128results about How to "Avoid unfolding" patented technology

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stiched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stiched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stiched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.

A system for easily transferring an intraocular lens (IOL) from an inserter into a patient's eye. The system includes an inserter handpiece with a holding station for receiving or storing an IOL. The IOL may be pre-loaded within the holding station during manufacture, and the inserter handpiece coupled to a delivery tube so that the entire system is ready for use by a surgeon to implant an IOL. The IOL may have an optic and leading and trailing haptics coupled to the optic, and the holding station may be capable of manipulating the haptics as desired to facilitate transfer of the IOL through the delivery tube into the eye. For instance, the holding station may fold one or both of the haptics over the optic. Preferably, the holding station maintains the haptics in their folded positions during transfer of the IOL into the delivery tube. The holding station desirably maintains the IOL in a relaxed configuration during storage. A small opening on one side may be provided to introduce a narrow tool for folding one of the haptics over the optic.

A foldable bag, made of a flexible sheet or board like material having a plurality of fold lines, includes a bottom wall, two side walls respectively connected to two opposite sides of the bottom wall, and two connecting walls respectively connected with the side walls and the bottom wall to define a containing space therein. The side wall has a first fold line parallel to the bottom wall and is capable of being folded towards the center of the foldable bag. The connecting wall has two second fold lines respectively extended along the diagonal lines and intersected with each other, and a third fold line parallel to the bottom wall and extended through the intersection point of the two second lines, wherein the ends of the third fold line are connected to the respective ends of the first fold lines, wherein the second fold lines and the third fold lines are capable of being folded toward the center of the foldable bag.

A system for easily transferring an intraocular lens (IOL) from an inserter into a patient's eye. The system includes an inserter handpiece with a holding station for receiving or storing an IOL. The IOL may be pre-loaded within the holding station during manufacture, and the inserter handpiece coupled to a delivery tube so that the entire system is ready for use by a surgeon to implant an IOL. The IOL may have an optic and leading and trailing haptics coupled to the optic, and the holding station may be capable of manipulating the haptics as desired to facilitate transfer of the IOL through the delivery tube into the eye. For instance, the holding station may fold one or both of the haptics over the optic. Preferably, the holding station maintains the haptics in their folded positions during transfer of the IOL into the delivery tube. The holding station desirably maintains the IOL in a relaxed configuration during storage. A small opening on one side may be provided to introduce a narrow tool for folding one of the haptics over the optic.

The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.

The invention relates to β-catenin targeting peptides comprising an a-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.

A case for a portable display device is provided which can realize a large-sized screen by interconnecting a plurality of display elements. When the display elements are unfolded, the adjacent sides of the display elements closely contact each other, thereby minimizing the non-display area. When the display elements are folded, the outer surface of the display elements can be protected. The case includes a foldable panel housing receiving at least two flat display panel elements. The panel housing is provided with an opening such that when the panel housing is unfolded, the adjacent sides of the fiat display elements closes contact each other. The case further includes a hinge supporting member for providing the folding / unfolding operation of the panel housing and a cover for covering a side of the flat display elements, which is exposed through the opening, to protect the display elements.

A covering, such as a blanket or a poncho, that is successively convertible into and from a stadium seat cushion and a tote bag, employs a conversion means comprised of at least one fastening flap and at least one hanging pocket. The fastening flaps wrap around the folded covering and hold the folded covering in the desired configuration, while the hanging pocket holds small items or beverages while the user is using the folded covering as a seat cushion. The method of folding the covering to convert it from a blanket or poncho into a seat cushion and a tote bag is also described.

The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.

An articulated structure having a tubular inflatable casing that contains a fluid under pressure and that has a central axis along which there are defined at least one fixed-geometry segment and at least one variable-geometry segment, the arm including a deformation mechanism for deforming the variable-geometry segment, the casing and the deformation mechanism arranged so as to generate curvature of the variable-geometry segment in such a manner that the variable-geometry segment conserves a volume that is substantially constant. A robot arm including such a structure.

