Montmorillonite loaded calcium hydroxide antacid

A calcium hydroxide, montmorillonite technology, applied in the digestive system, aluminum/calcium/magnesium active ingredients, medical preparations with non-active ingredients, etc., can solve the problem of low alkali capacity, decreased solubility, and alkaline capacity of alkaline clay Increase and other problems to achieve the effect of avoiding irritation to mucous membranes, low solubility, and weakening alkaline strength

Active Publication Date: 2014-08-06
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Chinese Patent [Application (Patent) No.] ZL200510101332.X discloses alkaline calcium-based bentonite and its preparation method. The modified bentonite is prepared by a semi-dry method, which realizes the reaction of activated clay and calcium hydroxide, but due to the activated clay crystal An acid active center only reacts with one calcium hydroxide molecule, so its alkali capacity is not high; "Journal of Guangxi University (Natural Science Edition)" 2011, No. 3, pages 379-384 reported the preparation of alkaline clay and its fatty acid In the study of the removal mechanism, the montmorillonite was first activated by acid to form an acid active center on the surface of the wafer, and then the calcium hydroxide was loaded around the acid active center by a wet method to achieve multi-molecular layer loading, so that the alkaline clay The alkali capacity of the alkaline clay is greatly increased, and the solubility of the loaded calcium hydroxide is much lower than that of pure calcium hydroxide. The alkaline clay is used to remove free fatty acids in oils and fats. There is no report on antacids for humans or animals.

Method used

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  • Montmorillonite loaded calcium hydroxide antacid
  • Montmorillonite loaded calcium hydroxide antacid
  • Montmorillonite loaded calcium hydroxide antacid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The raw material of medicinal montmorillonite was ground and sieved with a 200-mesh sieve, and the sieved samples were taken for particle size distribution determination and BET method specific surface area analysis.

[0034] Table 1 shows the particle size distribution results of the medicinal montmorillonite raw material, and Table 2 shows the BET method specific surface area analysis results.

Embodiment 2

[0036] Take 20g of medicinal montmorillonite, add deionized water to disperse it, then add hydrochloric acid to make the acid mass content of the reaction solution reach 14%, the mass ratio of montmorillonite to the reaction solution is 1:4, after standing for 10 hours, The temperature was raised to 90°C, stirred for 4.5 hours, and the waste acid was separated by filtration, washed with deionized water until pH>5, and dried by filtration to obtain wet acid-activated montmorillonite.

[0037] Table 1 shows the particle size distribution results of the acid-activated montmorillonite, and Table 2 shows the BET method specific surface area analysis results.

Embodiment 3

[0039] Take 20g of medicinal montmorillonite, add deionized water to disperse it, then add hydrochloric acid to make the acid mass content of the reaction solution reach 14%, the mass ratio of montmorillonite to the reaction solution is 1:4, after standing for 10 hours, High temperature to 90°C, stirring and reacting for 4.5 hours, filtering to separate the waste acid, washing with deionized water to pH>5, filtering to obtain wet acid activated montmorillonite; calcium hydroxide and deionized Mix water according to the mass ratio of 1:3, stir and disperse to obtain lime emulsion; add wet acid-activated montmorillonite into deionized water at a solid-to-liquid ratio of 1:12.5, stir for 30 minutes, then add lime milk at a uniform speed at 75°C , the addition time is 4 hours, continue to stir for 1 hour after the addition, and finally add 0.2% stearic acid by mass of montmorillonite for surface modification, stirring and modifying time is 10 minutes, filter, dry and pulverize to o...

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Abstract

The invention aims to provide a montmorillonite loaded calcium hydroxide antacid which uses montmorillonite loaded calcium hydroxide as the antacid on the basis of acid activation of montmorillonite loaded calcium hydroxide, and solves the conventional problem caused by direct contact of active components of the antacid and the gastric mucosa, wherein the montmorillonite has a gastric mucosa protection function simultaneously. The montmorillonite loaded calcium hydroxide antacid is characterized in that the antacid takes medicinal montmorillonite as the raw material, the montmorillonite is taken as a carrier after acid activation, loaded calcium hydroxide serves as an active ingredient, fatty acid is adopted for surface modification, the carrier of the obtained antacid is stable and insoluble, calcium hydroxide serving as the active ingredient can be continuously and firmly loaded on the carrier, the alkaline intensity is weakened, excessive taking of the antacid cannot cause too high gastric pH, and further, the carrier improves the dispersibility of calcium hydroxide serving as the active ingredient and forms a protective barrier, so that mucosa stimulation is avoided.

Description

technical field [0001] The present invention relates to calcium hydroxide antacids supported by montmorillonite. More specifically, it relates to a new type of antacid agent in which calcium hydroxide loaded on montmorillonite is especially used as an active ingredient. It uses montmorillonite as a carrier and calcium hydroxide as an active ingredient. The montmorillonite carrier can not only prevent strong alkaline Calcium hydroxide is in direct contact with the inner wall of the stomach, and it is also an excellent gastric mucosal protective agent. Background technique [0002] Antacids are the most commonly used drugs for the treatment of peptic ulcer, mostly weakly basic compounds, such as aluminum hydroxide, magnesium hydroxide, sodium bicarbonate, calcium carbonate and aluminum magnesium carbonate. Because the weakly alkaline compound is in direct contact with the inner wall of the stomach, it will cause mucous membrane pain, especially when there is an ulcer on the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/08A61K47/04A61P1/04
CPCA61K9/48A61K9/4891A61K33/06A61K33/12A61P1/04A61P9/12A61P17/02A61K2300/00
Inventor 韦藤幼丁泳锋诸葛六英童张法黄伊琳陈玲玉张国孟
Owner GUANGXI UNIV
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