Rumex hanus plant compounded tablet candy for dispelling effects of alcohol and protecting liver and preparation method of Rumex hanus plant compounded tablet candy

Abstract

The invention discloses a rumex hanus plant compounded tablet candy capable of dispelling the effects of alcohol and protecting the liver and a preparation method of the rumex hanus plant compounded tablet candy capable of dispelling the effects of alcohol and protecting the liver. Comprising the following raw materials in parts by weight: 15-25 parts of rumex hanus, 10-20 parts of arabinose, 10-15 parts of radix puerariae powder, 8-12 parts of hovenia dulcis thunb powder, 8-10 parts of silybum marianum seed oil microcapsule powder, 5-8 parts of L-glutamine, 3-5 parts of an acid-base regulator and 13-20 parts of auxiliary materials. The invention relates to rumex hanus plant compounded tablet candies capable of dispelling effects of alcohol and protecting liver. According to the invention, rumex hanus is taken as a core raw material, and through component compounding and process optimization, the tabletted candy which takes the rumex hanus active component as a leading component and has multiple target points for dispelling effects of alcohol and protecting liver is prepared, so that triple effects of intestinal barrier protection, alcohol metabolism acceleration and hepatocyte repair are realized. The prepared functional food with rumex hanus as the core is used for preventing drunkenness before drinking, reducing alcohol absorption during drinking, accelerating sobering after drinking and repairing liver and intestine injury caused by alcohol, and is particularly suitable for high-frequency drinking crowds and crowds with vulnerable liver functions.

Description

Technical Field

[0001] The invention relates to a candy for sobering up and protecting the liver and a preparation method thereof, in particular to a candy for sobering up and protecting the liver compounded with foliage plants and a preparation method thereof. Background Art

[0002] Rumex spp. (Rumex spp.) is rich in protein (28%-36%), polyphenols (such as flavonoids and quercetin), minerals (calcium, iron, and zinc), and vitamins (such as vitamin C and B vitamins). Modern research indicates that its extract can alleviate liver damage by inhibiting the NF-κB inflammatory pathway and improve intestinal mucosal barrier function by promoting the growth of intestinal lactobacilli. However, the current use of umbellifer in functional foods is limited to primary additions, and systematic formulation design with umbellifer as the core has not yet been established.

[0003] The pathological mechanism of alcoholic liver damage involves a dysregulation of the "gut-liver axis," whereby alcohol damages the intestinal mucosal barrier, leading to the entry of endotoxins into the liver and triggering an inflammatory response. The polyphenols in edible grasses can scavenge free radicals (such as hydroxyl radicals) produced by alcohol metabolism, and the amino acids they contain (such as leucine) can promote mitochondrial repair in liver cells, making them ideal core liver-protecting ingredients. However, existing alcohol-detoxifying and liver-protecting products have the following drawbacks: 1) Single core ingredient, insufficient synergistic protection of the liver and intestine: Most of the alcohol-relieving and liver-protecting products on the market are centered around Pueraria root, milk thistle, etc., and lack in-depth development of plant resources such as edible leaf grasses that have both high nutrition and strong antioxidant properties, making it difficult to achieve "intestine-liver" dual-organ linkage protection.

[0004] 2) Insufficient utilization of the active ingredients of foliage grass: In existing technologies, foliage grass (or similar plants) are mostly added as auxiliary ingredients, and no exclusive process is designed for its protein, polyphenols, minerals and other components, resulting in the failure to fully utilize its core functions such as anti-oxidation and mucosal repair.

[0005] 3) The formulation process does not match the characteristics of phyllostachys: phyllostachys contains heat-sensitive ingredients. Traditional high-temperature granulation or long-term drying can easily lead to active degradation. In addition, the existing formula does not solve the compatibility problem with other ingredients (such as milk thistle seed oil microcapsule powder), affecting product stability. Summary of the Invention

[0006] In order to solve the deficiencies of the above technologies, the present invention provides a leafy herb compound alcohol-relieving and liver-protecting compressed candy and a preparation method thereof.

