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Method for preparing honeysuckle chlorogenic acid

A technology of honeysuckle chlorogenic acid and honeysuckle, applied in the separation/purification of carboxylic acid esters, organic chemistry, etc., can solve the problems of unsatisfactory separation effect of chlorogenic acid, long process flow, difficult filtration, etc., and achieve easy continuous production operation , short process flow and high separation efficiency

Inactive Publication Date: 2011-04-06
GUANGXI JINHONGXIN BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The purpose of the present invention is to overcome the difficulty in filtration caused by the small amount of honeysuckle in the prior art due to the large amount of precipitation in the impurity removal and purification process, the long process flow, the difficulty in continuous operation, the unsatisfactory separation effect of chlorogenic acid, and the difficulty in industrial production. technical problem, a preparation method of honeysuckle chlorogenic acid is provided

Method used

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  • Method for preparing honeysuckle chlorogenic acid
  • Method for preparing honeysuckle chlorogenic acid

Examples

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Embodiment 1

[0039] Add 5 parts by weight of dried honeysuckle flowers and leaves and branches of raw materials that have been removed, coarsely crushed or cut into sections into a stainless steel reaction tank, add deionized water in a ratio of 1:3 parts by weight of raw materials and water, and add the antioxidant sodium bisulfite The usage amount is 1.0 / 10,000 of the total feeding amount, the pH value is adjusted to 3.2, the extraction is heated and kept for three times, the temperature is controlled at 65-67°C, the holding time is 1.2h, and the extracts are combined. Then the extract is introduced into a stainless steel reaction tank for concentration under reduced pressure, the temperature is controlled to be ≤60°C, the vacuum degree is ≥0.08MPa, and concentrated into an extract of 8 degrees Baume. Then the concentrated extract is added in a stainless steel reaction kettle, ethanol with 180 times the weight of the raw material honeysuckle is added, and 40 parts by weight of inorganic s...

Embodiment 2

[0042] Add 5 parts by weight of dried gold and silver flowers that have been removed, coarsely crushed or cut into sections into an aluminum alloy reaction tank, add deionized water in a ratio of 1:3 parts by weight of raw materials and water, and add antioxidant sodium bisulfite to The total feeding amount is 1.4 / 10,000, the pH value is adjusted to 3.2, heating and heat preservation is carried out for three times for extraction, the temperature is controlled at 67-69°C, the heat preservation time is 1-1.5h, and the extracts are combined. Then the extract is introduced into an enamel reaction kettle for concentration under reduced pressure, the temperature is controlled to be ≤60°C, the vacuum degree is ≥0.08MPa, and concentrated into an extract of 7.8 degrees Baume. Then put the concentrated extract into the enamel reaction kettle, add 200 parts by weight of raw material honeysuckle ethanol, 0.113 parts by weight of methyl polypropylene glycol, and add 40 parts by weight of in...

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Abstract

The invention discloses a method for preparing honeysuckle chlorogenic acid, comprising the following steps of: carrying out water extraction on honeysuckle and branches and leaves of honeysuckle, which are used as raw materials, and then forming a dual-aqueous phase system by mixing a water soluble organic solvent together with a saline solution and a water soluble compound in proportion; then dissolving total extract into the dual-aqueous phase system for distribution so that the average concentration of the extract in two phases is 30-50 percent to achieve distribution balance; then extracting with an extracting agent which is not solvable with the two aqueous phases to separate out extract liquor; firstly removing impurities the polarity of which is lower than that of the chlorogenic acid; performing a three-phase extracting method, i.e. extracting the rest dual-aqueous phase with another extracting agent; carrying out selective direct enrichment and separating purification to obtain a chlorogenic acid initial product; and then decolorizing, crystallizing and drying to obtain the chlorogenic acid product with the mass fraction of 95 percent. The method simplifies production process, has better repeatability and no pollutant emission, and is suitable for industrial production; and the chlorogenic acid produced by using the method has high mass fraction.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a preparation method of honeysuckle chlorogenic acid. Background technique [0002] Chlorogenic acid (cNorogenic acid) is a phenylpropanoid substance synthesized by plants during aerobic respiration. It is one of the main active ingredients of many Chinese herbal medicines such as honeysuckle, Eucommia, capillary, etc. important active ingredients. The content of chlorogenic acid in honeysuckle is 1.81-2.92%, the content of chlorogenic acid in old leaves during the wintering period is 1.41 times that of flowers, and the content of chlorogenic acid in leaves is equivalent to 4 times that of vines. The economic yield index of overwintering old leaves and pruned branches and leaves is 1.5 times that of dried honeysuckle flowers. Therefore, it is a waste of natural resources to only use flowers as medicinal raw materials, beverages, and cosmetic raw materials in modern times. Chlor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48
Inventor 罗亚东关健敏
Owner GUANGXI JINHONGXIN BIOTECH
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