A release mechanism for stroller includes a seat portion comprising a pair of positioning bars disposed transversely for fixedly locking two sides of frame of baby stroller so as to extend the frame in an expanded position. A handle grip is disposed between the pair of positioning bars, wherein the handle grip forces the positioning bars to disengage from two sides of the frame so that the stroller can be folded in a collapsed position. A user has to carry the baby outside of the seat portion before folding the frame since the handle grip is arranged at the seat portion of baby stroller. The structure of the present invention has the advantages of not only folding the stroller by a single hand but avoiding the dangers which might be caused if the user accidentally and inadvertently folds the stroller upon operating.

The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.

The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.

A locking device for a carton comprising a first part and a second part complementary to the first part, the first part comprising a first panel (12) having an aperture for receiving the second part, the second part comprising a tab (22) coupled to a second panel, the tab having a fold line (15a, 15b) foldable to form a leading edge, the tab being inserted into the aperture in a folded condition, the tab comprising at least one engaging edge (30a, 30b) for engaging with the first panel.

The invention discloses a waterborne rescue device which comprises a hull, and a control module, airbags, airbag retractors, inflation valves and motors are arranged on the hull; the airbag retractorsare arranged at the outer sides of the hull, and the airbags are connected to the airbag retractors; and the control module is connected with the motors, the motors are respectively connected with the airbag retractors and the inflation valves, and the inflation valves are connected with the airbags. According to the waterborne rescue device, single chip microcomputers are utilized for controlling inflated airbags to complete automatic expansion, automatic shrinkage and inflation and deflation effects on the inflated airbags, lifesaving needs are met, the effect of independently supporting ato-be-rescued target below the to-be-rescued target under the condition that whether the to-be-rescued target has a self-rescue ability or not is unknown is achieved, and the rescue reliability is increased; and the airbags are controlled by rotating shafts of the motors to expand and shrink, thereby being convenient for switching between a working mode and a storage mode, convenient for storage and transport and safer.

A shim for a turbomachine blade is disclosed. The shim includes two branches which wrap around flanks of a blade root, and two tabs. Each of the tabs extend from one end of a respective one of the two branches. The tabs are folded towards each other and are interconnected in such a manner as to prevent them from unfolding. Advantageously, the shim includes a connection part which interconnects the tabs in such a manner as to prevent them from unfolding. The connection part is assembled to the tabs in such a manner as to allow the branches of the shim to spread apart. For example, the connection part can be suitable for stretching in the direction for spreading the branches apart.

A skywatcher's tripod has a seat mounted on a rider support that swivels 360 degrees on a base having upwardly foldable tripod legs. A post forms a forward end of the rider support. An extension arm configured to secure a tripod head for attachment of a surveillance device is axially slidable in a holder that is pivotally secured to the upper end of the post for rotation towards the seated user. The user sights on targets from horizon to zenith depending on the rotated position of the holder and the extension of the arm. The seat folds against the post outboard of the folded tripod legs and is held in folded position by a folded leg that abuts a handle that extends from a bottom side of the seat. The rider support includes a swivel lock and a combination holder / extension arm lock.

A damping mechanism comprises a first damping seat and a second damping seat which are fixed in relative positions in the longitudinal direction, is provided with a moving groove transversely arrangedon the first damping seat, a shaft rod capable of transversely moving in the moving groove, and a sliding block facing the first damping seat and elastically sliding on the second damping seat, the shaft rod comprises a spherical end part which faces the sliding block and protrudes out of the moving groove, the sliding block protrudes towards the spherical end part to form a protruding block, inclined faces are formed on the two transverse sides of the protruding block, and the spherical end part can cross the protruding block along the inclined faces in the moving process, so that the spherical end part is switched between the two states of the two transverse sides of the protruding block. The invention further provides a folding display device and communication equipment.

