Extraction method for antibiosis antiviral active placement from honeysuckle

A technology of antiviral activity and active site, applied in the directions of antiviral agents, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of high tannin, low content of active ingredients, adverse reactions of preparations, etc.

Inactive Publication Date: 2003-09-03
RUNTONG BIOLOGICAL MEDICINE HEILONGJIANG PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although honeysuckle has a good clinical basis, there are still many problems in the extraction of its active ingredients and active parts. The main reason is that the process is relatively simple. The content of active ingredients is low, and impurities such as tannin are relatively high, which often bring adverse reactions to the preparation

Method used

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  • Extraction method for antibiosis antiviral active placement from honeysuckle
  • Extraction method for antibiosis antiviral active placement from honeysuckle
  • Extraction method for antibiosis antiviral active placement from honeysuckle

Examples

Experimental program
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Effect test

Embodiment 1

[0016] (1) Take honeysuckle, wash, dry, coarsely pulverize, add water to decoct twice, each time the water consumption is 15 times of the dry weight of honeysuckle, the decoction temperature is 90°C, the decoction time is 60 minutes, and the water extract is combined , filter, and concentrate the filtrate to a concentration of 1.1 when measured at 80°C, and let it cool;

[0017] (2) The concentrated paste of honeysuckle is precipitated with ethanol, that is, add ethanol to the concentrated paste, and stir fully at the same time. Concentrate and recover ethanol under pressure to obtain honeysuckle alcohol washing concentrated paste, the relative density of which is 1.08-1.18 when measured at 60°C;

[0018] (3) Honeysuckle Alcohol Wash Concentrated Liquid Cream is diluted with appropriate amount of distilled water, and passed into the pretreated D 101 Daye adsorption resin column, first elute with distilled water with 3-6 times the volume of the column bed, and then elute with ...

Embodiment 2

[0022] (1) Take honeysuckle, wash, dry, coarsely pulverize, add water to decoct twice, each time the water consumption is 30 times of the dry weight of honeysuckle, decocting temperature is 100 ℃, decocting time is 90 minutes, and the water extract is combined , filter, and concentrate the filtrate to a concentration of 1.08-1.20 when measured at 80°C, and let it cool;

[0023] (2) The concentrated ointment of honeysuckle is precipitated with ethanol, that is, add ethanol to the concentrated ointment, and stir fully at the same time. Concentrate and recover ethanol under pressure to obtain honeysuckle alcohol washing concentrated paste, the relative density of which is 1.08-1.18 when measured at 60°C;

[0024] (3) Honeysuckle Alcohol Wash Concentrated Liquid Cream is diluted with appropriate amount of distilled water, and passed into the pretreated D 101 Macroporous adsorption resin column, first elute with distilled water with 3-6 times the volume of the column bed, and then...

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Abstract

A process for extracting the antibacterial and antivirus components from honeysuckle flower includes such steps as extracting in alcohol solution, adsorbing by macroreticular resin adsorbent, eluting, adsorbing by polyamide column, and eluting. Its quality standard based on the chlorogenic acid or isochlorogenic acid as reference is defined. Its advantages are high content (25-80%) and low cost.

Description

technical field [0001] The present invention relates to the extraction process of honeysuckle as a raw material for heat-clearing and detoxifying traditional Chinese medicine made into single or compound preparations, especially the extraction process of the antibacterial and antiviral active parts of honeysuckle with chlorogenic acid isochlorogenic acid as the index component. The present invention also relates to the disclosure The quality standard of the active part of honeysuckle with chlorogenic acid isochlorogenic acid as the index component was established. It belongs to the field of traditional Chinese medicine. Background technique [0002] Honeysuckle is the dried flower bud of Lonicera Japonica Thunb, a plant of Lonicera japonica, which has the functions of clearing away heat and detoxification, cooling wind and heat, etc. In the past ten years, many single and compound preparations have been developed using it as a raw material. These preparations are clinically ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P31/04A61P31/12
Inventor 吴立军田玉忠遆铁军
Owner RUNTONG BIOLOGICAL MEDICINE HEILONGJIANG PROV
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