Composition used for protecting gastric mucosa and application thereof

A composition and gastric mucosal technology, applied in the field of pharmaceutical preparations, can solve the problems of treating the symptoms but not the root cause, not seeing, and not being able to take care of both acute and chronic diseases, and achieve the effects of relieving stomach discomfort, uniform distribution, and preventing stomach diseases

Inactive Publication Date: 2015-08-19
TIANJIN TROPJOIN HEALTH TECH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs used clinically to treat serious gastric mucosal injuries are mainly anti-inflammatory and analgesic drugs. These drugs can only relieve gastric pain, and cannot take into account both acute and chronic d...

Method used

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  • Composition used for protecting gastric mucosa and application thereof
  • Composition used for protecting gastric mucosa and application thereof
  • Composition used for protecting gastric mucosa and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. Preparation of compositions for protecting gastric mucosa

[0041] Table 1.6 representative compositions (parts by weight) formula

[0042]

[0043] The preparation method of this embodiment composition (chewable tablet) is as follows:

[0044] 1. Prepare Hericium erinaceus extract:

[0045] Take Hericium erinaceus, add 30 times the weight of water, extract at a temperature of 80 degrees Celsius for 4 hours, concentrate and dry the extract, and obtain Hericium erinaceus extract.

[0046] 2. Prepare Poria cocos extract:

[0047] Take the original medicinal material of Poria cocos, add 50 times of 1mol / L NaOH solution, extract 3 times for 1 hour each time, combine the extracts from the 3 times, concentrate and dry to obtain Poria cocos extract.

[0048] 3. Prepare astragalus extract:

[0049] Take the raw medicinal material of Astragalus membranaceus, extract twice with 8 times the weight of water, each time for 2 hours, combine the water extracts twic...

Embodiment 2

[0075] Embodiment 2. The animal experiment of the protection gastric mucosa function of product of the present invention

[0076] 1 Materials and methods

[0077] 1.1 Samples: 6 compositions prepared in Example 1, specifications "0.6g / tablet, the recommended dosage for human oral administration is 6 tablets per person (adult) per day, and the adult body weight is calculated as 60kg, and the equivalent dose is 0.06g / kgBW and Single-ingredient samples of Hericium erinaceus, Poria cocos, Radix Astragali and Codonopsis pilosula of the same specification in composition F.

[0078] 1.2 Experimental animals and environment: 40 SPF-grade healthy SD male rats, weighing 170.2±5.7g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People’s Liberation Army, experimental animal license number: SYXK (Beijing) 2012-003, animal The laboratory is a barrier system, using the license number: SCXK-(military)-2012-0004. Experimental animal r...

Embodiment 3

[0103] Example 3. Comparison of the composition of the present invention with related products

[0104] X1: Granules prepared by the prescription disclosed in Example 1 of Patent Application No. 200810115341.8

[0105] X1 uses a wide variety of traditional Chinese medicines in its formula, including as many as 13 kinds of herbs such as Codonopsis pilosula, Gallus gallinaceae, Chuanqiong, aconite, and dried ginger. The preparation is complicated, and at the same time, Chuanqiong and aconite have certain toxic and side effects and are not included in the health care product raw material catalogue. Among them, the composition (F) of the present invention has a simpler production process and a lot fewer types of components, but the effect of the present invention is better. The composition of the present invention has the significant advantage of having no toxic side effects and can be taken for a long time.

[0106] X2: The pill disclosed in the patent embodiment with applicati...

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Abstract

The invention discloses a composition used for protecting gastric mucosa and an application thereof. The active components of the composition are prepared from the following raw materials in parts by weight: 55-85 parts of monkey head mushroom, 44-131 parts of poria cocos, 37-83 parts of radix astragali, 36-93 parts of dangshen. The composition is prepared by adopting a scientific and reasonable production technology based on the traditional Chinese medicine life cultivation and health preservation theory, is clear and definite in functions, controllable in quality and safe to take; and all the components in the composition are matched and cooperated, and auxiliary materials are added for conditioning the taste, so that the composition is better in taste and easier to take. The composition has a good effect of protecting gastric mucosa, not only can alleviate stomach discomfort symptoms, but also can play a preventive effect on gastric diseases.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a composition for protecting gastric mucosa and its application. Background technique [0002] The entire inner surface of the stomach is covered with a layer of mucosal tissue, which can secrete mucus and form a gastric mucus-mucosal barrier to protect gastric tissue. The stomach mainly absorbs decomposed water and grains, and there are two main reasons for the damage of the gastric mucosa: one is due to improper diet, excessive hunger and fullness, or overeating fat and sweet, stagnant food, obstructed qi mechanism, poor spleen movement, and gastric insufficiency. The second is caused by anxiety, anger, liver qi imbalance, and intrusion against the stomach. Gastric mucosal injury will cause gastritis, gastric ulcer and other diseases. [0003] To prevent gastric mucosal damage, protecting gastric mucosa is more expensive than "nurturing". Appropriate dieta...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P1/00
Inventor 鲁延达
Owner TIANJIN TROPJOIN HEALTH TECH GRP
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