139 results about "Increased sizes" patented technology

PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation period for a drug-PEG conjugate, followed by hydrolytic breakdown of the conjugate and release of the bound molecule. In some cases, drugs that demonstrate reduced activity when permanently coupled to PEG maintain a therapeutically suitable activity when coupled to a degradable PEG in accordance with the invention. The PEG derivatives of the invention can be used to impart improved water solubility, increased size, a slower rate of kidney clearance, and reduced immunogenicity to a conjugate formed by attachment thereto. Controlled hydrolytic release of the bound molecule into an aqueous environment can then enhance the drug's delivery profile by providing a delivery system which employs such polymers and utilizes the teachings provided herein.

Data items contained in personal information are displayed in manner that is indicative of both the importance and the urgency of the data items. A first visual cue is assigned to the data item based on an importance of the data item. The first visual cue may cause more important items to be displayed with increased size and less important items to be displayed with decreased size. A second visual cue is assigned to the data item based on an urgency of the data item. The second visual cue may cause more urgent items to be displayed in a first color and less important items to be displayed in a second color. The data item is displayed using the first and second visual cue as to provide a visual indication as to both the importance and urgency of the data item.

Switchable holographic optical elements (HOEs) can used in systems and methods for projecting three-dimensional images, or for projecting two-dimensional tiled images with increased size and / or resolution. One of the methods may include sequentially displaying first, second, and third color components of a first two-dimensional image at an object plane. The first two dimensional image represents a first slice of a three-dimensional image. As the first, second, and third color components are displayed, first, second and third HOEs may be activated so that the activated first switchable HOE focuses the first color component of the first two-dimensional image onto a first image plane, the activated second switchable HOE focuses the second color component of the first two-dimensional image onto the first image plane, and the wherein the activated third switchable HOE focuses the third color component of the first two-dimensional image onto the first image plane. It is noted that the first, second, and third HOEs may be activated concurrently or sequentially with the display of the first, second, or third color components of the first two-dimensional image. After the first, second, and third color components are displayed, the first, second and third switchable HOEs are deactivated. Then, first, second, and third color components of a second two-dimensional image are sequentially displayed. The second two-dimensional image represents a second slice of the three-dimensional image. A fourth switchable HOE may be activated to focus the first color component of the second two-dimensional image onto a second image plane. The second image plane is adjacent to the first image plane.

Nucleic acid sequencing methods and related devices, products and kits are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of the target nucleic acid, wherein the individual subunits comprise a probe and a reporter construct. The subunit encodes sequence information in its reporter construct that is less than sequence information in the corresponding portion of the target nucleic acid. The reduced information allows for reduced resolution requirements on the detection system and for increased size of resolvable reporter groups.

A method includes forming a plurality of trenches to define a fin, forming a first layer of insulating material in the trenches, forming a sidewall spacer on opposite sides of the fin above an upper surface of the first layer, removing the first layer and performing a fin-trimming etching process to define a plurality of increased-size trenches. The method also includes forming a first oxidation-blocking layer of insulating material in the increased-size trenches, forming a second layer of insulating material above the oxidation-blocking layer, and performing a thermal anneal process to convert at least a part of the portion of the fin that is in contact with the second layer of insulating material into an oxide fin isolation region