Amorphous hydrocolloid dressing containing liposome and preparation method thereof

A liposome and hydrocolloid technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of not actively providing nutrition or active anti-inflammation and anti-exudation of drugs, long healing time, and single function, so as to promote Wound healing, non-toxic side effects, good effect

Active Publication Date: 2017-03-08
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the vast majority of these existing hydrogel dressings or hydrocolloid dressings only have the function of passively absorbing fluid and maintaining the microenvironment of the wound surface, resulting in a long healing time. The effect, the function is very single
[0004] There is no report about the liposome-containing amorphous hydrocolloid dressing

Method used

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  • Amorphous hydrocolloid dressing containing liposome and preparation method thereof
  • Amorphous hydrocolloid dressing containing liposome and preparation method thereof
  • Amorphous hydrocolloid dressing containing liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A liposome-containing amorphous hydrocolloid dressing consisting of the following raw materials:

[0041]

[0042]

[0043] Wherein, the liposome solution is an amino acid liposome solution, which is prepared as follows:

[0044] First weigh 10g of soybean lecithin and 6g of cholesterol and put them in a clean container, heat 161ml of processing water to 40°C, stir for 25min, and control the speed of the stirring paddle at 1500r / min to obtain the oil phase; then weigh 0.3ml of cysteine ​​hydrochloride g. Put 0.03g of tryptophan in a clean container, dissolve in 646ml of processing water, then add 0.4g of valine, 0.5g of isoleucine, 0.8g of leucine, 0.2g of lysine acetate, and 0.06 g, 0.09g of phenylalanine, 0.1g of threonine, 0.1g of arginine, 0.2g of glycine, and 0.05g of proline; then add in sequence vitamin A 0.03g, vitamin C 0.3g, vitamin E 0.4g, 0.1g of vitamin K, 200g of sodium alginate (sodium alginate), and finally 4g of potassium sorbate, stirred to diss...

Embodiment 2

[0053] A liposome-containing amorphous hydrocolloid dressing consisting of the following raw materials:

[0054]

[0055]

[0056] Wherein, the liposome solution is an amino acid liposome solution, which is prepared as follows:

[0057] First weigh 50g of soybean lecithin and 80g of cholesterol and put them in a clean container, heat 350ml of processing water to 90°C, stir for 300min, and control the speed of the stirring paddle at 6000r / min to obtain the oil phase; then weigh 1.2 g. Put 0.6g of tryptophan in a clean container, dissolve in 340ml of processing water, then add 1.3g of valine, 2g of isoleucine, 2.5g of leucine, 1.2g of lysine acetate, and 0.5g of methionine , phenylalanine 0.7g, threonine 0.6g, arginine 1.6g, glycine 2g, proline 0.3g; then add auxiliary materials vitamin A 2g, vitamin C 2g, vitamin E 3g, vitamin K 0.1g, Sodium alginate (sodium alginate) 65g, finally add 0.5g of ethylparaben, stir to make it dissolve and mix, and obtain the water phase; the...

Embodiment 3

[0066] A liposome-containing amorphous hydrocolloid dressing consisting of the following raw materials:

[0067]

[0068] Wherein, the liposome solution is an amino acid liposome solution, which is prepared as follows:

[0069] Dissolve 15mg of asiaticoside, 15mg of tea polyphenols, 5mg of each of the 12 kinds of amino acids (K, W, F, M, T, I, L, V, Y, R, Q, C) and 5mg of vitamin C in 5mL of purified water , to form an inner water phase; accurately weigh 1720mg of soybean lecithin, 160mg of cholesterol, dissolve them completely in 15mL of medical absolute ethanol, add 1.25mL of tea tree oil, and mix well to form a lipid phase; accurately weigh 275mg of asiaticoside, tea polyphenol 275mg, 120mg of each of the above amino acids, 115mg of vitamin C, dissolved in 75mL of purified water to form an outer water phase; in a 45°C water bath, first inject the inner water phase into the lipid phase for emulsification to form a W / O primary emulsion, and then Inject the primary emulsio...

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Abstract

The present invention discloses an amorphous hydrocolloid dressing containing liposome, and a preparation method thereof. The amorphous hydrocolloid dressing comprises the following raw materials by mass: 10-40% of a liposome solution, 2-10% of polyethylene glycol (PEG) having a molecular weight of more than 1000, 10-35% of propylene glycol, 0.1-2% of polyvinyl alcohol (PVA), 10-35% of glycerol, 15-50% of a high water-absorbing substance, 0.1-2% of an antibacterial agent, 0.1-2% of an antioxidant, and 0.1-2% of an anti-inflammatory and anti-seepage material. According to the present invention, the three-step operation comprising liposome solution modification and hydrocolloid matrix preparation, hydrocolloid water-absorbing base particle dispersion and hydrocolloid dressing forming is performed to prepare the amorphous hydrocolloid dressing; and the amorphous hydrocolloid dressing has characteristics of good effect, rapid effect, no toxic-side effect, active anti-seepage effect, active antibacterial function, and healing promoting.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a liposome-containing amorphous hydrocolloid dressing, and also relates to a preparation method of the liposome-containing amorphous hydrocolloid dressing. Background technique [0002] Wound dressings can be divided into primary and secondary dressings, absorbent dressings, non-stick dressings, occlusive dressings or semi-occlusive dressings, hydrophilic or hydrophobic dressings, hydrocolloid dressings or hydrogel dressings, and absorbable dressings according to their functions. And the 8 categories of medicated dressings. [0003] At present, most of the dressings used for the treatment of exudative wounds are hydrogel dressings or hydrocolloid dressings. However, the vast majority of these existing hydrogel dressings or hydrocolloid dressings only have the function of passively absorbing fluid and maintaining the microenvironment of the wound surface, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/24A61L15/44A61L15/42
Inventor 黄昌平陈阶华德洪赵宁宁
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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