Toad peptide antibiotics separated from toad maggots and preparation method of antibacterial drugs thereof

Abstract

The invention provides toad peptide antibiotics separated from toad maggots and a preparation method of antibacterial drugs thereof. The preparation method comprises the following steps: taking toad maggots as raw materials; carrying out ultrafiltration and microfiltration, gel chromatography separation, ultrasonic standing wave liquid preparation chromatography and the like by adopting a solvent extraction method and an ion-exchange resin adsorption method; freeze-drying to prepare the toad peptide antibiotics; and combining the active components with appropriate excipients to prepare tablets, capsules, suppositories, ointments, enteric tablets and the like to be used for treating various diseases. The drugs prepared by the invention have the advantages of wide antibacterial range, specific drug components, controllable quality and stable performance and have industrial production values.

Description

Toad maggot isolation toadin antibiotic and preparation method of antibacterial medicine Technical field The invention relates to the preparation of a medicine, in particular to a toad maggot isolated toadin antibiotic and a preparation method of the antibacterial medicine. Background technique Toads are amphibians with long exposed skin. In order to resist the invasion of external microorganisms and various pathogens, their bodies gradually form a defense mechanism. Their skin secretes a large amount of substances that can effectively kill microorganisms and resist the invasion of harmful environmental factors. The main component of secretions is peptides. Zasloff discovered the Xenopus antibacterial peptide Magainin from the skin of Xenopus laevis. Gibson et al. isolated the antibacterial peptides of the Bombinirlike family from the skin of toads, and successively extracted them from the skin secretions of local frogs in Australia. To the various antibacterial peptides of th...

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