Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- GENENTECH INC
- Publication Date
- 2002-06-27
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
[0001] This is a non-provisional application filed under 37 CFR 1.53(b)(1), claiming priority under USC Section 119(e) to provisional Application Ser. No. 601 / ______ (to be assigned) filed on Jan. 23, 1996.
[0003] 1. Field of the Invention
[0004] This invention relates generally to the use of anti-CD18 antibodies for treating stroke. In particular, it relates to the use of anti-CD18 antibodies for improving clinical outcome by increasing cerebral blood flow and / or reducing infarct size in focal ischemic stroke caused by obstruction of a main cerebral artery.
[0005] 2. Description of Related Art
[0006] Stroke is a general term for acute brain damage resulting from disease of blood vessels. This presents a serious problem to society, with about 500,000 people dying from or becoming permanently disabled by stroke in the United States each year. Stroke can be classified into two main categories: hemorrhagic stroke (resulting from leakage of blood outside of the normal blood vessels) and isc...