[0007] In order to solve the above technical problems, the technical solution adopted by the present invention is: a foliage plant compound alcohol-relieving and liver-protecting compressed candy, comprising the following raw materials in parts by weight: 15-25 parts of foliage plants, 10-20 parts of arabinose, 10-15 parts of kudzu root powder, 8-12 parts of Hovenia dulcis powder, 8-10 parts of milk thistle seed oil microcapsule powder, 5-8 parts of L-glutamine, 3-5 parts of acid-base regulator, and 13-20 parts of auxiliary materials.

[0008] Preferably, the raw materials include the following parts by weight: 18-22 parts of edible leaf grass, 13-17 parts of arabinose, 11-14 parts of kudzu root powder, 9-11 parts of Hovenia dulcis powder, 8.5-9.5 parts of milk thistle seed oil microcapsule powder, 5.5-7.5 parts of L-glutamine, 3.5-4.5 parts of acid-base regulator, and 15-18 parts of auxiliary materials.

[0009] Preferably, the acid-base regulator is citric acid and sodium citrate in a mass ratio of 3:1.

[0010] Preferably, the auxiliary materials include: 12-18 parts of microcrystalline cellulose and 1-2 parts of stearic acid.

[0011] A leafy herb compound alcohol-relieving and liver-protecting compressed candy comprises the following steps: Step S1, pretreatment of the foliage grass: ultrafinely grinding and sieving the freeze-dried foliage grass leaves, and then sealing and refrigerating them for later use to prevent oxidation of the active ingredients; Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: adding the edible grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder into a mixer with a cooling jacket in sequence and mixing them evenly; Add ethanol solution to the above mixture, make a soft material, sieve it through a mesh screen to make wet granules, and dry it; Among them, the soft material for making soft materials refers to the wet granular material made by wet granulation process in the pharmaceutical process; Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder pre-mixed with microcrystalline cellulose, L-glutamine, acid-base regulator, and stearic acid to the dried wet granules in sequence, and mixing for 15-25 minutes; The mixture is compressed into 0.5-0.8 g / tablet using a variable frequency tablet press, thereby increasing the proportion of the effective ingredients of the leaf-eating grass, with a hardness of 9-11 kg, taking into account both disintegration and portability.

[0012] Preferably, in step S1, the leafy grass is crushed to 115-125 mesh to retain the integrity of the cell wall and delay the release of polyphenols, and the temperature of the sealed refrigerated storage is ≤4°C.

[0013] Preferably, in step S3, the temperature of the mixer is controlled at 25±2° C., and the mixture is mixed at a low speed of 10-20 r / min for 30-50 min to prevent mechanical heat from damaging the structure of the chlorophyll protein.

[0014] Preferably, in step S3, the volume fraction of the ethanol solution is 50%, the ethanol solution contains 0.1% vitamin C as a stabilizer, and is dried at 45-55° C. for 4.5-5.5 hours to a moisture content of ≤4%, and the mesh size of the sieve is 22-26 meshes.

[0015] Preferably, in step S4, the pressure gradient adjustment range is: initial 8 kN → peak 10 kN → end 9 kN.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1) The specific weight ratio of ophiopogon japonicum to arabinose and silymarin forms an ophiopogon japonicum-dominated ternary compound system of "intestinal absorption inhibition, liver cell protection, and antioxidant effects." The polyphenols in ophiopogon japonicum work synergistically with silymarin to enhance the antioxidant capacity of liver cells. 2) Gut-liver axis synergistic mechanism: The combination of soluble dietary fiber from leafy grasses and L-glutamine indirectly mitigates liver damage by regulating intestinal flora and repairing the intestinal mucosa. Leafy grass protein and L-glutamine work together to repair the gastrointestinal mucosa, reducing alcohol-induced intestinal irritation and, in turn, reducing the liver's detoxification burden. 3) A combination of ultra-fine grinding (120 mesh), low-temperature mixing (≤25°C), and drying at a temperature limit of 50°C for freeze-dried phyllostachys maximizes the activity of its polyphenols and proteins. A proprietary low-temperature granulation process retains more than 95% of the active ingredients in the phyllostachys, ensuring the product's stable efficacy throughout its 24-month shelf life. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION

[0018] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0019] In the prior art, edible grass is only added as ordinary plant powder (usually ≤5 parts). The present invention uses edible grass as the first core ingredient (15-25 parts). Its polyphenol content (≥5 mg / g) is three times that of similar products, and its antioxidant capacity (DPPH scavenging rate) is increased by 45% (experimental data: IC50 of the product of the present invention = 1.2 mg / mL, IC50 of the comparative product = 2.2 mg / mL).

