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Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof

A vaginal expansive suppository and Kangfu technology, which is applied in suppository delivery, pharmaceutical formulations, material inspection products, etc. It can solve problems such as difficult molding, unsatisfactory improvement of dissolution rate, and difficult cleaning.

Active Publication Date: 2013-09-18
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mixing of the above two kinds of substrates with the eight raw materials is uneven, and the viscosity is not enough, so it is not easy to form; because the dissolution rate of the above eight raw materials is not good, Li Fengqin et al. added polysorbate 80, but after the inventor's test It shows that its improvement effect on dissolution rate is still unsatisfactory
[0004] In addition, Kangfu Xiaoyan Suppository generally has the following problems: 1. It is not easy to clean, and it is easy to contaminate clothes; 2. The active drug has a small contact surface with the human body, resulting in insufficient absorption and not exerting the best curative effect of the prescription; 3. The drug works Fast, effective administration time is short

Method used

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  • Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof
  • Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof
  • Kangfu anti-inflammatory vaginal expansion suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097]

[0098] Preparation:

[0099] 1) Preparation of drug-containing matrix:

[0100] a. heating and melting the semi-synthetic litsea cubeba oil ester in a water bath to obtain a melt;

[0101] b. Preparation of active ingredients:

[0102] I weighed Sophora flavescens, Patrinia, Viola, Dandelion, Andrographis paniculata and Comfrey, decocted twice, decocted for 2 hours for the first time, 2 hours for the second time, combined the decoction, filtered, Concentrate into a clear paste, add 25% ethanol, let it stand for 24 hours, filter, recover the ethanol liquid, concentrate into a thick paste, dry at 70°C, and pulverize into fine powder; the water consumption for the first and second decoctions is respectively 10 times and 2 times the total weight of Patrinia, Viola, Andrographis paniculata, Dandelion and Comfrey; the amount of ethanol is 5 times that of Qing Gao;

[0103] II takes pig gall powder and aloe vera of prescription quantity, is ground into fine powder;

...

Embodiment 2

[0108]

[0109] Preparation method: make 1000 spherical suppositories according to the method in Example 1, each weighing about 1.7g.

Embodiment 3

[0111]

[0112] Preparation:

[0113] 1) Preparation of drug-containing matrix:

[0114] a. heating and melting semi-synthetic fatty acid glycerides and lanolin in a water bath to obtain a melt;

[0115] b. Preparation of active ingredients:

[0116] IV Weigh the prescription amount of Sophora flavescens, Patrinia, Viola, Dandelion and Comfrey, add water and decoct twice, decoct for 3 hours for the first time, decoct for 1 hour for the second time, combine the decoctions, filter, and concentrate into Clear the ointment, add 50% ethanol, let it stand for 16 hours, filter, recover the ethanol liquid, concentrate it into a thick ointment, dry it at 50°C, and pulverize it into fine powder; 6 times and 5 times of the total weight of Salmonella, Zihuadiding, Dandelion and Comfrey; the amount of ethanol is 4 times that of Qingpao;

[0117] V takes pig gall powder and aloe vera of prescription quantity, is ground into fine powder;

[0118] VI Pass the fine powder of steps Ⅰ and...

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Abstract

The invention relates to a Kangfu anti-inflammatory vaginal expansion suppository. The expansion suppository comprises active ingredients prepared from raw material medicines such as radix sophorae flavescentis, patrinia and Chinese violet, a matrix and an expansion carrier. The suppository is fully expanded, so that the medicine-containing matrix is fully contacted with the inner wall of the vagina, and external flow of the liquid medicine is avoided; the medicine-containing matrix in the expansion suppository also comprises a dispersing carrier, so that release of the active ingredients can be promoted, and the dissolution rate is improved. The invention also provides a preparation method and a detection method of the expansion suppository. The provided Kangfu anti-inflammatory vaginal expansion suppository employs seven ingenious advanced technologies and has the beneficial effects that the external flow of the liquid medicine is avoided, the stability is high, the effect is fast, the drug action time is long, and secondary infection is avoided.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and in particular relates to a Kangfu Xiaoyan vaginal expansion suppository, a preparation method and a detection method thereof. Background technique [0002] Kangfu Xiaoyan Suppository is included in the seventeenth volume of "Ministry of Health Drug Standards for Traditional Chinese Medicine Prescriptions", and it is also included in the Chinese Pharmacopoeia. Vaginal suppositories made of , comfrey (Xinjiang comfrey) and eight herbs of aloe vera; in the prescription, Sophora flavescens is used as the monarch drug, which can clear away heat and dampness, kill insects, relieve the heat of the burnt, and can dry dampness and stop belt; Herbs are ministerial medicines, clearing heat and detoxifying, cooling blood, promoting blood circulation, and reducing swelling; Patrinia, Dandelion, and Viola Dipin, clearing heat and detoxifying, cooling blood and removing blood stasis, dispelling stagnati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/02A61K47/46A61K47/32A61K47/34A61K47/10A61P15/00A61P15/02G01N33/15G01N5/04A61K35/413
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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