177 results about "Non antibiotic" patented technology

A medical product is provided that is selected from at least one of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body. A coating is included with at least one of, a non-antibiotic, antimicrobial and / or antiviral substance that prevents further local, non-systemic, colonization of infections.

The present invention relates to a system for regulating gene expression in prokaryotes using modified tetracycline repressor proteins. In particular, the present invention relates to modified tetracycline repressor proteins that exhibit a "reverse" phenotype in prokaryotic organisms, nucleic acids encoding these repressor proteins, methods for identifying and preparing these proteins, and methods for using these proteins for regulating gene expression in prokaryotic organisms, in drug screening assays and for identifying non-antibiotic compounds that are specific inducers of these modified repressor proteins.

The present invention relates to a method for breeding chick of environment-friendly chick feed. According to the method, the worry about residues of antibiotics can be eliminated to improve the trust of consumers. In addition, the compost produced by chickens produced by feeding the non-antibiotic feed has good quality, and the environment will not be polluted because the critter manure with residual antibiotic will not be discharged. The invention provides an environment-friendly chick feed made by mixing Chinese medicinal materials without any antibiotic, simultaneously supplies the environment-friendly chick feed all together with anti-stress agents, digestive agents, high-content nutritional agents, vitamins, and garlic extracts. In addition, a circs for chicken maintenance, a circs that chick indicating symptoms of influenza, a circs of lowered immunity caused by bacilli diseases, and a circs of diarrhea due to bad digestion or enteritis are divided, and then suitable feeds are respectively supplied.

The invention discloses a non-antibiotic sucking pig milk replacer, which comprises various raw materials as follows: puffed corn, puffed soybean, plasma protein powder, steamed fish meal, soybean protein concentrate, low protein whey powder, lactose, fermented soybean meal, glucose, cane sugar, salt, anti-oxidant, lysine, threonine, methionine, tryptophan, zinc oxide, butyrin, microecology preparation, compound acidifying agent, compound enzyme preparation, compound vitamin premix and compound mineral matter premix. The invention employs synergism between butyrin, zinc oxide, acidifying agent and microecology preparation, and in the prerequisite that the antibiotics are not used, the product can help pigling to realize early stage weaning and get rid of weaning stress, and adjust sucking pig gastrointestinal tract health, control diarrhea, increase survival rate, and comprehensively improve immunity and disease resistance of sucking pig.

The invention discloses a biological non-antibiotic complete feed for piglets and a preparation method thereof, and belongs to the technical field of animal feed. The invention solves the defects that current piglet feed rich in antibiotics destroys the intestine colony balance of piglets and reduces the piglet immunity. The feed comprises main ingredients of corn, extruded corn flour, dehulled soybean meal, wheat bran, degreased rice bran meal, peanut meal, germ meal and corn alcohol lees. The preparation method is as below: first fully stirring to mix stone powder, calcium hydrogen phosphate and salt into an additive semi-finished product, then adding corn and extruded corn powder, spraying oil for stirring granulation, so as to obtain biological non-antibiotic complete feed for piglets. The feed provided by the invention is mainly used for the piglets with yet incompletely developed immune system.

The invention provides a non-antibiotics compound feed for a suckling pig. The non-antibiotics compound feed comprises the following components in parts by weight: 430 to 450 parts of extruded corn, 80 to 90 parts of fermented soybean meal, 150 to 160 parts of expanded soybean meal, 150 to 180 parts of milk powder with high protein, 20 to 30 parts of plasma protein, 1 to 3 parts of yeast nucleotide, 40 to 50 parts of super steamed fish meal, 12 to 15 parts of monocalcium phosphate, 1.5 to 1.75 part of 50% choline, 25 to 30 parts of saccharose, 3 to 5 parts of composite acidifier, 5 to 8 parts of stone powder, 3 to 5 parts of 98.5% L-lysine, 2 to 3 parts of table salt, 1 to 1.5 part of threonine, 0.2 to 0.3 part of 98.5% DL-methionine, 0.5 part of multifunctional complex enzyme preparation, 0.4 part of decavitamin for pig, 0.25 part of antioxidant, 0.2 to 0.3 part of combined microecologics, 1 to 1.5 part of nanometer montmorillonite, 1 part of plant extract, and 2 parts of compound trace element.

This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.