[0020] This invention is the first to achieve intestinal flora regulation (40% proliferation of Lactobacillus), intestinal mucosal repair (30% increase in ZO-1 protein expression) and liver cell protection (improved liver cell survival rate at an alcohol concentration of 50mM) through the combination of "dietary fiber + polyphenols + protein" of edible grass, covering two more key targets than single-ingredient products.

[0021] Breakthrough in activity retention: The low-temperature process of the present invention enables the retention rate of foliar grass polyphenols to reach 92% (75% for traditional process), and the stability test 6 months after tableting shows that the polyphenol content has only decreased by 3% (the comparison product decreased by 15%), ensuring the long-term effect of taking.

[0022] Example 1 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 15g foliage-based herb, 10g arabinose, 10g kudzu root powder, 8g hovenia dulcis fruit powder, 8g milk thistle seed oil microcapsule powder, 5g L-glutamine, 3g citric acid and sodium citrate in a mass ratio of 3:1, 12g microcrystalline cellulose, and 1g stearic acid.

[0023] A leafy herb compound alcohol-relieving and liver-protecting compressed candy, such as Figure 1 As shown, the following steps are included: Step S1, pretreatment of phyllophagous grass: ultrafinely crush the freeze-dried phyllophagous grass leaves to 115 mesh, sieve, seal and refrigerate to ≤4°C for later use.

[0024] Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: add the edible grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder in sequence into a mixer with a cooling jacket and mix at a low speed of 10 r / min for 30 minutes; the temperature of the mixer is controlled at 25° C. Add 50% by volume ethanol solution containing 0.1% vitamin C as a stabilizer to the above mixture, make a soft material, pass through a 22-mesh sieve to make wet granules, and dry at 45°C for 4.5 hours to a moisture content of ≤4%; Protein protection mechanism: The denaturation temperature of foliage grass protein is 35°C. Controlling the mixer temperature at 25°C can avoid the destruction of the protein secondary structure caused by mechanical heat accumulation (DSC detection shows that the protein thermal denaturation peak does not shift after treatment at 25°C).

[0025] 50°C is the upper limit of the temperature tolerance of foliage grass polyphenols; The effects of adding vitamin C include the following two aspects: 1) Antioxidant mechanism: Vitamin C can preferentially react with oxygen free radicals in the system, protecting foliar polyphenols (such as quercetin) from oxidation and maintaining their free radical scavenging activity.

[0026] 2) Stability data: The polyphenol retention rate in the experimental group supplemented with vitamin C increased by 17% compared to the group without vitamin C (tested after 2 weeks of accelerated testing at 45°C).

[0027] Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder pre-mixed with microcrystalline cellulose, L-glutamine, acid-base regulator, and stearic acid to the dried wet granules in sequence, and mixing for 15 minutes; A variable frequency tablet press was used with a pressure gradient adjustment range of: initial 8 kN → peak 10 kN → end 9 kN. The mixture was pressed into 0.5 g / tablets with a hardness of 9 kg.

[0028] Since the particle size of milk thistle seed oil microcapsule powder is small (about 5-10μm), direct addition is prone to electrostatic adsorption, resulting in uneven mixing. After it is premixed with microcrystalline cellulose (porous structure carrier), its dispersibility can be increased through physical adsorption, avoiding component segregation during tableting.

[0029] Experimental verification: Comparing the content uniformity of the premixed and non-premixed groups, the standard deviation of silymarin content in the premixed group was <2%, while that in the non-premixed group reached 8% (data from 3 batches of parallel experiments).

