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Coating having endothelium bionic function and preparation method of coating

A bionic function and coating technology, applied in the field of biomedical engineering materials, can solve the problems of unsatisfactory long-term clinical follow-up results and achieve the effect of improving biocompatibility, increasing success rate, and high endothelial bionic function

Inactive Publication Date: 2017-10-03
CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most current strategies for improving the surface modification of cardiovascular materials only focus on improving the biocompatibility of a certain aspect of the material.
The short-term implantation effect is remarkable, but the long-term clinical follow-up results are not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method with an endothelial biomimetic functional coating, the steps of which are:

[0023] A. Deposition of plasma polyallylamine film

[0024] Preparation of plasma-polymerized films rich in amine groups on the surface: the vascular stent (316L SS, Ti and its alloys, Ti-O, Ti-N, Co-Cr alloys, Fe and its alloys, Zn and its alloys, Mg and its Alloy substrate) into the film deposition reaction chamber, when the reaction chamber is vacuumed to 0.01-2Pa, argon with a flow rate of 0.5-5 sccm is introduced as the discharge gas, and allylamine as the reaction gas is introduced to make the working pressure be 1-10Pa, under the conditions of RF power 5-10W, negative bias voltage 0-150V, and pulse duty ratio 5-100%, the plasma polyallylamine film deposition lasts 5-60 minutes, that is, in the blood vessel A thin film of amino-rich plasma polyallylamine is deposited on the surface of the stent.

[0025] B. Co-immobilization of 3,3-dithiodipropionic acid and heparin...

Embodiment 2

[0029] A preparation method with an endothelial biomimetic functional coating, the steps of which are:

[0030] A. Deposition of plasma polyallylamine film

[0031] Preparation of plasma-polymerized films rich in amine groups on the surface: the vascular stent (316L SS, Ti and its alloys, Ti-O, Ti-N, Co-Cr alloys, Fe and its alloys, Zn and its alloys, Mg and its Alloy substrate) into the film deposition reaction chamber, when the reaction chamber is vacuumed to 0.01-2Pa, argon with a flow rate of 0.5-5 sccm is introduced as the discharge gas, and allylamine as the reaction gas is introduced to make the working pressure be 1-10Pa, under the conditions of RF power 5-10W, negative bias voltage 0-150V, and pulse duty ratio 5-100%, the plasma polyallylamine film deposition lasts 5-60 minutes, that is, in the blood vessel A thin film of amino-rich plasma polyallylamine is deposited on the surface of the stent.

[0032] B. Co-immobilization of cystine and heparin sodium

[0033] D...

Embodiment 3

[0036] A preparation method with an endothelial biomimetic functional coating, the steps of which are:

[0037] A. Deposition of plasma polyallylamine film

[0038] Preparation of plasma-polymerized films rich in amine groups on the surface: the vascular stent (316L SS, Ti and its alloys, Ti-O, Ti-N, Co-Cr alloys, Fe and its alloys, Zn and its alloys, Mg and its Alloy substrate) into the film deposition reaction chamber, when the reaction chamber is vacuumed to 0.01-2Pa, argon with a flow rate of 0.5-5 sccm is introduced as the discharge gas, and allylamine as the reaction gas is introduced to make the working pressure be 1-10Pa, under the conditions of RF power 5-10W, negative bias voltage 0-150V, and pulse duty ratio 5-100%, the plasma polyallylamine film deposition lasts 5-60 minutes, that is, in the blood vessel A thin film of amino-rich plasma polyallylamine is deposited on the surface of the stent.

[0039] B. Co-immobilization of lipoic acid and heparin sodium

[0040]...

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PUM

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Abstract

The invention discloses a coating having an endothelium bionic function and a preparation method of the coating. The coating is applied to surface modification of cardiovascular implants and blood contact materials; and a carboxyl disulfide bond containing compound, which has nitric oxide catalytic activity, and heparin are immobilized on the surface of the coating rich in amino. The functional coating shows an endothelium-like bionic function; the coating not only offers an excellent anti-coagulation property but also integrates excellent functions of inhibiting proliferation of smooth muscle cells and promoting growth of endothelial cells; and the coating can be widely applied to surface treatment of such medical apparatuses as vascular stents, artificial blood vessels, extracorporeal circulation catheters, central venous catheters and the like.

Description

technical field [0001] The invention relates to biomedical engineering materials, especially the technology for preparing coatings with endothelial bionic functions. Background technique [0002] Cardiovascular disease, often associated with atherosclerosis, is a leading cause of death and disability worldwide. Since Sigwart reported the first human coronary artery stent implantation in 1987, metallic vascular stent implantation has become one of the most common treatments for severe cardiovascular disease. However, stent expansion easily damages the surrounding vascular tissue. Vascular tissue trauma leads to thrombosis, inflammation, vascular intimal hyperplasia, and matrix deposition / vascular remodeling. The results of 3-6 months of implantation show that the rate of in-stent restenosis is as high as 20-30%. The application of artificial blood vessels, especially small-diameter artificial blood vessels (<5mm), can also lead to the proliferation of smooth muscle cells...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16A61L27/34A61L27/54A61L33/10
CPCA61L27/34A61L27/54A61L31/10A61L31/16A61L33/0011A61L33/08A61L2300/214A61L2300/236A61L2300/42A61L2300/422C08L79/02
Inventor 黄楠齐鹏凯杨志禄杨莹
Owner CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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