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Co-administration of a thrombolytic and an anti-CD18 antibody in stroke

a technology of anticd18 and thrombolytic, which is applied in the field of anti-cd18 antibodies for treating stroke, can solve the problems of increasing cerebral blood flow, reducing the size of infarct, and serious problems for society

Inactive Publication Date: 2002-06-27
GENENTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This presents a serious problem to society, with about 500,000 people dying from or becoming permanently disabled by stroke in the United States each year.
Preferably, the method results in an increase in cerebral blood flow and a decrease in infarct size resulting from the systemic hypoperfusion.

Method used

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  • Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
  • Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
  • Co-administration of a thrombolytic and an anti-CD18 antibody in stroke

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[0126] This study investigated the effect of anti-CD18 antibody (MHM23) and t-PA in a rabbit model of thromboembolic stroke. In this model, a single blood clot is introduced into the middle cerebral and posterior communicating arteries (which are "main cerebral arteries"). The arterial obstruction (i.e., the dot) remains in place throughout the experiment (unless it is enzymatically removed by t-PA). The following rabbit model is thought to correlate well with the physiological progression of thromboembolic stroke in humans.

Materials and Methods

[0127] The rabbit model of thromboembolic stroke used in the current study has been previously described in detail (Bednar et al., Neurol. Res., 16:129-132 (1994); Gross et al., Stroke, 24:558-562 (1993); Kohut et al., Stroke, 23:93-97 (1992); Wilson et al., Neurosurgery, 31:929-934 (1992)). See, also, Gross et al., Neurosurgery, 36(6):1172-1177 (1995).

[0128] Briefly, New Zealand white rabbits (Charles River, Calif.) (both males and females; ...

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Abstract

A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and / or reducing infarct size is described which involves administering an effective amount of an ant-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.

Description

[0001] This is a non-provisional application filed under 37 CFR 1.53(b)(1), claiming priority under USC Section 119(e) to provisional Application Ser. No. 601 / ______ (to be assigned) filed on Jan. 23, 1996.[0003] 1. Field of the Invention[0004] This invention relates generally to the use of anti-CD18 antibodies for treating stroke. In particular, it relates to the use of anti-CD18 antibodies for improving clinical outcome by increasing cerebral blood flow and / or reducing infarct size in focal ischemic stroke caused by obstruction of a main cerebral artery.[0005] 2. Description of Related Art[0006] Stroke is a general term for acute brain damage resulting from disease of blood vessels. This presents a serious problem to society, with about 500,000 people dying from or becoming permanently disabled by stroke in the United States each year. Stroke can be classified into two main categories: hemorrhagic stroke (resulting from leakage of blood outside of the normal blood vessels) and isc...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61K38/18A61K38/49A61K39/395C07K16/28
CPCA61K38/49A61K39/3955A61K2039/505C07K16/2821C07K16/2845C07K2316/96Y10S514/822C07K2317/54C07K2317/24A61K2300/00C07K2317/76A61P9/00
Inventor BEDNAR, MARTIN M.GROSS, CORDELL E.THOMAS, G. ROGERGROSS, LINDA J.
Owner GENENTECH INC
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