A additive for the non-antibiotic compound feed is prepared from vegetative Chinese-medicinal materials, spirulina powder, oligoisomaltose, flixweed seed oil, composite vitamine and minerals. Its advantages are sure medical action, high gowth speed and high quality of meat.

The invention relates to a pure non-antibiotic feed additive, which is made by the following components with the weight ratio: 8 to 15 percent of yellow wine yeast, 8 to 15 percent of vinegar yeast, 8 to 15 percent of sauce yeast, 5 to 7 percent of yeast powders, 20 to 26 percent of glucoamylase, 5 to 7 percent of polygonum multiflorum thumb, 2 to 5 percent of garden anemone, 5 to 7 percent of spine date seeds, 5 to 7 percent of astragalus and 15 to 20 percent of coarse bran. The pure non-antibiotic feed additive has the advantages of simplicity, greenness, environmental protection, high efficiency, etc; wherein, medicines are acted with the yellow wine yeast, the vinegar yeast, the sauce yeast and the yeast under the synergism to exert the composition force to ensure that the live pigs grow well, and the immunity of the live pigs is greatly enhanced.

The invention discloses a feed special for a low-fat meat chicken without antibiotic, which consists of the following by weight percentage: 10-25 of lactobacillus fermented material and 75-90 of main material, wherein the lactobacillus fermented material consists of the following raw materials: cotton dregs, rapeseed dregs, bran, peanut meal, maize and lactobacillus fermented liquid; and the main material consists of the following raw materials: bean dregs, maize protein powder, maize flour stone dust, calcium hydrophosphate, orexin and growth promotion agents, flavoring agents and trace elements. 10-25 percent of the obtained lactobacillus fermented material is taken according to the percentage of the total weight of the feed for bagging, and 75-90 percent of the obtained main material is taken according to the percentage of the total weight of the feed for packing after bagging, thus the feed special for the meat chicken is prepared. The chicken fed by the feed which is prepared by uniformly mixing the lactobacillus fermented material and the main material have pork type meat quality, abundant muscles, less fat and high protein content, are inspected to have no chloromycetin, terramycin, aureomycin and sulfanilamide medicaments by the national meat product supervision and inspection center and completely reach a non-antibiotic standard and meet the requirement of food security of the European Union.

Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and / or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.

The invention relates to a solidified goat yogurt containing probiotics and a preparation method thereof, and main raw materials comprise non-antibiotic fresh goat milk, non-antibiotic goat milk powder, white sugar, streptococcus thermophilus, lactobacillus bulgaricus and lactobacillus casei. The product can improve the content of solid matters in the goat milk, realize the high solidification strength of the product and be difficult to produce the phenomenon of demulsification by adding the goat milk powder into the fresh goat milk. The solidified goat yogurt has the advantages of smooth surface, luster, smooth taste, mellow and thick milky scent and no goat flavor. The lactobacillus casei is simultaneously added, thereby being more conductive to regulating the intestinal health of human body.

A preparation method of additive-free normal-temperature yoghourt comprises the following steps: uniformly mixing 88-95% of pre-sterilized non-antibiotic milk, 4-8% of a sweetener and 1-2% of starch,homogenizing, and pasteurizing the homogenized liquid; cooling the sterilized mixed liquid, fermenting by adding a starter culture which accounts for 0.003-0.009 wt% of mass of the mixed liquid, and carrying out demulsification when acidity reaches 79-90 degree T; homogenizing and carrying out pipe sterilization, and cooling to 20-35 DGE C after sterilization to obtain the product. According to the normal-temperature yoghourt, mass content of total protein and fat is 2.5-3.0 wt%, mass content of carbohydrate is 6.6-11.8 wt%, acidity is 70-80 degree T, and viscosity is 500-700 cP. A burden sheet of a present normal-temperature fermented dairy product is simplified, the burdening of a product only takes 4-5 min, and no stabilizing agent is added. The product prepared in the invention has cream mouthfeel, is smooth and refreshing, and can be placed at normal temperature for 6 months. Microorganisms of the product accord with national standards within the shelf-life. The product has stableperformance and there is no layering or whey separating phenomenon.

