner SUNDIA MEDITECH COMPANY LTD
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