Controlled vapor deposition of biocompatible coatings for medical devices

Inactive Publication Date: 2006-11-09
APPLIED MICROSTRUCTURES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0068] Oxide/polyethylene glycol coatings providing hydrophilicity can also be deposited, using the present method, over the surfaces of various medical devices and implants, which are intended for various time periods of use. Internal devices such as smart bio-chips, which may include internal diagnostic devices are excellent applications for coated structures. External devices such as contact lenses, external diagnostic devices (including microfluidic devices), and catheters, for example, provide excellent applications for coated s

Problems solved by technology

While this technique enables efficient coating deposition, it frequently results in limited control over the surface properties of the applied coating.
In the case of coating a surface of a medical device which must function on a nanometer scale, use of liquid phase processing limits device yield due to contamination and capillary forces.
However, the common vapor-phase deposition methods may not permit sufficient control of the molecular level reactions taking place during the deposition of surface bonding layers or during the deposition of functional coatings, when the deposited coating needs to exhibit functional surface properties on a nanometer (nm) scale.
(Abstract) The introduction of the article explains that bone and dental implant technology is currently inadequate.
The bond between bone and implant materials (such as Ti and metal alloys) is said to fail, requiring additional surgery to remove and replace the implant after only a few years of use.
Too small an RMS surface is said to

Method used

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  • Controlled vapor deposition of biocompatible coatings for medical devices
  • Controlled vapor deposition of biocompatible coatings for medical devices
  • Controlled vapor deposition of biocompatible coatings for medical devices

Examples

Experimental program
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example one

[0112] The vapor deposition techniques described previously herein were used to coat devices such as implantable (intraocular) lenses with a hydrophilic oxide / polyethylene glycol coating. Prior to deposition of the coating, the device surface was pre-treated by exposure to an oxygen plasma (150-200 sccm O2 at an RF power of about 200 W and a process chamber pressure of 0.3 Torr in an Applied MicroStructures' MVD™ process chamber) for 5 minutes in order to clean the surface and create hydroxyl availability on a substrate surface (by way of example and not by way of limitation).

[0113] Following oxygen plasma treatment of the lens, SiCl4 was charged to the process chamber from a SiCl4 vapor reservoir, where the SiCl4 vapor pressure in the vapor reservoir was 18 Torr, creating a partial pressure of 2.3 Torr in the coating process chamber. Within 5 seconds, a first volume of H2O vapor was charged to the process chamber from a H2O vapor reservoir, where the H2O vapor pressure in the vapo...

example two

[0148] Deposition of a Silicon Oxide Layer Having a Controlled Number of OH

[0149] Reactive Sites Available On the Oxide Layer Surface

[0150] A technique for adjusting the hydrophobicity / hydrophilicity of a substrate surface (so that the surface is converted from hydrophobic to hydrophilic or so that a hydrophilic surface is made more hydrophilic, for example) may also be viewed as adjusting the number of OH reactive sites available on the surface of the substrate. One such technique is to apply an oxide coating over the substrate surface while providing the desired concentration of OH reactive sites available on the oxide surface. A schematic 200 of the mechanism of oxide formation in shown in FIG. 2. In particular, a substrate 202 has OH groups 204 present on the substrate surface 203. A chlorosilane 208, such as the tetrachlorosilane shown, and water 206 are reacted with the OH groups 204, either simultaneously or in sequence, to produce the oxide layer 205 shown on surface 203 o...

example three

[0152] In the preferred embodiment discussed below, the silicon oxide coating was applied over a glass substrate. The glass substrate was treated with an oxygen plasma in the presence of residual moisture which was present in the process chamber (after pump down of the chamber to about 20 mTorr) to provide a clean surface (free from organic contaminants) and to provide the initial OH groups on the glass surface.

[0153] Various process conditions for the subsequent reaction of the OH groups on the glass surface with vaporous tetrachlorosilane and water are provided below in Table 2, along with data related to the thickness and roughness of the oxide coating obtained and the contact angle (indicating hydrophobicity / hydrophilicity) obtained under the respective process conditions. A lower contact angle indicates increased hydrophilicity and an increase in the number of available OH groups on the silicon oxide surface.

TABLE 2Deposition of a Silicon Oxide Layer of Varying Hydrophilicit...

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Abstract

We have developed an improved vapor-phase deposition method and apparatus for the application of layers and coatings on various substrates. The method and apparatus are useful in the fabrication of biofunctional devices, Bio-MEMS devices, and in the fabrication of microfluidic devices for biological applications. In one important embodiment, oxide/polyethylene glycol coatings provide increased hydrophilicity and improved biocompatibility for medical devices and implants.

Description

[0001] This application is related to U.S. patent application Ser. No. ______, filed Apr. 21, 2005, and entitled “Controlled Vapor Deposition of Multilayered Coatings Adhered By An Oxide Layer”, which is a continuation in part of U.S. patent application Ser. No. 10 / 996,520, filed Nov. 23, 2004, and entitled “Controlled Vapor Deposition of Multilayered Coatings Adhered by an Oxide Layer”, which is a continuation in part of U.S. patent application Ser. No. 10 / 862,047, filed Jun. 4, 2004, and entitled “Controlled Deposition of Silicon-Containing Coatings Adhered by an Oxide Layer”, which is currently pending. This application is also related to U.S. patent application Ser. No. 11 / 048,513, filed Jan. 31, 2005, and entitled “High Aspect Ratio Performance Coatings for Biological Microfluidics”, which is also a continuation in part of U.S. patent application Ser. No. 10 / 862,047 which is recited above. All four of these U.S. Patent Applications are hereby incorporated by reference in their ...

Claims

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Application Information

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IPC IPC(8): A61L33/00
CPCA61L27/34A61L29/085A61L31/10B82Y30/00B82Y40/00Y10T428/261C08L71/02Y10T428/31667
Inventor KOBRIN, BORISNOWAK, ROMUALDCHINN, JEFFREY D.YI, RICHARD C.
Owner APPLIED MICROSTRUCTURES
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