The invention relates to anti-fatigue medicinal liquor capable of tonifying kidney yang, prepared from the following raw materials: buckwheat wine and the following Chinese herbal medicines: sealwort, American ginseng, Chinese date, peach kernel, cordyceps militaris, male silkworm chrysalis, bee milk and honey. According to the anti-fatigue medicinal liquor capable of tonifying kidney yang disclosed by the invention, the buckwheat wine can be fully used for invigorating blood circulation, carrying medicine and increase energy, the American ginseng is used for tonifying primordial qi and eliminating physical fatigue, the sealwort can tonify the liver and kidney and can support the healthy energy and encourage yang, the Chinese date can nourish blood and calm the nerves and can relieve fatigue, the peach kernel can invigorate blood circulation to remove blood stasis, can improve blood supply of the brain and can repair nerve injury, and the cordyceps militaris, male silkworm chrysalis and bee milk can invigorate kidney qi, add energy and encourage yang. The medicines are mutually matched, fatigue can be well eliminated, the kidney can be tonified, and yang can be encouraged, thus the medicinal liquor disclosed by the invention is applicable to men and women.