Disclosed is a manual tool capable of unfolding only one work accessory. The conventional manual tools may bring hidden risk to safety with more than two work accessories that may be unfolded simultaneously. According to the present invention, an associated accessory is arranged for a working state of a first work accessory and a second work accessory to transform from a folding state to an unfolding state; in the folding state where the first work accessory and the second work accessory are both folded, the associated accessory does not prevent any work accessory from unfolding; while in the unfolding state where one of the two work accessories is unfolded and the other one is folded, the associated accessory prevents the other one from unfolding, so as to ensure that only one work accessory can be unfolded during use, and if the unfolded work accessory is left unfolded, the other work accessory cannot be unfolded, thereby eliminating the safety risk caused by unfolding multiple work accessories at the same time.

The present invention provides ease of installation of toilet paper rolls on a vertical spindle sitting on a plate that prevents the unrolling of the paper. The floor free standing unit has a provision to store spare rolls on the pole, the spindle supports a decorative plate for decoration. A second unit is a wall mounted unit with a flex arm that could move the plate and spindle from right to left. A third is a wall mounted fixed unit. All three units are built with the same basic elements, plate and spindle. Each units' spindle supports a decorative plate.

Provided is a guide plate used for a side air bag. The guide plate comprises a fixing element fixed on the inner surface of the vehicle body, a bearing element bending from the lower end of the fixing element and extending to the passenger space of the vehicle, and a keeping element extending from the surface of the fixing element to the passenger space of the vehicle. The guide plate prevents the side air bag from extending upwards. The force unfolding the side air bag pipe is concentrated so as to allow the side air bag pipe to unfold correctly by opening the head lining.

The present invention provides a brick carrying handcart with a tension force adjusting function. The handcart comprises wheels, a brick accommodating part which is formed by a rear wall and two side walls; two bottom plate structures for closing or opening a brick supporting area; a movement part for opening the bottom plate structures to the two sides, wherein the movement part comprises a pair of rotating shafts passing through a support and a pair of connecting parts; a movement rod, the lower end of which is connected with an inner side of the connecting part through a first connecting ring; a movement lever arranged on the upper part of the movement rod and linked with the movement rod, the free end is provided with a handle, the connecting end is rotatingly connected with a first supporting part fixed on the rear wall plate; and a locking part provided with a locking device. Through adopting the handcart, bricks can be orderly entrucked, the bricks can be prevented from being damaged when unloading, the whole state of entrucking can be kept when unloading the bricks, the space flexible use and working can be enhanced, and beneficial effects can be realized.

An electrochemical cell includes a housing having a first end and a vent located at the first end that is configured to deploy from the housing to allow the expulsion of gases from within the cell. The electrochemical cell also includes at least one projection extending outward from the first end adjacent the vent. The at least one projection is configured to prevent accidental deployment of the vent.

A fastener device for fastening an article on a support plate, and the resulting assembly, which fastener device comprises: a hollow body that is secured to the support plate; a slider that is secured to the article and that is suitable for being engaged in the hollow body; and blocking means.The blocking means comprise both at least one side opening that passes through the hollow body and also an elastically-deformable blocking tab that is carried by the slider and that, during engagement of the slider in the hollow body, is for deploying sideways into the side opening and for bearing simultaneously beneath the support plate so as to oppose any longitudinal removal of the slider, and against the slider so as to oppose any longitudinal thrust of the slider, and thus define a first blocking position.

A driver assistance apparatus for a vehicle includes an object detection sensor that acquires data in at least one of a driving direction of the vehicle and around the vehicle. The driver assistance apparatus also includes a processor that detects, based on the acquired data, an object and determines, based on the acquired data, at least one attribute of the detected object. The processor detects that the vehicle has collided with the object and determines, based on detecting that the object has collided with the vehicle and based on the at least one attribute of the object, whether to perform a hood lift-up or pedestrian protection airbag deployment. The processor further provides a control signal for the hood lift-up or the pedestrian protection airbag deployment based on determining whether to perform the hood lift-up or the pedestrian protection airbag deployment.