[0030] Leafy grasses provide polyphenols (≥5%), proteins (≥20%), and minerals, which can scavenge free radicals, repair liver cell membranes, and regulate intestinal flora; Arabinose synergizes with foliage polyphenols to inhibit intestinal sucrase activity, reduce alcohol absorption, and simultaneously proliferate bifidobacteria that foliage promotes growth; Pueraria root powder (40% puerarin) further enhances the activity of alcohol dehydrogenase and accelerates alcohol metabolism based on the activation of liver cells by foliar grass protein; The saponins in Hovenia dulcis powder (saponins 20%) combine with the flavonoids in the herb to inhibit the gastric mucosal alcohol transporter (AQP9), delaying the entry of alcohol into the blood; The silymarin in milk thistle seed oil microcapsule powder (60% silymarin) and foliar herb polyphenols form a "membrane protection-antioxidation" double defense line, stabilizing liver cell membranes and scavenging acetaldehyde-induced ROS; L-glutamine works synergistically with glutamic acid in leafy grasses to quickly repair alcohol-damaged intestinal villi and strengthen the protection of the "gut-liver axis"; The acid-base regulator adjusts the pH to 4.8-5.2, which is suitable for the optimal stabilization environment of edible grass polyphenols and improves the taste; Microcrystalline cellulose is used as a carrier for the leaf-eating grass powder to enhance the compressibility of the particles, and its porous structure facilitates the rapid dissolution of the active ingredients of the leaf-eating grass; Stearic acid can reduce the adhesion of leaf-eating grass powder to equipment, ensuring uniform distribution of ingredients during tableting.

[0031] Leafy grass polyphenols (quercetin, chlorogenic acid) directly remove hydroxyl radicals (・OH) produced by alcohol metabolism, inhibiting lipid peroxidation and reducing the production of MDA (malondialdehyde) by 35%; Leafy grass protein (containing methionine) acts as a methyl donor, promoting the synthesis of glutathione (GSH) in the liver and enhancing the detoxification ability of liver cells (GSH-Px glutathione peroxidase activity increased by 28%).

[0032] The soluble dietary fiber in leafy grass (accounting for 8%-10%) provides a substrate for intestinal probiotics (such as Lactobacillus, whose growth is promoted by leafy grass), with a proliferation rate of 40%, inhibiting endotoxin-producing Bacteroides and reducing portal vein endotoxin levels by 25%; L-glutamine and free amino acids from foliage (leucine, isoleucine) work together to repair intestinal mucosal tight junction proteins (ZO-1, Occludin), reducing intestinal permeability by 30% and cutting off the pathway of "intestinal toxins damaging the liver."

[0033] Ultrafine grinding preserves the cell walls of foliage grasses, achieving sustained release of polyphenols (dissolution rate reaches 75% in 2 hours, 20% higher than traditional grinding process); The low-temperature mixing and drying process enables the retention rate of foliage grass polyphenols to reach 92% (about 75% in traditional processes) and the protein denaturation rate to be less than 5%.

[0034] This invention uses ophiopogon as its core ingredient. Through ingredient compounding and process optimization, it produces a multi-target synergistic, alcohol-detoxifying, liver-protecting compressed candy, primarily based on the active ingredients of ophiopogon. The product achieves the triple benefits of "intestinal barrier protection, accelerated alcohol metabolism, and liver cell repair." This functional food, with ophiopogon as its core ingredient, is used to prevent drunkenness before drinking, reduce alcohol absorption during drinking, accelerate sobering after drinking, and repair alcohol-induced liver and intestinal damage. It is particularly suitable for frequent drinkers and those with vulnerable liver function.

[0035] Example 2 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 25g of foliage-based herb, 20g of arabinose, 15g of kudzu root powder, 12g of hovenia dulcis fruit powder, 10g of milk thistle seed oil microcapsule powder, 8g of L-glutamine, 5g of citric acid and sodium citrate in a mass ratio of 3:1, 18g of microcrystalline cellulose, and 2g of stearic acid.

[0036] A leafy herb compound alcohol-relieving and liver-protecting compressed candy comprises the following steps: Step S1, pretreatment of phyllophagous grass: ultrafinely crush the freeze-dried phyllophagous grass leaves to 125 mesh, sieve, seal and refrigerate to ≤4°C for later use.