The invention discloses a feed special for a low-fat meat duck without antibiotic and fishy smell, which consists of the following components by weight percentage: 10-25 of lactobacillus fermented material and 75-90 of main material, wherein the lactobacillus fermented material consists of the following raw materials: cotton dregs, rapeseed dregs, bran, peanut meal, maize and lactobacillus fermented liquid; and the main material consists of the following raw materials: bean dregs, maize protein powder, orexin and growth promotion agents, de-fishy agents, stone dust, calcium hydrophosphate, trace elements and maize flour. 10-25 percent of the obtained lactobacillus fermented material is taken according to the percentage of the total weight of the feed for bagging, and 75-90 percent of the obtained main material is taken according to the percentage of the total weight of the feed for packing after bagging, thus the feed special for the meat duck is prepared. The duck fed by the feed which is prepared by uniformly mixing the lactobacillus fermented material and the main material has pork type meat quality, abundant muscles, less fat and high protein content, is inspected to have no chloromycetin, terramycin, aureomycin and sulfanilamide medicaments by the national meat product supervision and inspection center and completely reaches a non-antibiotic standard and meets the requirement of food security of the European Union.

The invention relates to an emission reduction dry-type culture method for producing nonreactive pork. The method uses pig feeds, which contain feedstuff additive premix, and active water agent to feed the pigs. An organic adhesive layer is laid inside a pig shed. The active water agent contains natural plant extract and bacillus subtilis, and is drunk by the pigs through a leak protection and filtering water device arranged inside the pig shed. The feedstuff additive premix contains NSP enzyme, micro-ecological agent, plant extract and acidifier. The method can prevent the pigs from having intestinal bacteria and viral diseases and respiratory diseases, and reduce the discharge of fecaluria and living water, harmful gas produced by pig fecaluria and stench, and through which prevents the breeding of flies. At the same time of producing nonreactive port, the method can reduce the pollution caused by excreta.

The invention relates to a biological lysozyme compound preparation and a preparation method thereof. The preparation method comprises the following steps: dissolving lysozyme, amino acid, proteolytic enzyme, lysostaphin and peroxidase in water according to a certain proportion, transferring the mixed solution into a mixing tank, adding sorbitol, hydrated silica, aluminium hydroxide, glycerol, sodium lauroyl sarcosine, edible essence, cellulose gum, carrageenan, hydroxyethyl cellulose, sodium phytate, saccharin sodium, strontium chloride, trisodium phosphate, borneols, sodium borate, cinnabar, natrii sulfas exsiccatus and allantoin according to corresponding proportion, reacting for 47-49 h under a constant temperature condition of 38-42 DEG C to prepare the activated biological lysozyme compound preparation finished product. The biological lysozyme compound preparation belongs to a novel non-hormonic and non-antibiotic protein function preparation, has extremely great capacities of bacteriolyzing, reducing inflammation and enhancing immunity, and various effects of resisting various infections and promoting rehabilitation.

The invention relates to a non-antibiotic feed prepared by adding a mixture to a compound bacterium liquid and carrying out solid fermentation. The compound bacterium liquid is prepared by mixing 1-3 parts by weight of lactobacillus paracasei liquid, 1-3 parts by weight of aspergillus oryzae liquid and 1-3 parts by weight of candida utilis liquid. Compared with common pig feeds, the non-antibiotic feed has the advantages that the non-antibiotic feed is reasonable in compatibility, has obvious curative effects and can achieve the effect of obviously reducing the diarrhea rates of pigs; experiments prove that the non-antibiotic feed has special effects on improvement of diarrhea of pigs; without western medicines-antibiotics, the feed does not have toxic or side effect or drug resistance and is pollution-free.

Neurotherapeutically effective pharmaceutical compositions are described that include carboxypeptidase E inhibitors. One class of carboxypeptidase E inhibitors found to exhibit significant neurotropic activity are β-lactam compounds, particularly penam and cephem β-lactam antibiotics and non-antibiotic derivatives thereof.

The invention discloses microorganism fermented aquatic feed without antibiotics. The aquatic feed consists of microorganism fermentation culture, mineral trace elements, compound vitamin preparations, phagostimulant, bran, flour, fish meal, bean pulp, lecithin, fish oil, microecology water environment modifier and phytase. The microorganism fermented aquatic feed can significantly improve the immunity and the survival rate of aquatic livestock.

