Antioxidative peptide of nanorana pleskei and application of antioxidant peptide

By extracting and preparing antioxidant peptides from alpine wool frogs, the skin aging and damage caused by ultraviolet radiation is solved, and effective antioxidant and anti-inflammatory protection is achieved on the skin.

CN119899256AActive Publication Date: 2025-04-29SICHUAN DINGKE PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202510310524.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-17
Publication Date
2025-04-29
Estimated Expiration
2045-03-17

AI Technical Summary

Technical Problem

The prior art is difficult to effectively solve the skin aging and damage caused by ultraviolet radiation, especially in amphibians such as alpine wool frogs, which lack in-depth research and application of antioxidant peptides.

Method used

A cyclic peptide antioxidant peptide consisting of 29 amino acids is extracted from the alpine womb and prepared. This peptide has antioxidant and anti-inflammatory activity by forming disulfide bonds and can be used to prepare antioxidant or anti-inflammatory drugs, health care products, skin care products or cosmetics.

Benefits of technology

The antioxidant peptide of the alpine wool frog shows good anti-inflammatory and antioxidant effects, can protect DNA from oxidative damage, inhibit UVB-induced degradation of skin collagen fibers and inflammatory response, and alleviate skin damage in mice caused by ultraviolet radiation.

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Abstract

The invention discloses a nanorana alpine antioxidative peptide and application thereof. The antioxidative peptide is a cyclic peptide composed of 29 amino acids, the amino acid sequence of the antioxidative peptide is as shown in SEQ ID NO.1, and cysteine at the seventh position and cysteine at the twelfth position form an intramolecular disulfide bond. The invention further discloses nucleotide for coding the antioxidative peptide of the nanorana pleskei. The antioxidative peptide has good anti-inflammatory and anti-oxidation effects, can protect plasmid DNA damaged by H2O2, inhibits accumulation of CuSO4 induced zebrafish larva active oxygen and migration of neutrophil, and relieves mouse skin injury induced by UVB radiation.
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