[0037] Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: add the edible grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder in sequence into a mixer with a cooling jacket and mix at a low speed of 20 r / min for 50 minutes; the temperature of the mixer is controlled at 27° C. Add 50% by volume ethanol solution containing 0.1% vitamin C as a stabilizer to the above mixture, make a soft material, pass through a 26-mesh sieve to make wet granules, and dry at 55°C for 5.5 hours to a moisture content of ≤4%; Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder premixed with microcrystalline cellulose, L-glutamine, a pH regulator, and stearic acid to the dried wet granules in sequence, and mixing for 25 minutes; A variable frequency tablet press was used with a pressure gradient adjustment range of: initial 8 kN → peak 10 kN → end 9 kN. The mixture was pressed into 0.8 g / tablets with a hardness of 11 kg.

[0038] Example 3 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 20g of foliage-based herb, 15g of arabinose, 12g of kudzu root powder, 10g of hovenia dulcis fruit powder, 9g of milk thistle seed oil microcapsule powder, 6g of L-glutamine, 4g of citric acid and sodium citrate in a mass ratio of 3:1, 15g of microcrystalline cellulose, and 1.5g of stearic acid.

[0039] A leafy herb compound alcohol-relieving and liver-protecting compressed candy comprises the following steps: Step S1, pretreatment of phyllophagous grass: ultrafinely crush the freeze-dried phyllophagous grass leaves to 120 mesh, sieve, seal and refrigerate for later use, and the sealed and refrigerated storage temperature is ≤4°C.

[0040] Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: add the leafy grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder in sequence into a mixer with a cooling jacket and mix at a low speed of 15 r / min for 40 minutes; the temperature of the mixer is controlled at 26° C. Add 50% by volume ethanol solution containing 0.1% vitamin C as a stabilizer to the above mixture, make a soft material, pass through a 24-mesh sieve to make wet granules, and dry at 50°C for 5 hours to a moisture content of ≤4%; Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder premixed with microcrystalline cellulose, L-glutamine, a pH regulator, and stearic acid to the dried wet granules in sequence, and mixing for 20 minutes; A variable frequency tablet press was used with a pressure gradient adjustment range of: initial 8 kN → peak 10 kN → end 9 kN. The mixture was pressed into 0.6 g / tablets with a hardness of 10 kg.

[0041] Example 4 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 16g foliage-based herb, 12g arabinose, 11g kudzu root powder, 9g hovenia dulcis fruit powder, 8g milk thistle seed oil microcapsule powder, 7g L-glutamine, 4g citric acid and sodium citrate in a mass ratio of 3:1, 13g microcrystalline cellulose, and 1g stearic acid.

[0042] A leafy herb compound alcohol-relieving and liver-protecting compressed candy comprises the following steps: Step S1, pretreatment of phyllophagous grass: ultrafinely crush the freeze-dried phyllophagous grass leaves to 117 mesh, sieve, seal and refrigerate for later use, and the sealed and refrigerated storage temperature is ≤4°C.

[0043] Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: add the edible grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder in sequence into a mixer with a cooling jacket and mix at a low speed of 12 r / min for 35 minutes; the temperature of the mixer is controlled at 25° C. Add 50% by volume ethanol solution containing 0.1% vitamin C as a stabilizer to the above mixture, make a soft material, pass through a 23-mesh sieve to make wet granules, and dry at 50°C for 5 hours to a moisture content of ≤4%; Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder premixed with microcrystalline cellulose, L-glutamine, a pH regulator, and stearic acid to the dried wet granules in sequence, and mixing for 20 minutes; A variable frequency tablet press was used with a pressure gradient adjustment range of: initial 8 kN → peak 10 kN → end 9 kN. The mixture was pressed into 0.7 g / tablets with a hardness of 9 kg.

[0044] Example 5 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 23g of foliage-based herb, 18g of arabinose, 14g of kudzu root powder, 11g of hovenia dulcis fruit powder, 10g of milk thistle seed oil microcapsule powder, 7g of L-glutamine, 4g of citric acid and sodium citrate in a mass ratio of 3:1, 16g of microcrystalline cellulose, and 2g of stearic acid.

[0045] The preparation method of the alcohol-relieving and liver-protecting compressed candy in this example is the same as that in Example 3.

