Application of Japanese climbing fern spore in preparing lead excretion medicines or health products
A technology of sea sand and health care products, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulas containing active ingredients.
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Embodiment 1
[0013] 50 healthy Kunming mice, clean grade, half male and half female, body weight 20±2g, divided into 5 groups, namely blank control group, lead-exposed model group, 3 decoctions of high, medium and low seaweed whole grass Dosage group, 10 rats in each group. Lead acetate was dissolved in distilled water and injected intraperitoneally at 40 mg / kg to establish a lead-exposed animal model in mice.
[0014] The water decoction of Haijinsha whole grass is prepared by conventional water decoction method and concentrated. The different dosage groups of the water decoction include high-dose group (9g / kg), middle-dose group (6g / kg), low-dose group (3g / kg), Each group was given the drug by intragastric administration, and the other groups were given the same amount of normal saline, and the experiment continued for 6 weeks. After the administration, take 40ul of blood from the right femoral vein of the mouse, put it into a covered plastic centrifuge tube filled with 0.36ml of 1% nit...
Embodiment 2
[0020] 50 healthy Kunming mice, clean grade, half male and half female, body weight 20±2g, divided into 5 groups, namely blank control group, lead-exposed model group, 3 decoctions of high, medium and low seaweed whole grass Dosage group, 10 rats in each group. Lead acetate was dissolved in distilled water and injected intraperitoneally at 40 mg / kg to establish a lead-exposed animal model in mice.
[0021] According to the same weight ratio, take Haijinsha powder (made by pulverizing mature spores and whole plants in the same weight ratio) and chrysanthemum, and prepare Haijinsha chrysanthemum water decoction by conventional water decoction method, concentrate, and administer by intragastric administration in each drug group, different Dosage groups include high-dose group (9g / kg), middle-dose group (6g / kg), and low-dose group (3g / kg) by intragastric administration respectively, and all the other groups are given equivalent normal saline by oral administration. 6 weeks. Afte...
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