The invention discloses a growing rabbit non-antibiotic feed for Rex rabbit. The non-antibiotic feed comprises the following components: corn, extruded soybean, wheat middling, bran, bean pulp, clove, corn bran, rice bran and hull, rapeseed meal, pine needle meal, sawdust, DDGS (distillers dried grains with soluble), glucose, composite vitamin, calcium hydrophosphate, zeolite powder, methionine, lysine, edible salt, bilineurine, Kanghuasu, ferrous sulfate, manganese sulfate, copper sulfate, zinc oxide, potassium iodide, sodium selenite and cobalt dichloride. According to the growing rabbit non-antibiotic feed for Rex rabbit, antibiotics are not required to be added to the feed, so that the feed has good palatability, the disease resistance of the growing Rex rabbit can be strengthened, the intestinal development can be promoted, intestinal infection can be prevented, and the incidence rate of diarrhea and abdominal distention of the growing Rex rabbit can be reduced. The growing Rex rabbit is high in growing speed, and the fur and meat of the Rex fed by the feed are high in quality.

The invention discloses a Lac shuttle vector, comprising at least (a) a region which regulates a plasmid copy number; (b) an eukaryotic gene expression cassette, which comprises at least an eukaryotic gene transcriptional promoter sequence, a multiple cloning site and a transcriptional terminator sequence; (c) a lactic acid bacteria plasmid sequence, which comprises a plus origin of replication, and a nucleic acid sequence encoding for a protein which relates to the lactic acid bacteria plasmid replication; and (d) a non-antibiotic resistance selection gene and the promoter sequence thereof. The Lac shuttle vector features a non-antibiotic resistance gene as a selection marker, which is useful in pharmaceuticals and foods.

The invention belongs to the field of biological gene, disclosing the recombination and expression of a rotavirus Vp6 gene and Bacterium acidi lactic nonresistance expression vector and it is characterized in: digesting the cloning vector and vector taking thyA gene as a selection pressure using Sac I and KpnI, purifying and recovering, linking the products with T4 DNA ligase, transforming to thyA gene-deficient E. coli competence E. coli X13, culturing in the medium, and screening to obtain prokaryotic recombinant expression plasmid through growing functional redeem, inducing positive bacteria for expression using threonine to obtain high expression of the recombinant plasmid. Molecular weight of fusion protein is about 44.88 KD. Beneficial effects are: VP6 protein is RV-group-specific antigen, locating at the virus endoconch, occupying 51%of the virus particles. As VP6 mainly stimulates organism to generate mucosal immune antibody sIgA, it plays a very important role in the mucosal immune, thus advanced development of rotavirus Vp6 mediated gene oral mucosal immune genetically engineered vaccine has important significance.

The invention discloses a method of producing an organic milk, comprising: a) planting pasture grasses in an environment where three indexed, the soil, water quality and atmosphere all reach the specified requirements of organic standards, using organic fertilizers and using or not using biological pesticide in the planting course, and adopting biotechnology or physical technology to prevent insects or weed; the pasture grasses are as many as possible and adapt to the whether; the pasture grasses are grown from non-gene-modified seeds and germchits; b) using natural insemination method to breed or using non-gene-modified spermatic fluid to breed through artificial insemination; c) using scattered fences to breed; using mixed foodstuff in which the proportion of organic feedstuff is more than or equal to 95% and that of coarse fodder is more than or equal to 60% to feed cows; using non-antibiotic medicines to prevent and treat diseases; d) using low-temperature processing technique to process milk.

The invention relates to a novel compound and studies preparation and application of the compound. A preparation method of the compound comprises: enabling poly IC, at least one cationic stabilizing agent and soluble calcium salt to be in contact in a liquid reaction system, wherein the cationic stabilizing agent is a water soluble non-antibiotic amino compound, the molecular weight of the water soluble non-antibiotic amino compound is less than or equal to 5kDa, or the cationic stabilizing agent is a graft formed by the water soluble non-antibiotic amino compound and one or more of methoxy polyethylene glycol, polyethylene glycol, polyethyleneimine, folic acid and galactose. The viscosity and the molecular mass of the compound are moderate, the compound is used to make a drug conveniently, the chemical property of the compound is stable, and the compound is not easy to degrade after long-term storage, is safe to use, obviously strengthens the nonspecific immunoreaction of the body when used separately, fulfills the purposes of preventing and treating diseases, has better anti-tumor anti-virus antibacterial (superbacteria) effects when being used with other drugs, and is easy to beabsorbed by a patient.