[0046] Example 6 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 19g foliage-based herb, 14g arabinose, 12g kudzu root powder, 10g hovenia dulcis fruit powder, 8g milk thistle seed oil microcapsule powder, 5g L-glutamine, 4g citric acid and sodium citrate in a mass ratio of 3:1, 14g microcrystalline cellulose, and 1g stearic acid.

[0047] The preparation method of the alcohol-relieving and liver-protecting compressed candy in this example is the same as that in Example 3.

[0048] Example 7 A foliage-based herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 21g of foliage-based herb, 16g of arabinose, 13g of kudzu root powder, 9g of hovenia dulcis fruit powder, 10g of milk thistle seed oil microcapsule powder, 8g of L-glutamine, 4g of citric acid and sodium citrate in a mass ratio of 3:1, 15g of microcrystalline cellulose, and 2g of stearic acid.

[0049] The preparation method of the alcohol-relieving and liver-protecting compressed candy in this example is the same as that in Example 3.

[0050] Comparative Example 1 A leafy herb compounded alcohol-relieving and liver-protecting compressed candy comprises the following raw materials in the following formula amounts: 16g of arabinose, 13g of kudzu root powder, 9g of hovenia dulcis fruit powder, 10g of milk thistle seed oil microcapsule powder, 8g of L-glutamine, 4g of citric acid and sodium citrate in a mass ratio of 3:1, 15g of microcrystalline cellulose, and 2g of stearic acid.

[0051] The preparation method of the alcohol-relieving and liver-protecting compressed candy in this embodiment is the same as that in Example 1.

[0052] The hangover symptom relief effect of the present invention was tested using Example 1 and Comparative Example 1.

[0053] 1. Reduced MDA production Experimental method: An alcohol metabolism model (ethanol + NADPH system) was constructed in vitro, and the compressed candy extract prepared in Example 1 of the present invention (concentration 1 mg / mL) was added to detect the content of the lipid peroxidation product MDA.

[0054] Comparative data: The MDA content in the control group was 2.3 nmol / mL, while that in the experimental group was 1.5 nmol / mL, with an inhibition rate of 34.8% (n=6, P<0.05). 2. Increased GSH-Px activity Experimental model: C57BL / 6 mice were gavaged with ethanol (5 g / kg) and then administered with the product prepared in Example 1 of the present invention (200 mg / kg). The glutathione peroxidase activity in the liver tissue was detected.

[0055] Results: The GSH-Px activity in the model group was 12.5 U / mg prot, and that in the experimental group was 15.9 U / mg prot (n=8, P<0.01).

[0056] 3. Lactobacillus proliferation rate reaches 40% In vitro culture experiment: The extract of phalaenopsis (1% concentration) was added to the Lactobacillus culture medium and cultured anaerobically at 37°C for 24 hours. The colony count showed that the OD600 value increased from 0.3 to 0.42, and the proliferation rate was 40% (vs. the blank group).

[0057] 4. Reduced intestinal permeability Animal experiments: After rats were gavaged with alcohol, intestinal mucosal permeability (expressed as sodium fluorescein permeability) was measured. The permeability in the experimental group was 0.21±0.03, while that in the model group was 0.30±0.04, a decrease of 29.7% (n=6, P<0.05).

[0058] 5. Sustained release effect of ultrafine grinding (2h dissolution rate 75%) Testing method: Using the paddle method (rotation speed 100 rpm, pH 1.2 buffer), the polyphenol dissolution rate of 120 mesh crushing was compared with that of traditional 80 mesh crushing.

[0059] Data comparison: The 2h dissolution rate of the 120-mesh group was 75%, and that of the 80-mesh group was 55%, an increase of 20% (n=3). 6. Activity retention rate of low temperature process (polyphenol retention rate 92%) Accelerated experiments: Samples were placed in an environment of 60°C and 75% humidity for one month, and polyphenol content was measured. The low-temperature process group retained 92% of the polyphenol content, while the traditional high-temperature granulation group only retained 75% (n=3, P<0.01).

[0060] The above embodiments are not limitations of the present invention, and the present invention is not limited to the above examples. Any changes, modifications, additions or substitutions made by technicians in this technical field within the scope of the technical solution of the present invention also fall within the scope of protection of the present invention.

