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Progestational hormone composition, and its slow-release suppository device and preparation of said device

A composition and progestogen technology, which are applied in the field of sustained-release suppository devices and progestogen compositions, can solve the problems of not being able to control the amount of drug release well, affecting the control of mass production of livestock, and contusion of receptors by drug delivery devices. , to achieve the effect of simple manufacturing method, reduced adhesion and ingenious technology

Inactive Publication Date: 2007-01-10
天津市中意畜牧科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The main problem of the known technology is that the drug device is easy to adhere to the vaginal wall and cannot control the drug release well; in addition, the contusion of the receptor by the drug delivery device causes the receptor to cause inflammation, thereby affecting the mass production of livestock. control

Method used

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  • Progestational hormone composition, and its slow-release suppository device and preparation of said device
  • Progestational hormone composition, and its slow-release suppository device and preparation of said device
  • Progestational hormone composition, and its slow-release suppository device and preparation of said device

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0083] Preparation of a slow-release suppository device:

[0084]Prepare the progestogen composition according to the aforementioned progestogen composition preparation method, measure the progestogen composition of proportioning amount, and measure the silica gel sheet of proportioning amount. The hardness of the silica gel is most suitable at 30 degrees. Spread the material evenly on the silica gel sheet, then fold the silica gel sheet in half towards the direction where the progesterone composition layer is laid, and flatten it, so that the progestin composition is evenly sandwiched between the two layers of silica gel sheets, and the progestin composition layer will be sandwiched The silica gel sheet of the material layer is put into a mixer and mixed until uniform, the mixing speed is 20-40 rpm, and the mixing time is 8-15 minutes, which is more suitable;

[0085] In particular, kneading for 10 minutes at a speed of 30 rpm to fully mix the progesterone composition and sil...

experiment example

[0090] Place the above-mentioned formed drug combination device in the deep vagina of the ewe, take it out after 13 days, and wash the place where it is placed with physiological saline containing antibiotics, and test it with a test ram after 12 hours.

[0091] 1. Comparative experiment on estrus rate of livestock:

[0092] test group

Comparison group A

Comparison group B

Handle only number

Estrus only counts

50 pieces

48 (96%)

50 pieces

44 (88%)

50

40(80％)

[0093] Compared with the comparison group A, the estrus rate of the sheep in the experimental group is 8 percentage points higher than that of the comparison group B, and the sheep estrus rate is 16 percentage points higher, which shows that the use of the present invention has a prominent effect on the synchronous estrus of female animals.

[0094] 2. Contrast experiment of simultaneous estrus in livestock:

[0095] test group

Comparison...

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Abstract

The present invention relates to a progestogen composition. Said progestogen composition is formed from 27-31% of fluoropregestin, 2-2.7% of ethinyl estradiol, 8-10% of lauric acid, 37-40% of ethyl alcohol, 0.3-0.6% of carbomer and 6-10% of propylene glycol, and the rest is pure water. Besides, said invention also provides the delayed-release suppository device of said progestogen composition and its preparation method.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a progesterone composition for promoting estrus synchronization in livestock such as cattle and sheep, a slow-release suppository device with the composition, and preparation of the device. Background technique [0002] In the animal husbandry industry, the estrus of female livestock is periodically treated, and some hormone preparations are used to artificially control and adjust the process of a group of female livestock, such as the estrus cycle of ewes, so that they can concentrate on estrus within a predetermined time, so that there is a plan Reasonable organization of mating is an important task in the industrialization of animal husbandry. [0003] There are usually two types of estrus synchronous drugs currently used in livestock, one is preparations for inhibiting estrus, which belong to progestin substances, such as progesterone,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/569A61K9/02A61P15/08A61K31/565
Inventor 冯建忠张效生
Owner 天津市中意畜牧科技发展有限公司
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