The invention discloses an antibody against staphylococcal enterotoxin B and application thereof. The heavy chain of the antibody against staphylococcal enterotoxin B has variable regions CDR1, CDR2 and CDR3 of which the amino acid sequences are shown in SEQ ID NO. 5, SEQ ID No. 6 and SEQ ID No. 7, or is composed of CDR variants with equivalent functions; and light chain of the antibody against staphylococcal enterotoxin B has variable regions CDR1, CDR2 and CDR3 of which the amino acid sequences are shown in SEQ ID NO. 9, SEQ ID No. 10 and SEQ ID No. 11, or is composed of CDR variants with equivalent functions. The antibody against staphylococcal enterotoxin B is capable of specifically binding with staphylococcal enterotoxin B or free enterotoxin B; and thus, the antibody can be used fortreating, preventing and diagnosing staphylococcus aureus infection. Therefore, the antibody against staphylococcal enterotoxin B will be an important research direction in the fields of "non-antibiotic" treatment of methicillin-resistant staphylococcus aureus infection and drug resistance development control.

The invention relates to a non-antibiotic cow feed containing Chinese herbal medicine additives, and belongs to the field of animal feeds. The feed solves the problems that the physique of cows is poor and milk production amount and milk production quality cannot be ensured due to the existing feeds. The feed is prepared from the following raw materials in parts by weight: 30-40 parts of corn, 5-15 parts of wheat, 10-20 parts of cottonseed meal, 20-30 parts of soybean meal, 5-15 parts of bean dregs, 3-12 parts of bran, 3-10 parts of vegetable oil, 5-10 parts of stone powder, 0.5-1 part of table salt, 0.5 part of premix, and 3 parts of Chinese herbal medicine additives. The non-antibiotic cow feed disclosed by the invention does not contain chemical additives such as hormones and antibiotics and is comprehensive in nutrition and rich in protein. The feed is easy for cows to digest and absorb, the organism immunity of the cows can be enhanced, the milk production amount can be increased, and the milk quality can be improved.

The invention discloses a non-antibiotics functional concentrated feed for sows during gestation. The feed mainly comprises flaked barley, alfalfa, tofu skin, sugar beet pulp, phytase, NSP enzyme, glucose oxidase, NCG, flaxseed oil, VC, organic trace elements, a cortex eucommiae extract and yeast cell walls. By virtue of intestinal microecology nutrition and disease-resistant nutrition, intestinal digestive systems of the sows are kept healthy, the autoimmunity of the sows is improved, and the purpose of no antibiotics is achieved; in addition, by virtue of adding high-quality feed raw materials and screening placenta nutrients, the fetal growth and development can be promoted, embryo losses are reduced, and the primary uniformity and vitality of piglets are improved.

The invention relates to a novel compound, and researches the preparation, application and other aspects of the compound. The compound is prepared from at least the following components under suitableconditions: polyinosinic cells, cationic stabilizers and soluble calcium salts, wherein, the cationic stabilizer is a non-antibiotic amino compound with a molecular weight less than or equal to 5 kilodalton or a graft formed by the non-antibiotic amino compound and one or more of polyethylene glycol monomethyl ether, polyethylene glycol, polyethyleneimine, folic acid and galactose. The compound has moderate viscosity and molecular mass, convenient pharmacy, stable chemical properties, difficult degradation during long-term storage and safe use. The compound can significantly enhance the nonspecific immune response of the body when the compound is used alone to achieve the purpose of preventing and treating diseases, and has better anti-tumor, anti-virus and anti (super) bacteria functionswhen the compound is used in combination with other medicines and is easy to be absorbed by patients.

The invention discloses a weaned piglet non-antibiotics feed, which comprises a specific antibacterial peptide and a plant essential oil component and has the effects of improving body immunity of piglets, inhibiting reproduction of harmful bacteria, preventing diarrhea and increasing feed intake of the piglets. The feed can improve immunity and has the anti-bacterial, pest-killing and anti-oxidizing effects, can improve appetite of the piglet and improve digestion and absorption, effectively inhibits parasites, has antibacterial and mildew-proofing effects and can inhibit ulcer. The feed, by completely combining physiological properties of the weaned piglets, can effectively solve the problems of incomplete immune functions, poor disease resistance and high diarrhea incidence of the weaned piglet, etc., thereby increasing daily weight gain of the piglets. The feed can completely replace antibiotics, thereby ensuring intestinal health of the piglet. The feed is an ideal piglet feed.