Claims

1. A leafy herbaceous plant compounded alcohol-relieving and liver-protecting compressed candy, characterized by: The invention comprises the following raw materials in parts by weight: 15-25 parts of edible leaf grass, 10-20 parts of arabinose, 10-15 parts of kudzu root powder, 8-12 parts of hovenia dulcis fruit powder, 8-10 parts of milk thistle seed oil microcapsule powder, 5-8 parts of L-glutamine, 3-5 parts of acid-base regulator and 13-20 parts of auxiliary materials.

2. The leafy herb compound alcohol-relieving and liver-protecting compressed candy according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 18-22 parts of edible leaf grass, 13-17 parts of arabinose, 11-14 parts of kudzu root powder, 9-11 parts of hovenia dulcis fruit powder, 8.5-9.5 parts of milk thistle seed oil microcapsule powder, 5.5-7.5 parts of L-glutamine, 3.5-4.5 parts of acid-base regulator and 15-18 parts of auxiliary materials.

3. The leafy herb compound alcohol-relieving and liver-protecting compressed candy according to claim 2, characterized in that: The acid-base regulator is citric acid and sodium citrate in a mass ratio of 3:

1.

4. The leafy herb compound alcohol-relieving and liver-protecting compressed candy according to claim 3, characterized in that: The auxiliary materials include: 12-18 parts of microcrystalline cellulose and 1-2 parts of stearic acid.

5. A method for preparing the leaf-eating herbaceous plant-based alcohol-relief and liver-protecting compressed candy according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step S1, pretreatment of the foliage grass: ultrafinely grinding and sieving the freeze-dried foliage grass leaves, and then sealing and refrigerating them for later use to prevent oxidation of the active ingredients; Step S2, weighing ingredients: weighing the formulated amounts of edible leaf grass, arabinose, kudzu root powder, Hovenia dulcis fruit powder, milk thistle seed oil microcapsule powder, L-glutamine, acid-base regulator, microcrystalline cellulose, and stearic acid respectively; Step S3, low-temperature mixing and granulation: adding the edible grass powder, arabinose, kudzu root powder, and Hovenia dulcis powder into a mixer with a cooling jacket in sequence and mixing them evenly; Add ethanol solution to the above mixture, make a soft material, sieve it through a mesh screen to make wet granules, and dry it; Step S4, total mixing and tableting: adding milk thistle seed oil microcapsule powder pre-mixed with microcrystalline cellulose, L-glutamine, acid-base regulator, and stearic acid to the dried wet granules in sequence, and mixing for 15-25 minutes; The mixture is compressed into 0.5-0.8 g / tablet using a variable frequency tablet press, thereby increasing the proportion of the effective ingredients of the leaf-eating grass, with a hardness of 9-11 kg, taking into account both disintegration and portability.

6. The method for preparing the leafy herb compound alcohol-relieving and liver-protecting compressed candy according to claim 5, characterized in that: In step S1, the leafy grass is crushed to 115-125 meshes to retain the integrity of the cell wall and delay the release of polyphenols, and the temperature of the sealed and refrigerated storage is ≤4°C.

7. The method for preparing the leafy herbaceous plant compound alcohol-relieving and liver-protecting compressed candy according to claim 5, characterized in that: In step S3, the temperature of the mixer is controlled at 25±2° C., and the mixture is mixed at a low speed of 10-20 r / min for 30-50 min to prevent mechanical heat from damaging the structure of the chlorophyll protein.

8. The method for preparing the leafy herbaceous plant compound alcohol-relieving and liver-protecting compressed candy according to claim 5, characterized in that: In step S3, the volume fraction of the ethanol solution is 50%, the ethanol solution contains 0.1% vitamin C as a stabilizer, and is dried at 45-55° C. for 4.5-5.5 hours to a moisture content of ≤4%, and the mesh size of the sieve is 22-26 meshes.

9. The method for preparing the leafy herbaceous plant compound alcohol-relieving and liver-protecting compressed candy according to claim 5, characterized in that: In step S4, the pressure gradient adjustment range is: initial 8 kN → peak 10 kN → end 9 kN.

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