Method for detecting quality of compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins

A quality detection method and compound amino acid technology, applied in measuring devices, weighing by removing certain components, instruments, etc., can solve the problems of consuming large plasma resources and expensive costs

Active Publication Date: 2011-05-25
GUIZHOU MAQIKA PHARMA
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Problems solved by technology

Intravenous plasma albumin is commonly used clinically. Although it can significa...

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  • Method for detecting quality of compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins
  • Method for detecting quality of compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins
  • Method for detecting quality of compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins

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Embodiment Construction

[0133] Determination method Take the content of this product under the item of difference in filling amount, grind it finely, and accurately weigh an appropriate amount (about the amount equivalent to 1 capsule) and put it in a 100ml measuring bottle, add 0.01mol / L hydrochloric acid solution (containing 0.1% metaphosphoric acid ) about 80ml, sonicate for 30 minutes, let cool, dilute to the mark, shake well, and filter; accurately measure 10μl of the filtrate and inject it into the liquid chromatograph, and record the chromatogram; take vitamin C and vitamin B 1 , Vitamin B 6 Take an appropriate amount of nicotinamide reference substance, accurately weighed, dissolve with 0.01mol / L hydrochloric acid solution (containing 0.1% metaphosphoric acid) and quantitatively dilute to make a mixture containing 0.2mg, 0.05mg, 0.025mg and 0.02mg in each 1ml Solution, as the reference substance solution (temporary new preparation), measured with the same method; calculated by the peak area ...

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Abstract

The invention discloses a method for detecting the quality of a compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins, mainly comprising the steps of detecting whether the inclusion of the capsule is yellow or tangerine powder or particles, differentiating, checking the loss on drying and measuring the contents of amino acids, vitamin C, niacinamide, vitamin B1, vitamin B6, vitamin B2, calcium pantothenate, folic acid, vitamin A, vitamin D2, vitamin E and 5-hydroxy o-aminobenzoic acid in the capsule by adopting the high-performance liquid chromatography. The method for detecting the quality of the compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins is scientific and reasonable, has high degree of accuracy, good repeatability, can comprehensively and effectively control the quality of the compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins, and can ensure the clinical efficacy of the preparation.

Description

technical field [0001] The invention relates to a quality detection method of medicines, in particular to a (miracle) compound amino acid (8) vitamin (11) capsule quality detection method, which belongs to the technical field of traditional Chinese medicines. Background technique [0002] In patients with liver cirrhosis, the liver cells are damaged, and the protein synthesis ability is reduced, so that the serum protein, especially the albumin level, is significantly reduced. Intravenous administration of plasma albumin is often used clinically. Although it can significantly increase the albumin level, it is expensive and consumes a lot of plasma resources. With the advent of domestic oral compound amino acids, oral supplementation of amino acids has become possible. The compound amino acid (8) vitamin (11) capsule is composed of 8 kinds of essential amino acids and 11 kinds of vitamins, which can enhance the synthesis of human protein and improve the immunity of the body....

Claims

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Application Information

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IPC IPC(8): G01N5/04G01N30/02G01N30/36
Inventor 张芝庭
Owner GUIZHOU MAQIKA PHARMA
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