Phosphatide compound of resveratrol compounds and method for preparing the same and the application thereof

A technology of phospholipid complex and resveratrol, which is applied in the directions of active ingredients of hydroxyl compounds, medical preparations of non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as complex structure, improve solubility, increase The effect of medicine

Inactive Publication Date: 2008-01-02
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies have found that many types of natural active ingredients have special affinity with phospholipids, which are mainly believed to be combined by hydrogen bonds, and the structure is relatively complex

Method used

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  • Phosphatide compound of resveratrol compounds and method for preparing the same and the application thereof
  • Phosphatide compound of resveratrol compounds and method for preparing the same and the application thereof
  • Phosphatide compound of resveratrol compounds and method for preparing the same and the application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The phospholipid complex of resveratrol compound, its composition comprises: resveratrol compound and phospholipid, the weight and number ratio of described resveratrol compound and phospholipid is 1: 6, takes trans-resveratrol Add 1 g of retrol, 6 g of refined soybean lecithin, add 60 ml of acetone, heat and reflux at 70° C. and stir for 4 hours until the solution is clear, recover the solvent, and dry in vacuum to obtain the phospholipid complex of the resveratrol compound of the present invention , the compound is pulverized through an 80-mesh sieve for later use.

Embodiment 2

[0043] The phospholipid complex of resveratrol compounds described in Example 1 comprises: resveratrol compounds and phospholipids, and the ratio of parts by weight of said resveratrol compounds to phospholipids is 1:4 , take 1 g of trans-resveratrol glycosides, 4 g of lecithin, add 50 mL of methanol, heat and reflux at 80 ° C and stir for 4 hours until the solution is clear, recover the solvent, and dry in vacuum to obtain the resveratrol glycoside phospholipid complex of the present invention things. The compound is pulverized and passed through an 80-mesh sieve for later use.

Embodiment 3

[0045] The phospholipid complex of resveratrol compounds described in Example 1 comprises: resveratrol compounds and phospholipids, and the ratio of parts by weight of said resveratrol compounds to phospholipids is 1:4 , take 1 g of cis-resveratrol, 4 g of lecithin, add 40 mL of chloroform, heat and reflux at 60° C. and stir for 4 hours until the solution is clear, recover the solvent, and dry in vacuum to obtain the cis-resveratrol phospholipid complex of the present invention. things. The compound is pulverized and passed through an 80-mesh sieve for later use.

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Abstract

The invention relates to resveratrol phosphatide compound, the preparation method and its applciaiton. The resveratrol mainly comprises stilbenes parent nucleus, and is slightly soluble or insoluble in water, and is not stable. So the biological utilization rate is low and medical effect is reduced and the parenteral administration is limited. The key is to increase its solubility, so the resveratrol phosphatide compound is needed by market. The resveratrol phosphatide compound comprises resveratrol and phosphatide, with the weight proportion being 1: 0.5-50.The product can be used to prepare tablet, capsule, granule, suppository, injection, or freeze dried or compound tablet.

Description

technical field [0001] The invention relates to a medicine, in particular to a phospholipid complex of a resveratrol compound and its preparation method and application. Background technique [0002] Resveratrol (Reseveratrol), also known as 3,5,4'-trihydroxystilbene, is produced in grape leaf epidermis and berry pericarp, and is the result of the plant's response to fungal disease infection. It is in a free state (cis- , trans-) and glycoside-bound state (cis-, trans-) exist in two forms, and both have antioxidant properties. They are an important phytoalexin in grapes. Resveratrol compounds are generally obtained from Polygonum cuspidatum (RhizomaPolygoni Cuspidati) and grapes are extracted and isolated, and can also be obtained by synthesis. According to literature reports, resveratrol compounds have antioxidant capacity, can inhibit the synthesis of triglycerides, resist lipid peroxidation and scavenge free radicals, prevent aging, anti-tumor, protect cardiovascular, ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K31/7034A61K47/24A61P39/06A61P35/00A61P1/16A61P29/00A61P31/04
Inventor 李强赵学玲
Owner HEILONGJIANG UNIV
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